ATE489396T1 - Detektion von nucleinsäureunterschieden mit hilfe von endonucleasespaltungs-/ligaseabgabereaktionen und kapillarelektrophoresen oder mikroarrays - Google Patents
Detektion von nucleinsäureunterschieden mit hilfe von endonucleasespaltungs-/ligaseabgabereaktionen und kapillarelektrophoresen oder mikroarraysInfo
- Publication number
- ATE489396T1 ATE489396T1 AT05807317T AT05807317T ATE489396T1 AT E489396 T1 ATE489396 T1 AT E489396T1 AT 05807317 T AT05807317 T AT 05807317T AT 05807317 T AT05807317 T AT 05807317T AT E489396 T1 ATE489396 T1 AT E489396T1
- Authority
- AT
- Austria
- Prior art keywords
- ligase
- microarrays
- detection
- nucleic acid
- capillary electrophoresis
- Prior art date
Links
- 238000003776 cleavage reaction Methods 0.000 title abstract 3
- 230000007017 scission Effects 0.000 title abstract 3
- 102000004533 Endonucleases Human genes 0.000 title abstract 2
- 108010042407 Endonucleases Proteins 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title abstract 2
- 102000003960 Ligases Human genes 0.000 title 1
- 108090000364 Ligases Proteins 0.000 title 1
- 238000005251 capillar electrophoresis Methods 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 238000002493 microarray Methods 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 3
- 125000003729 nucleotide group Chemical group 0.000 abstract 3
- 108091027305 Heteroduplex Proteins 0.000 abstract 2
- 239000012634 fragment Substances 0.000 abstract 2
- 102000012410 DNA Ligases Human genes 0.000 abstract 1
- 108010061982 DNA Ligases Proteins 0.000 abstract 1
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 238000003780 insertion Methods 0.000 abstract 1
- 230000037431 insertion Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 102000054765 polymorphisms of proteins Human genes 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C12Q1/683—Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Mathematical Physics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Theoretical Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US60393704P | 2004-08-24 | 2004-08-24 | |
| US60385504P | 2004-08-24 | 2004-08-24 | |
| PCT/US2005/029966 WO2006023919A2 (en) | 2004-08-24 | 2005-08-23 | Detection of nucleic acid differences using endonuclease cleavage/ligas releasing reactions and capillary electrophoresis or microarrays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE489396T1 true ATE489396T1 (de) | 2010-12-15 |
Family
ID=35968293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05807317T ATE489396T1 (de) | 2004-08-24 | 2005-08-23 | Detektion von nucleinsäureunterschieden mit hilfe von endonucleasespaltungs-/ligaseabgabereaktionen und kapillarelektrophoresen oder mikroarrays |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7709201B2 (de) |
| EP (1) | EP1789589B1 (de) |
| CN (1) | CN101124337B (de) |
| AT (1) | ATE489396T1 (de) |
| DE (1) | DE602005024987D1 (de) |
| WO (1) | WO2006023919A2 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006053259A2 (en) * | 2004-11-12 | 2006-05-18 | Transgenomic, Inc. | Fluorescent mutation detection with mismatch cutting dna endonucleases |
| US20090226904A1 (en) * | 2005-12-01 | 2009-09-10 | University Of Bergen | Diagnosis and treatment of exocrine pancreatic dysfunction and diabetes |
| FR2920159A1 (fr) * | 2007-08-20 | 2009-02-27 | Serial Genetics Sas Soc Par Ac | Methode et reactifs pour la quantification, la comparaison et l'identification d'alleles sur support solide |
| WO2009098988A1 (ja) * | 2008-02-04 | 2009-08-13 | Genecare Research Institute Co., Ltd. | siRNA検出方法 |
| JP5588970B2 (ja) | 2008-05-27 | 2014-09-10 | ダコ・デンマーク・エー／エス | ハイブリダイゼーション組成物及び方法 |
| EP2326732A4 (de) | 2008-08-26 | 2012-11-14 | Fluidigm Corp | Testverfahren für erhöhten durchsatz von proben und/oder targets |
| US9303287B2 (en) * | 2009-02-26 | 2016-04-05 | Dako Denmark A/S | Compositions and methods for RNA hybridization applications |
| SG174617A1 (en) | 2009-04-02 | 2011-10-28 | Fluidigm Corp | Multi-primer amplification method for barcoding of target nucleic acids |
| ES2541710T3 (es) * | 2009-11-03 | 2015-07-23 | Sva Statens Veterinärmedicinska Anstalt | Procedimiento de genotipado |
| US20130059294A1 (en) * | 2010-05-16 | 2013-03-07 | Xiangdong Ren | Identification of polymorphic hepatitis b viruses and kras oncogene mutations and clinical use |
| US20120094279A1 (en) * | 2010-07-19 | 2012-04-19 | Jiwu Wang | Use of enzymes for altering ratios of partially matched polynucleotides |
| US10533223B2 (en) | 2010-08-06 | 2020-01-14 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US11203786B2 (en) | 2010-08-06 | 2021-12-21 | Ariosa Diagnostics, Inc. | Detection of target nucleic acids using hybridization |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US11031095B2 (en) | 2010-08-06 | 2021-06-08 | Ariosa Diagnostics, Inc. | Assay systems for determination of fetal copy number variation |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| US10167508B2 (en) | 2010-08-06 | 2019-01-01 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US20130261003A1 (en) | 2010-08-06 | 2013-10-03 | Ariosa Diagnostics, In. | Ligation-based detection of genetic variants |
| US20140342940A1 (en) | 2011-01-25 | 2014-11-20 | Ariosa Diagnostics, Inc. | Detection of Target Nucleic Acids using Hybridization |
| US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| US11270781B2 (en) | 2011-01-25 | 2022-03-08 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
| US20120190020A1 (en) | 2011-01-25 | 2012-07-26 | Aria Diagnostics, Inc. | Detection of genetic abnormalities |
| US8756020B2 (en) | 2011-01-25 | 2014-06-17 | Ariosa Diagnostics, Inc. | Enhanced risk probabilities using biomolecule estimations |
| US9994897B2 (en) | 2013-03-08 | 2018-06-12 | Ariosa Diagnostics, Inc. | Non-invasive fetal sex determination |
| WO2012118745A1 (en) | 2011-02-28 | 2012-09-07 | Arnold Oliphant | Assay systems for detection of aneuploidy and sex determination |
| EP3495497B1 (de) | 2011-04-28 | 2021-03-24 | Life Technologies Corporation | Verfahren und zusammensetzungen für multiplex-pcr |
| CN103502475A (zh) * | 2011-05-06 | 2014-01-08 | 凯杰有限公司 | 包含内部标记引物的核酸的测序、扩增和检测方法 |
| SG10201605049QA (en) | 2011-05-20 | 2016-07-28 | Fluidigm Corp | Nucleic acid encoding reactions |
| US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
| US10662465B2 (en) | 2011-09-30 | 2020-05-26 | Agilent Technologies, Inc. | Hybridization compositions and methods using formamide |
| US11118226B2 (en) | 2011-10-21 | 2021-09-14 | Agilent Technologies, Inc. | Hybridization compositions and methods |
| WO2013177206A2 (en) | 2012-05-21 | 2013-11-28 | Fluidigm Corporation | Single-particle analysis of particle populations |
| US10289800B2 (en) | 2012-05-21 | 2019-05-14 | Ariosa Diagnostics, Inc. | Processes for calculating phased fetal genomic sequences |
| EP2875156A4 (de) | 2012-07-19 | 2016-02-24 | Ariosa Diagnostics Inc | Sequentielle ligationsbasierte multiplex-detektion von genetischen varianten |
| WO2014071070A1 (en) * | 2012-11-01 | 2014-05-08 | Pacific Biosciences Of California, Inc. | Compositions and methods for selection of nucleic acids |
| JP6009649B2 (ja) * | 2013-03-14 | 2016-10-19 | タカラバイオ株式会社 | 耐熱性のミスマッチエンドヌクレアーゼの利用方法 |
| WO2014200579A1 (en) | 2013-06-13 | 2014-12-18 | Ariosa Diagnostics, Inc. | Statistical analysis for non-invasive sex chromosome aneuploidy determination |
| EP3074528A1 (de) * | 2013-11-26 | 2016-10-05 | Qiagen GmbH | Erzeugung von ligationsbereiten dna-amplicons |
| PT3204520T (pt) * | 2014-10-08 | 2020-04-16 | Univ Cornell | Método de identificação e quantificação da expressão de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação |
| US9464318B2 (en) | 2015-02-11 | 2016-10-11 | Paragon Genomics, Inc. | Methods and compositions for reducing non-specific amplification products |
| US10421993B2 (en) | 2015-02-11 | 2019-09-24 | Paragon Genomics, Inc. | Methods and compositions for reducing non-specific amplification products |
| US10385387B2 (en) | 2015-04-20 | 2019-08-20 | Pacific Biosciences Of California, Inc. | Methods for selectively amplifying and tagging nucleic acids |
| CN105420361B (zh) * | 2015-12-14 | 2018-08-14 | 福建医科大学 | 基于酶切灵敏检测人类egfr基因突变的方法及试剂盒 |
| CN108603224B (zh) | 2015-12-16 | 2022-06-28 | 富鲁达公司 | 高水平多路复用扩增 |
| JP5997407B1 (ja) * | 2016-04-21 | 2016-09-28 | 日鉄住金環境株式会社 | 多項目増幅手法 |
| WO2018132459A1 (en) | 2017-01-10 | 2018-07-19 | Paragon Genomics, Inc. | Methods and compositions for reducing redundant molecular barcodes created in primer extension reactions |
| CN108728430B (zh) * | 2017-04-21 | 2022-04-05 | 胤安国际（辽宁）基因科技股份有限公司 | 一种制备含有多个重复单元dna长探针的方法 |
| WO2019099081A1 (en) * | 2017-11-16 | 2019-05-23 | New England Biolabs, Inc. | Mapping the location, type and strand of damaged and/or mismatched nucleotides in double-stranded dna |
| CN109828785B (zh) * | 2019-01-23 | 2022-04-12 | 复旦大学 | 一种采用gpu加速的近似代码克隆检测方法 |
| US10941453B1 (en) | 2020-05-20 | 2021-03-09 | Paragon Genomics, Inc. | High throughput detection of pathogen RNA in clinical specimens |
| US11680293B1 (en) | 2022-04-21 | 2023-06-20 | Paragon Genomics, Inc. | Methods and compositions for amplifying DNA and generating DNA sequencing results from target-enriched DNA molecules |
| US12091715B2 (en) | 2022-04-21 | 2024-09-17 | Paragon Genomics, Inc. | Methods and compositions for reducing base errors of massive parallel sequencing using triseq sequencing |
| CN118599973B (zh) * | 2024-07-02 | 2026-01-20 | 安徽农业大学 | 一种重叠pcr酶切联用的鉴定方法及试剂盒 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0528882T3 (da) | 1990-05-03 | 2008-01-14 | Cornell Res Foundation Inc | DNA-amplifikationssystem til påvisning af genetiske sygdomme ved hjælp af termostabil ligase |
| EP2332957B1 (de) | 1996-02-09 | 2015-04-08 | Cornell Research Foundation, Inc. | Detektion von Unterschieden in der Sequenz von Nukleinsäuren mittels der Ligasedetektionsreaktion und adressierbaren Arrays |
| AU2002230526A1 (en) * | 2000-12-01 | 2002-06-11 | Cornell Research Foundation, Inc. | Detection of nucleic acid differences using combined endonuclease cleavage and ligation reactions |
-
2005
- 2005-08-23 DE DE602005024987T patent/DE602005024987D1/de not_active Expired - Lifetime
- 2005-08-23 CN CN2005800363964A patent/CN101124337B/zh not_active Expired - Fee Related
- 2005-08-23 US US11/574,286 patent/US7709201B2/en not_active Expired - Fee Related
- 2005-08-23 WO PCT/US2005/029966 patent/WO2006023919A2/en not_active Ceased
- 2005-08-23 AT AT05807317T patent/ATE489396T1/de not_active IP Right Cessation
- 2005-08-23 EP EP05807317A patent/EP1789589B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN101124337A (zh) | 2008-02-13 |
| EP1789589B1 (de) | 2010-11-24 |
| WO2006023919A3 (en) | 2007-08-09 |
| DE602005024987D1 (de) | 2011-01-05 |
| US7709201B2 (en) | 2010-05-04 |
| EP1789589A4 (de) | 2009-03-04 |
| US20090123913A1 (en) | 2009-05-14 |
| CN101124337B (zh) | 2010-11-17 |
| WO2006023919A2 (en) | 2006-03-02 |
| EP1789589A2 (de) | 2007-05-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |