ATE490954T1 - Estergebundene geminitensidverbindungen zur verwendung in der gentherapie - Google Patents
Estergebundene geminitensidverbindungen zur verwendung in der gentherapieInfo
- Publication number
- ATE490954T1 ATE490954T1 AT06701592T AT06701592T ATE490954T1 AT E490954 T1 ATE490954 T1 AT E490954T1 AT 06701592 T AT06701592 T AT 06701592T AT 06701592 T AT06701592 T AT 06701592T AT E490954 T1 ATE490954 T1 AT E490954T1
- Authority
- AT
- Austria
- Prior art keywords
- ester
- gemini surfactant
- surfactant compounds
- gene therapy
- linked
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000004094 surface-active agent Substances 0.000 title abstract 3
- 238000001415 gene therapy Methods 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 2
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0502482.3A GB0502482D0 (en) | 2005-02-07 | 2005-02-07 | Novel compounds |
| PCT/EP2006/000998 WO2006082088A1 (en) | 2005-02-07 | 2006-02-03 | Ester-linked gemini surfactant compounds for use in gene therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE490954T1 true ATE490954T1 (de) | 2010-12-15 |
Family
ID=34355904
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06701592T ATE490954T1 (de) | 2005-02-07 | 2006-02-03 | Estergebundene geminitensidverbindungen zur verwendung in der gentherapie |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7425645B2 (de) |
| EP (1) | EP1848684B1 (de) |
| JP (1) | JP4991567B2 (de) |
| AT (1) | ATE490954T1 (de) |
| DE (1) | DE602006018709D1 (de) |
| ES (1) | ES2357140T3 (de) |
| GB (1) | GB0502482D0 (de) |
| WO (1) | WO2006082088A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1912679A4 (de) * | 2005-06-15 | 2009-07-29 | Massachusetts Inst Technology | Aminhaltige lipide und ihre verwendungen |
| MX363224B (es) * | 2006-10-03 | 2019-03-15 | Alnylam Pharmaceuticals Inc | Formulaciones que contienen lipidos. |
| WO2010053572A2 (en) | 2008-11-07 | 2010-05-14 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| RS58405B1 (sr) | 2009-12-01 | 2019-04-30 | Translate Bio Inc | Stereoidni derivati za isporuku irnk u humanim genetskim oboljenjima |
| EP2609135A4 (de) | 2010-08-26 | 2015-05-20 | Massachusetts Inst Technology | Poly(beta-amino-alkohole), ihre herstellung und verwendungen davon |
| US20120136073A1 (en) | 2010-11-15 | 2012-05-31 | Life Technologies Corporation | Amine-Containing Transfection Reagents and methods for making and using same |
| US8546338B2 (en) | 2010-12-08 | 2013-10-01 | Johnson & Johnson Consumer Companies, Inc. | Self-assembling hydrogels based on dicephalic peptide amphiphiles |
| EP2691443B1 (de) | 2011-03-28 | 2021-02-17 | Massachusetts Institute of Technology | Konjugierte lipomers und ihre verwendung |
| SMT201900445T1 (it) | 2011-06-08 | 2019-09-09 | Translate Bio Inc | Composizione di nanoparticelle lipidiche e metodi per il rilascio di mrna |
| EA032088B1 (ru) | 2011-10-27 | 2019-04-30 | Массачусетс Инститьют Оф Текнолоджи | Аминокислотные производные, функционализованные на n-конце, способные образовывать микросферы, инкапсулирующие лекарственное средство |
| EP3536787A1 (de) | 2012-06-08 | 2019-09-11 | Translate Bio, Inc. | Nukleaseresistente polynukleotide und verwendungen davon |
| EP2882706A1 (de) | 2012-08-13 | 2015-06-17 | Massachusetts Institute of Technology | Aminhaltige lipoide und ihre verwendungen |
| KR20210122917A (ko) | 2013-03-14 | 2021-10-12 | 샤이어 휴먼 지네틱 테라피즈 인크. | Cftr mrna 조성물 및 관련 방법 및 사용 |
| EP4446413A3 (de) | 2013-03-14 | 2024-12-18 | Translate Bio, Inc. | Verfahren zur reinigung von messenger-rna |
| WO2014179562A1 (en) | 2013-05-01 | 2014-11-06 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| JP6525435B2 (ja) | 2013-10-22 | 2019-06-12 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | メッセンジャーrnaの送達のための脂質製剤 |
| EA034103B1 (ru) | 2013-10-22 | 2019-12-27 | Транслейт Био, Инк. | СПОСОБ ЛЕЧЕНИЯ ФЕНИЛКЕТОНУРИИ С ПРИМЕНЕНИЕМ мРНК |
| EP3060303B1 (de) | 2013-10-22 | 2018-11-14 | Translate Bio, Inc. | Mrna-therapie für argininosuccinat-synthase-mangel |
| EP3636742B1 (de) | 2014-04-25 | 2025-11-05 | Translate Bio, Inc. | Verfahren zur reinigung von messenger-rna |
| EP3148552B1 (de) | 2014-05-30 | 2019-07-31 | Translate Bio, Inc. | Biologisch abbaubare lipide zur freisetzung von nukleinsäuren |
| SG11201610670WA (en) | 2014-06-24 | 2017-01-27 | Shire Human Genetic Therapies | Stereochemically enriched compositions for delivery of nucleic acids |
| WO2016004202A1 (en) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| CA2990172A1 (en) | 2015-06-19 | 2016-12-22 | Massachusetts Institute Of Technology | Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell |
| AU2018224326B2 (en) | 2017-02-27 | 2024-01-04 | Translate Bio, Inc. | Novel codon-optimized CFTR mRNA |
| US11173190B2 (en) | 2017-05-16 | 2021-11-16 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mRNA encoding CFTR |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| AU2019384557B2 (en) | 2018-11-21 | 2025-07-17 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of nebulized mRNA encoding CFTR |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05104878A (ja) * | 1991-10-17 | 1993-04-27 | Fuji Photo Film Co Ltd | オフセツト印刷用不感脂化処理液 |
| US5565290A (en) | 1991-07-30 | 1996-10-15 | Fuji Photo Film Co., Ltd. | Desensitizing solution for offset printing |
| EP0725651B1 (de) * | 1993-10-29 | 1999-08-11 | Smithkline Beecham Corporation | Blutregulierende peptide |
| WO1995027705A1 (en) | 1994-04-08 | 1995-10-19 | Bracco International B.V. | Aromatic amide compounds and metal chelates thereof |
| AU3986097A (en) * | 1996-08-27 | 1998-03-19 | University Of Akron, The | Lipophilic polyamine esters for the site specific delivery of nitric oxide in pharmaceutical use |
| GB9914045D0 (en) * | 1999-06-16 | 1999-08-18 | Smithkline Beecham Plc | Novel compounds |
| EP1261620A2 (de) * | 2000-02-07 | 2002-12-04 | Roche Diagnostics Corporation | Kationische amphiphile zur verwendung bei der nucleinsäuretransfektin |
| WO2004087656A1 (de) * | 2003-04-03 | 2004-10-14 | Schering Aktiengesellschaft | Konjugate 2,4-ethano- und 2,4-propano-überbrückter 3,6,9-triaza-nonansäure-3n, 6n, 9,9n-tetraessigsäure- und entsprechender phosphorsäuremethylen-derivate und deren abkömmlinge mit biomolekülen, verfahren zu deren herstellung und deren verwendung zur herstellung |
| GB0425555D0 (en) * | 2004-11-19 | 2004-12-22 | Glaxo Group Ltd | Novel compounds |
| GB0425556D0 (en) * | 2004-11-19 | 2004-12-22 | Glaxo Group Ltd | Novel compounds |
-
2005
- 2005-02-07 GB GBGB0502482.3A patent/GB0502482D0/en not_active Ceased
-
2006
- 2006-02-03 JP JP2007553550A patent/JP4991567B2/ja not_active Expired - Fee Related
- 2006-02-03 DE DE602006018709T patent/DE602006018709D1/de not_active Expired - Lifetime
- 2006-02-03 EP EP06701592A patent/EP1848684B1/de not_active Expired - Lifetime
- 2006-02-03 WO PCT/EP2006/000998 patent/WO2006082088A1/en not_active Ceased
- 2006-02-03 ES ES06701592T patent/ES2357140T3/es not_active Expired - Lifetime
- 2006-02-03 US US11/815,570 patent/US7425645B2/en not_active Expired - Fee Related
- 2006-02-03 AT AT06701592T patent/ATE490954T1/de not_active IP Right Cessation
-
2008
- 2008-08-04 US US12/185,144 patent/US7569720B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20080293829A1 (en) | 2008-11-27 |
| EP1848684B1 (de) | 2010-12-08 |
| DE602006018709D1 (de) | 2011-01-20 |
| JP4991567B2 (ja) | 2012-08-01 |
| EP1848684A1 (de) | 2007-10-31 |
| JP2009525259A (ja) | 2009-07-09 |
| US20080058279A1 (en) | 2008-03-06 |
| ES2357140T3 (es) | 2011-04-19 |
| WO2006082088A1 (en) | 2006-08-10 |
| US7425645B2 (en) | 2008-09-16 |
| GB0502482D0 (en) | 2005-03-16 |
| US7569720B2 (en) | 2009-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |