ATE491038T1 - Verfahren und nukleinsäuren zur analyse von kolonkrebs - Google Patents

Verfahren und nukleinsäuren zur analyse von kolonkrebs

Info

Publication number: ATE491038T1
Authority: AT; Austria
Prior art keywords: nucleic acids; colon cancer; cell proliferative; proliferative disorders; analyzing
Prior art date: 2002-02-27

Application number

AT03742964T

Other languages

English (en)

Inventor

Peter Adorjan

Matthias Burger

Sabine Maier

Ralf Lesche

Susan Cottrell

Suzanne Mooney

Original Assignee

Epigenomics Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-02-27

Filing date

2003-02-27

Publication date

2010-12-15

2003-02-27 Application filed by Epigenomics Ag filed Critical Epigenomics Ag

2010-12-15 Application granted granted Critical

2010-12-15 Publication of ATE491038T1 publication Critical patent/ATE491038T1/de

Links

238000000034 method Methods 0.000 title abstract 2
206010009944 Colon cancer Diseases 0.000 title 1
208000029742 colonic neoplasm Diseases 0.000 title 1
150000007523 nucleic acids Chemical class 0.000 title 1
102000039446 nucleic acids Human genes 0.000 title 1
108020004707 nucleic acids Proteins 0.000 title 1
210000001072 colon Anatomy 0.000 abstract 2
230000002062 proliferating effect Effects 0.000 abstract 2
230000030933 DNA methylation on cytosine Effects 0.000 abstract 1
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
238000003745 diagnosis Methods 0.000 abstract 1
230000004069 differentiation Effects 0.000 abstract 1
230000001973 epigenetic effect Effects 0.000 abstract 1
230000002068 genetic effect Effects 0.000 abstract 1
238000012544 monitoring process Methods 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Immunology (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Genetics & Genomics (AREA)
Wood Science & Technology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Hospice & Palliative Care (AREA)
Biochemistry (AREA)
Oncology (AREA)
Biophysics (AREA)
Physics & Mathematics (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Investigating Or Analysing Biological Materials (AREA)
Apparatus Associated With Microorganisms And Enzymes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

AT03742964T 2002-02-27 2003-02-27 Verfahren und nukleinsäuren zur analyse von kolonkrebs ATE491038T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP02004551A EP1340818A1 (de)	2002-02-27	2002-02-27	Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen
PCT/EP2003/002034 WO2003072820A2 (en)	2002-02-27	2003-02-27	Method and nucleic acids for the analysis of colon cell proliferative disorders

Publications (1)

Publication Number	Publication Date
ATE491038T1 true ATE491038T1 (de)	2010-12-15

Family

ID=27675653

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
AT03742934T ATE376596T1 (de)	2002-02-27	2003-02-13	Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen
AT03714760T ATE431429T1 (de)	2002-02-27	2003-02-27	Verfahren und nukleinsäuren zur analyse von kolonkrebszellen
AT03742964T ATE491038T1 (de)	2002-02-27	2003-02-27	Verfahren und nukleinsäuren zur analyse von kolonkrebs

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT03742934T ATE376596T1 (de)	2002-02-27	2003-02-13	Verfahren und nukleinsäuren zur analyse von störungen der proliferation kolorektaler zellen
AT03714760T ATE431429T1 (de)	2002-02-27	2003-02-27	Verfahren und nukleinsäuren zur analyse von kolonkrebszellen

Country Status (9)

Country	Link
US (6)	US8691503B2 (de)
EP (4)	EP1340818A1 (de)
JP (3)	JP2005518218A (de)
AT (3)	ATE376596T1 (de)
AU (3)	AU2003210265A1 (de)
CA (1)	CA2451982A1 (de)
DE (3)	DE60317045T2 (de)
ES (2)	ES2295607T3 (de)
WO (3)	WO2003072812A2 (de)

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WO2006002344A1 (en) *	2004-06-23	2006-01-05	Epigenomics Ag	Methods and nucleic acids for the detection of metastasis of colon cell proliferative disorders
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US7932027B2 (en)	2005-02-16	2011-04-26	Epigenomics Ag	Method for determining the methylation pattern of a polynucleic acid
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WO2010053539A2 (en) *	2008-11-05	2010-05-14	The Texas A&M University System	Methods for detecting colorectal diseases and disorders
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EP2886659A1 (de) *	2013-12-20	2015-06-24	AIT Austrian Institute of Technology GmbH	Genmethylierung basierend auf der Diagnose von Kolorektalkrebs

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2002
- 2002-02-27 EP EP02004551A patent/EP1340818A1/de not_active Withdrawn
2003
- 2003-02-13 AU AU2003210265A patent/AU2003210265A1/en not_active Abandoned
- 2003-02-13 JP JP2003571492A patent/JP2005518218A/ja active Pending
- 2003-02-13 US US10/482,823 patent/US8691503B2/en not_active Expired - Fee Related
- 2003-02-13 ES ES03742934T patent/ES2295607T3/es not_active Expired - Lifetime
- 2003-02-13 DE DE60317045T patent/DE60317045T2/de not_active Expired - Lifetime
- 2003-02-13 WO PCT/EP2003/001457 patent/WO2003072812A2/en not_active Ceased
- 2003-02-13 AT AT03742934T patent/ATE376596T1/de not_active IP Right Cessation
- 2003-02-13 CA CA002451982A patent/CA2451982A1/en not_active Abandoned
- 2003-02-13 EP EP03742934A patent/EP1478784B1/de not_active Expired - Lifetime
- 2003-02-27 EP EP03742964A patent/EP1481095B1/de not_active Expired - Lifetime
- 2003-02-27 AU AU2003219002A patent/AU2003219002B2/en not_active Ceased
- 2003-02-27 DE DE60327600T patent/DE60327600D1/de not_active Expired - Lifetime
- 2003-02-27 WO PCT/EP2003/002034 patent/WO2003072820A2/en not_active Ceased
- 2003-02-27 AT AT03714760T patent/ATE431429T1/de not_active IP Right Cessation
- 2003-02-27 DE DE60335245T patent/DE60335245D1/de not_active Expired - Lifetime
- 2003-02-27 JP JP2003571501A patent/JP2005518220A/ja active Pending
- 2003-02-27 AT AT03742964T patent/ATE491038T1/de not_active IP Right Cessation
- 2003-02-27 AU AU2003248349A patent/AU2003248349B2/en not_active Ceased
- 2003-02-27 US US10/506,111 patent/US20060246433A1/en not_active Abandoned
- 2003-02-27 ES ES03714760T patent/ES2325363T3/es not_active Expired - Lifetime
- 2003-02-27 EP EP03714760A patent/EP1478778B1/de not_active Expired - Lifetime
- 2003-02-27 JP JP2003571500A patent/JP2005518219A/ja active Pending
- 2003-02-27 US US10/506,089 patent/US20060234224A1/en not_active Abandoned
- 2003-02-27 WO PCT/EP2003/002035 patent/WO2003072821A2/en not_active Ceased
2010
- 2010-06-04 US US12/794,449 patent/US9988683B2/en not_active Expired - Lifetime
2014
- 2014-02-21 US US14/186,984 patent/US20140179563A1/en not_active Abandoned
- 2014-11-25 US US14/553,566 patent/US20150275312A1/en not_active Abandoned

Also Published As

Publication number	Publication date
DE60317045D1 (de)	2007-12-06
ATE431429T1 (de)	2009-05-15
US20050003463A1 (en)	2005-01-06
EP1481095B1 (de)	2010-12-08
US8691503B2 (en)	2014-04-08
US9988683B2 (en)	2018-06-05
AU2003210265A1 (en)	2003-09-09
US20060246433A1 (en)	2006-11-02
ES2295607T3 (es)	2008-04-16
ES2325363T3 (es)	2009-09-02
JP2005518220A (ja)	2005-06-23
WO2003072812A3 (en)	2003-10-23
US20110046005A1 (en)	2011-02-24
US20150275312A1 (en)	2015-10-01
EP1481095A2 (de)	2004-12-01
WO2003072812A2 (en)	2003-09-04
ATE376596T1 (de)	2007-11-15
WO2003072820A2 (en)	2003-09-04
AU2003248349B2 (en)	2008-05-01
AU2003248349A1 (en)	2003-09-09
EP1478778A2 (de)	2004-11-24
DE60317045T2 (de)	2008-08-07
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