ATE486851T1 - Verfahren zur herstellung von montekulast - Google Patents

Verfahren zur herstellung von montekulast

Info

Publication number: ATE486851T1
Authority: AT; Austria
Prior art keywords: formula; montecuload; producing; reaction; compound
Prior art date: 2007-01-09

Application number

AT08700826T

Other languages

English (en)

Inventor

Ales Halama

Josef Jirman

Original Assignee

Zentiva Ks

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-01-09

Filing date

2008-01-08

Publication date

2010-11-15

2008-01-08 Application filed by Zentiva Ks filed Critical Zentiva Ks

2010-11-15 Application granted granted Critical

2010-11-15 Publication of ATE486851T1 publication Critical patent/ATE486851T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 abstract 1
239000002202 Polyethylene glycol Substances 0.000 abstract 1
239000004721 Polyphenylene oxide Substances 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
150000003983 crown ethers Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
239000012442 inert solvent Substances 0.000 abstract 1
229960005127 montelukast Drugs 0.000 abstract 1
229920000570 polyether Polymers 0.000 abstract 1
229920001223 polyethylene glycol Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D323/00—Heterocyclic compounds containing more than two oxygen atoms as the only ring hetero atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Quinoline Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicinal Preparation (AREA)

AT08700826T 2007-01-09 2008-01-08 Verfahren zur herstellung von montekulast ATE486851T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
CZ20070020A CZ302238B6 (cs)	2007-01-09	2007-01-09	Zpusob prípravy montelukastu
PCT/CZ2008/000002 WO2008083635A1 (en)	2007-01-09	2008-01-08	A method for the preparation of montelukast

Publications (1)

Publication Number	Publication Date
ATE486851T1 true ATE486851T1 (de)	2010-11-15

Family

ID=39365931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08700826T ATE486851T1 (de)	2007-01-09	2008-01-08	Verfahren zur herstellung von montekulast

Country Status (10)

Country	Link
US (1)	US20100174083A1 (de)
EP (1)	EP2118063B1 (de)
AT (1)	ATE486851T1 (de)
CZ (1)	CZ302238B6 (de)
DE (1)	DE602008003311D1 (de)
EA (1)	EA200900961A1 (de)
ES (1)	ES2354589T3 (de)
PL (1)	PL2118063T3 (de)
UA (1)	UA97511C2 (de)
WO (1)	WO2008083635A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1904448B1 (de)	2005-07-05	2011-02-02	Teva Pharmaceutical Industries, Ltd.	Reinigung von montelukast
JP6119127B2 (ja) *	2012-06-25	2017-04-26	大日本印刷株式会社	モンテルカストの製造法
JP6162004B2 (ja) *	2013-09-10	2017-07-12	株式会社トクヤマ	モンテルカストナトリウム中間体の分析方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7547787B2 (en) *	2004-04-21	2009-06-16	Teva Pharmaceutical Industries Ltd.	Processes for preparing montelukast sodium

2007
- 2007-01-09 CZ CZ20070020A patent/CZ302238B6/cs not_active IP Right Cessation
2008
- 2008-01-08 DE DE602008003311T patent/DE602008003311D1/de active Active
- 2008-01-08 ES ES08700826T patent/ES2354589T3/es active Active
- 2008-01-08 PL PL08700826T patent/PL2118063T3/pl unknown
- 2008-01-08 EA EA200900961A patent/EA200900961A1/ru unknown
- 2008-01-08 AT AT08700826T patent/ATE486851T1/de not_active IP Right Cessation
- 2008-01-08 EP EP08700826A patent/EP2118063B1/de not_active Not-in-force
- 2008-01-08 WO PCT/CZ2008/000002 patent/WO2008083635A1/en not_active Ceased
- 2008-01-08 UA UAA200908448A patent/UA97511C2/ru unknown
- 2008-01-08 US US12/522,407 patent/US20100174083A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CZ302238B6 (cs)	2011-01-05
EP2118063B1 (de)	2010-11-03
UA97511C2 (ru)	2012-02-27
EP2118063A1 (de)	2009-11-18
WO2008083635A1 (en)	2008-07-17
ES2354589T3 (es)	2011-03-16
EA200900961A1 (ru)	2010-02-26
WO2008083635B1 (en)	2008-10-09
CZ200720A3 (cs)	2009-03-04
US20100174083A1 (en)	2010-07-08
PL2118063T3 (pl)	2011-04-29
DE602008003311D1 (de)	2010-12-16

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Legal Events

Date	Code	Title	Description
2011-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties