ATE486093T1 - Antikörper, die spezifische für probnp(1-108) sind, und ihre verwendung zur diagnose von herzinfarkt - Google Patents

Antikörper, die spezifische für probnp(1-108) sind, und ihre verwendung zur diagnose von herzinfarkt

Info

Publication number
ATE486093T1
ATE486093T1 AT03756532T AT03756532T ATE486093T1 AT E486093 T1 ATE486093 T1 AT E486093T1 AT 03756532 T AT03756532 T AT 03756532T AT 03756532 T AT03756532 T AT 03756532T AT E486093 T1 ATE486093 T1 AT E486093T1
Authority
AT
Austria
Prior art keywords
pro
probnp
iii
ser
arg
Prior art date
Application number
AT03756532T
Other languages
English (en)
Inventor
Bernard Pau
Isabelle Giuliani
Francois Rieunier
Original Assignee
Bio Rad Pasteur
Centre Nat Rech Scient
Univ Montpellier I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Rad Pasteur, Centre Nat Rech Scient, Univ Montpellier I filed Critical Bio Rad Pasteur
Application granted granted Critical
Publication of ATE486093T1 publication Critical patent/ATE486093T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/58—Atrial natriuretic factor complex; Atriopeptin; Atrial natriuretic peptide [ANP]; Cardionatrin; Cardiodilatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT03756532T 2002-08-07 2003-08-07 Antikörper, die spezifische für probnp(1-108) sind, und ihre verwendung zur diagnose von herzinfarkt ATE486093T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0210063A FR2843396B1 (fr) 2002-08-07 2002-08-07 Anticorps specifiques pour le diagnostic de l'insuffisance cardiaque
PCT/FR2003/002483 WO2004014952A2 (fr) 2002-08-07 2003-08-07 Anticorps specifiques du probnp (1-108) pour le diagnostic de l'insuffisance cardiaque

Publications (1)

Publication Number Publication Date
ATE486093T1 true ATE486093T1 (de) 2010-11-15

Family

ID=30470996

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03756532T ATE486093T1 (de) 2002-08-07 2003-08-07 Antikörper, die spezifische für probnp(1-108) sind, und ihre verwendung zur diagnose von herzinfarkt

Country Status (12)

Country Link
US (1) US7553937B2 (de)
EP (1) EP1527101B1 (de)
JP (1) JP4576232B2 (de)
CN (1) CN100467489C (de)
AT (1) ATE486093T1 (de)
AU (1) AU2003282194B2 (de)
CA (1) CA2494140C (de)
DE (1) DE60334696D1 (de)
ES (1) ES2354608T3 (de)
FR (1) FR2843396B1 (de)
RU (1) RU2315773C2 (de)
WO (1) WO2004014952A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524635B2 (en) * 2003-04-17 2009-04-28 Biosite Incorporated Methods and compositions for measuring natriuretic peptides and uses thereof
AT500800B1 (de) * 2004-09-08 2008-07-15 Biomedica Medizinprodukte Gmbh Verfahren zur bestimmung von probnp
US7300494B2 (en) * 2005-02-24 2007-11-27 Hamilton Sundstrand Corporation On-board inert gas generation system with compressor surge protection
DE102007010834A1 (de) * 2007-03-03 2008-09-04 Brahms Aktiengesellschaft Diagnose und Risikostratifizierung von Herzinsuffizienz für NYHA I Patienten
AT504942B1 (de) 2007-03-07 2009-08-15 Biomedica Medizinprodukte Gmbh Verfahren zur bestimmung von probnp
WO2010012509A1 (en) * 2008-08-01 2010-02-04 Bio-Rad Pasteur Method for the in vitro diagnosis of stroke
FR2919611B1 (fr) 2007-08-03 2009-10-23 Bio Rad Pasteur Sa Nouvel epitope du bnp (1-32) et anticorps diriges contre cet epitope
EP2612867A1 (de) * 2007-11-01 2013-07-10 Perseid Therapeutics LLC Immunsuppressive Polypeptide und Nucleinsäuren
US9366680B2 (en) * 2008-08-28 2016-06-14 Shimadzu Corporation Method for evaluating myocardial ischemic state using blood sample
EP2376919B1 (de) * 2008-12-08 2015-04-29 Alere San Diego, Inc. Kombinierte natriuretische peptidtests
CA2751090A1 (en) * 2009-01-30 2010-08-05 Electrophoretics Limited Method for the in vitro diagnosis of stroke
JP5362487B2 (ja) * 2009-08-27 2013-12-11 塩野義製薬株式会社 ｐｒｏＢＮＰ−１０８の新規用途
EP2478367B2 (de) 2009-09-14 2018-04-04 Koninklijke Philips N.V. Hochsensitiver Immunoassay mit grossen Partikelmarkern
US20120021431A1 (en) * 2010-02-25 2012-01-26 Toshio Nishikimi Diagnostic methods using bnp
US8778699B2 (en) 2010-08-04 2014-07-15 Idexx Laboratories, Inc. Detection of degradation products of canine NT-proBNP
US8407182B1 (en) 2011-01-21 2013-03-26 Symantec Corporation Systems and methods for facilitating long-distance live migrations of virtual machines
US8527990B1 (en) 2011-04-29 2013-09-03 Symantec Corporation Systems and methods for migrating virtual machines
AU2012262154B2 (en) 2011-05-31 2016-08-04 Idexx Laboratories, Inc. Detection of degradation products of feline NT-proBNP
CN102887943B (zh) * 2012-08-30 2016-08-03 重庆业为基生物科技有限公司 氨基末端脑钠肽的b细胞表位肽段及其应用
CN103012595B (zh) * 2012-12-17 2014-05-21 同昕生物技术（北京）有限公司 稳定的NT-proBNP校准品及应用
RU2569459C1 (ru) * 2014-12-02 2015-11-27 Федеральное государственное бюджетное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения России (ФГБУ "РКНПК" МЗ РФ) Способ дифференциальной диагностики этиологии хронической сердечной недостаточности
RU2569458C1 (ru) * 2014-12-02 2015-11-27 Федеральное государственное бюджетное учреждение "Российский кардиологический научно-производственный комплекс" Министерства здравоохранения России (ФГБУ "РКНПК" МЗ РФ) Способ диагностики хронической сердечной недостаточности путем использования циркулирующих уровней микрорнк
US11867696B2 (en) * 2015-02-06 2024-01-09 Cell Idx, Inc. Antigen-coupled immunoreagents
US10368774B2 (en) 2015-07-30 2019-08-06 Medtronic, Inc. Absolute intrathoracic impedance based scheme to stratify patients for risk of a heart failure event
CN105349545A (zh) * 2015-12-14 2016-02-24 中国人民解放军军事医学科学院基础医学研究所 一种NT-proBNP核酸适配体及其应用
US11931207B2 (en) 2018-12-11 2024-03-19 Eko.Ai Pte. Ltd. Artificial intelligence (AI) recognition of echocardiogram images to enhance a mobile ultrasound device
US12400762B2 (en) 2018-12-11 2025-08-26 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and diagnosis of cardiac amyloidosis and hypertrophic cardiomyopathy
US11446009B2 (en) 2018-12-11 2022-09-20 Eko.Ai Pte. Ltd. Clinical workflow to diagnose heart disease based on cardiac biomarker measurements and AI recognition of 2D and doppler modality echocardiogram images
US12001939B2 (en) 2018-12-11 2024-06-04 Eko.Ai Pte. Ltd. Artificial intelligence (AI)-based guidance for an ultrasound device to improve capture of echo image views
US12322100B2 (en) 2018-12-11 2025-06-03 Eko.Ai Pte. Ltd. Automatic clinical workflow that recognizes and analyzes 2D and doppler modality echocardiogram images for automated cardiac measurements and grading of aortic stenosis severity
CN109678958B (zh) * 2019-01-31 2022-03-18 重庆探生科技有限公司 一种人NT-proBNP特异性重组羊单克隆抗体及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211686D0 (en) * 1992-06-03 1992-07-15 Medisinsk Innovation A S Chemical compounds
AU1172495A (en) * 1993-11-05 1995-05-23 Centocor Inc. Platelet-specific chimeric immunoglobulin and methods of use therefor
DE69733560T2 (de) * 1996-03-04 2006-05-11 Scios Inc., Fremont TESTVERFAHREN UND REAGENZIEN ZUR QUANTIFIZIERUNG VON hBNP
ES2256952T3 (es) * 1997-09-11 2006-07-16 SHIONOGI & CO., LTD. Inmunoanalisis para bnp.
US6117644A (en) * 1998-06-04 2000-09-12 Ottawa Heart Institute Research Corporation Predicting and detecting cardiac allograft rejection
GB9827348D0 (en) * 1998-12-12 1999-02-03 Univ Leicester Natriuretic peptide
PL204235B1 (pl) * 1999-01-29 2009-12-31 Roche Diagnostics Gmbh Sposób wykrywania natywnego N-końcowego proBNP, zastosowanie tego sposobu, zastosowanie zrekombinowanego N-końcowego proBNP, przeciwciała przeciw zrekombinowanemu N-końcowemu proBNP, linie komórkowe i sposoby wytwarzania przeciwciał poliklonalnych i monoklonalnych
AUPS169202A0 (en) * 2002-04-11 2002-05-16 Goetze, Jens Peter Neuropeptide assay
US7341838B2 (en) * 2003-04-17 2008-03-11 Biosite Incorporated Polypeptides related to natriuretic peptides and methods of their identification and use
CN100497393C (zh) * 2003-05-12 2009-06-10 霍夫曼-拉罗奇有限公司 用结合脑钠尿肽前体分子氨基酸41-46的单克隆抗体检测脑钠尿肽前体分子的方法
DE10355731A1 (de) * 2003-11-28 2005-06-30 Roche Diagnostics Gmbh Analytischer Sandwichtest zur Bestimmung von NT-proBNP

Also Published As

Publication number Publication date
CN100467489C (zh) 2009-03-11
JP2006514609A (ja) 2006-05-11
ES2354608T3 (es) 2011-03-16
AU2003282194B2 (en) 2008-10-30
US20070299016A1 (en) 2007-12-27
CN1678635A (zh) 2005-10-05
AU2003282194A1 (en) 2004-02-25
WO2004014952A2 (fr) 2004-02-19
DE60334696D1 (de) 2010-12-09
RU2315773C2 (ru) 2008-01-27
FR2843396A1 (fr) 2004-02-13
JP4576232B2 (ja) 2010-11-04
FR2843396B1 (fr) 2005-04-15
WO2004014952A3 (fr) 2004-04-08
CA2494140A1 (fr) 2004-02-19
US7553937B2 (en) 2009-06-30
EP1527101B1 (de) 2010-10-27
EP1527101A2 (de) 2005-05-04
CA2494140C (fr) 2011-11-01
RU2005106230A (ru) 2005-10-10

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