ATE488577T1 - Mutiertes ionenkanalprotein enthaltende viren - Google Patents
Mutiertes ionenkanalprotein enthaltende virenInfo
- Publication number
- ATE488577T1 ATE488577T1 AT01928486T AT01928486T ATE488577T1 AT E488577 T1 ATE488577 T1 AT E488577T1 AT 01928486 T AT01928486 T AT 01928486T AT 01928486 T AT01928486 T AT 01928486T AT E488577 T1 ATE488577 T1 AT E488577T1
- Authority
- AT
- Austria
- Prior art keywords
- ion channel
- channel protein
- viruses containing
- containing mutated
- mutated ion
- Prior art date
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 102000034573 Channels Human genes 0.000 title 1
- 108091006146 Channels Proteins 0.000 title 1
- 108090000862 Ion Channels Proteins 0.000 abstract 1
- 102000004310 Ion Channels Human genes 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16161—Methods of inactivation or attenuation
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19720900P | 2000-04-14 | 2000-04-14 | |
| PCT/US2001/011963 WO2001079273A2 (en) | 2000-04-14 | 2001-04-12 | Viruses comprising mutated ion channel protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE488577T1 true ATE488577T1 (de) | 2010-12-15 |
Family
ID=22728471
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01928486T ATE488577T1 (de) | 2000-04-14 | 2001-04-12 | Mutiertes ionenkanalprotein enthaltende viren |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6872395B2 (de) |
| EP (1) | EP1276852B1 (de) |
| JP (1) | JP4927290B2 (de) |
| AT (1) | ATE488577T1 (de) |
| AU (2) | AU5533601A (de) |
| CA (1) | CA2406180C (de) |
| DE (1) | DE60143476D1 (de) |
| HK (1) | HK1052949B (de) |
| WO (1) | WO2001079273A2 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6872395B2 (en) | 2000-04-14 | 2005-03-29 | Wisconsin Alumni Research Foundation | Viruses comprising mutant ion channel protein |
| AU2003219745B8 (en) * | 2002-02-13 | 2008-10-09 | Wisconsin Alumni Research Foundation | Signal for packaging of influenza virus vectors |
| KR101011410B1 (ko) * | 2002-02-13 | 2011-01-28 | 위스콘신 얼럼나이 리서어치 화운데이션 | 인플루엔자 바이러스 벡터의 패키징을 위한 신호 |
| US20060160759A1 (en) * | 2002-09-28 | 2006-07-20 | Jianzhu Chen | Influenza therapeutic |
| CA2957200C (en) * | 2002-10-16 | 2020-05-26 | Gen-Probe Incorporated | Compositions and methods for detecting west nile virus |
| US7927840B2 (en) | 2006-09-11 | 2011-04-19 | Gen Probe Incorporated | Method for detecting West Nile Virus nucleic acids in the 3′ non-coding region |
| ES2217967B1 (es) * | 2003-03-31 | 2006-01-01 | Consejo Sup. Investig. Cientificas | Procedimiento de produccion de particulas virales vacias (vlps) del virus inductor de la bursitis infecciosa (ibdv), composiciones necesarias para su puesta a punto y su uso en la elaboracion de vacunas frente al ibdv. |
| NZ542935A (en) * | 2003-04-23 | 2008-08-29 | Wisconsin Alumni Res Found | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| EA012965B1 (ru) * | 2003-05-28 | 2010-02-26 | Висконсин Эламни Рисёч Фаундэйшн | Композиция для получения реассортантного рекомбинантного вируса гриппа, способ получения указанного вируса и реассортантный рекомбинантный вирус гриппа |
| ES2307346B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias (vlps(-vp4)) del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
| ES2307345B1 (es) * | 2004-01-21 | 2009-11-13 | Consejo Sup. Investig. Cientificas | Capsidas vacias quimericas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), su procedimiento de obtencion y aplicaciones. |
| WO2006019955A2 (en) | 2004-07-14 | 2006-02-23 | President And Fellows Of Harvard College | Antiviral methods and compositions |
| EP1814990A2 (de) | 2004-11-19 | 2007-08-08 | Wisconsin Alumni Research Foundation | Rekombinante influenza-vektoren mit transkriptionseinheiten, die in tandem vorliegen |
| ES2310062B1 (es) * | 2005-07-15 | 2009-11-13 | Bionostra, S.L. | Particulas pseudovirales vacias quimericas derivadas del virus causante de la enfermedad de la bursitis infecciosa (ibdv), procedimiento de obtencion y aplicaciones. |
| ES2555544T3 (es) | 2006-03-07 | 2016-01-04 | Vaxinnate Corporation | Composiciones que incluyen hemaglutinina, métodos de preparación y métodos de uso de las mismas |
| CN101472941B (zh) | 2006-03-31 | 2017-08-08 | 沃弗-威斯康星校友研究基金会 | 用于疫苗的高滴度重组流感病毒 |
| US20080020371A1 (en) * | 2006-04-14 | 2008-01-24 | German Thomas L | Reverse Genetics System |
| US9101578B2 (en) * | 2006-05-01 | 2015-08-11 | Technovax, Inc. | Polyvalent influenza virus-like particle (VLP) compositions |
| RU2009105099A (ru) | 2006-07-14 | 2010-08-27 | Санофи Пастер Байолоджикс Ко. (Us) | Конструирование рекомбинантных вирусных вакцин путем прямой транспозон-опосредованной инсерции чужеродных иммунологических детерминант в белки векторного вируса |
| KR20090096414A (ko) | 2006-09-29 | 2009-09-10 | 사노피 파스테르 바이오로직스 씨오 | 재조합 리노바이러스 벡터 |
| US8597661B2 (en) | 2007-05-04 | 2013-12-03 | Wisconsin Alumni Research Foundation | Neuraminidase-deficient live influenza vaccines |
| WO2008156778A2 (en) * | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
| US9056898B2 (en) * | 2007-09-20 | 2015-06-16 | Washington University | Attenuated RNA virus and applications thereof |
| US20110003393A1 (en) * | 2007-10-25 | 2011-01-06 | President And Fellows Of Harvard College | Systems and methods for studying influenza |
| JP2013507990A (ja) | 2009-10-26 | 2013-03-07 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| KR102080061B1 (ko) | 2011-06-24 | 2020-02-21 | 플루젠, 인코퍼레이티드 | 인플루엔자 바이러스 돌연변이체들 및 그들의 용도들 |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| EP3341018B1 (de) | 2015-08-28 | 2026-05-20 | Wisconsin Alumni Res Found | Herstellung von infektiösen influenzaviren mittels virusähnlicher partikel |
| CN109477074B (zh) | 2016-02-19 | 2023-01-24 | 威斯康星旧生研究基金会 | 用于疫苗开发的改进的乙型流感病毒复制 |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| JP7783047B2 (ja) | 2018-08-07 | 2025-12-09 | ウィスコンシン アルムニ リサーチ ファンデイション | 組換えの生物学的に封じ込められたフィロウイルスワクチン |
| EP3840780A1 (de) | 2018-08-20 | 2021-06-30 | Wisconsin Alumni Research Foundation | Vektoren zur auslösung von immunantworten auf nicht-dominante epitope im hämagglutinin (ha)-protein |
| WO2020167432A2 (en) | 2019-01-23 | 2020-08-20 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| WO2020163804A1 (en) | 2019-02-08 | 2020-08-13 | Wisconsin Alumni Research Foundation (Warf) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| US12616745B2 (en) | 2019-06-07 | 2026-05-05 | Flugen, Inc. | Influenza virus backbone |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス |
| EP4093415A1 (de) | 2020-01-24 | 2022-11-30 | Wisconsin Alumni Research Foundation (WARF) | Rekombinante influenza-viren mit stabilisiertem na |
| US12290562B2 (en) | 2020-03-25 | 2025-05-06 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| MX2023000881A (es) | 2020-07-21 | 2023-02-22 | Flugen Inc | Estructura genomica del virus de la influenza. |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ219515A (en) | 1987-02-10 | 1989-09-27 | Wellcome Found | Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope |
| US5840520A (en) | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
| US5919676A (en) | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| US5994526A (en) | 1996-06-21 | 1999-11-30 | Plant Genetic Systems | Gene expression in plants |
| WO1999007839A2 (en) | 1997-08-05 | 1999-02-18 | Vlaams Interuniversitair Instituut Voor Biotechnologie | Immunoprotective influenza antigen and its use in vaccination |
| EP1035209A1 (de) | 1999-03-06 | 2000-09-13 | ARTEMIS Pharmaceuticals GmbH | Stabile rekombinante Influenzaviren, die frei von Helfervirus sind |
| US6686168B1 (en) | 1999-11-04 | 2004-02-03 | Zymogenetics, Inc. | Cell surface display of proteins by recombinant host cells |
| US6872395B2 (en) * | 2000-04-14 | 2005-03-29 | Wisconsin Alumni Research Foundation | Viruses comprising mutant ion channel protein |
| NZ542935A (en) | 2003-04-23 | 2008-08-29 | Wisconsin Alumni Res Found | Recombinant influenza viruses holding a mutation in a transmembrane protein gene |
| CN101472941B (zh) * | 2006-03-31 | 2017-08-08 | 沃弗-威斯康星校友研究基金会 | 用于疫苗的高滴度重组流感病毒 |
-
2001
- 2001-04-12 US US09/834,095 patent/US6872395B2/en not_active Expired - Lifetime
- 2001-04-12 EP EP01928486A patent/EP1276852B1/de not_active Expired - Lifetime
- 2001-04-12 JP JP2001576868A patent/JP4927290B2/ja not_active Expired - Lifetime
- 2001-04-12 HK HK03105001.3A patent/HK1052949B/en not_active IP Right Cessation
- 2001-04-12 WO PCT/US2001/011963 patent/WO2001079273A2/en not_active Ceased
- 2001-04-12 AU AU5533601A patent/AU5533601A/xx active Pending
- 2001-04-12 AT AT01928486T patent/ATE488577T1/de not_active IP Right Cessation
- 2001-04-12 CA CA2406180A patent/CA2406180C/en not_active Expired - Lifetime
- 2001-04-12 DE DE60143476T patent/DE60143476D1/de not_active Expired - Lifetime
- 2001-04-12 AU AU2001255336A patent/AU2001255336B8/en not_active Expired
-
2005
- 2005-01-26 US US11/043,768 patent/US8057806B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004500830A (ja) | 2004-01-15 |
| HK1052949A1 (en) | 2003-10-03 |
| EP1276852B1 (de) | 2010-11-17 |
| JP4927290B2 (ja) | 2012-05-09 |
| CA2406180A1 (en) | 2001-10-25 |
| AU5533601A (en) | 2001-10-30 |
| DE60143476D1 (de) | 2010-12-30 |
| EP1276852A2 (de) | 2003-01-22 |
| AU2001255336B2 (en) | 2005-09-29 |
| US6872395B2 (en) | 2005-03-29 |
| US20050232950A1 (en) | 2005-10-20 |
| CA2406180C (en) | 2013-05-28 |
| WO2001079273A2 (en) | 2001-10-25 |
| US20030194694A1 (en) | 2003-10-16 |
| WO2001079273A3 (en) | 2002-07-18 |
| US8057806B2 (en) | 2011-11-15 |
| HK1052949B (en) | 2011-04-29 |
| AU2001255336B8 (en) | 2005-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |