ATE496123T1 - Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden - Google Patents

Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden

Info

Publication number
ATE496123T1
ATE496123T1 AT01905377T AT01905377T ATE496123T1 AT E496123 T1 ATE496123 T1 AT E496123T1 AT 01905377 T AT01905377 T AT 01905377T AT 01905377 T AT01905377 T AT 01905377T AT E496123 T1 ATE496123 T1 AT E496123T1
Authority
AT
Austria
Prior art keywords
tram
code
nucleic acids
methods based
serine proteases
Prior art date
Application number
AT01905377T
Other languages
English (en)
Inventor
Edwin Madison
Edgar Ong
Jiunn-Chern Yeh
Original Assignee
Dendreon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/657,986 external-priority patent/US6797504B1/en
Application filed by Dendreon Corp filed Critical Dendreon Corp
Application granted granted Critical
Publication of ATE496123T1 publication Critical patent/ATE496123T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Laminated Bodies (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
AT01905377T 2000-02-03 2001-02-02 Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden ATE496123T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17998200P 2000-02-03 2000-02-03
US18354200P 2000-02-18 2000-02-18
US21312400P 2000-06-22 2000-06-22
US22097000P 2000-07-26 2000-07-26
US09/657,986 US6797504B1 (en) 2000-09-08 2000-09-08 Inhibitors of serine protease activity of matriptase or MTSP1
US23484000P 2000-09-22 2000-09-22
PCT/US2001/003471 WO2001057194A2 (en) 2000-02-03 2001-02-02 Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon

Publications (1)

Publication Number Publication Date
ATE496123T1 true ATE496123T1 (de) 2011-02-15

Family

ID=27558705

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01905377T ATE496123T1 (de) 2000-02-03 2001-02-02 Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden

Country Status (9)

Country Link
EP (1) EP1252300B1 (de)
JP (1) JP2003521920A (de)
KR (1) KR20020073576A (de)
AT (1) ATE496123T1 (de)
AU (1) AU2001233262A1 (de)
CA (1) CA2396774A1 (de)
DE (1) DE60143880D1 (de)
IL (1) IL150168A0 (de)
WO (1) WO2001057194A2 (de)

