ATE440888T1 - Verfahren zur herstellung von glatiramer - Google Patents
Verfahren zur herstellung von glatiramerInfo
- Publication number
- ATE440888T1 ATE440888T1 AT05824006T AT05824006T ATE440888T1 AT E440888 T1 ATE440888 T1 AT E440888T1 AT 05824006 T AT05824006 T AT 05824006T AT 05824006 T AT05824006 T AT 05824006T AT E440888 T1 ATE440888 T1 AT E440888T1
- Authority
- AT
- Austria
- Prior art keywords
- glatiramer
- producing
- producing glatiramer
- Prior art date
Links
- YLOCGHYTXIINAI-XKUOMLDTSA-N (2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 YLOCGHYTXIINAI-XKUOMLDTSA-N 0.000 title 1
- 108010072051 Glatiramer Acetate Proteins 0.000 title 1
- 229940042385 glatiramer Drugs 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polyamides (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62334604P | 2004-10-29 | 2004-10-29 | |
| US65153505P | 2005-02-09 | 2005-02-09 | |
| US65137205P | 2005-02-09 | 2005-02-09 | |
| US72390105P | 2005-10-05 | 2005-10-05 | |
| PCT/US2005/039003 WO2006050122A1 (en) | 2004-10-29 | 2005-10-27 | Processes for preparing glatiramer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE440888T1 true ATE440888T1 (de) | 2009-09-15 |
Family
ID=36046637
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05824006T ATE440888T1 (de) | 2004-10-29 | 2005-10-27 | Verfahren zur herstellung von glatiramer |
Country Status (14)
| Country | Link |
|---|---|
| US (5) | US20060154862A1 (de) |
| EP (1) | EP1807467B1 (de) |
| JP (1) | JP5297653B2 (de) |
| CN (1) | CN101044188B (de) |
| AR (1) | AR052321A1 (de) |
| AT (1) | ATE440888T1 (de) |
| AU (1) | AU2005302500B2 (de) |
| CA (1) | CA2583589C (de) |
| DE (1) | DE602005016292D1 (de) |
| ES (1) | ES2331015T3 (de) |
| IL (2) | IL182581A (de) |
| SI (1) | SI1807467T1 (de) |
| TW (1) | TWI307349B (de) |
| WO (1) | WO2006050122A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1459065B1 (de) | 2001-12-04 | 2010-07-28 | Teva Pharmaceutical Industries, Ltd. | Verfahren zur messung der wirkstärke von glatirameracetat |
| HRP20160455T1 (hr) | 2004-09-09 | 2016-07-15 | Yeda Research And Development Co., Ltd. | Smjese polipeptida, sastavi koji ih sadrže i postupci za njihovu pripremu, te njihove primjene |
| DE602005016292D1 (de) * | 2004-10-29 | 2009-10-08 | Sandoz Ag | Verfahren zur herstellung von glatiramer |
| US20070161566A1 (en) * | 2006-01-11 | 2007-07-12 | Teva Pharmaceutical Industries, Ltd. | Method of treating multiple sclerosis |
| SI2046817T1 (sl) * | 2006-07-05 | 2010-04-30 | Momenta Pharmaceuticals Inc | Izboljšani postopek za pripravo kopolimera-1 |
| ES2477232T5 (es) | 2007-06-21 | 2017-11-23 | Momenta Pharmaceuticals, Inc. | Análisis de copolímeros |
| US20090035816A1 (en) * | 2007-08-02 | 2009-02-05 | Scinopharm Taiwan Ltd. | Process for the preparation of a polypeptide |
| ES2449865T5 (es) | 2008-04-16 | 2022-11-18 | Momenta Pharmaceuticals Inc | Análisis de composiciones de copolímeros de aminoácidos |
| PL2307448T3 (pl) | 2008-08-07 | 2015-10-30 | Sigma Aldrich Co Llc | Wytwarzanie polilizyny i poliornityny o małym ciężarze cząsteczkowym z wysoką wydajnością |
| KR20110059606A (ko) * | 2008-08-07 | 2011-06-02 | 시노팜 타이완 리미티드 | 글라티라머 아세테이트의 합성 |
| AR074881A1 (es) | 2008-12-24 | 2011-02-16 | Synthon Bv | Un proceso para purificar una mezcla de polimeros |
| RU2011144566A (ru) | 2009-04-03 | 2013-05-10 | Момента Фармасьютикалз, Инк. | Контроль сополимерных композиций |
| PT2275086E (pt) | 2009-07-15 | 2012-05-18 | Teva Pharma | Formulação de volume reduzido de acetato de glatirâmero e métodos de administração |
| US8920373B2 (en) | 2009-07-15 | 2014-12-30 | Teva Pharmaceutical Industries, Ltd. | Reduced volume formulation of glatiramer acetate and methods of administration |
| RS55607B1 (sr) | 2009-08-20 | 2017-06-30 | Yeda Research & Development Company Ltd | Niskofrekventna terapija glatiramer acetatom |
| MX2012005749A (es) * | 2009-11-17 | 2012-10-03 | Ares Trading Sa | Metodos para mejorar el diseño, la biodisponibilidad de composiciones de polimero de secuencia dirigida, por medio de la deteccion basada en proteinas del suero, de composiciones de polimero de secuencia dirigida. |
| USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
| US8759302B2 (en) | 2010-03-16 | 2014-06-24 | Teva Pharmaceutical Industries, Ltd. | Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis |
| MX2012012489A (es) * | 2010-04-27 | 2012-12-17 | Reddys Lab Ltd Dr | Preparacion de polipeptidos y sales de los mismos. |
| JP2013535474A (ja) * | 2010-07-29 | 2013-09-12 | ドクター レディズ ラボラトリーズ リミテッド | グラチラマー酢酸塩の分子量マーカー |
| EA025780B1 (ru) | 2010-10-11 | 2017-01-30 | Тева Фармасьютикал Индастриз Лтд. | Цитокиновые биомаркеры в качестве биомаркеров, прогнозирующих клинический ответ на глатирамер ацетат |
| ES2654291T3 (es) | 2011-02-14 | 2018-02-13 | Usv Private Limited | Copolímero-1, proceso para la preparación y sus métodos de análisis |
| WO2012114167A1 (en) * | 2011-02-24 | 2012-08-30 | Biocon Limited | Processes for the preparation of glatiramer acetate |
| WO2013009864A1 (en) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Structure assessment of heterogeneous polypeptide mixtures |
| WO2013009885A2 (en) | 2011-07-11 | 2013-01-17 | Momenta Pharmaceuticals, Inc. | Evaluation of copolymer diethylamide |
| US8575198B1 (en) | 2011-09-07 | 2013-11-05 | Momenta Pharmaceuticals, Inc. | In-process control for the manufacture of glatiramer acetate |
| MX2014004309A (es) | 2011-10-10 | 2015-07-06 | Teva Pharma | Polimorfismos de nucleotidos individuales utiles para predecir una respuesta clinica para el acetato de glatiramer. |
| AU2012330728A1 (en) * | 2011-11-03 | 2014-06-26 | Biocon Limited | Process for the preparation of random polypeptides and employing circular dichroism as a guidance tool for the manufacture of glatiramer acetate |
| US20140045740A1 (en) * | 2012-08-13 | 2014-02-13 | Momenta Pharmaceuticals, Inc. | Analysis of glatiramer acetate |
| US9155775B1 (en) | 2015-01-28 | 2015-10-13 | Teva Pharmaceutical Industries, Ltd. | Process for manufacturing glatiramer acetate product |
| WO2017165664A1 (en) | 2016-03-23 | 2017-09-28 | A.L.M Holding Company | Batch asphalt mix plant |
| US12097292B2 (en) | 2016-08-28 | 2024-09-24 | Mapi Pharma Ltd. | Process for preparing microparticles containing glatiramer acetate |
| AU2017319728B2 (en) | 2016-08-31 | 2024-09-05 | Mapi Pharma Ltd | Depot systems comprising glatiramer acetate |
| IL316573A (en) | 2017-03-26 | 2024-12-01 | Mapi Pharma Ltd | Storage systems containing glatiramer acetate for the treatment of multiple sclerosis |
| CN107082796B (zh) * | 2017-05-02 | 2020-06-09 | 江苏大学 | 一种提纯蛋白酶解物中小分子多肽的方法 |
| GB2579600B (en) | 2018-12-05 | 2023-07-05 | Byotrol Plc | Anti-viral composition |
| AU2020298486B2 (en) | 2019-07-01 | 2025-03-27 | A.L.M Holding Company | Microwave heating system with suppression tunnel and related features |
| US12690098B2 (en) | 2021-05-19 | 2026-07-21 | A.L.M. Holding Company | Microwave waste heating system and related features |
| AU2022463711A1 (en) | 2021-09-08 | 2024-03-07 | A.L.M. Holding Company | Microwave heating applied to mining and related features |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2657972A (en) | 1952-09-06 | 1953-11-03 | Robert B Woodward | Copolymer of l-leucine and dl-phenylalanine |
| US3704282A (en) | 1971-04-09 | 1972-11-28 | Sidney Spector | Catecholamine antigens and antibodies specific therefor |
| IL36670A (en) * | 1971-04-21 | 1974-09-10 | Sela M | Therapeutic basic copolymers of amino acids |
| HU174500B (hu) * | 1976-05-05 | 1980-01-28 | Richter Gedeon Vegyeszet | Sposob poluchenija slozhnogo oktapeptidamid-sul'fatnogo ehfira kholecistokhinin-pankreozimina |
| JPS6053535A (ja) | 1983-09-02 | 1985-03-27 | Nitto Boseki Co Ltd | 規則性ポリアミノ酸樹脂の製造方法 |
| SU1182051A1 (ru) | 1984-04-28 | 1985-09-30 | Таджикский государственный университет им.В.И.Ленина | Политрипептиды,обладающие энантовой селективностью в реакци х гидролиза @ -нитрофениловых эфиров карбобензокси - @ - и @ -аланина |
| AU596986B2 (en) | 1985-06-18 | 1990-05-24 | Emory University | Biologically-active copolymers |
| DD257174A3 (de) | 1985-12-20 | 1988-06-08 | Ve Forschungszentrum Biotechno | Verfahren zur herstellung der peptide z-ala-ala-lon-p-nitranilid oder z-asp-phe-ome mit metalloprotease |
| CA2009996A1 (en) | 1989-02-17 | 1990-08-17 | Kathleen S. Cook | Process for making genes encoding random polymers of amino acids |
| DE3930733A1 (de) | 1989-09-14 | 1991-03-28 | Roehm Gmbh | Verfahren zur herstellung eines komplexierten arzneimittels |
| IL113812A (en) * | 1994-05-24 | 2000-06-29 | Yeda Res & Dev | Copolymer-1 pharmaceutical compositions containing it and its use |
| GB9411292D0 (en) | 1994-06-06 | 1994-07-27 | Teva Pharma | Pharmaceuticals compositions |
| CA2213317C (en) * | 1996-01-16 | 2001-07-03 | Lumigen, Inc. | Chemiluminescent compositions for reaction with phosphatase enzymes, and methods of use |
| US6271198B1 (en) * | 1996-11-06 | 2001-08-07 | Genentech, Inc. | Constrained helical peptides and methods of making same |
| US6214791B1 (en) | 1997-01-10 | 2001-04-10 | Yeda Research And Development Co. Ltd. | Treatment of multiple sclerosis through ingestion or inhalation of copolymer-1 |
| US6514935B1 (en) * | 1997-03-14 | 2003-02-04 | President And Fellows Of Harvard | Methods of treating hypertension |
| US6632541B2 (en) * | 1998-02-10 | 2003-10-14 | Sumitomo Chemical Company, Limited | Olefin-based copolymer composition |
| US7906153B2 (en) | 1998-04-08 | 2011-03-15 | Theta Biomedical Consulting & Development Co., Inc. | Anti-inflammatory compositions for treating multiple sclerosis |
| IL141423A (en) | 1998-08-27 | 2005-09-25 | Teva Pharma | Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
| US6800287B2 (en) | 1998-09-25 | 2004-10-05 | Yeda Research And Development Co., Ltd. | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| US6514938B1 (en) | 1998-09-25 | 2003-02-04 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Copolymer 1 related polypeptides for use as molecular weight markers and for therapeutic use |
| AU775073C (en) | 1998-11-12 | 2007-05-03 | Yeda Research And Development Co. Ltd. | Pharmaceutical compositions comprising synthetic peptide copolymers and methods for preventing and treating GVHD and HVGD |
| JP2000256395A (ja) * | 1999-01-07 | 2000-09-19 | Takeda Chem Ind Ltd | ポリオール類、その製造法および用途 |
| US6872739B1 (en) | 1999-06-04 | 2005-03-29 | Vereniging Voor Christelijk Wetenshappelikjk Onderwijs | Use of riluzole for the treatment of multiple sclerosis |
| US6531130B1 (en) | 1999-07-06 | 2003-03-11 | The Board Of Trustees Of The Leland Stanford University | Treatment of demyelinating autoimmune disease with ordered peptides |
| US6963008B2 (en) | 1999-07-19 | 2005-11-08 | Teva Pharmaceutical Industries Ltd. | Hydrate forms of alendronate sodium, processes for manufacture thereof, and pharmaceutical compositions thereof |
| US6995237B1 (en) | 1999-10-27 | 2006-02-07 | Cel-Sci Corporation | Preparation and composition of peptides useful for treatment of autoimmune and transplant related graft versus host conditions |
| HK1054507B (zh) | 2000-01-20 | 2008-10-31 | 耶达研究及发展有限公司 | 共聚物1和相关肽和多肽及其处理过的t细胞在神经保护性治疗中的用途 |
| US20020077278A1 (en) * | 2000-06-05 | 2002-06-20 | Yong V. Wee | Use of glatiramer acetate (copolymer 1) in the treatment of central nervous system disorders |
| WO2002059143A2 (en) | 2001-01-24 | 2002-08-01 | President And Fellows Of Harvard College | Therapeutic peptides for demyelinating conditions |
| US6936599B2 (en) | 2001-04-25 | 2005-08-30 | The Regents Of The University Of California | Estriol therapy for multiple sclerosis and other autoimmune diseases |
| PE20030701A1 (es) | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
| WO2004043995A2 (en) * | 2002-11-13 | 2004-05-27 | Apotex Pharmachem Inc. | Process for the preparation of glatiramer acetate by polymerisation of n-carboxy anhydrides of l-alanine, l-tyrosine, benzyl l-glutamate and benzyloxycarbonyl l-lysine |
| CA2411786C (en) * | 2002-11-13 | 2009-01-27 | Brantford Chemicals Inc. | A process for the preparation of polypeptides from n-carboxyanhydrides of amino acids |
| US6936539B2 (en) | 2003-09-24 | 2005-08-30 | Micron Technology, Inc. | Antireflective coating for use during the manufacture of a semiconductor device |
| DK1799703T3 (da) | 2004-09-09 | 2010-04-19 | Teva Pharma | Fremgangsmåde til fremstilling af blandinger af polypeptider ved hjælp af oprenset hydrogenbromid |
| DE602005016292D1 (de) * | 2004-10-29 | 2009-10-08 | Sandoz Ag | Verfahren zur herstellung von glatiramer |
| US8420605B2 (en) * | 2005-09-07 | 2013-04-16 | The University Of Strathclyde | Hydrogel compositions |
-
2005
- 2005-10-27 DE DE602005016292T patent/DE602005016292D1/de not_active Expired - Lifetime
- 2005-10-27 SI SI200530809T patent/SI1807467T1/sl unknown
- 2005-10-27 JP JP2007539184A patent/JP5297653B2/ja not_active Expired - Fee Related
- 2005-10-27 AT AT05824006T patent/ATE440888T1/de active
- 2005-10-27 AR ARP050104513A patent/AR052321A1/es not_active Application Discontinuation
- 2005-10-27 CN CN2005800357997A patent/CN101044188B/zh not_active Expired - Fee Related
- 2005-10-27 CA CA2583589A patent/CA2583589C/en not_active Expired - Fee Related
- 2005-10-27 ES ES05824006T patent/ES2331015T3/es not_active Expired - Lifetime
- 2005-10-27 EP EP05824006A patent/EP1807467B1/de not_active Expired - Lifetime
- 2005-10-27 WO PCT/US2005/039003 patent/WO2006050122A1/en not_active Ceased
- 2005-10-27 AU AU2005302500A patent/AU2005302500B2/en not_active Ceased
- 2005-10-28 US US11/262,122 patent/US20060154862A1/en not_active Abandoned
- 2005-10-28 TW TW094137997A patent/TWI307349B/zh not_active IP Right Cessation
-
2007
- 2007-04-16 IL IL182581A patent/IL182581A/en not_active IP Right Cessation
- 2007-09-27 US US11/904,422 patent/US8536305B2/en not_active Expired - Fee Related
-
2010
- 2010-03-18 US US12/726,571 patent/US8729229B2/en not_active Expired - Fee Related
- 2010-03-19 US US12/727,758 patent/US20100174048A1/en not_active Abandoned
- 2010-03-19 US US12/727,653 patent/US20100234566A1/en not_active Abandoned
-
2014
- 2014-07-10 IL IL233618A patent/IL233618A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL182581A (en) | 2015-09-24 |
| DE602005016292D1 (de) | 2009-10-08 |
| JP5297653B2 (ja) | 2013-09-25 |
| US20080021200A1 (en) | 2008-01-24 |
| US8729229B2 (en) | 2014-05-20 |
| IL233618A0 (en) | 2014-08-31 |
| CA2583589C (en) | 2012-04-24 |
| AU2005302500A1 (en) | 2006-05-11 |
| US20060154862A1 (en) | 2006-07-13 |
| EP1807467A1 (de) | 2007-07-18 |
| JP2008518930A (ja) | 2008-06-05 |
| CA2583589A1 (en) | 2006-05-11 |
| SI1807467T1 (sl) | 2009-12-31 |
| US20100174048A1 (en) | 2010-07-08 |
| IL182581A0 (en) | 2007-07-24 |
| ES2331015T3 (es) | 2009-12-18 |
| US20100234272A1 (en) | 2010-09-16 |
| TWI307349B (en) | 2009-03-11 |
| IL233618A (en) | 2016-05-31 |
| TW200634051A (en) | 2006-10-01 |
| CN101044188A (zh) | 2007-09-26 |
| WO2006050122A1 (en) | 2006-05-11 |
| US20100234566A1 (en) | 2010-09-16 |
| US8536305B2 (en) | 2013-09-17 |
| AR052321A1 (es) | 2007-03-14 |
| CN101044188B (zh) | 2010-08-04 |
| AU2005302500B2 (en) | 2008-11-27 |
| EP1807467B1 (de) | 2009-08-26 |
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