ATE491045T1 - Strategien mit hohem durchsatz zur identifizierung und zum nachweis von polymorphismen - Google Patents

Strategien mit hohem durchsatz zur identifizierung und zum nachweis von polymorphismen

Info

Publication number
ATE491045T1
ATE491045T1 AT06757808T AT06757808T ATE491045T1 AT E491045 T1 ATE491045 T1 AT E491045T1 AT 06757808 T AT06757808 T AT 06757808T AT 06757808 T AT06757808 T AT 06757808T AT E491045 T1 ATE491045 T1 AT E491045T1
Authority
AT
Austria
Prior art keywords
single nucleotide
nucleotide polymorphisms
immune cell
polymorphisms
libraries
Prior art date
Application number
AT06757808T
Other languages
English (en)
Inventor
Eijk Michael Van
Der Poel Henricus Van
Original Assignee
Keygene Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keygene Nv filed Critical Keygene Nv
Application granted granted Critical
Publication of ATE491045T1 publication Critical patent/ATE491045T1/de

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1065—Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/04—Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/10—Methods of screening libraries by measuring physical properties, e.g. mass

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT06757808T 2005-06-23 2006-06-23 Strategien mit hohem durchsatz zur identifizierung und zum nachweis von polymorphismen ATE491045T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US69305305P 2005-06-23 2005-06-23
EP06075104 2006-01-16
US75903406P 2006-01-17 2006-01-17
PCT/NL2006/000311 WO2006137733A1 (en) 2005-06-23 2006-06-23 Strategies for high throughput identification and detection of polymorphisms

Publications (1)

Publication Number Publication Date
ATE491045T1 true ATE491045T1 (de) 2010-12-15

Family

ID=36940150

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06757808T ATE491045T1 (de) 2005-06-23 2006-06-23 Strategien mit hohem durchsatz zur identifizierung und zum nachweis von polymorphismen
AT10184351T ATE557105T1 (de) 2005-06-23 2006-06-23 Strategien für eine hohe durchsatzidentifikation und erkennung von polymorphismen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT10184351T ATE557105T1 (de) 2005-06-23 2006-06-23 Strategien für eine hohe durchsatzidentifikation und erkennung von polymorphismen

Country Status (9)

Country Link
US (15) US8785353B2 (de)
EP (3) EP2302070B1 (de)
JP (2) JP5220597B2 (de)
CN (3) CN102925561B (de)
AT (2) ATE491045T1 (de)
DE (1) DE602006018744D1 (de)
DK (2) DK2302070T3 (de)
ES (2) ES2393318T3 (de)
WO (1) WO2006137733A1 (de)

Families Citing this family (155)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006122215A2 (en) 2005-05-10 2006-11-16 State Of Oregon Acting By & Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods of mapping polymorphisms and polymorphism microarrays
DK2302070T3 (da) * 2005-06-23 2012-11-26 Keygene Nv Strategier til identifikation og detektion af polymorfismer med højt gennemløb
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
WO2007037678A2 (en) 2005-09-29 2007-04-05 Keygene N.V. High throughput screening of mutagenized populations
CN101365803B (zh) * 2005-12-22 2013-03-20 关键基因股份有限公司 采用高通量测序技术的改进的转录谱描述策略
CN103937899B (zh) 2005-12-22 2017-09-08 凯津公司 用于基于aflp的高通量多态性检测的方法
US7932029B1 (en) * 2006-01-04 2011-04-26 Si Lok Methods for nucleic acid mapping and identification of fine-structural-variations in nucleic acids and utilities
EP3239304B1 (de) * 2006-04-04 2020-08-19 Keygene N.V. Nachweis von molekularmarkern mit hohem durchsatz auf der basis von aflp und mit hoher durchsatzsequenzierung
US8053191B2 (en) 2006-08-31 2011-11-08 Westend Asset Clearinghouse Company, Llc Iterative nucleic acid assembly using activation of vector-encoded traits
AR066922A1 (es) 2007-06-08 2009-09-23 Monsanto Technology Llc Metodos de mejoramiento molecular del germoplasma de una planta por secuenciamiento dirigido
US8124336B2 (en) 2007-09-26 2012-02-28 Population Genetics Technologies Ltd Methods and compositions for reducing the complexity of a nucleic acid sample
EP2367937B1 (de) * 2008-12-04 2013-04-17 Keygene N.V. Verfahren zur reduzierung von wiederholungssequenzen in adapter-ligierten restriktionsfragmenten
US9085798B2 (en) 2009-04-30 2015-07-21 Prognosys Biosciences, Inc. Nucleic acid constructs and methods of use
JP5799484B2 (ja) * 2009-12-14 2015-10-28 トヨタ自動車株式会社 Ｄｎａマイクロアレイにおけるプローブ設計方法、当該方法により設計されたプローブを有するｄｎａマイクロアレイ
WO2011127099A1 (en) 2010-04-05 2011-10-13 Prognosys Biosciences, Inc. Spatially encoded biological assays
US10787701B2 (en) 2010-04-05 2020-09-29 Prognosys Biosciences, Inc. Spatially encoded biological assays
US20190300945A1 (en) 2010-04-05 2019-10-03 Prognosys Biosciences, Inc. Spatially Encoded Biological Assays
US9080210B2 (en) 2010-06-09 2015-07-14 Keygene N.V. High throughput screening using combinatorial sequence barcodes
WO2012005595A2 (en) * 2010-07-09 2012-01-12 Wouter Leonard De Laat V3-d genomic region of interest sequencing strategies
CN102409046B (zh) * 2010-09-21 2013-09-18 深圳华大基因科技服务有限公司 小分子rna标签
CN102409048B (zh) * 2010-09-21 2013-10-23 深圳华大基因科技服务有限公司 一种基于高通量测序的dna标签文库构建方法
GB201016484D0 (en) 2010-09-30 2010-11-17 Geneseque As Method
CN103502448B (zh) 2010-11-12 2017-03-29 Gen9股份有限公司 核酸合成的方法和设备
WO2012064975A1 (en) 2010-11-12 2012-05-18 Gen9, Inc. Protein arrays and methods of using and making the same
CA2823815A1 (en) * 2011-01-14 2012-07-19 Keygene N.V. Paired end random sequence based genotyping
GB201106254D0 (en) 2011-04-13 2011-05-25 Frisen Jonas Method and product
CN103764849A (zh) 2011-06-27 2014-04-30 佛罗里达大学研究基金公司 降低基因组复杂度和多态性检测的方法
LT2944693T (lt) 2011-08-26 2019-08-26 Gen9, Inc. Kompozicijos ir būdai, skirti nukleorūgščių didelio tikslumo sąrankai
CN102567652A (zh) * 2011-12-13 2012-07-11 上海大学 一种面向snp数据的筛选方法
EP2802666B1 (de) 2012-01-13 2018-09-19 Data2Bio Genotypisierung durch eine sequenzierung der nächsten generation
WO2013123442A1 (en) 2012-02-17 2013-08-22 Fred Hutchinson Cancer Research Center Compositions and methods for accurately identifying mutations
PT2828218T (pt) 2012-03-20 2020-11-11 Univ Washington Through Its Center For Commercialization Métodos para baixar a taxa de erro da sequenciação paralela massiva de adn utilizando sequenciação duplex de consensus
US9150853B2 (en) 2012-03-21 2015-10-06 Gen9, Inc. Methods for screening proteins using DNA encoded chemical libraries as templates for enzyme catalysis
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
CA2871505C (en) * 2012-04-24 2021-10-12 Gen9, Inc. Methods for sorting nucleic acids and multiplexed preparative in vitro cloning
US20130281308A1 (en) * 2012-04-24 2013-10-24 Gen9, Inc. Methods for sorting nucleic acids and preparative in vitro cloning
