ATE487381T1 - Verfahren zur induzierung der differenzierung in stammzellen, verfahren zur erzeugung von gewebe mit von mikroorganen und stammzellen abgeleiteten gerüstmatrizes, verfahren zur herstellung adulter stammzellen und verfahren zur kontinuierlichen erzeugung von stammzellen mittels implantation von mikroorganen als quellen für stammzellen - Google Patents
Verfahren zur induzierung der differenzierung in stammzellen, verfahren zur erzeugung von gewebe mit von mikroorganen und stammzellen abgeleiteten gerüstmatrizes, verfahren zur herstellung adulter stammzellen und verfahren zur kontinuierlichen erzeugung von stammzellen mittels implantation von mikroorganen als quellen für stammzellenInfo
- Publication number
- ATE487381T1 ATE487381T1 AT03706861T AT03706861T ATE487381T1 AT E487381 T1 ATE487381 T1 AT E487381T1 AT 03706861 T AT03706861 T AT 03706861T AT 03706861 T AT03706861 T AT 03706861T AT E487381 T1 ATE487381 T1 AT E487381T1
- Authority
- AT
- Austria
- Prior art keywords
- stem cells
- microorgan
- generating
- nen
- implantation
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 210000004504 adult stem cell Anatomy 0.000 title abstract 2
- 210000000130 stem cell Anatomy 0.000 title 3
- 230000004069 differentiation Effects 0.000 title 1
- 238000002513 implantation Methods 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 210000001671 embryonic stem cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0688—Cells from the lungs or the respiratory tract
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/045,018 US7297540B2 (en) | 2002-01-15 | 2002-01-15 | Methods of generating tissue using devitalized, acellular scaffold matrices derived from micro-organs |
| PCT/IL2003/000037 WO2003060062A2 (en) | 2002-01-15 | 2003-01-14 | Methods of inducing differentiation in stem cells, methods of generating tissue using scaffold matrices derived from micro-organs and stem cells, methods of producing adult stem cells and methods of continuously generating stem cells by implantation of micro-organs as sources of stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE487381T1 true ATE487381T1 (de) | 2010-11-15 |
Family
ID=21935560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03706861T ATE487381T1 (de) | 2002-01-15 | 2003-01-14 | Verfahren zur induzierung der differenzierung in stammzellen, verfahren zur erzeugung von gewebe mit von mikroorganen und stammzellen abgeleiteten gerüstmatrizes, verfahren zur herstellung adulter stammzellen und verfahren zur kontinuierlichen erzeugung von stammzellen mittels implantation von mikroorganen als quellen für stammzellen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7297540B2 (de) |
| EP (1) | EP1471788B1 (de) |
| AT (1) | ATE487381T1 (de) |
| AU (1) | AU2003208567A1 (de) |
| DE (1) | DE60334887D1 (de) |
| IL (1) | IL162728A0 (de) |
| WO (1) | WO2003060062A2 (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040043006A1 (en) * | 2002-08-27 | 2004-03-04 | Badylak Stephen F. | Tissue regenerative composition |
| US6576265B1 (en) * | 1999-12-22 | 2003-06-10 | Acell, Inc. | Tissue regenerative composition, method of making, and method of use thereof |
| US8088568B2 (en) | 2001-11-05 | 2012-01-03 | Medgentics, Inc. | Dermal micro-organs, methods and apparatuses for producing and using the same |
| US8501396B2 (en) | 2001-11-05 | 2013-08-06 | Medgenics Medical Israel Ltd. | Dermal micro-organs, methods and apparatuses for producing and using the same |
| US7468242B2 (en) | 2001-11-05 | 2008-12-23 | Medgenics, Inc. | Dermal micro organs, methods and apparatuses for producing and using the same |
| US20040175366A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Scaffold for cell growth and differentiation |
| US20040176855A1 (en) * | 2003-03-07 | 2004-09-09 | Acell, Inc. | Decellularized liver for repair of tissue and treatment of organ deficiency |
| CA2788000C (en) | 2003-05-01 | 2016-03-15 | Medgenics Inc. | Apparatus for harvesting a dermal micro-organ |
| CA2530490A1 (en) | 2003-06-25 | 2005-01-13 | Stephen F. Badylak | Conditioned matrix compositions for tissue restoration |
| DE102004017476B4 (de) * | 2004-04-08 | 2009-03-26 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung einer Epithelzellen enthaltenden Zellzusammensetzung |
| US20060134781A1 (en) * | 2004-12-07 | 2006-06-22 | Bacterin International, Inc. | Three-dimensional cell culture system |
| CN101268183B (zh) | 2005-04-21 | 2011-11-30 | 麻省理工学院 | 改变对外源和内源免疫原（包括同系和非同系细胞、组织或器官）的免疫应答的材料和方法 |
| CN101878757A (zh) | 2005-06-21 | 2010-11-10 | 渗透治疗有限公司 | 用于增强血管通路的方法和组合物 |
| AU2006311482B2 (en) * | 2005-11-08 | 2011-08-25 | Georgia Tech Research Corporation | Acellularized biomaterial from embryonic stem cells |
| US8038595B2 (en) * | 2006-01-25 | 2011-10-18 | Beth Israel Deaconess Medical Center | Devices and methods for tissue transplant and regeneration |
| US8454948B2 (en) | 2006-09-14 | 2013-06-04 | Medgenics Medical Israel Ltd. | Long lasting drug formulations |
| JP2010504909A (ja) | 2006-09-14 | 2010-02-18 | メドジェニクス・メディカル・イスラエル・リミテッド | 長期持続性の医薬製剤 |
| US8574567B2 (en) | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| EP2607477B1 (de) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Multipotente stammzellen und ihre verwendung |
| US20110217274A1 (en) | 2007-05-29 | 2011-09-08 | Reld Christopher B | Methods for production and uses of multipotent ,pluripotent, differentiated and disease-resistant cell populations |
| US9192695B2 (en) | 2008-11-20 | 2015-11-24 | Allosource | Allografts combined with tissue derived stem cells for bone healing |
| IL196820A0 (en) | 2009-02-01 | 2009-11-18 | Yissum Res Dev Co | Devitalized, acellular scaffold matrices derived from micro-organs seeded with various cells |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| AU2011268458B2 (en) | 2010-06-15 | 2014-06-12 | Medgenics Medical Israel Ltd. | Long lasting drug formulations |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| US8701980B2 (en) | 2011-10-27 | 2014-04-22 | Veltek Associates, Inc. | Air sample tracking system and method |
| WO2013075091A1 (en) | 2011-11-17 | 2013-05-23 | Allosource | Multi-piece machine graft systems and methods |
| EP2964154A4 (de) | 2013-03-07 | 2016-08-17 | Allosource | Knochenallotransplatsysteme und -verfahren mit konsistentem kalziumgehalt |
| WO2014150784A1 (en) | 2013-03-15 | 2014-09-25 | Allosource | Cell repopulated collagen matrix for soft tissue repair and regeneration |
| WO2015017500A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US9730796B2 (en) | 2014-05-16 | 2017-08-15 | Allosource | Composite bone constructs and methods |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| WO2019006328A1 (en) | 2017-06-30 | 2019-01-03 | Allosource | CELL BONE GRAFTS, AND METHODS OF MAKING AND USING |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266480A (en) * | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| CA1340581C (en) * | 1986-11-20 | 1999-06-08 | Joseph P. Vacanti | Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices |
| US5888720A (en) | 1992-10-27 | 1999-03-30 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs |
| US6472200B1 (en) | 1999-07-23 | 2002-10-29 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Device and method for performing a biological modification of a fluid |
| US5855610A (en) * | 1995-05-19 | 1999-01-05 | Children's Medical Center Corporation | Engineering of strong, pliable tissues |
| US5861313A (en) * | 1995-06-07 | 1999-01-19 | Ontogeny, Inc. | Method of isolating bile duct progenitor cells |
| EP1181355A4 (de) * | 1997-01-16 | 2005-05-04 | Yissum Res Dev Co | Vorrichtung und methode zur durchführung einer biologischen veränderung eines fluides |
| EP1064353B1 (de) * | 1998-03-18 | 2002-11-06 | Massachusetts Institute Of Technology | Vaskularisierte perfundierte anordnungen für mikrogewebe und mikroorgane |
| US6326201B1 (en) * | 1999-02-10 | 2001-12-04 | Curis, Inc. | Pancreatic progenitor cells, methods and uses related thereto |
| CA2377541A1 (en) | 1999-06-25 | 2001-01-04 | Eduardo N. Mitrani | Method of inducing angiogenesis by micro-organs |
| CA2419817C (en) * | 2000-08-16 | 2014-11-18 | Duke University | Decellularized tissue engineered constructs and tissues |
-
2002
- 2002-01-15 US US10/045,018 patent/US7297540B2/en not_active Expired - Lifetime
-
2003
- 2003-01-14 WO PCT/IL2003/000037 patent/WO2003060062A2/en not_active Ceased
- 2003-01-14 IL IL16272803A patent/IL162728A0/xx unknown
- 2003-01-14 EP EP03706861A patent/EP1471788B1/de not_active Expired - Lifetime
- 2003-01-14 AT AT03706861T patent/ATE487381T1/de not_active IP Right Cessation
- 2003-01-14 AU AU2003208567A patent/AU2003208567A1/en not_active Abandoned
- 2003-01-14 DE DE60334887T patent/DE60334887D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1471788A4 (de) | 2006-02-01 |
| AU2003208567A1 (en) | 2003-07-30 |
| IL162728A0 (en) | 2005-11-20 |
| US7297540B2 (en) | 2007-11-20 |
| WO2003060062A2 (en) | 2003-07-24 |
| EP1471788B1 (de) | 2010-11-10 |
| DE60334887D1 (de) | 2010-12-23 |
| US20030148510A1 (en) | 2003-08-07 |
| EP1471788A2 (de) | 2004-11-03 |
| AU2003208567A8 (en) | 2003-07-30 |
| WO2003060062A3 (en) | 2004-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |