ATE489956T1 - Formulierungen enthaltend salicylate und deren verwendung zur behandlung von entzündlicher darmerkrankung - Google Patents
Formulierungen enthaltend salicylate und deren verwendung zur behandlung von entzündlicher darmerkrankungInfo
- Publication number
- ATE489956T1 ATE489956T1 AT04769427T AT04769427T ATE489956T1 AT E489956 T1 ATE489956 T1 AT E489956T1 AT 04769427 T AT04769427 T AT 04769427T AT 04769427 T AT04769427 T AT 04769427T AT E489956 T1 ATE489956 T1 AT E489956T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- formulations
- inflammatory bowel
- bowel disease
- treatment
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 5
- 208000022559 Inflammatory bowel disease Diseases 0.000 title abstract 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 abstract 1
- 206010009900 Colitis ulcerative Diseases 0.000 abstract 1
- 208000011231 Crohn disease Diseases 0.000 abstract 1
- 201000006704 Ulcerative Colitis Diseases 0.000 abstract 1
- 229960004909 aminosalicylic acid Drugs 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000012377 drug delivery Methods 0.000 abstract 1
- 210000000936 intestine Anatomy 0.000 abstract 1
- KBOPZPXVLCULAV-UHFFFAOYSA-N mesalamine Chemical compound NC1=CC=C(O)C(C(O)=O)=C1 KBOPZPXVLCULAV-UHFFFAOYSA-N 0.000 abstract 1
- 229960004963 mesalazine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/606—Salicylic acid; Derivatives thereof having amino groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/655—Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/02—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides
- C07C245/06—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings
- C07C245/08—Azo compounds, i.e. compounds having the free valencies of —N=N— groups attached to different atoms, e.g. diazohydroxides with nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings with the two nitrogen atoms of azo groups bound to carbon atoms of six-membered aromatic rings, e.g. azobenzene
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49936503P | 2003-09-03 | 2003-09-03 | |
| PCT/IB2004/003059 WO2005021009A2 (en) | 2003-09-03 | 2004-09-02 | Formulations and methods of treating inflammatory bowel disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE489956T1 true ATE489956T1 (de) | 2010-12-15 |
Family
ID=34272809
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04769427T ATE489956T1 (de) | 2003-09-03 | 2004-09-02 | Formulierungen enthaltend salicylate und deren verwendung zur behandlung von entzündlicher darmerkrankung |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7737133B2 (de) |
| EP (1) | EP1663253B1 (de) |
| JP (1) | JP5108304B2 (de) |
| AT (1) | ATE489956T1 (de) |
| AU (1) | AU2004267953A1 (de) |
| CA (1) | CA2535923A1 (de) |
| DE (1) | DE602004030353D1 (de) |
| ES (1) | ES2353761T3 (de) |
| IL (1) | IL173684A0 (de) |
| MX (1) | MXPA06002048A (de) |
| NO (1) | NO20061489L (de) |
| WO (1) | WO2005021009A2 (de) |
| ZA (1) | ZA200601356B (de) |
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| WO2004112756A1 (en) | 2003-06-26 | 2004-12-29 | Isa Odidi | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| US7825106B2 (en) * | 2003-09-03 | 2010-11-02 | Agi Therapeutics Ltd. | Modified release formulations and methods of treating inflammatory bowel disease |
| US7737133B2 (en) * | 2003-09-03 | 2010-06-15 | Agi Therapeutics Ltd. | Formulations and methods of treating inflammatory bowel disease |
| JP2007520495A (ja) | 2004-02-06 | 2007-07-26 | ボロディー トーマス ユリウス | 下痢型過敏性腸症候群におけるアミノサリチル酸の使用法 |
| US20080306029A1 (en) * | 2004-05-28 | 2008-12-11 | Salix Pharmaceuticals, Inc. | Prevention, Treatment, and Amelioration of Radiation Induced Enteritis |
| US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
| US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
| US20090017110A1 (en) * | 2005-05-31 | 2009-01-15 | Capricorn Pharma Inc. | Modified release formulations of anti-irritability drugs |
| US20070015689A1 (en) * | 2005-06-23 | 2007-01-18 | Alza Corporation | Complexation of metal ions with polypeptides |
| US7452872B2 (en) | 2005-08-24 | 2008-11-18 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| US8921344B2 (en) * | 2006-11-03 | 2014-12-30 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| CA2816276A1 (en) * | 2005-08-24 | 2007-03-01 | Salix Pharmaceuticals, Inc. | Balsalazide formulations and manufacture and use thereof |
| US8679545B2 (en) * | 2005-11-12 | 2014-03-25 | The Regents Of The University Of California | Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract |
| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| CN104825397A (zh) * | 2006-04-03 | 2015-08-12 | 伊萨·奥迪迪 | 含有机溶胶涂层的受控释放递送物件 |
| US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| US9095512B2 (en) * | 2006-08-11 | 2015-08-04 | Asahi Kasei Chemicals Corporation | Method for producing spherical base granules comprising hardly water-soluble drug |
| WO2008027557A2 (en) * | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| WO2008043107A2 (en) * | 2006-10-06 | 2008-04-10 | Alba Therapeutics Corporation | Use of tight junction antagonists to treat inflammatory bowel disease |
| EP2394643B1 (de) | 2006-11-17 | 2015-09-02 | Supernus Pharmaceuticals, Inc. | Topiramat-Formulierungen mit verzögerter Freisetzung |
| EP2363113B1 (de) * | 2006-12-04 | 2017-08-02 | Supernus Pharmaceuticals, Inc. | Topiramat-Formulierungen für verstärkte unmittelbare Freisetzung |
| US20100136125A1 (en) * | 2006-12-28 | 2010-06-03 | Jacobus Pharmaceutical Company, Inc. | Method of treating inflammatory bowel disease |
| US20100104656A1 (en) * | 2007-03-20 | 2010-04-29 | Paul Wan Sia Heng | Meltable Binder for Melt Granulation and/or Pelletization |
| US20090036414A1 (en) * | 2007-08-02 | 2009-02-05 | Mutual Pharmaceutical Company, Inc. | Mesalamine Formulations |
| JP2011500553A (ja) * | 2007-10-10 | 2011-01-06 | ルピン・リミテッド | ５−アミノサリチル酸またはその塩もしくは代謝産物の新規な結腸を標的とする調節放出性生体接着性製剤 |
| US20090162434A1 (en) * | 2007-12-21 | 2009-06-25 | Disphar International Bv | Mesalazine tablet |
| US20120093939A1 (en) * | 2008-12-17 | 2012-04-19 | Altheus Therapeutics, Inc. | Oral formulations |
| JP5783908B2 (ja) | 2008-12-19 | 2015-09-24 | スパーナス ファーマシューティカルズ インコーポレイテッド | 攻撃性を治療する方法 |
| EP3572074B1 (de) | 2010-03-31 | 2021-01-06 | Supernus Pharmaceuticals, Inc. | Stabilisierte formulierungen aus molindone |
| US8597683B2 (en) * | 2010-11-30 | 2013-12-03 | Watson Pharmaceuticals, Inc. | Modified release tranexamic acid formulation |
| EP2822542A1 (de) * | 2012-03-07 | 2015-01-14 | Santarus, Inc. | Gesteuerte freisetzung fester dosierungsformen von mesalamin |
| US20140141075A1 (en) | 2012-11-21 | 2014-05-22 | Warner Chilcott Company, Llc | 5-aminosalicylic acid capsule formulation |
| JP5897196B1 (ja) * | 2015-10-05 | 2016-03-30 | 大同化成工業株式会社 | 糖又は糖アルコール、膨潤型結合剤、崩壊剤及び高吸収性賦形剤を含む複合化造粒物及びその製造方法 |
| US20170119680A1 (en) | 2015-10-30 | 2017-05-04 | R.P. Scherer Technologies, Llc | Extended release film-coated capsules |
| WO2019136053A1 (en) * | 2018-01-03 | 2019-07-11 | Ferring B.V. | Oral liquid pharmaceutical compositions of aminosalicylates |
| US12053447B2 (en) | 2019-06-25 | 2024-08-06 | NuBioPharma, LLC | Oral solution and powder to liquid compositions of balsalazide |
| CN112569915B (zh) * | 2020-12-27 | 2023-06-23 | 王晓玉 | 一种煤矿井水除铀吸附剂、及其制备方法和应用 |
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| ITMI991316A1 (it) | 1999-06-14 | 2000-12-14 | Cip Ninety Two 92 S A | Composizioni farmaceutiche orali a rilascio modificato di mesalazina |
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| CA2359812C (en) | 2000-11-20 | 2004-02-10 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures |
| JP5502254B2 (ja) * | 2001-01-31 | 2014-05-28 | エボニック レーム ゲゼルシャフト ミット ベシュレンクテル ハフツング | 少なくとも２種類の異なる被覆ペレット形から成る多粒子剤形 |
| US7737133B2 (en) | 2003-09-03 | 2010-06-15 | Agi Therapeutics Ltd. | Formulations and methods of treating inflammatory bowel disease |
| US7825106B2 (en) * | 2003-09-03 | 2010-11-02 | Agi Therapeutics Ltd. | Modified release formulations and methods of treating inflammatory bowel disease |
-
2004
- 2004-09-01 US US10/930,743 patent/US7737133B2/en not_active Expired - Lifetime
- 2004-09-02 JP JP2006525214A patent/JP5108304B2/ja not_active Expired - Fee Related
- 2004-09-02 CA CA002535923A patent/CA2535923A1/en not_active Abandoned
- 2004-09-02 MX MXPA06002048A patent/MXPA06002048A/es not_active Application Discontinuation
- 2004-09-02 EP EP04769427A patent/EP1663253B1/de not_active Expired - Lifetime
- 2004-09-02 AT AT04769427T patent/ATE489956T1/de not_active IP Right Cessation
- 2004-09-02 DE DE602004030353T patent/DE602004030353D1/de not_active Expired - Lifetime
- 2004-09-02 WO PCT/IB2004/003059 patent/WO2005021009A2/en not_active Ceased
- 2004-09-02 AU AU2004267953A patent/AU2004267953A1/en not_active Abandoned
- 2004-09-02 ES ES04769427T patent/ES2353761T3/es not_active Expired - Lifetime
-
2006
- 2006-02-13 IL IL173684A patent/IL173684A0/en unknown
- 2006-02-15 ZA ZA200601356A patent/ZA200601356B/en unknown
- 2006-04-03 NO NO20061489A patent/NO20061489L/no not_active Application Discontinuation
-
2010
- 2010-06-10 US US12/797,655 patent/US7928092B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US20050090473A1 (en) | 2005-04-28 |
| EP1663253B1 (de) | 2010-12-01 |
| JP5108304B2 (ja) | 2012-12-26 |
| IL173684A0 (en) | 2006-07-05 |
| WO2005021009A2 (en) | 2005-03-10 |
| ZA200601356B (en) | 2007-07-25 |
| WO2005021009A3 (en) | 2005-07-14 |
| CA2535923A1 (en) | 2005-03-10 |
| US7737133B2 (en) | 2010-06-15 |
| US20100278917A1 (en) | 2010-11-04 |
| AU2004267953A1 (en) | 2005-03-10 |
| US7928092B2 (en) | 2011-04-19 |
| ES2353761T3 (es) | 2011-03-04 |
| NO20061489L (no) | 2006-05-30 |
| MXPA06002048A (es) | 2006-05-25 |
| EP1663253A2 (de) | 2006-06-07 |
| JP2007504212A (ja) | 2007-03-01 |
| DE602004030353D1 (de) | 2011-01-13 |
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| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |