ATE488576T1 - Schnellproduktion monoklonaler antikörper - Google Patents

Schnellproduktion monoklonaler antikörper

Info

Publication number
ATE488576T1
ATE488576T1 AT02723187T AT02723187T ATE488576T1 AT E488576 T1 ATE488576 T1 AT E488576T1 AT 02723187 T AT02723187 T AT 02723187T AT 02723187 T AT02723187 T AT 02723187T AT E488576 T1 ATE488576 T1 AT E488576T1
Authority
AT
Austria
Prior art keywords
monoclonal antibodies
rapid production
cells
hybridomas
myelomas
Prior art date
Application number
AT02723187T
Other languages
English (en)
Inventor
Richard Meagher
Vince Laterza
Original Assignee
Univ Georgia
Abeome Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgia, Abeome Corp filed Critical Univ Georgia
Application granted granted Critical
Publication of ATE488576T1 publication Critical patent/ATE488576T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • C12N5/163—Animal cells one of the fusion partners being a B or a T lymphocyte
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G01N33/5052—Cells of the immune system involving B-cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/02—Cells for production
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT02723187T 2001-02-20 2002-02-20 Schnellproduktion monoklonaler antikörper ATE488576T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27032201P 2001-02-20 2001-02-20
PCT/US2002/004936 WO2002066618A1 (en) 2001-02-20 2002-02-20 Rapid production of monoclonal antibodies

Publications (1)

Publication Number Publication Date
ATE488576T1 true ATE488576T1 (de) 2010-12-15

Family

ID=23030851

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02723187T ATE488576T1 (de) 2001-02-20 2002-02-20 Schnellproduktion monoklonaler antikörper

Country Status (8)

Country Link
US (3) US7148040B2 (de)
EP (2) EP1362093B1 (de)
JP (1) JP2004525627A (de)
AT (1) ATE488576T1 (de)
AU (1) AU2002253981B2 (de)
CA (1) CA2438818C (de)
DE (1) DE60238308D1 (de)
WO (1) WO2002066618A1 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002066618A1 (en) * 2001-02-20 2002-08-29 University Of Georgia Research Foundation, Inc. Rapid production of monoclonal antibodies
EP1535046A4 (de) * 2002-08-28 2006-09-13 Bionexus Ventures L L C Screening von antikörpern unter verwendung einer faseroptischen arrayeinrichtung mit der fähigkeit zur gleichzeitigen durchführung mehrerer funktionaler assays
PE20081216A1 (es) * 2006-09-01 2008-09-04 Therapeutic Human Polyclonals Inc Expresion mejorada de la inmunoglobulina humana o humanizada en animales transgenicos no humanos
WO2008128144A2 (en) * 2007-04-15 2008-10-23 Shuang Zhang Monoclonal antibody selecting system, and making and using thereof
EP2307453A1 (de) * 2008-06-16 2011-04-13 University Of Zurich Verfahren zur bereitstellung immunglobulinsezernierender b-lymphozyten und humaner antikörper
US8628927B2 (en) 2008-11-07 2014-01-14 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
EP2364368B1 (de) 2008-11-07 2014-01-15 Sequenta, Inc. Verfahren zur überwachung von krankheitszuständen mittels sequenzanalyse
US9528160B2 (en) 2008-11-07 2016-12-27 Adaptive Biotechnolgies Corp. Rare clonotypes and uses thereof
US9506119B2 (en) 2008-11-07 2016-11-29 Adaptive Biotechnologies Corp. Method of sequence determination using sequence tags
US9365901B2 (en) 2008-11-07 2016-06-14 Adaptive Biotechnologies Corp. Monitoring immunoglobulin heavy chain evolution in B-cell acute lymphoblastic leukemia
US8748103B2 (en) 2008-11-07 2014-06-10 Sequenta, Inc. Monitoring health and disease status using clonotype profiles
ES2726702T3 (es) 2009-01-15 2019-10-08 Adaptive Biotechnologies Corp Perfilado de la inmunidad adaptativa y métodos para la generación de anticuerpos monoclonales
WO2010151416A1 (en) 2009-06-25 2010-12-29 Fred Hutchinson Cancer Research Center Method of measuring adaptive immunity
WO2011068801A2 (en) 2009-12-01 2011-06-09 The Rockefeller University Methods for identifying compounds that modulate ion channel activity of a kir channel
US10662256B2 (en) 2010-07-26 2020-05-26 Trianni, Inc. Transgenic mammals and methods of use thereof
CN103025884B (zh) 2010-07-26 2015-11-25 特里安尼公司 转基因动物和使用方法
US10793829B2 (en) 2010-07-26 2020-10-06 Trianni, Inc. Transgenic mammals and methods of use thereof
US10385475B2 (en) 2011-09-12 2019-08-20 Adaptive Biotechnologies Corp. Random array sequencing of low-complexity libraries
EP2768982A4 (de) 2011-10-21 2015-06-03 Adaptive Biotechnologies Corp Quantifizierung von adaptiven immunzellgenomen in einer komplexen mischung von zellen
US9824179B2 (en) 2011-12-09 2017-11-21 Adaptive Biotechnologies Corp. Diagnosis of lymphoid malignancies and minimal residual disease detection
US9499865B2 (en) 2011-12-13 2016-11-22 Adaptive Biotechnologies Corp. Detection and measurement of tissue-infiltrating lymphocytes
US10233424B2 (en) 2011-12-22 2019-03-19 Elwha Llc Compositions and methods including cytotoxic B lymphocyte cell line expressing exogenous membrane immunoglobulin different from secreted immunoglobulin
US10745468B2 (en) 2011-12-22 2020-08-18 Kota Biotherapeutics, Llc Compositions and methods for modified B cells expressing reassigned biological agents
EP3372694A1 (de) 2012-03-05 2018-09-12 Adaptive Biotechnologies Corporation Festlegung von gepaarten immunrezeptorketten aus frequenzabgestimmten untereinheiten
HUE029357T2 (en) 2012-05-08 2017-02-28 Adaptive Biotechnologies Corp Preparations and devices for measuring and calibrating amplification distortion in multiplex PCR reactions
EP3330384B1 (de) 2012-10-01 2019-09-25 Adaptive Biotechnologies Corporation Immunkompetenzbeurteilung durch adaptive immunrezeptordiversität und klonalitätscharakterisierung
WO2015160439A2 (en) 2014-04-17 2015-10-22 Adaptive Biotechnologies Corporation Quantification of adaptive immune cell genomes in a complex mixture of cells
US9708657B2 (en) 2013-07-01 2017-07-18 Adaptive Biotechnologies Corp. Method for generating clonotype profiles using sequence tags
WO2015134787A2 (en) 2014-03-05 2015-09-11 Adaptive Biotechnologies Corporation Methods using randomer-containing synthetic molecules
US11390921B2 (en) 2014-04-01 2022-07-19 Adaptive Biotechnologies Corporation Determining WT-1 specific T cells and WT-1 specific T cell receptors (TCRs)
US10066265B2 (en) 2014-04-01 2018-09-04 Adaptive Biotechnologies Corp. Determining antigen-specific t-cells
CN111690052B (zh) * 2014-04-08 2024-06-04 瑞泽恩制药公司 具有人源化FC-γ受体的非人动物
CA2966201A1 (en) 2014-10-29 2016-05-06 Adaptive Biotechnologies Corp. Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
US10246701B2 (en) 2014-11-14 2019-04-02 Adaptive Biotechnologies Corp. Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture
AU2015353581A1 (en) 2014-11-25 2017-06-15 Adaptive Biotechnologies Corporation Characterization of adaptive immune response to vaccination or infection using immune repertoire sequencing
CA2976580A1 (en) 2015-02-24 2016-09-01 Adaptive Biotechnologies Corp. Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing
EP3277294B1 (de) 2015-04-01 2024-05-15 Adaptive Biotechnologies Corp. Verfahren zur identifizierung von menschlichen kompatiblen t-zell-rezeptoren spezifisch für ein antigen-ziel
PL413909A1 (pl) 2015-09-15 2017-03-27 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Odpowiedzialnością Sposób detekcji i selekcji komórek hybrydomalnych produkujących pożądane przeciwciała
US10813346B2 (en) 2015-12-03 2020-10-27 Trianni, Inc. Enhanced immunoglobulin diversity
EP4414484A3 (de) * 2016-02-04 2025-01-15 Trianni, Inc. Erhöhte produktion von immunglobulinen
US10428325B1 (en) 2016-09-21 2019-10-01 Adaptive Biotechnologies Corporation Identification of antigen-specific B cell receptors
JP6749593B2 (ja) * 2017-03-10 2020-09-02 国立大学法人横浜国立大学 モノクローナル抗体の製造方法
IL312457A (en) 2017-03-24 2024-06-01 Lankenau Inst Medical Res Methods and compositions for inducible extracellular membrane trapping of monoclonal immunoglobulins secreted by hybridomas
EP3612210A4 (de) 2017-04-19 2021-01-27 Board Of Regents, The University Of Texas System Manipulierte antigenrezeptoren exprimierende immunzellen
US11254980B1 (en) 2017-11-29 2022-02-22 Adaptive Biotechnologies Corporation Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements
US12473336B2 (en) 2018-02-21 2025-11-18 Board Of Regents, The University Of Texas System Methods for activation and expansion of natural killer cells and uses thereof
IL314733A (en) 2018-03-26 2024-10-01 Regeneron Pharma Humanized rodents for testing therapeutic agents
KR20220053596A (ko) 2019-08-30 2022-04-29 제넨테크, 인크. 치료 항체 발견을 위한 효율적인 하이브리도마 플랫폼의 개발

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5077195A (en) 1985-03-01 1991-12-31 Board Of Reagents, The University Of Texas System Polypeptides complementary to peptides or proteins having an amino acid sequence or nucleotide coding sequence at least partially known and methods of design therefor
US4978625A (en) 1987-10-19 1990-12-18 Becton, Dickinson And Company Fluorescence immunoassay using water insoluble dyes
US5264341A (en) 1989-08-30 1993-11-23 Eli Lilly And Company Selective cloning for high monoclonal antibody secreting hybridomas
CA2090126C (en) 1990-08-02 2002-10-22 John W. Schrader Methods for the production of proteins with a desired function
US5877397A (en) * 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
AU672969B2 (en) 1992-03-10 1996-10-24 United States of America, as represented by The Secretary, Department of Health & Human Services, The Exchangeable template reaction
US5464758A (en) * 1993-06-14 1995-11-07 Gossen; Manfred Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US6111166A (en) 1994-09-19 2000-08-29 Medarex, Incorporated Transgenic mice expressing human Fcα and β receptors
DE19900635A1 (de) 1999-01-11 2000-07-13 Deutsches Krebsforsch Selektion von monoklonalen Antikörpern
DE10192655D2 (de) * 2000-07-10 2003-06-12 Haring Bolivar Peter Verfahren zum Nachweis von Polynucleotidsequenzen
WO2002066618A1 (en) 2001-02-20 2002-08-29 University Of Georgia Research Foundation, Inc. Rapid production of monoclonal antibodies

Also Published As

Publication number Publication date
CA2438818A1 (en) 2002-08-29
JP2004525627A (ja) 2004-08-26
EP1362093A4 (de) 2004-05-19
EP2365062A1 (de) 2011-09-14
EP1362093B1 (de) 2010-11-17
US7629171B2 (en) 2009-12-08
US20100287632A1 (en) 2010-11-11
US20030162947A1 (en) 2003-08-28
EP2365062B1 (de) 2016-11-23
CA2438818C (en) 2013-07-02
US20070207539A1 (en) 2007-09-06
US8912385B2 (en) 2014-12-16
EP1362093A1 (de) 2003-11-19
DE60238308D1 (de) 2010-12-30
AU2002253981B2 (en) 2008-02-21
WO2002066618A1 (en) 2002-08-29
US7148040B2 (en) 2006-12-12

Similar Documents

Publication Publication Date Title
ATE488576T1 (de) Schnellproduktion monoklonaler antikörper
DK1414858T3 (da) Kamelid-enkeltkæde-VHH-antistoffer, fremgangsmåde til fremstilling heraf i et pattedyr samt anvendelser heraf
DE3580654D1 (de) Menschlicher hybridomfusionspartner zur herstellung menschlicher monoklonaler antikoerper.
NZ595450A (en) Antibodies to M-CSF
DE60235588D1 (de) Monoklonales Antikörper gegen das HCV Kernantigen
TR200300478T2 (tr) Hümanize antiLT-ß-R antikorları
ATE443723T1 (de) Monoklonale antikörper, kreuz-reaktive antikörper und deren produktionsverfahren
WO2004106385A3 (en) Monoclonal antibodies specific for buprenorphine and metabolites thereof
DK1092767T3 (da) Serinproteasespecifikke monoklonale antistoffer og anvendelse deraf
DK1506235T3 (da) Fremgangsmåde til produktion af monoklonale antistoffer
PT1343366E (pt) Estufa
DK1456238T3 (da) Produktion af F(ab')2-fragmenter i pattedyrceller
DE69434828D1 (de) Monoklonale Antikörper die Flk-2 Rezeptoren erkennen, und die Isolierung primitiver hämatopoietischer Stammzellpopulationen
SE0002835D0 (sv) Method and kit for production of monoclonal antibodies
DE3850993D1 (de) Monoklonaler Antikörper spezifisch gegen humane Pankreas-Phospholipase-A2.
EP1359161A3 (de) Monoklonaler Antikörper, der spezifische gegen tartratbeständige Säurephosphatase 5b gerichtet ist und dessen Verwendung
DE602005025414D1 (de) Immunnachweiskit in verbindung mit neuroglobin-enzym sowie verwendung davon
ATE148163T1 (de) Monoklonale antikörper gegen leptosphaeria
ATE343596T1 (de) Humane monoklonale antikörper gegen inselzellantigen ia-2
DE69124294D1 (de) Monoklonale Antikörper gegen Mycosphaerella-Arten
EP1026173A4 (de) Antihumane thymidylat-synthasemonoklonale antikörper und hybridomazellen zu deren herstellung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties