ATE496123T1 - Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden - Google Patents

Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden

Info

Publication number
ATE496123T1
ATE496123T1 AT01905377T AT01905377T ATE496123T1 AT E496123 T1 ATE496123 T1 AT E496123T1 AT 01905377 T AT01905377 T AT 01905377T AT 01905377 T AT01905377 T AT 01905377T AT E496123 T1 ATE496123 T1 AT E496123T1
Authority
AT
Austria
Prior art keywords
tram
code
nucleic acids
methods based
serine proteases
Prior art date
Application number
AT01905377T
Other languages
English (en)
Inventor
Edwin Madison
Edgar Ong
Jiunn-Chern Yeh
Original Assignee
Dendreon Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/657,986 external-priority patent/US6797504B1/en
Application filed by Dendreon Corp filed Critical Dendreon Corp
Application granted granted Critical
Publication of ATE496123T1 publication Critical patent/ATE496123T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Laminated Bodies (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
AT01905377T 2000-02-03 2001-02-02 Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden ATE496123T1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US17998200P 2000-02-03 2000-02-03
US18354200P 2000-02-18 2000-02-18
US21312400P 2000-06-22 2000-06-22
US22097000P 2000-07-26 2000-07-26
US09/657,986 US6797504B1 (en) 2000-09-08 2000-09-08 Inhibitors of serine protease activity of matriptase or MTSP1
US23484000P 2000-09-22 2000-09-22
PCT/US2001/003471 WO2001057194A2 (en) 2000-02-03 2001-02-02 Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon

Publications (1)

Publication Number Publication Date
ATE496123T1 true ATE496123T1 (de) 2011-02-15

Family

ID=27558705

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01905377T ATE496123T1 (de) 2000-02-03 2001-02-02 Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden

Country Status (9)

Country Link
EP (1) EP1252300B1 (de)
JP (1) JP2003521920A (de)
KR (1) KR20020073576A (de)
AT (1) ATE496123T1 (de)
AU (1) AU2001233262A1 (de)
CA (1) CA2396774A1 (de)
DE (1) DE60143880D1 (de)
IL (1) IL150168A0 (de)
WO (1) WO2001057194A2 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030039648A1 (en) 1998-09-16 2003-02-27 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7037667B1 (en) 1998-06-01 2006-05-02 Agensys, Inc. Tumor antigen useful in diagnosis and therapy of prostate and colon cancer
US6291663B1 (en) * 1999-03-03 2001-09-18 Board Of Trustees Of The University Of Arkansas TADG-12: a novel transmembrane serine protease overexpressed in a ovarian carcinoma
IL149340A0 (en) 1999-11-18 2002-11-10 Corvas Int Inc Nucleic acids encoding endotheliases, endotheliases and uses thereof
EP1280923A2 (de) 2000-04-28 2003-02-05 Millennium Pharmaceuticals, Inc. 14094, ein angehörige der menschlichen trypsin-familie, und dessen verwendungen
US6750034B1 (en) 2000-06-30 2004-06-15 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding human serine protease D-G
WO2002006455A2 (en) * 2000-07-19 2002-01-24 Bayer Aktiengesellschaft Regulation of human airway trypsin protease-like enzyme
US7157596B2 (en) 2000-09-08 2007-01-02 Dendreon Corporation Inhibitors of serine protease activity of matriptase or MTSP1
JP2004337001A (ja) * 2001-01-23 2004-12-02 Mochida Pharmaceut Co Ltd 新規なセリンプロテアーゼｍｐ４９３
WO2002072786A2 (en) 2001-03-13 2002-09-19 Corvas International, Inc. Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
AU2002254357A1 (en) 2001-03-22 2002-10-08 Dendreon Corporation Nucleic acid molecules encoding serine protease cvsp14, the encoded polypeptides and methods based thereon
CA2442089A1 (en) 2001-03-27 2002-10-03 Dendreon San Diego Llc Nucleic acid molecules encoding a transmembran serine protease 9, the encoded polypeptides and methods based thereon
US7112430B2 (en) 2001-05-14 2006-09-26 Dendreon Corporation Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
US7700293B2 (en) 2001-08-02 2010-04-20 The Regents Of The University Of Michigan Expression profile of prostate cancer
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US7332290B2 (en) 2001-08-02 2008-02-19 The Regents Of The University Of Michigan Dectection of AMACR cancer markers in urine
WO2003088898A2 (en) * 2002-04-17 2003-10-30 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
MXPA04011944A (es) * 2002-05-31 2005-03-31 Schering Ag Secuencias de control del gen corin humano.
AU2003252734A1 (en) * 2002-07-31 2004-02-16 Yamanouchi Pharmaceutical Co., Ltd. Novel serine protease
US6977170B2 (en) 2002-09-06 2005-12-20 Applera Corporation Isolated human hepsin/46 proteins, nucleic acid molecules encoding human hepsin/46 proteins, and uses thereof
US7939304B2 (en) 2002-10-02 2011-05-10 Catalyst Biosciences, Inc. Mutant MT-SP1 proteases with altered substrate specificity or activity
DE10258051A1 (de) * 2002-12-11 2004-07-22 Metagen Pharmaceuticals Gmbh Verwendung von an HAT bindenden Substanzen zur Diagnose und Behandlung des Plattenepithelkarzinoms der Lunge
US7019019B2 (en) 2002-12-23 2006-03-28 Dendreon Corporation Matriptase inhibitors and methods of use
JP4573332B2 (ja) 2003-01-24 2010-11-04 エーザイ・アール・アンド・ディー・マネジメント株式会社 Ｌｒｐ４／Ｃｏｒｉｎドーパミン産生ニューロン増殖前駆細胞マーカー
CA2527361A1 (en) 2003-06-11 2004-12-23 Schering Aktiengesellschaft Novel modified corin molecules having substitute activation sequences and uses thereof
JP2007530016A (ja) 2004-02-27 2007-11-01 ザ ジェネラル ホスピタル コーポレーション 発毛のための方法および組成物
JP5629423B2 (ja) 2004-04-12 2014-11-19 カタリスト バイオサイエンシーズ， インコーポレイテッド 野生型及び変異型ｍｔ−ｓｐ１による、ｖｅｇｆ及びｖｅｇｆ受容体の切断
DE102004023187A1 (de) * 2004-05-11 2005-12-01 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
KR101375603B1 (ko) 2004-07-22 2014-04-01 에자이 알앤드디 매니지먼트 가부시키가이샤 Ｌｒｐ４／Ｃｏｒｉｎ 도파민 생산 뉴런 전구 세포 마커
CA2627593C (en) 2005-08-18 2012-04-24 Eisai R & D Management Co., Ltd. Dopaminergic neuron proliferative progenitor cell marker nato3
JP5219819B2 (ja) 2005-10-21 2013-06-26 カタリスト・バイオサイエンシーズ・インコーポレイテッド 補体活性化を阻害する修飾プロテアーゼ
AU2007260953B2 (en) * 2006-06-22 2013-07-11 Genentech, Inc. Methods and compositions for modulating hepsin activation of urokinase-type plasminogen activator
WO2007149932A2 (en) 2006-06-22 2007-12-27 Genentech, Inc. Methods and compositions for targeting hepsin
SG175602A1 (en) 2006-07-05 2011-11-28 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
GB0614201D0 (en) * 2006-07-18 2006-08-23 Univ Cardiff Matriptase-2
AU2008284271B2 (en) 2007-08-07 2014-03-13 E. R. Squibb & Sons, L.L.C. Matriptase protein and uses thereof
KR101500670B1 (ko) * 2010-11-02 2015-03-10 인하대학교 산학협력단 암전이를 억제하는 항원 펩타이드, 이를 포함하는 암전이 백신, 암전이 억제 및 치료용 조성물 그리고 암전이 관련 표적물질 및 암전이 억제물질의 스크린 방법
JP6090937B2 (ja) 2011-07-27 2017-03-08 国立大学法人京都大学 新規ドーパミン産生神経前駆細胞マーカー
KR20160079818A (ko) 2013-11-25 2016-07-06 옥스포드 바이오테라퓨틱스 리미티드 암 치료용 항-매트립타제 항체
WO2017162659A1 (en) 2016-03-24 2017-09-28 Bayer Pharma Aktiengesellschaft Intracellular hepsin as therapeutic target for the treatment of cancer with centrosome amplification
EP3946412A4 (de) * 2019-04-05 2023-01-04 Azitra, Inc. Verfahren und zusammensetzungen zur behandlung von atopischer dermatitis mit rekombinanten mikroorganismen

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4952496A (en) 1984-03-30 1990-08-28 Associated Universities, Inc. Cloning and expression of the gene for bacteriophage T7 RNA polymerase
US5401629A (en) 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
ATE214633T1 (de) 1993-10-28 2002-04-15 Houston Advanced Res Ct Mikrofabriziertes poröses durchflussgerät
JPH09149790A (ja) * 1995-09-29 1997-06-10 Suntory Ltd 新規セリンプロテアーゼ
US6203979B1 (en) * 1998-01-16 2001-03-20 Incyte Pharmaceuticals, Inc. Human protease molecules
US5972616A (en) 1998-02-20 1999-10-26 The Board Of Trustees Of The University Of Arkansas TADG-15: an extracellular serine protease overexpressed in breast and ovarian carcinomas
ES2312205T3 (es) * 1998-03-10 2009-02-16 Genentech, Inc. Nuevo polipeptido y acidos nucleicos que lo codifican.
US6291663B1 (en) * 1999-03-03 2001-09-18 Board Of Trustees Of The University Of Arkansas TADG-12: a novel transmembrane serine protease overexpressed in a ovarian carcinoma
CA2378796A1 (en) * 1999-07-12 2001-01-18 Merck Patent Gesellschaft Mit Beschraenkter Haftung Seripancrin

Also Published As

Publication number Publication date
IL150168A0 (en) 2002-12-01
CA2396774A1 (en) 2001-08-09
JP2003521920A (ja) 2003-07-22
KR20020073576A (ko) 2002-09-27
DE60143880D1 (de) 2011-03-03
WO2001057194A2 (en) 2001-08-09
EP1252300B1 (de) 2011-01-19
AU2001233262A1 (en) 2001-08-14
WO2001057194A3 (en) 2002-03-28
EP1252300A2 (de) 2002-10-30

Similar Documents

Publication Publication Date Title
ATE496123T1 (de) Nukleinsäuren, welche für tramsmembran serin proteasen kodieren, die kodierten proteine und darauf basierende methoden
ATE323759T1 (de) Rückgewinnung eines proteins bei hohem ph-wert
ATE317441T1 (de) Cathepsin-02-protease
UA95438C2 (ru) Биспецифические антитела, которые замещают функциональные белки
ATE469911T1 (de) Isolierte nukleinsäuremoleküle die t-zellen induzierbare faktoren kodieren (tif), kodierte proteine und ihre anwendung
DE69739996D1 (de) Methoden und Zusammensetzungen zur Herstellung von Polypeptiden
ATE485303T1 (de) Isoformen von gehirn-natriuretischem peptid
ES2162277T3 (es) Sustratos e inhibidores de enzimas proteoliticos.
DE69937835D1 (de) Antikörper für apoptosemarker und anwendungsverfahren
ATE350470T1 (de) Durch thrombin spaltbare chimäre proteine
TR199902751T2 (xx) Proteaz inhibit�rleri.
ATE474926T1 (de) Verwendung von clya hemolysin fur ausscheidung von fusionprotein
ATE335485T1 (de) Quinolin-enthaltende alpha-ketoamid-basierte inhibitoren von cystein- und serin protease
WO2002077267A3 (en) Nucleic acid molecules encoding a transmembran serine protease 9, the encoded polypeptides and methods based thereon
IS6678A (is) Hvarfefni og prófanir fyrir ß-sekretasavirkni
WO2002092841A3 (en) Nucleic acid molecules encoding a transmembrane serine protease 10, the encoded polypeptides and methods based thereon
DK1150999T3 (da) Cyclosporinderivater og fremgangsmåde til fremstilling deraf
WO2002072786A3 (en) Nucleic acid molecules encoding a transmembrane serine protease 7, the encoded polypeptides and methods based thereon
WO2003004681A3 (en) Nucleic acid molecules encoding a transmembrane serine protease 20, the encoded polypeptides and methods based thereon
ATE501268T1 (de) Vorrichtungen und verfahren zur bestimmung von proteaseaktivität
ATE364689T1 (de) Nukleinsäuren, welche für endotheliasen kodieren, endotheliasen, sowie deren verwendung
AU8398801A (en) Two coloured fluorimetric protease assay
DK0942992T3 (da) O-fucosyltransferase
AR027327A1 (es) Procedimiento para la separacion einzimatica de racematos de derivados de aminometil-aril-ciclohezanol
DE60331414D1 (de) Aggrecanase-1- und -2-peptidsubstrate und verfahren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties