ATE487486T1 - Polypeptid-spaltungsprozess - Google Patents

Polypeptid-spaltungsprozess

Info

Publication number: ATE487486T1
Authority: AT; Austria
Prior art keywords: polypeptide; cleavage process; polypeptide cleavage; reaction mixture; formic acid
Prior art date: 2002-05-24

Application number

AT03771535T

Other languages

English (en)

Inventor

Jin Seog Seo

Barton Holmquist

Original Assignee

Medtronic Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-05-24

Filing date

2003-05-23

Publication date

2010-11-15

2003-05-23 Application filed by Medtronic Inc filed Critical Medtronic Inc

2010-11-15 Application granted granted Critical

2010-11-15 Publication of ATE487486T1 publication Critical patent/ATE487486T1/de

Links

229920001184 polypeptide Polymers 0.000 title abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
238000003776 cleavage reaction Methods 0.000 title abstract 3
230000007017 scission Effects 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 4
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 2
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
235000019253 formic acid Nutrition 0.000 abstract 2
239000011541 reaction mixture Substances 0.000 abstract 2
LVNMAAGSAUGNIC-BQBZGAKWSA-N Cys-His Chemical compound SC[C@H](N)C(=O)N[C@H](C(O)=O)CC1=CNC=N1 LVNMAAGSAUGNIC-BQBZGAKWSA-N 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
229910052763 palladium Inorganic materials 0.000 abstract 1
230000003381 solubilizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Endocrinology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT03771535T 2002-05-24 2003-05-23 Polypeptid-spaltungsprozess ATE487486T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US38348402P	2002-05-24	2002-05-24
PCT/US2003/016647 WO2004011599A2 (en)	2002-05-24	2003-05-23	Polypeptide cleavage process

Publications (1)

Publication Number	Publication Date
ATE487486T1 true ATE487486T1 (de)	2010-11-15

Family

ID=31188325

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03771535T ATE487486T1 (de)	2002-05-24	2003-05-23	Polypeptid-spaltungsprozess

Country Status (7)

Country	Link
US (1)	US7592432B2 (de)
EP (1)	EP1531836B1 (de)
AT (1)	ATE487486T1 (de)
AU (1)	AU2003276835A1 (de)
CA (1)	CA2485959C (de)
DE (1)	DE60334912D1 (de)
WO (1)	WO2004011599A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4638223B2 (ja)	2002-05-24	2011-02-23	メドトロニック，インコーポレイテッド	ポリペプチド切断方法
ATE487486T1 (de)	2002-05-24	2010-11-15	Medtronic Inc	Polypeptid-spaltungsprozess
WO2003099854A2 (en)	2002-05-24	2003-12-04	Nps Allelix Corp.	Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
AU2003243315B8 (en) *	2002-05-24	2009-05-21	Medtronic, Inc.	Peptide amidation process
US7318925B2 (en)	2003-08-08	2008-01-15	Amgen Fremont, Inc.	Methods of use for antibodies against parathyroid hormone
US7288253B2 (en)	2003-08-08	2007-10-30	Amgen Fremont, Inc.	Antibodies directed to parathyroid hormone (PTH) and uses thereof
HRP20120315T1 (hr)	2003-11-21	2012-05-31	Nps Pharmaceuticals	Proizvodnja peptida 2 nalik glukagonu i analoga

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1194795B (it) *	1981-05-13	1988-09-28	Pierrel Spa	Procedimento per la eliminazione del gruppo n-formile da peptidi n-formilati e da esteri di peptidi n-formilati
IL84110A (en)	1986-10-14	1992-11-15	Lilly Co Eli	Process for transforming a human insulin precursor to a human insulin
US5580751A (en)	1990-09-14	1996-12-03	Carlsberg A/S	Process for the preparation of C-terminally amidated peptides
US5352771A (en) *	1992-08-31	1994-10-04	Iowa State University Research Foundation Inc.	Hydrolysis of peptide bonds using Pt (II) and Pd (II) complexes
US5393924A (en)	1992-10-02	1995-02-28	Hoechst Celanese Corporation	Method for the preparation of arylalkanolamineacylates
US6376529B1 (en)	1995-06-07	2002-04-23	Peng Cho Tang	Mono- and bis-indolylquinones and prophylactic and therapeutic uses thereof
US5834243A (en) *	1996-07-19	1998-11-10	Bogosian; Gregg	Deformylation of f-Met peptides in bacterial expression systems
US6660758B1 (en)	1996-12-13	2003-12-09	The Scripps Research Institute	Epothilone analogs
JP4638223B2 (ja) *	2002-05-24	2011-02-23	メドトロニック，インコーポレイテッド	ポリペプチド切断方法
ATE487486T1 (de)	2002-05-24	2010-11-15	Medtronic Inc	Polypeptid-spaltungsprozess
AU2003243315B8 (en) *	2002-05-24	2009-05-21	Medtronic, Inc.	Peptide amidation process

2003
- 2003-05-23 AT AT03771535T patent/ATE487486T1/de not_active IP Right Cessation
- 2003-05-23 CA CA2485959A patent/CA2485959C/en not_active Expired - Fee Related
- 2003-05-23 AU AU2003276835A patent/AU2003276835A1/en not_active Abandoned
- 2003-05-23 EP EP03771535A patent/EP1531836B1/de not_active Expired - Lifetime
- 2003-05-23 DE DE60334912T patent/DE60334912D1/de not_active Expired - Lifetime
- 2003-05-23 WO PCT/US2003/016647 patent/WO2004011599A2/en not_active Ceased
2004
- 2004-11-24 US US10/997,822 patent/US7592432B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2485959C (en)	2012-04-24
DE60334912D1 (de)	2010-12-23
EP1531836A4 (de)	2008-11-05
EP1531836B1 (de)	2010-11-10
WO2004011599A3 (en)	2004-08-26
US20050227314A1 (en)	2005-10-13
EP1531836A2 (de)	2005-05-25
AU2003276835A1 (en)	2004-02-16
CA2485959A1 (en)	2004-02-05
US7592432B2 (en)	2009-09-22
AU2003276835A8 (en)	2004-02-16
WO2004011599A2 (en)	2004-02-05

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Legal Events

Date	Code	Title	Description
2011-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties