ATE484517T1 - Höhe konstitutive produktion von anthrax oberflächenschutzantigen - Google Patents
Höhe konstitutive produktion von anthrax oberflächenschutzantigenInfo
- Publication number
- ATE484517T1 ATE484517T1 AT01274653T AT01274653T ATE484517T1 AT E484517 T1 ATE484517 T1 AT E484517T1 AT 01274653 T AT01274653 T AT 01274653T AT 01274653 T AT01274653 T AT 01274653T AT E484517 T1 ATE484517 T1 AT E484517T1
- Authority
- AT
- Austria
- Prior art keywords
- cells
- anthrax
- coli
- followed
- surface protection
- Prior art date
Links
- 241000193738 Bacillus anthracis Species 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 241000588724 Escherichia coli Species 0.000 abstract 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 abstract 2
- 239000004202 carbamide Substances 0.000 abstract 2
- 241000620209 Escherichia coli DH5[alpha] Species 0.000 abstract 1
- 101150105115 PA gene Proteins 0.000 abstract 1
- 101710194807 Protective antigen Proteins 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 abstract 1
- 230000009089 cytolysis Effects 0.000 abstract 1
- 238000003936 denaturing gel electrophoresis Methods 0.000 abstract 1
- 239000013613 expression plasmid Substances 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000003306 harvesting Methods 0.000 abstract 1
- 239000006228 supernatant Substances 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
- 238000001262 western blot Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Aiming, Guidance, Guns With A Light Source, Armor, Camouflage, And Targets (AREA)
- Laminated Bodies (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1127DE2001 IN190590B (de) | 2001-11-05 | 2001-11-05 | |
| PCT/IN2001/000215 WO2003040179A1 (en) | 2001-11-05 | 2001-12-07 | High level constitutive production of anthrax protective antigen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE484517T1 true ATE484517T1 (de) | 2010-10-15 |
Family
ID=11097131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01274653T ATE484517T1 (de) | 2001-11-05 | 2001-12-07 | Höhe konstitutive produktion von anthrax oberflächenschutzantigen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7329513B2 (de) |
| EP (1) | EP1442052B1 (de) |
| JP (1) | JP2005510215A (de) |
| CN (1) | CN100347189C (de) |
| AT (1) | ATE484517T1 (de) |
| BR (1) | BRPI0117173A2 (de) |
| CA (1) | CA2465679A1 (de) |
| DE (1) | DE60143276D1 (de) |
| IL (1) | IL161725A0 (de) |
| IN (1) | IN190590B (de) |
| MX (1) | MXPA04004281A (de) |
| RU (1) | RU2288272C2 (de) |
| UA (1) | UA80809C2 (de) |
| WO (1) | WO2003040179A1 (de) |
| ZA (1) | ZA200403396B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA80809C2 (en) * | 2001-11-05 | 2007-11-12 | Process for preparation of protective antigen protein of anthracis with e.coli | |
| AU2004272972A1 (en) | 2003-05-22 | 2005-03-24 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| AU2003271835A1 (en) * | 2003-06-06 | 2005-01-04 | Avecia Limited | Process for the separation of proteins |
| US20060246079A1 (en) * | 2003-11-14 | 2006-11-02 | Morrow Phillip R | Neutralizing human antibodies to anthrax toxin |
| WO2005081749A2 (en) * | 2004-01-23 | 2005-09-09 | Avanir Pharmaceuticals, Inc. | Neutralizing human antibodies to anthraxtoxin |
| US7355027B2 (en) | 2004-06-16 | 2008-04-08 | Dynport Vaccine Company Llc | Bacillus anthracis protective antigen |
| US8101735B2 (en) | 2004-06-16 | 2012-01-24 | Health Protection Agency | Preparation of protective antigen |
| CN100336908C (zh) * | 2004-09-10 | 2007-09-12 | 中国人民解放军军事医学科学院微生物流行病研究所 | 一种制备重组炭疽保护性抗原的方法及其专用表达质粒 |
| EP1919504B1 (de) | 2005-08-03 | 2013-10-16 | iBio, Inc. | Antikörper gegen bacillus anthracis protektiv antigen |
| US8277816B2 (en) * | 2006-02-13 | 2012-10-02 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
| AU2007215080A1 (en) | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Influenza antigens, vaccine compositions, and related methods |
| GB0607462D0 (en) * | 2006-04-13 | 2006-05-24 | Avecia Ltd | Assay |
| EP2021021A2 (de) * | 2006-05-12 | 2009-02-11 | Oklahoma Medical Research Foundation | Anthrax-zusammensetzungen und verfahren zu ihrer herstellung und anwendung |
| EP2264143A3 (de) | 2006-06-30 | 2012-03-07 | University Of Georgia Research Foundation, Inc. | Anthrax-Kohlenhydrate sowie Synthese und Verwendungen davon |
| US8420607B2 (en) | 2006-06-30 | 2013-04-16 | University Of Georgia Research Foundation, Inc. | Anthrax carbohydrates, synthesis and uses thereof |
| US8404252B2 (en) | 2007-07-11 | 2013-03-26 | Fraunhofer Usa, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| WO2009126355A2 (en) * | 2008-01-28 | 2009-10-15 | Baxter International, Inc. | Methods of increasing recombinant production of bacillus anthracis protective antigen |
| WO2010037046A1 (en) | 2008-09-28 | 2010-04-01 | Fraunhofer Usa, Inc. | Humanized neuraminidase antibody and methods of use thereof |
| JP5701760B2 (ja) * | 2008-10-02 | 2015-04-15 | ファーマシーネ，インコーポレイテッド | 炭疽菌ワクチン製剤とその用途 |
| US20100183675A1 (en) * | 2009-01-22 | 2010-07-22 | Allan Watkinson | Stable vaccine compositions and methods of use |
| EP2483307A1 (de) | 2009-09-29 | 2012-08-08 | Fraunhofer USA, Inc. | Influenza-hämagglutinin-antikörper, zusammensetzungen daraus und zugehörige verfahren |
| US20120301951A1 (en) * | 2010-11-18 | 2012-11-29 | E. I. Du Pont De Nemours And Company | Prevention of contamination of nutrient feed reservoirs & feed lines in bioreactor systems |
| RU2633508C1 (ru) * | 2016-12-27 | 2017-10-12 | Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук (ФИЦ Биотехнологии РАН) | Штамм E. coli - продуцент изолированного домена 1 протективного антигена Bacillus anthracis в форме вирусоподобных частиц |
| RU2633504C1 (ru) * | 2016-12-27 | 2017-10-12 | Федеральное государственное учреждение "Федеральный исследовательский центр "Фундаментальные основы биотехнологии" Российской академии наук (ФИЦ Биотехнологии РАН) | Штамм E.coli - продуцент полноразмерного протективного антигена Bacillus anthracis в форме вирусоподобных частиц |
| CN115125224B (zh) * | 2022-08-11 | 2023-07-18 | 福州大学 | 一种可规模化生产具有活性的dna聚合酶的方法 |
| CN117093572A (zh) * | 2023-08-24 | 2023-11-21 | 中国建设银行股份有限公司 | 数据补录方法、装置、设备、存储介质及产品 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591631A (en) * | 1993-02-12 | 1997-01-07 | The United States Of America As Represented By The Department Of Health And Human Services | Anthrax toxin fusion proteins, nucleic acid encoding same |
| US5677274A (en) * | 1993-02-12 | 1997-10-14 | The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Anthrax toxin fusion proteins and related methods |
| US5800821A (en) * | 1995-03-10 | 1998-09-01 | New England Medical Center Hospitals, Inc. | Bacterial spores as a heat stable vaccine delivery system |
| GB9618107D0 (en) * | 1996-08-30 | 1996-10-09 | Secr Defence | Vaccine production |
| AU3550599A (en) * | 1998-04-07 | 1999-10-25 | Wisconsin Alumni Research Foundation | Enterotoxin-deficient bacillus |
| US20020086032A1 (en) * | 1999-02-02 | 2002-07-04 | Mahan Michael J. | Producing antibodies with attenuated bacteria with altered DNA adenine methylase activity |
| AU2002365262A1 (en) * | 2001-10-01 | 2003-07-15 | Ethan Bier | A method for generating overexpression of alleles in genes of unknown function |
| UA80809C2 (en) * | 2001-11-05 | 2007-11-12 | Process for preparation of protective antigen protein of anthracis with e.coli | |
| US7763451B2 (en) * | 2001-11-09 | 2010-07-27 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for preparing Bacillus anthracis protective antigen for use in vaccines |
-
2001
- 2001-07-12 UA UA20040503327A patent/UA80809C2/uk unknown
- 2001-11-05 IN IN1127DE2001 patent/IN190590B/en unknown
- 2001-12-07 MX MXPA04004281A patent/MXPA04004281A/es not_active Application Discontinuation
- 2001-12-07 BR BRPI0117173A patent/BRPI0117173A2/pt not_active IP Right Cessation
- 2001-12-07 CN CNB018239226A patent/CN100347189C/zh not_active Expired - Fee Related
- 2001-12-07 IL IL16172501A patent/IL161725A0/xx unknown
- 2001-12-07 US US10/494,680 patent/US7329513B2/en not_active Expired - Fee Related
- 2001-12-07 CA CA002465679A patent/CA2465679A1/en not_active Abandoned
- 2001-12-07 RU RU2004117085/13A patent/RU2288272C2/ru not_active IP Right Cessation
- 2001-12-07 JP JP2003542224A patent/JP2005510215A/ja active Pending
- 2001-12-07 WO PCT/IN2001/000215 patent/WO2003040179A1/en not_active Ceased
- 2001-12-07 EP EP01274653A patent/EP1442052B1/de not_active Expired - Lifetime
- 2001-12-07 AT AT01274653T patent/ATE484517T1/de not_active IP Right Cessation
- 2001-12-07 DE DE60143276T patent/DE60143276D1/de not_active Expired - Lifetime
-
2004
- 2004-05-05 ZA ZA200403396A patent/ZA200403396B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IN190590B (de) | 2003-08-09 |
| IL161725A0 (en) | 2005-11-20 |
| HK1072610A1 (zh) | 2005-09-02 |
| BRPI0117173A2 (pt) | 2018-04-17 |
| CA2465679A1 (en) | 2003-05-15 |
| EP1442052A1 (de) | 2004-08-04 |
| WO2003040179A1 (en) | 2003-05-15 |
| EP1442052B1 (de) | 2010-10-13 |
| US20050054038A1 (en) | 2005-03-10 |
| DE60143276D1 (de) | 2010-11-25 |
| US7329513B2 (en) | 2008-02-12 |
| ZA200403396B (en) | 2005-08-05 |
| MXPA04004281A (es) | 2005-03-31 |
| CN100347189C (zh) | 2007-11-07 |
| CN1582298A (zh) | 2005-02-16 |
| UA80809C2 (en) | 2007-11-12 |
| RU2288272C2 (ru) | 2006-11-27 |
| JP2005510215A (ja) | 2005-04-21 |
| RU2004117085A (ru) | 2005-03-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE484517T1 (de) | Höhe konstitutive produktion von anthrax oberflächenschutzantigen | |
| Reif et al. | Semisynthesis of biologically active glycoforms of the human cytokine interleukin 6 | |
| CY1110494T1 (el) | Μεταστροφες μεταβολικου ρυθμου σε ζυμωσεις που εκφραζουν ανασυνδυασμενες πρωτεϊνες | |
| CA2417415A1 (en) | Expression of biologically active polypeptides in duckweed | |
| EP0737747A3 (de) | Cytoplasmatische Expression von Antikörpern, Antikörperfragmenten und Antikörperfragment-Fusionsmolekülen in E. coli | |
| Saunders et al. | Heterologous gene expression in filamentous fungi | |
| NZ508863A (en) | Generation of multiple gene products from chimeric fusion proteins by cleavage with ubiquitous endoproteases | |
| CN102533839B (zh) | 融合表达含有二硫键蛋白质的方法 | |
| CN102659928A (zh) | 一种人工合成的信号肽及其应用 | |
| Kawasaki et al. | Folding-Dependentin VitroProtein Splicing of theSaccharomyces cerevisiae VMA1Protozyme | |
| KR100614020B1 (ko) | 폴리펩티드의 재조합 생산을 위한 향상된 방법 | |
| DE69634137D1 (de) | Protein mit pflanzenschützenden eigenschaften | |
| CN101921315B (zh) | 一种人工合成的信号肽及其应用 | |
| CA2082802C (en) | Method for expressing polypeptides in cyanobacteria | |
| CN103483423A (zh) | 一种人工合成的信号肽及其应用 | |
| Kunes et al. | Expression of antibodies using single‐open reading frame vector design and polyprotein processing from mammalian cells | |
| Qin et al. | Genomic cloning, expression and recombinant protein purification of α and β subunits of the allophycocyanin gene (apc) from the cyanobacterium Anacystis nidulans UTEX 625 | |
| ATE201903T1 (de) | Peptide-familie, genannt xenoxine | |
| Schendel | Overview of Protein Expression in E. coli | |
| RU94046397A (ru) | Линия клеток млекопитающих, композиция, способы получения и очистки полипептида | |
| Palma et al. | Expression and Purification of a Tuber borchii Fruitbody‐Specific Protein, TBF‐1, from Escherichia coli: Generation of Polyclonal Antibodies | |
| CN104059128B (zh) | 一种人工合成的信号肽及其应用 | |
| RU2315105C1 (ru) | ШТАММ ДРОЖЖЕЙ PICHIA PASTORIS PS107(pPIC9HAbIL-2), ЯВЛЯЮЩИЙСЯ ПРОДУЦЕНТОМ ГИБРИДНОГО БЕЛКА, СОСТОЯЩЕГО ИЗ АЛЬБУМИНА ПЛАЗМЫ КРОВИ ЧЕЛОВЕКА И ИНТЕРЛЕЙКИНА-2 ЧЕЛОВЕКА, РЕКОМБИНАНТНАЯ ПЛАЗМИДА pPIC9HAbIL-2 И СПОСОБ ЕЕ КОНСТРУИРОВАНИЯ | |
| CN118325937A (zh) | 基于密码子优化的酵母表达系统表达Net1蛋白的方法 | |
| Nguyen et al. | Expression and purification of thioredoxin-his6-ZmDREB2. 7 fusion protein in Escherichia coli for raising antibodies |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |