ATE487483T1 - Verwendung von 4,17-beta-dihydroxyandrost-4-en-3- on zur behandlung von krebs - Google Patents

Verwendung von 4,17-beta-dihydroxyandrost-4-en-3- on zur behandlung von krebs

Info

Publication number
ATE487483T1
ATE487483T1 AT07725140T AT07725140T ATE487483T1 AT E487483 T1 ATE487483 T1 AT E487483T1 AT 07725140 T AT07725140 T AT 07725140T AT 07725140 T AT07725140 T AT 07725140T AT E487483 T1 ATE487483 T1 AT E487483T1
Authority
AT
Austria
Prior art keywords
dihydroxyandrost
beta
treat cancer
hormone
hydroxytestosterone
Prior art date
Application number
AT07725140T
Other languages
English (en)
Inventor
Alexander Tobias Teichmann
Original Assignee
Mabel Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mabel Gmbh filed Critical Mabel Gmbh
Application granted granted Critical
Publication of ATE487483T1 publication Critical patent/ATE487483T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT07725140T 2006-05-12 2007-05-11 Verwendung von 4,17-beta-dihydroxyandrost-4-en-3- on zur behandlung von krebs ATE487483T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74712406P 2006-05-12 2006-05-12
EP06009894A EP1854465A1 (de) 2006-05-12 2006-05-12 Verwendung von 4,17 beta-dihydroxyandrost-4-ene-3-one zur Behandlung von Krebs
PCT/EP2007/004220 WO2007131736A2 (en) 2006-05-12 2007-05-11 Use of 4, 17 beta-dihydroxyandrost-4-ene-3-one for treating cancers

Publications (1)

Publication Number Publication Date
ATE487483T1 true ATE487483T1 (de) 2010-11-15

Family

ID=37075285

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07725140T ATE487483T1 (de) 2006-05-12 2007-05-11 Verwendung von 4,17-beta-dihydroxyandrost-4-en-3- on zur behandlung von krebs

Country Status (15)

Country Link
US (3) US9138477B2 (de)
EP (3) EP1854465A1 (de)
JP (2) JP5363309B2 (de)
KR (2) KR101403895B1 (de)
CN (2) CN101443017B (de)
AT (1) ATE487483T1 (de)
AU (2) AU2007251822B2 (de)
CA (2) CA2651354C (de)
DE (1) DE602007010447D1 (de)
DK (2) DK2018170T3 (de)
ES (2) ES2391839T3 (de)
PL (2) PL2018170T3 (de)
PT (2) PT2018169E (de)
SI (2) SI2018170T1 (de)
WO (2) WO2007131736A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1854465A1 (de) 2006-05-12 2007-11-14 Alexander Tobias Teichmann Verwendung von 4,17 beta-dihydroxyandrost-4-ene-3-one zur Behandlung von Krebs
DK2060300T3 (da) * 2007-11-13 2015-06-22 Curadis Gmbh C-19-steroider til terapeutiske anvendelser
ES2574933T3 (es) * 2007-11-13 2016-06-23 Athenion Ag Esteroides de C-19 para usos cosméticos
FR2964323B1 (fr) * 2010-09-08 2012-11-09 Jean Pierre Raynaud Utilisation de la testosterone chez un patient en deficit androgenique et atteint d'un cancer de la prostate
CA2812438A1 (en) * 2010-10-01 2012-04-05 Indiana University Research And Technology Corporation Treatment of symptoms associated with menopause
ES2694582T3 (es) * 2011-01-31 2018-12-21 Lucolas-M.D. Ltd. Combinaciones de inhibidores de aromatasa y antioxidantes
WO2015055179A1 (de) * 2013-10-15 2015-04-23 Chelac Holding Gmbh Steroid-carbonsäureester, zusammensetzungen, enthaltend steroid-carbonsäureester und verwendung dieser bei lokal topischer applikation für kosmetische oder dermatologische zwecke
NO3040075T3 (de) * 2014-12-30 2018-02-10
WO2018049042A1 (en) * 2016-09-07 2018-03-15 The Wistar Institute Of Anatomy And Biology Methods and compositions for treating cancers by inhibiting estrogen signaling in myeloid-derived suppressor cells
CN108727453A (zh) * 2017-04-20 2018-11-02 华东理工大学 新型pd-1抑制剂及其应用
EP3632445A1 (de) * 2018-10-04 2020-04-08 Curadis GmbH Kombinationen mit einem c-19-steroid zur behandlung von krebs
RU2679625C1 (ru) * 2018-11-08 2019-02-12 Ильясов Шамиль Сионович ПРИМЕНЕНИЕ 3-О-СУЛЬФАМОИЛОКСИ-6-ОКСА-7β-МЕТИЛ-D-ГОМО-8α-ЭСТРА-1,3,5(10)-ТРИЕН-17а-ОНА ДЛЯ ЛЕЧЕНИЯ РАКА МОЛОЧНОЙ ЖЕЛЕЗЫ, ВКЛЮЧАЯ ТРИЖДЫ-НЕГАТИВНУЮ ФОРМУ, И СПОСОБ ЕГО ПОЛУЧЕНИЯ
EP3666276A1 (de) * 2018-12-14 2020-06-17 dcic Biopharmaceutical Limited Medikament gegen östrogen-rezeptor-beta (erbeta)-positiven brusttumor

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA639855A (en) 1962-04-17 Societa Farmaceutici Italia 4-halo-3-keto-.delta.4-steroids
BE552152A (de) *
US2744120A (en) 1953-01-14 1956-05-01 Olin Mathieson 1-dehydrotestololactone
US2762818A (en) * 1955-05-26 1956-09-11 Searle & Co 4-hydroxytestosterone and esters thereof
US4235893A (en) * 1978-05-08 1980-11-25 Brodie Angela M Ester derivatives of 4-hydroxy-4-androstene-3,17-dione and a method for inhibiting estrogen biosynthesis
US4322416A (en) * 1980-06-27 1982-03-30 Merrell Dow Pharmaceuticals Inc. 10-Alkynyl steroids
US4289762A (en) * 1980-06-27 1981-09-15 Merrell Dow Pharmaceuticals Inc. 10-(1,2-Propadienyl) steroids as irreversible aromatase inhibitors
DE3121153A1 (de) 1981-05-22 1982-12-09 Schering Ag, 1000 Berlin Und 4619 Bergkamen "verwendung von aromatase-hemmern zur prophylaxe und therapie der prostatahyperplasie"
DE3362176D1 (en) 1982-07-14 1986-03-27 Akzo Nv Novel 19-thio-androstane derivatives
GB8721384D0 (en) 1987-09-11 1987-10-21 Erba Farmitalia 17-substituted andro-sta-1 4-dien-3-one derivatives
AU7736300A (en) 1999-09-30 2001-04-30 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment of androgen receptor driven conditions
DE10049736A1 (de) * 2000-09-29 2002-04-18 Jenapharm Gmbh 17alpha-Fluoralkylsteroide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE10054294A1 (de) * 2000-11-02 2002-05-16 Heinrich Wieland Topische Behandlung bei der Mastalgie
US20030229063A1 (en) * 2002-06-05 2003-12-11 Llewellyn William Charles Use of 4-hydroxytestosterone to lower estrogen levels in humans
US20030049307A1 (en) * 2002-08-15 2003-03-13 Gyurik Robert J. Pharmaceutical composition
GB2398495B (en) * 2003-01-23 2007-08-22 Kent G Lau A drug delivery preparation comprising at least one anti-tumour drug and a topical carrier for the drug
RU2006106768A (ru) * 2003-08-07 2007-09-20 Шеринг Корпорейшн (US) Новые ингибиторы фарнезилпротеинтрансферазы как противоопухолевые агенты
AU2004280264A1 (en) * 2003-10-09 2005-04-21 Merck Hdac Research, Llc Thiophene and benzothiophene hydroxamic acid derivatives
US20080050387A1 (en) 2003-12-12 2008-02-28 Chawnshang Chang Non-Androgen Dependent Roles for Androgen Receptor and Non-Androgen Related Inhibitors of Androgen Receptor
CN101014365B (zh) * 2004-07-16 2011-04-13 辉瑞产品公司 使用抗-igf-1r抗体联合治疗非血液的恶性肿瘤
EP1854465A1 (de) * 2006-05-12 2007-11-14 Alexander Tobias Teichmann Verwendung von 4,17 beta-dihydroxyandrost-4-ene-3-one zur Behandlung von Krebs

Also Published As

Publication number Publication date
PT2018169E (pt) 2011-01-19
CA2652057C (en) 2015-07-07
US20100061975A1 (en) 2010-03-11
WO2007131736A2 (en) 2007-11-22
CN101443016B (zh) 2012-09-05
JP2009536931A (ja) 2009-10-22
DK2018169T3 (da) 2011-02-07
EP2018169B1 (de) 2010-11-10
CN101443017B (zh) 2013-07-31
JP2009536932A (ja) 2009-10-22
WO2007131736A3 (en) 2008-03-06
KR101403895B1 (ko) 2014-06-20
US9138477B2 (en) 2015-09-22
SI2018169T1 (sl) 2011-02-28
PL2018170T3 (pl) 2013-01-31
EP2018170A2 (de) 2009-01-28
US20160030448A1 (en) 2016-02-04
PT2018170E (pt) 2012-10-25
CN101443017A (zh) 2009-05-27
US9610292B2 (en) 2017-04-04
DK2018170T3 (da) 2012-10-22
AU2007251823A1 (en) 2007-11-22
CA2651354A1 (en) 2007-11-22
SI2018170T1 (sl) 2012-12-31
ES2391839T3 (es) 2012-11-30
PL2018169T3 (pl) 2011-04-29
KR20090009855A (ko) 2009-01-23
WO2007131737A2 (en) 2007-11-22
AU2007251823B2 (en) 2012-09-06
JP5363310B2 (ja) 2013-12-11
DE602007010447D1 (de) 2010-12-23
EP1854465A1 (de) 2007-11-14
JP5363309B2 (ja) 2013-12-11
WO2007131737A3 (en) 2008-05-02
US9114163B2 (en) 2015-08-25
ES2355530T3 (es) 2011-03-28
EP2018169A2 (de) 2009-01-28
EP2018170B1 (de) 2012-07-25
CN101443016A (zh) 2009-05-27
AU2007251822A1 (en) 2007-11-22
KR20090010189A (ko) 2009-01-29
US20090111784A1 (en) 2009-04-30
KR101403893B1 (ko) 2014-06-20
AU2007251822B2 (en) 2012-08-16
CA2652057A1 (en) 2007-11-22
CA2651354C (en) 2015-11-17

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