ATE489107T1 - Sichere, mutierte virale impfstoffe - Google Patents

Sichere, mutierte virale impfstoffe

Info

Publication number
ATE489107T1
ATE489107T1 AT04801973T AT04801973T ATE489107T1 AT E489107 T1 ATE489107 T1 AT E489107T1 AT 04801973 T AT04801973 T AT 04801973T AT 04801973 T AT04801973 T AT 04801973T AT E489107 T1 ATE489107 T1 AT E489107T1
Authority
AT
Austria
Prior art keywords
viruses
vaccines
safe
viral vaccines
mutations
Prior art date
Application number
AT04801973T
Other languages
English (en)
Inventor
Siao-Kun Wan Welch
Jay Gregory Calvert
Michael K O'hara
Xuemei Cao
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34272474&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE489107(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of ATE489107T1 publication Critical patent/ATE489107T1/de

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24311Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24322New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/24011Flaviviridae
    • C12N2770/24311Pestivirus, e.g. bovine viral diarrhea virus
    • C12N2770/24334Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04801973T 2003-07-29 2004-07-26 Sichere, mutierte virale impfstoffe ATE489107T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49083403P 2003-07-29 2003-07-29
PCT/US2004/024011 WO2005021034A2 (en) 2003-07-29 2004-07-26 Safe mutant viral vaccines

Publications (1)

Publication Number Publication Date
ATE489107T1 true ATE489107T1 (de) 2010-12-15

Family

ID=34272474

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04801973T ATE489107T1 (de) 2003-07-29 2004-07-26 Sichere, mutierte virale impfstoffe

Country Status (27)

Country Link
US (2) US7361357B2 (de)
EP (1) EP1651263B9 (de)
JP (1) JP4662931B2 (de)
KR (1) KR100810820B1 (de)
CN (1) CN1976717A (de)
AT (1) ATE489107T1 (de)
AU (1) AU2004268514B2 (de)
BR (1) BRPI0413107A (de)
CA (1) CA2533877C (de)
CY (1) CY1110995T1 (de)
DE (1) DE602004030253D1 (de)
DK (1) DK1651263T3 (de)
EA (1) EA009391B1 (de)
ES (1) ES2355276T3 (de)
IL (1) IL173338A0 (de)
IS (1) IS8254A (de)
NO (1) NO20060931L (de)
NZ (1) NZ545612A (de)
PL (1) PL1651263T3 (de)
PT (1) PT1651263E (de)
RS (1) RS51456B (de)
SI (1) SI1651263T1 (de)
TN (1) TNSN06031A1 (de)
TW (1) TWI342783B (de)
UA (1) UA85845C2 (de)
WO (1) WO2005021034A2 (de)
ZA (1) ZA200600585B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179473B2 (en) 1998-06-05 2007-02-20 Boehringer Ingelheim Vetmedica Gmbh Attenuated pestiviruses
US7135561B2 (en) * 2001-09-06 2006-11-14 Boehringer Ingelheim Vetmedica Gmbh Infectious bovine viral diarrhea virus clone
US7361357B2 (en) * 2003-07-29 2008-04-22 Pfizer Inc. Safe mutant viral vaccines
US7572455B2 (en) * 2004-05-19 2009-08-11 Boehringer Ingelheim Vetmedica Gmbh Vaccine comprising an attenuated pestivirus
US8834891B2 (en) * 2005-03-14 2014-09-16 Boehringer Ingelheim Vetmedica, Inc. Immunogenic compositions comprising Lawsonia intracellularis
US20090068223A1 (en) * 2005-11-15 2009-03-12 Boehringer Ingelheim Vetmedica, Inc. Combination vaccine comprising an attenuated bovine viral diarrhea virus
US7666585B2 (en) * 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
US8114852B2 (en) * 2008-01-15 2012-02-14 The United States Of America As Represented By The Secretary Of Agriculture N-linked glycosylation alteration in E1 glycoprotein of classical swine fever virus and novel classical swine fever virus vaccine
UY31930A (es) * 2008-06-25 2010-01-29 Boheringer Ingelheim Pharma Kg Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante
WO2010064164A1 (en) * 2008-12-03 2010-06-10 Pfizer Inc. Bovine viral diarrhea virus with a modified erns protein
US8846054B2 (en) * 2009-01-09 2014-09-30 Boehringer Ingelheim Vetmedica, Inc. Method of treating pregnant cows and/or heifers
WO2012092053A1 (en) * 2010-12-27 2012-07-05 Eli Lilly And Company Bovine viral diarrhea virus type 1b vaccine compositions and methods
RU2457859C1 (ru) * 2011-01-12 2012-08-10 Федеральное государственное бюджетное учреждение "Федеральный центр охраны здоровья животных" (ФГБУ "ВНИИЗЖ") Вакцина против вирусной диареи крупного рогатого скота
CN105985413A (zh) * 2015-02-28 2016-10-05 中国科学院上海巴斯德研究所 新的甲型流感病毒哺乳动物细胞适应株及其制备和应用
KR102580161B1 (ko) 2017-08-02 2023-09-20 순천향대학교 산학협력단 백신의 중추신경계 안전성 검사를 위한 양성대조군의 제조방법 및 이를 이용한 검사 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US6001613A (en) * 1996-05-24 1999-12-14 Board Of Regents Of University Of Nebraska Plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus, chimeric derivatives thereof, and method of producing an infectious bovine viral diarrhea virus using said plasmid
ES2232934T3 (es) 1997-02-14 2005-06-01 MERCK & CO., INC. Formulaciones de vacunas a base de polinucleotidos.
RS20050177A (sr) 2002-08-26 2007-06-04 Pfizer Products Inc., Vakcina za infekcije respiratornog i reproduktivnog sistema kod stoke
US7563449B2 (en) * 2003-04-21 2009-07-21 Pfizer Inc, Methods for reducing cattle reproductive diseases
US7361357B2 (en) 2003-07-29 2008-04-22 Pfizer Inc. Safe mutant viral vaccines

Also Published As

Publication number Publication date
EP1651263B9 (de) 2011-02-16
ZA200600585B (en) 2007-03-28
JP2007500702A (ja) 2007-01-18
EA200600121A1 (ru) 2006-10-27
EP1651263A2 (de) 2006-05-03
IS8254A (is) 2006-01-23
CN1976717A (zh) 2007-06-06
DE602004030253D1 (de) 2011-01-05
TW200514568A (en) 2005-05-01
RS20060045A (sr) 2008-06-05
ES2355276T3 (es) 2011-03-24
EP1651263B1 (de) 2010-11-24
PL1651263T3 (pl) 2011-04-29
BRPI0413107A (pt) 2006-10-03
US7361357B2 (en) 2008-04-22
ES2355276T9 (es) 2011-03-25
WO2005021034A3 (en) 2005-12-29
CA2533877C (en) 2011-09-06
US20050053621A1 (en) 2005-03-10
TNSN06031A1 (fr) 2007-10-03
KR20060092198A (ko) 2006-08-22
EA009391B1 (ru) 2007-12-28
US20080286302A1 (en) 2008-11-20
CY1110995T1 (el) 2015-06-11
RS51456B (sr) 2011-04-30
US7754222B2 (en) 2010-07-13
JP4662931B2 (ja) 2011-03-30
AU2004268514A1 (en) 2005-03-10
DK1651263T3 (da) 2011-01-31
UA85845C2 (uk) 2009-03-10
WO2005021034A2 (en) 2005-03-10
KR100810820B1 (ko) 2008-03-06
NO20060931L (no) 2006-04-27
TWI342783B (en) 2011-06-01
NZ545612A (en) 2009-11-27
AU2004268514B2 (en) 2010-01-21
SI1651263T1 (sl) 2011-02-28
CA2533877A1 (en) 2005-03-10
IL173338A0 (en) 2006-06-11
PT1651263E (pt) 2011-01-25

Similar Documents

Publication Publication Date Title
CY1110995T1 (el) Ασφαλη μεταλλακτικα ιικα εμβολια
Heaton et al. Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins
MXPA03011412A (es) Alteracion de caracteristicas de aceite en plantas.
FI3581650T3 (fi) IX-tekijän polypeptidimutantti, sen käyttöjä ja menetelmä sen valmistamiseksi
SI1554301T1 (sl) VAKCINA ZA DENGO, KI VSEBUJE SKUPNO DELECIJO 30 NUKLEOTIDOV V 3ĹľUTR TIPOV 1 IN 2 DENGE
UA97623C2 (ru) Растение, содержащее мутацию в домене с ahas белка, которая обеспечивает повышенную толерантность к имидазолиноновым гербицидам
WO2011119716A3 (en) Flavivirus host range mutations and uses thereof
WO2021216775A3 (en) Antigen-encoding cassettes
ATE413888T1 (de) Salmonella vakzine
NO20004781D0 (no) Svekkede bakterier anvendelige i vaksiner
D’Andrea et al. A detailed comparative analysis on the overall codon usage patterns in hepatitis A virus
Xie et al. Expanding PAM recognition and enhancing base editing activity of Cas9 variants with non‐PI domain mutations derived from xCas9
ATE518953T1 (de) Verwendung einer mutagenen dna-polymerase zur herstellung willkürlicher mutationen
WO2012003320A3 (en) Flavivirus host-range mutations and uses thereof
WO2011060534A8 (en) Trim5alpha mutants and uses thereof
Akaishi Comparison of insertion, deletion, and point mutations in the genomes of human adenovirus HAdvC-2 and SARS-CoV-2
ATE408013T1 (de) Infektiöses cdna klon des gb-virus b und dessen verwendungen
McEachern Telomeres: guardians of genomic integrity or double agents of evolution?
Badel et al. The global distribution and evolutionary history of the pT26‐2 archaeal plasmid family
AU2003277909A1 (en) Recombinant mva strains as potential vaccines against p. falciparum malaria
BR0110128A (pt) Mutante de bactéria láctica superprodutora de exopolissacarìdeos, utilização do mesmo e ácido nucleico codificando uma alfa-fosfoglucomutase
Bosch et al. Coding biases and viral fitness
Takahata et al. Complete sequence analysis of two cryptic plasmids from B ifidobacterium kashiwanohense JCM 15439 (type strain) isolated from healthy infant feces
WO2001087939A3 (en) Genes required for natural competence, proteins, and their use
Baumdicker The site frequency spectrum of dispensable genes

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1651263

Country of ref document: EP