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US20030039648A1 (en) 1998-09-16 2003-02-27 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7037667B1 (en) 1998-06-01 2006-05-02 Agensys, Inc. Tumor antigen useful in diagnosis and therapy of prostate and colon cancer
US6291663B1 (en) * 1999-03-03 2001-09-18 Board Of Trustees Of The University Of Arkansas TADG-12: a novel transmembrane serine protease overexpressed in a ovarian carcinoma
EP1230349B1 (de) 1999-11-18 2007-06-13 Dendreon Corporation Nukleinsäuren, welche für endotheliasen kodieren, endotheliasen, sowie deren verwendung
EP1280923A2 (de) 2000-04-28 2003-02-05 Millennium Pharmaceuticals, Inc. 14094, ein angehörige der menschlichen trypsin-familie, und dessen verwendungen
US6750034B1 (en) 2000-06-30 2004-06-15 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding human serine protease D-G
WO2002006455A2 (en) * 2000-07-19 2002-01-24 Bayer Aktiengesellschaft Regulation of human airway trypsin protease-like enzyme
US7157596B2 (en) 2000-09-08 2007-01-02 Dendreon Corporation Inhibitors of serine protease activity of matriptase or MTSP1
JP2004337001A (ja) * 2001-01-23 2004-12-02 Mochida Pharmaceut Co Ltd 新規なセリンプロテアーゼｍｐ４９３
AU2002305052A1 (en) 2001-03-13 2002-09-24 Corvas International, Inc. Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
EP1383884A4 (de) 2001-03-22 2004-12-15 Dendreon Corp Serinprotease cvsp14 codierende nukleinsäuremoleküle, die codierten polypeptide sowie darauf beruhende verfahren
NZ527971A (en) 2001-03-27 2006-03-31 Dendreon Corp Nucleic acid molecules encoding a transmembrane serine protease 9, the encoded polypeptides and methods based thereon
WO2002092841A2 (en) 2001-05-14 2002-11-21 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
US7700293B2 (en) 2001-08-02 2010-04-20 The Regents Of The University Of Michigan Expression profile of prostate cancer
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US7332290B2 (en) 2001-08-02 2008-02-19 The Regents Of The University Of Michigan Dectection of AMACR cancer markers in urine
EP1494709A4 (de) * 2002-04-17 2006-06-28 Genentech Inc Zusammensetzungen und verfahren zur tumordiagnose und -behandlung
IL165244A0 (en) * 2002-05-31 2005-12-18 Schering Ag Control sequences of the human corin gene
WO2004011654A1 (ja) * 2002-07-31 2004-02-05 Yamanouchi Pharmaceutical Co., Ltd. 新規セリンプロテアーゼ
US6977170B2 (en) 2002-09-06 2005-12-20 Applera Corporation Isolated human hepsin/46 proteins, nucleic acid molecules encoding human hepsin/46 proteins, and uses thereof
US7939304B2 (en) 2002-10-02 2011-05-10 Catalyst Biosciences, Inc. Mutant MT-SP1 proteases with altered substrate specificity or activity
DE10258051A1 (de) * 2002-12-11 2004-07-22 Metagen Pharmaceuticals Gmbh Verwendung von an HAT bindenden Substanzen zur Diagnose und Behandlung des Plattenepithelkarzinoms der Lunge
US7019019B2 (en) 2002-12-23 2006-03-28 Dendreon Corporation Matriptase inhibitors and methods of use
WO2004065599A1 (ja) * 2003-01-24 2004-08-05 Eisai Co., Ltd. Lrp4/Corinドーパミン産生ニューロン増殖前駆細胞マーカー
US7176013B2 (en) * 2003-06-11 2007-02-13 Schering Aktiengesellschaft Modified corin molecules having substitute activation sequences and uses thereof
WO2005084223A2 (en) 2004-02-27 2005-09-15 The General Hospital Corporation Methods and compositions for hair growth
AU2005244271B2 (en) 2004-04-12 2010-04-08 Vertex Pharmaceuticals Incorporated Cleavage of VEGF and VEGF receptor by wildtype and mutant MT-SP1
DE102004023187A1 (de) * 2004-05-11 2005-12-01 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
AU2005264579B2 (en) 2004-07-22 2010-06-10 Eisai R&D Management Co., Ltd. Lrp4/Corin dopaminergic neuron progenitor cell markers
CN101292031A (zh) 2005-08-18 2008-10-22 卫材R&D管理有限公司 多巴胺能神经元增殖祖细胞的标记物Nato3
MX2008004693A (es) 2005-10-21 2008-09-03 Catalyst Biosciences Inc Proteasas modificadas que inhiben la activacion del complemento.
US20100061996A1 (en) * 2006-06-22 2010-03-11 Genentech, Inc. Methods and compositions for modulating hepsin activation of urokinase-type plasminogen activator
ZA200810225B (en) 2006-06-22 2010-03-31 Genentech Inc Methods and compositions for targeting hepsin
NZ596269A (en) 2006-07-05 2012-12-21 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
GB0614201D0 (en) * 2006-07-18 2006-08-23 Univ Cardiff Matriptase-2
JP5864856B2 (ja) 2007-08-07 2016-02-17 オックスフォード ビオトヘラペウトイクス エルティーディー． マトリプターゼタンパク質及びその使用
KR101500670B1 (ko) * 2010-11-02 2015-03-10 인하대학교 산학협력단 암전이를 억제하는 항원 펩타이드, 이를 포함하는 암전이 백신, 암전이 억제 및 치료용 조성물 그리고 암전이 관련 표적물질 및 암전이 억제물질의 스크린 방법
JP6090937B2 (ja) 2011-07-27 2017-03-08 国立大学法人京都大学 新規ドーパミン産生神経前駆細胞マーカー
WO2015075477A1 (en) 2013-11-25 2015-05-28 Oxford Biotherapeutics Ltd Antibodies anti matriptase for the treatment of cancer
WO2017162659A1 (en) 2016-03-24 2017-09-28 Bayer Pharma Aktiengesellschaft Intracellular hepsin as therapeutic target for the treatment of cancer with centrosome amplification
EP3946412A4 (de) * 2019-04-05 2023-01-04 Azitra, Inc. Verfahren und zusammensetzungen zur behandlung von atopischer dermatitis mit rekombinanten mikroorganismen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
DK1157743T3 (da) 1993-10-28 2009-07-06 Houston Advanced Res Ct Mikrofremstillet poröst gennemströmningsapparat til diskret påvisning af bindingsreaktioner
JPH09149790A (ja) * 1995-09-29 1997-06-10 Suntory Ltd 新規セリンプロテアーゼ
WO1999046281A2 (en) * 1998-03-10 1999-09-16 Genentech, Inc. Novel polypeptides and nucleic acids encoding the same
US6203979B1 (en) * 1998-01-16 2001-03-20 Incyte Pharmaceuticals, Inc. Human protease molecules
US5972616A (en) 1998-02-20 1999-10-26 The Board Of Trustees Of The University Of Arkansas TADG-15: an extracellular serine protease overexpressed in breast and ovarian carcinomas
US6291663B1 (en) * 1999-03-03 2001-09-18 Board Of Trustees Of The University Of Arkansas TADG-12: a novel transmembrane serine protease overexpressed in a ovarian carcinoma
EP1194569A2 (de) * 1999-07-12 2002-04-10 MERCK PATENT GmbH Seripankrin

Also Published As

Publication number Publication date
JP2003521920A (ja) 2003-07-22
WO2001057194A3 (en) 2002-03-28
EP1252300B1 (de) 2011-01-19
AU2001233262A1 (en) 2001-08-14
DE60143880D1 (de) 2011-03-03
IL150168A0 (en) 2002-12-01
CA2396774A1 (en) 2001-08-09
EP1252300A2 (de) 2002-10-30
KR20020073576A (ko) 2002-09-27
WO2001057194A2 (en) 2001-08-09

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