ATE547537T1 - Verfahren zur bestimmung der dna-methylierung in blut- oder urinproben - Google Patents
Verfahren zur bestimmung der dna-methylierung in blut- oder urinprobenInfo
- Publication number
- ATE547537T1 ATE547537T1 AT06750657T AT06750657T ATE547537T1 AT E547537 T1 ATE547537 T1 AT E547537T1 AT 06750657 T AT06750657 T AT 06750657T AT 06750657 T AT06750657 T AT 06750657T AT E547537 T1 ATE547537 T1 AT E547537T1
- Authority
- AT
- Austria
- Prior art keywords
- dna
- remote sample
- blood
- methods
- compositions
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000007067 DNA methylation Effects 0.000 title 1
- 239000008280 blood Substances 0.000 title 1
- 210000004369 blood Anatomy 0.000 title 1
- 210000002700 urine Anatomy 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical class NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000013412 genome amplification Methods 0.000 abstract 1
- 230000011987 methylation Effects 0.000 abstract 1
- 238000007069 methylation reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2523/00—Reactions characterised by treatment of reaction samples
- C12Q2523/10—Characterised by chemical treatment
- C12Q2523/125—Bisulfite(s)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- General Chemical & Material Sciences (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67224205P | 2005-04-15 | 2005-04-15 | |
| US67699705P | 2005-05-02 | 2005-05-02 | |
| US69752105P | 2005-07-08 | 2005-07-08 | |
| US72360205P | 2005-10-04 | 2005-10-04 | |
| US78024806P | 2006-03-08 | 2006-03-08 | |
| PCT/US2006/014667 WO2006113770A1 (en) | 2005-04-15 | 2006-04-17 | A method for providing dna fragments derived from a remote sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE547537T1 true ATE547537T1 (de) | 2012-03-15 |
Family
ID=36808881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06750657T ATE547537T1 (de) | 2005-04-15 | 2006-04-17 | Verfahren zur bestimmung der dna-methylierung in blut- oder urinproben |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US10731215B2 (de) |
| EP (2) | EP2481810A1 (de) |
| JP (2) | JP5133238B2 (de) |
| AT (1) | ATE547537T1 (de) |
| AU (1) | AU2006236363B2 (de) |
| CA (1) | CA2603815C (de) |
| CY (1) | CY1112852T1 (de) |
| DK (1) | DK1871912T3 (de) |
| ES (1) | ES2382746T3 (de) |
| PL (1) | PL1871912T3 (de) |
| PT (1) | PT1871912E (de) |
| SI (1) | SI1871912T1 (de) |
| WO (1) | WO2006113770A1 (de) |
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| JP2594377Y2 (ja) | 1993-06-30 | 1999-04-26 | 東レ株式会社 | 布帛擦過用粗面材 |
| US7846693B2 (en) | 2003-09-04 | 2010-12-07 | Human Genetic Signatures Pty. Ltd. | Nucleic acid detection assay |
| US7833942B2 (en) | 2004-12-03 | 2010-11-16 | Human Genetic Signatures Pty. Ltd. | Methods for simplifying microbial nucleic acids by chemical modification of cytosines |
| US8343738B2 (en) | 2005-09-14 | 2013-01-01 | Human Genetic Signatures Pty. Ltd. | Assay for screening for potential cervical cancer |
| GB0700374D0 (en) | 2007-01-09 | 2007-02-14 | Oncomethylome Sciences S A | NDRG family methylation markers |
| WO2008135512A2 (en) * | 2007-05-02 | 2008-11-13 | Jerzy Paszkowski | Dna amplification method |
| US8623599B2 (en) * | 2007-06-08 | 2014-01-07 | Epigenomics Ag | Method for methylation analysis |
| US8685675B2 (en) | 2007-11-27 | 2014-04-01 | Human Genetic Signatures Pty. Ltd. | Enzymes for amplification and copying bisulphite modified nucleic acids |
| EP2071035A1 (de) | 2007-12-13 | 2009-06-17 | Epigenomics AG | Vermittler und Verstärkungsverfahren |
| US9115386B2 (en) | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
| US20110306099A1 (en) * | 2008-11-03 | 2011-12-15 | Matthew Beasley | Method of cloning dna |
| EP2189538A1 (de) | 2008-11-21 | 2010-05-26 | Epigenomics AG | Analysemolekül und Verfahren zur Analyse einer Nucleotid-Position in einer Nukleinsäure |
| US9234456B2 (en) | 2009-10-06 | 2016-01-12 | Cummins Ltd. | Turbomachine |
| WO2011135058A2 (en) | 2010-04-30 | 2011-11-03 | Mdxhealth Sa | Methods for detecting epigenetic modifications |
| US8916344B2 (en) | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| GB201105726D0 (en) | 2011-04-04 | 2011-05-18 | Cummins Ltd | A turbine |
| US10140420B2 (en) | 2011-10-12 | 2018-11-27 | Merge Healthcare Incorporation | Systems and methods for independent assessment of image data |
| EP3425065B1 (de) | 2011-12-13 | 2021-04-21 | Oslo Universitetssykehus HF | Verfahren und kits zur detektion des methylierungsstatus |
| CN104955960A (zh) | 2012-11-30 | 2015-09-30 | 剑桥表现遗传学有限公司 | 用于修饰的核苷酸的氧化剂 |
| CA2902916C (en) | 2013-03-14 | 2018-08-28 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| CN105637369B (zh) * | 2013-10-22 | 2017-07-28 | 株式会社日立高新技术 | 自动分析装置 |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| US10435755B2 (en) | 2015-03-27 | 2019-10-08 | Exact Sciences Development Company, Llc | Detecting esophageal disorders |
| CN114574585A (zh) | 2015-08-31 | 2022-06-03 | 梅约医药教育及研究基金会 | 检测胃肿瘤 |
| EP3355939A4 (de) | 2015-09-30 | 2019-04-17 | Trustees of Boston University | Mikrobielle deadman- und passcode-not-ausschalter |
| CN108350485A (zh) | 2015-10-30 | 2018-07-31 | 精密科学发展有限责任公司 | 血浆dna的多重扩增检测测定以及分离和检测 |
| CN109563546B (zh) | 2016-05-05 | 2022-09-09 | 精密科学发展有限责任公司 | 通过分析甲基化dna来检测肺肿瘤 |
| WO2018017710A1 (en) | 2016-07-19 | 2018-01-25 | Exact Sciences Development Company, Llc | Nucleic acid control molecules from non-human organisms |
| KR102892245B1 (ko) | 2017-01-27 | 2025-11-27 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| WO2018195217A1 (en) | 2017-04-19 | 2018-10-25 | Singlera Genomics, Inc. | Compositions and methods for library construction and sequence analysis |
| CN107058553A (zh) * | 2017-05-05 | 2017-08-18 | 武汉爱基百客生物科技有限公司 | 一种分子ssr标记技术 |
| DE102017212164A1 (de) * | 2017-07-17 | 2019-01-17 | Robert Bosch Gmbh | Verbindungsvorrichtung für ein Abgasmesssystem |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| AU2019234843B2 (en) | 2018-03-13 | 2025-12-04 | Grail, Inc. | Anomalous fragment detection and classification |
| US12234514B2 (en) | 2018-12-21 | 2025-02-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free DNA samples |
| US12305242B2 (en) | 2020-04-24 | 2025-05-20 | The Johns Hopkins University | Methods and related aspects for quantitative polymerase chain reaction to determine fractional abundance |
| EP4083231A1 (de) | 2020-07-30 | 2022-11-02 | Cambridge Epigenetix Limited | Zusammensetzungen und verfahren zur nukleinsäureanalyse |
| CN112708546B (zh) * | 2021-01-13 | 2023-11-07 | 苏州缔因安生物科技有限公司 | 一种全集成核酸即时检测装置及其应用 |
| US11332777B1 (en) * | 2021-10-28 | 2022-05-17 | URIT Medical Electronic Co., Ltd. | Methods and reagent kits for bisulfite conversion of DNA |
| WO2025171113A1 (en) * | 2024-02-09 | 2025-08-14 | Grail, Inc. | Liquid processing system and related methods |
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| DE10010282B4 (de) | 2000-02-25 | 2006-11-16 | Epigenomics Ag | Verfahren zur Detektion von Cytosin-Methylierung in DNA Proben |
| DE10010280B4 (de) | 2000-02-25 | 2006-08-10 | Epigenomics Ag | Verfahren zur Detektion von Cytosin-Methylierung in DNA Proben |
| US20040048254A1 (en) | 2000-03-15 | 2004-03-11 | Alexander Olek | Diagnosis of diseases associated with tumor supressor genes and oncogenes |
| DE10032529A1 (de) | 2000-06-30 | 2002-02-07 | Epigenomics Ag | Diagnose von bedeutenden genetischen Parametern innerhalb des Major Histocompatibility Complex (MHC) |
| DE20121973U1 (de) | 2000-03-15 | 2003-12-24 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit dem Zellzyklus assoziierten Krankheiten |
| DE10013847A1 (de) | 2000-03-15 | 2001-09-27 | Epigenomics Ag | Oligonukleotide oder PNA-Oligomere und Verfahren zur parallelen Detektion des Methylierungszustandes genomischer DNA |
| DE10019058A1 (de) | 2000-04-06 | 2001-12-20 | Epigenomics Ag | Detektion von Variationen des DNA-Methylierungsprofils |
| DE20121977U1 (de) | 2000-03-15 | 2003-12-24 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit Tumor-Suppressorgenen und Onkogenen assoziierten Krankheiten |
| DE20121969U1 (de) | 2000-04-06 | 2003-12-24 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit DNA Reparatur assoziierten Krankheiten |
| DE20121964U1 (de) | 2000-04-06 | 2004-01-15 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit dem Metabolismus assoziierten Krankheiten |
| DE20121968U1 (de) | 2000-04-06 | 2003-12-18 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit Apoptose assoziierten Krankheiten |
| DE20121970U1 (de) | 2000-04-06 | 2003-12-24 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit der Genregulation assoziierten Krankheiten |
| DE20121974U1 (de) | 2000-04-06 | 2003-12-24 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit DNA Replikation assoziierten Krankheiten |
| WO2001077375A2 (en) | 2000-04-06 | 2001-10-18 | Epigenomics Ag | Diagnosis of diseases associated with gene regulation |
| DE20121960U1 (de) | 2000-04-06 | 2004-01-15 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit Metastase assoziierten Krankheiten |
| DE20121965U1 (de) | 2000-04-06 | 2003-12-24 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit DNA Addukten assoziierten Krankheiten |
| DE20121972U1 (de) | 2000-04-06 | 2003-12-24 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit DNA Transkription assoziierten Krankheiten |
| DE10029915B4 (de) | 2000-06-19 | 2005-06-16 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungen |
| DE20121979U1 (de) | 2000-06-30 | 2003-12-24 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit der Zellsignalisierung assoziierten Krankheiten |
| DE20121978U1 (de) | 2000-06-30 | 2004-01-15 | Epigenomics Ag | Nukleinsäuren für die Analyse von Astrocytomen |
| DE20121961U1 (de) | 2000-06-30 | 2003-12-18 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit der Signaltransduktion assoziierten Krankheiten |
| WO2002002807A2 (en) | 2000-06-30 | 2002-01-10 | Epigenomics Ag | Diagnosis of diseases associated with cell signalling |
| DE20121963U1 (de) | 2000-06-30 | 2003-12-18 | Epigenomics Ag | Nukleinsäuren für die Diagnose von mit Entwicklungsgenen assoziierten Krankheiten |
| DE20121975U1 (de) | 2000-06-30 | 2004-01-15 | Epigenomics Ag | Nukleinsäuren für die Differenzierung von Astrocytomen, Oligoastrocytomen und Oligodendrogliom-Tumorzellen |
| DE20121967U1 (de) | 2000-06-30 | 2003-12-18 | Epigenomics Ag | Nukleinsäuren für die Diagnose von Verhaltensstörungen, neurologischen Erkrankungen und Krebs |
| DE20121966U1 (de) | 2000-06-30 | 2003-11-20 | Epigenomics AG, 10435 Berlin | Nukleinsäuren für die Diagnose von mit dem Immunsystem assoziierten Krankheiten |
| DE20121971U1 (de) | 2000-06-30 | 2003-12-24 | Epigenomics Ag | Nukleinsäuren für die Pharmakogenomische Methylierungsanalyse |
| DE10037769A1 (de) | 2000-08-03 | 2002-02-21 | Epigenomics Gmbh | Diagnose von mit CD24 assoziierten Krankheiten |
| US7214485B2 (en) | 2000-08-25 | 2007-05-08 | Lovelace Respiratory Research Institute | Nested methylation-specific polymerase chain reaction cancer detection method |
| IL154663A0 (en) | 2000-09-01 | 2003-09-17 | Epigenomics Ag | Method for determining the degree of methylation of defined cytosines in genomic dna in the sequence context 5'-cpg-3' |
| WO2002024056A2 (en) * | 2000-09-20 | 2002-03-28 | Case Western Reserve University | METHODS AND COMPOSITIONS FOR DETECTING CANCERS ASSOCIATED WITH METHYLATION OF hMLH1PROMOTER DNA |
| DE10054972A1 (de) | 2000-11-06 | 2002-06-06 | Epigenomics Ag | Diagnose von mit humos assoziierten Krankheiten |
| DE10054974A1 (de) | 2000-11-06 | 2002-06-06 | Epigenomics Ag | Diagnose von mit Cdk4 assoziierten Krankheiten |
| DE10061338A1 (de) | 2000-12-06 | 2002-06-20 | Epigenomics Ag | Diagnose von mit Angiogenese assoziierten Krankheiten |
| DE10112515B4 (de) | 2001-03-09 | 2004-02-12 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
| EP1410304A2 (de) | 2001-03-26 | 2004-04-21 | Epigenomics AG | Verfahren zur epigenetischen merkmalauswahl |
| JP2005501527A (ja) * | 2001-05-30 | 2005-01-20 | ストラタジーン カリフォルニア | 無作為な核酸変異誘発のための組成物及び方法 |
| DE10128508A1 (de) | 2001-06-14 | 2003-02-06 | Epigenomics Ag | Verfahren und Nukleinsäuren für die Differenzierung von Prostata-Tumoren |
| DE10130800B4 (de) * | 2001-06-22 | 2005-06-23 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierung mit hoher Sensitivität |
| DE10139283A1 (de) | 2001-08-09 | 2003-03-13 | Epigenomics Ag | Verfahren und Nukleinsäuren zur Analyse von Colon-Krebs |
| US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| AU2002341891A1 (en) * | 2001-09-26 | 2003-04-07 | Epigenx Pharmaceuticals, Inc. | Assays for dna methylation changes |
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| AU2002352143A1 (en) | 2001-11-23 | 2003-06-10 | Epigenomics Ag | Method and nucleic acids for the analysis of a lymphoid cell proliferative disorder |
| DE10161625A1 (de) | 2001-12-14 | 2003-07-10 | Epigenomics Ag | Verfahren und Nukleinsäuren für die Analyse einer Lungenzell-Zellteilungsstörung |
| WO2003064701A2 (en) * | 2002-01-30 | 2003-08-07 | Epigenomics Ag | Method for the analysis of cytosine methylation patterns |
| EP1340818A1 (de) | 2002-02-27 | 2003-09-03 | Epigenomics AG | Verfahren und Nukleinsäuren zur Analyse von Kolonkrebszellen |
| WO2003085132A2 (en) | 2002-04-09 | 2003-10-16 | Epigenomics Ag | Method for analysis of methylated nucleic acids |
| EP1369493B1 (de) | 2002-06-05 | 2006-09-13 | Epigenomics AG | Verfahren zur quantitiven Bestimmung des Methylierungsgrades von Cytosinen in CpG-Positionen |
| DE10230692A1 (de) | 2002-07-08 | 2004-02-12 | Epigenomics Ag | Verfahren und Nukleinsäuren für die Analyse von Methylierungsmustern innerhalb des DD3-Gens |
| DE10255104A1 (de) | 2002-08-27 | 2004-03-11 | Epigenomics Ag | Verfahren und Nukleinsäuren für die Analyse von proliferativen Erkrankungen von Brustzellen |
| EP1554407B1 (de) | 2002-10-01 | 2009-07-29 | Epigenomics AG | Verfahren für die behandlung von proliferativen erkrankungen von brustzellen |
| DE10245779A1 (de) | 2002-10-01 | 2004-04-29 | Epigenomics Ag | Verfahren und Nukleinsäuren für die verbesserte Behandlung von proliferativen Erkrankungen von Brustzellen |
| EP2418287B1 (de) * | 2002-10-11 | 2013-09-18 | Erasmus Universiteit Rotterdam | Primer für PCR-basierte Studien der Klonalität des TCR-beta Gens |
| US8067205B2 (en) * | 2003-03-28 | 2011-11-29 | Japan As Represented By Director General Of National Rehabilitation Center For Persons With Disabilities | Method of synthesizing cDNA |
| WO2005001141A2 (en) | 2003-06-23 | 2005-01-06 | Epigenomics Ag | Methods and nucleic acids for analyses of colorectal cell proliferative disorders |
| DE10338308B4 (de) | 2003-08-15 | 2006-10-19 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungen in DNA |
| CA2540310A1 (en) | 2003-10-09 | 2005-04-28 | Epigenomics Ag | Improved bisulfite conversion of dna |
| DE602004030430D1 (de) | 2004-06-23 | 2011-01-20 | Epigenomics Ag | Verfahren zur Quantifizierung von methylierter DNS |
| GB2424946A (en) * | 2005-04-05 | 2006-10-11 | Stratec Biomedical Systems Ag | A detection system for substance binding using up-converting fluorescent probes |
| CN102725424B (zh) * | 2010-01-25 | 2014-07-09 | Rd生物科技公司 | 靶核酸的自折叠扩增 |
| EP2531608B1 (de) * | 2010-02-05 | 2020-08-19 | Siemens Healthcare Diagnostics Inc. | Verfahren zur erhöhung einer multiplex-ebene durch externalisierung passiver referenzen in polymerase-kettenreaktionen |
| ES2623859T3 (es) * | 2010-03-04 | 2017-07-12 | Miacom Diagnostics Gmbh | FISH múltiple mejorada |
| WO2012162161A1 (en) * | 2011-05-20 | 2012-11-29 | Phthisis Diagnostics | Microsporidia detection system and method |
-
2006
- 2006-04-17 WO PCT/US2006/014667 patent/WO2006113770A1/en not_active Ceased
- 2006-04-17 ES ES06750657T patent/ES2382746T3/es not_active Expired - Lifetime
- 2006-04-17 PL PL06750657T patent/PL1871912T3/pl unknown
- 2006-04-17 EP EP11009406A patent/EP2481810A1/de not_active Withdrawn
- 2006-04-17 SI SI200631314T patent/SI1871912T1/sl unknown
- 2006-04-17 EP EP06750657A patent/EP1871912B1/de not_active Expired - Lifetime
- 2006-04-17 CA CA2603815A patent/CA2603815C/en not_active Expired - Lifetime
- 2006-04-17 JP JP2008506828A patent/JP5133238B2/ja not_active Expired - Fee Related
- 2006-04-17 DK DK06750657.6T patent/DK1871912T3/da active
- 2006-04-17 AU AU2006236363A patent/AU2006236363B2/en not_active Ceased
- 2006-04-17 PT PT06750657T patent/PT1871912E/pt unknown
- 2006-04-17 US US11/910,887 patent/US10731215B2/en active Active
- 2006-04-17 AT AT06750657T patent/ATE547537T1/de active
-
2012
- 2012-03-05 JP JP2012048559A patent/JP5674696B2/ja not_active Expired - Fee Related
- 2012-05-11 CY CY20121100439T patent/CY1112852T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2382746T3 (es) | 2012-06-13 |
| JP2012105679A (ja) | 2012-06-07 |
| PT1871912E (pt) | 2012-05-25 |
| CA2603815C (en) | 2017-09-26 |
| DK1871912T3 (da) | 2012-05-14 |
| AU2006236363A8 (en) | 2009-03-05 |
| CY1112852T1 (el) | 2016-02-10 |
| WO2006113770A1 (en) | 2006-10-26 |
| US20110059432A1 (en) | 2011-03-10 |
| EP2481810A1 (de) | 2012-08-01 |
| SI1871912T1 (sl) | 2012-06-29 |
| JP5674696B2 (ja) | 2015-02-25 |
| PL1871912T3 (pl) | 2012-07-31 |
| US10731215B2 (en) | 2020-08-04 |
| AU2006236363A1 (en) | 2006-10-26 |
| EP1871912A1 (de) | 2008-01-02 |
| EP1871912B1 (de) | 2012-02-29 |
| CA2603815A1 (en) | 2006-10-26 |
| AU2006236363B2 (en) | 2012-11-01 |
| JP2008537888A (ja) | 2008-10-02 |
| JP5133238B2 (ja) | 2013-01-30 |
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