ATE440888T1 - Verfahren zur herstellung von glatiramer - Google Patents

Verfahren zur herstellung von glatiramer

Info

Publication number
ATE440888T1
ATE440888T1 AT05824006T AT05824006T ATE440888T1 AT E440888 T1 ATE440888 T1 AT E440888T1 AT 05824006 T AT05824006 T AT 05824006T AT 05824006 T AT05824006 T AT 05824006T AT E440888 T1 ATE440888 T1 AT E440888T1
Authority
AT
Austria
Prior art keywords
glatiramer
producing
producing glatiramer
Prior art date
Application number
AT05824006T
Other languages
English (en)
Inventor
Anup Ray
Hiren Patel
Johannes Ludescher
Mariappan Anbazhagan
Mahendra Patel
Ingolf Macher
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE440888T1 publication Critical patent/ATE440888T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10Alpha-amino-carboxylic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT05824006T 2004-10-29 2005-10-27 Verfahren zur herstellung von glatiramer ATE440888T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US62334604P 2004-10-29 2004-10-29
US65153505P 2005-02-09 2005-02-09
US65137205P 2005-02-09 2005-02-09
US72390105P 2005-10-05 2005-10-05
PCT/US2005/039003 WO2006050122A1 (en) 2004-10-29 2005-10-27 Processes for preparing glatiramer

Publications (1)

Publication Number Publication Date
ATE440888T1 true ATE440888T1 (de) 2009-09-15

Family

ID=36046637

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05824006T ATE440888T1 (de) 2004-10-29 2005-10-27 Verfahren zur herstellung von glatiramer

Country Status (14)

Country Link
US (5) US20060154862A1 (de)
EP (1) EP1807467B1 (de)
JP (1) JP5297653B2 (de)
CN (1) CN101044188B (de)
AR (1) AR052321A1 (de)
AT (1) ATE440888T1 (de)
AU (1) AU2005302500B2 (de)
CA (1) CA2583589C (de)
DE (1) DE602005016292D1 (de)
ES (1) ES2331015T3 (de)
IL (2) IL182581A (de)
SI (1) SI1807467T1 (de)
TW (1) TWI307349B (de)
WO (1) WO2006050122A1 (de)

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HRP20160455T1 (hr) 2004-09-09 2016-07-15 Yeda Research And Development Co., Ltd. Smjese polipeptida, sastavi koji ih sadrže i postupci za njihovu pripremu, te njihove primjene
AR052321A1 (es) * 2004-10-29 2007-03-14 Sandoz Ag Procesos para la preparacion de un polipeptido
WO2007081975A2 (en) * 2006-01-11 2007-07-19 Teva Pharmaceutical Industries, Ltd. Method of treating multiple sclerosis
JP2009542864A (ja) * 2006-07-05 2009-12-03 モメンタ ファーマシューティカルズ インコーポレイテッド コポリマー1の調製のための改良法
US8753833B2 (en) 2007-06-21 2014-06-17 Momenta Pharmaceuticals, Inc. Copolymer assay
WO2009017775A2 (en) * 2007-08-02 2009-02-05 Scinopharm Taiwan Ltd. Process for the preparation of a polypeptide
ES2449865T5 (es) 2008-04-16 2022-11-18 Momenta Pharmaceuticals Inc Análisis de composiciones de copolímeros de aminoácidos
US8399600B2 (en) 2008-08-07 2013-03-19 Sigma-Aldrich Co. Llc Preparation of low molecular weight polylysine and polyornithine in high yield
KR20110059606A (ko) * 2008-08-07 2011-06-02 시노팜 타이완 리미티드 글라티라머 아세테이트의 합성
AR074881A1 (es) 2008-12-24 2011-02-16 Synthon Bv Un proceso para purificar una mezcla de polimeros
RU2011144566A (ru) 2009-04-03 2013-05-10 Момента Фармасьютикалз, Инк. Контроль сополимерных композиций
CA2697570C (en) * 2009-07-15 2011-11-01 Teva Pharmaceutical Industries, Ltd. Reduced volume formulation of glatiramer acetate and methods of administration
US8920373B2 (en) 2009-07-15 2014-12-30 Teva Pharmaceutical Industries, Ltd. Reduced volume formulation of glatiramer acetate and methods of administration
NZ598661A (en) 2009-08-20 2013-02-22 Yeda Res & Dev Low frequency glatiramer acetate therapy
EP2526420A4 (de) * 2009-11-17 2013-09-18 Ares Trading Sa Verfahren zur verbesserung der gestalt, bioverfügbarkeit und effizienz von zufälligen sequenzpolymerzusammensetzungen mit serumproteinbasiertem nachweis von zufälligen sequenzpolymerzusammensetzungen
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
US8759302B2 (en) 2010-03-16 2014-06-24 Teva Pharmaceutical Industries, Ltd. Methods of treating a subject afflicted with an autoimmune disease using predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
JP2013529194A (ja) * 2010-04-27 2013-07-18 ドクター レディズ ラボラトリーズ リミテッド ポリペプチドおよびその塩の調製
US9109006B2 (en) * 2010-07-29 2015-08-18 Santhanakrishnan Srinivasan Glatiramer acetate molecular weight markers
CA2814500A1 (en) 2010-10-11 2012-04-19 Teva Pharmaceutical Industries Ltd Cytokine biomarkers as predictive biomarkers of clinical response for glatiramer acetate
CA2827275A1 (en) 2011-02-14 2012-09-20 Usv Limited Copolymer-1, process for preparation and analytical methods thereof
WO2012114167A1 (en) * 2011-02-24 2012-08-30 Biocon Limited Processes for the preparation of glatiramer acetate
WO2013009864A1 (en) 2011-07-11 2013-01-17 Momenta Pharmaceuticals, Inc. Structure assessment of heterogeneous polypeptide mixtures
WO2013009885A2 (en) 2011-07-11 2013-01-17 Momenta Pharmaceuticals, Inc. Evaluation of copolymer diethylamide
US8575198B1 (en) 2011-09-07 2013-11-05 Momenta Pharmaceuticals, Inc. In-process control for the manufacture of glatiramer acetate
HK1200274A1 (en) 2011-10-10 2015-08-07 Teva Pharmaceutical Industries Ltd. Single nucleotide polymorphisms useful to predict clinical response for glatiramer acetate
AU2012330728A1 (en) * 2011-11-03 2014-06-26 Biocon Limited Process for the preparation of random polypeptides and employing circular dichroism as a guidance tool for the manufacture of glatiramer acetate
US20140045740A1 (en) * 2012-08-13 2014-02-13 Momenta Pharmaceuticals, Inc. Analysis of glatiramer acetate
US9155775B1 (en) 2015-01-28 2015-10-13 Teva Pharmaceutical Industries, Ltd. Process for manufacturing glatiramer acetate product
WO2017165664A1 (en) 2016-03-23 2017-09-28 A.L.M Holding Company Batch asphalt mix plant
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
CN109982712A (zh) 2016-08-31 2019-07-05 Mapi医药公司 包含醋酸格拉替雷的储库系统
CN110382052A (zh) 2017-03-26 2019-10-25 Mapi医药公司 用于治疗进展型形式的多发性硬化症的格拉替雷储库系统
CN107082796B (zh) * 2017-05-02 2020-06-09 江苏大学 一种提纯蛋白酶解物中小分子多肽的方法
GB2579600B (en) 2018-12-05 2023-07-05 Byotrol Plc Anti-viral composition
MX2022000043A (es) 2019-07-01 2022-04-20 Alm Holding Co Sistema de calentamiento por microondas con tunel de supresion y caracteristicas relacionadas.
US12604376B2 (en) 2021-09-08 2026-04-14 A.L.M. Holding Company Microwave heating applied to mining and related features

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Also Published As

Publication number Publication date
US20100234566A1 (en) 2010-09-16
US20080021200A1 (en) 2008-01-24
DE602005016292D1 (de) 2009-10-08
JP2008518930A (ja) 2008-06-05
TW200634051A (en) 2006-10-01
CN101044188A (zh) 2007-09-26
EP1807467A1 (de) 2007-07-18
IL233618A0 (en) 2014-08-31
WO2006050122A1 (en) 2006-05-11
AU2005302500A1 (en) 2006-05-11
SI1807467T1 (sl) 2009-12-31
US20100234272A1 (en) 2010-09-16
AU2005302500B2 (en) 2008-11-27
CA2583589A1 (en) 2006-05-11
US20100174048A1 (en) 2010-07-08
US20060154862A1 (en) 2006-07-13
TWI307349B (en) 2009-03-11
AR052321A1 (es) 2007-03-14
IL182581A0 (en) 2007-07-24
US8536305B2 (en) 2013-09-17
US8729229B2 (en) 2014-05-20
IL182581A (en) 2015-09-24
EP1807467B1 (de) 2009-08-26
IL233618A (en) 2016-05-31
JP5297653B2 (ja) 2013-09-25
ES2331015T3 (es) 2009-12-18
CN101044188B (zh) 2010-08-04
CA2583589C (en) 2012-04-24

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