KR101890140B1 (ko) 2012-05-07 2018-09-28 삼성전자주식회사 카메라 장치를 이용하여 디스플레이 장치를 제어하는 방법 및 이를 적용한 모바일 장치, 디스플레이 장치, 그리고 시스템
EP4148142B1 (de) 2012-05-21 2025-08-13 The Scripps Research Institute Verfahren zur probenvorbereitung
IL236303B (en) 2012-06-25 2022-07-01 Gen9 Inc Methods for high-throughput nucleic acid assembly and sequencing
US20150011396A1 (en) 2012-07-09 2015-01-08 Benjamin G. Schroeder Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing
US20160040229A1 (en) 2013-08-16 2016-02-11 Guardant Health, Inc. Systems and methods to detect rare mutations and copy number variation
GB201217888D0 (en) 2012-10-05 2012-11-21 Univ Leuven Kath High-throughput genotyping by sequencing of single cell
EP4592400A3 (de) 2012-10-17 2025-10-29 10x Genomics Sweden AB Verfahren und produkt zur optimierung einer lokalisierten oder räumlichen detektion einer genexpression in einer gewebeprobe
EP4414990A3 (de) 2013-01-17 2024-11-06 Personalis, Inc. Verfahren und systeme zur genetischen analyse
US9822408B2 (en) 2013-03-15 2017-11-21 Nugen Technologies, Inc. Sequential sequencing
CA2916662C (en) 2013-06-25 2022-03-08 Prognosys Biosciences, Inc. Methods and systems for determining spatial patterns of biological targets in a sample
WO2015031689A1 (en) 2013-08-30 2015-03-05 Personalis, Inc. Methods and systems for genomic analysis
CA2921067A1 (en) * 2013-09-30 2015-04-02 Qiagen Gmbh Dna-adapter-molecules for the preparation of dna-libraries and method for producing them and use
WO2015051275A1 (en) 2013-10-03 2015-04-09 Personalis, Inc. Methods for analyzing genotypes
GB201319779D0 (en) * 2013-11-08 2013-12-25 Cartagenia N V Genetic analysis method
WO2015073711A1 (en) 2013-11-13 2015-05-21 Nugen Technologies, Inc. Compositions and methods for identification of a duplicate sequencing read
GB201413929D0 (en) 2014-08-06 2014-09-17 Geneseque As Method
US10450562B2 (en) 2014-09-09 2019-10-22 Igenomx International Genomics Corporation Methods and compositions for rapid nucleic acid library preparation
US10125399B2 (en) 2014-10-30 2018-11-13 Personalis, Inc. Methods for using mosaicism in nucleic acids sampled distal to their origin
CN104450697B (zh) * 2014-12-02 2017-01-11 中国科学院海洋研究所 一种与牡蛎抗病毒特性相关的snp标记及其应用
EP3901282B1 (de) 2015-04-10 2023-06-28 Spatial Transcriptomics AB Räumlich getrennte multiplex-nukleinsäureanalyse von biologischen proben
EP3307908B1 (de) 2015-06-09 2019-09-11 Life Technologies Corporation Verfahren zur molekularen markierung
CA3006792A1 (en) 2015-12-08 2017-06-15 Twinstrand Biosciences, Inc. Improved adapters, methods, and compositions for duplex sequencing
CN105420363A (zh) * 2015-12-15 2016-03-23 江苏省中国科学院植物研究所 一种适用于狗牙根基因差异表达研究的cDNA-AFLP方法
WO2017162754A1 (en) 2016-03-22 2017-09-28 Vib Vzw Means and methods for amplifying nucleotide sequences
US11384382B2 (en) 2016-04-14 2022-07-12 Guardant Health, Inc. Methods of attaching adapters to sample nucleic acids
ES3002715T3 (en) 2016-04-14 2025-03-07 Guardant Health Inc Methods for early detection of cancer
US11299783B2 (en) 2016-05-27 2022-04-12 Personalis, Inc. Methods and systems for genetic analysis
CN106480191A (zh) * 2016-10-20 2017-03-08 南昌大学 一种河蛏蚌f型线粒体基因组全序列扩增的方法
US11441188B2 (en) 2016-11-15 2022-09-13 Quest Diagnostics Investments Llc Methods for detecting DNA mutations using Mitra tip extraction
WO2018093723A1 (en) * 2016-11-15 2018-05-24 Quest Diagnostics Investments Llc Methods for detecting cystic fibrosis mutations using mitra tip extraction
WO2018183942A1 (en) 2017-03-31 2018-10-04 Grail, Inc. Improved library preparation and use thereof for sequencing-based error correction and/or variant identification
US12492430B2 (en) 2017-04-11 2025-12-09 Tecan Genomics, Inc. Library quantitation and qualification
AU2018260627B2 (en) * 2017-04-23 2024-08-22 Illumina Cambridge Limited Compositions and methods for improving sample identification in indexed nucleic acid libraries
JP7056012B2 (ja) * 2017-05-19 2022-04-19 トヨタ自動車株式会社 ランダムプライマーセット、及びこれを用いたｄｎａライブラリーの作製方法
WO2019060716A1 (en) 2017-09-25 2019-03-28 Freenome Holdings, Inc. SAMPLE EXTRACTION METHODS AND SYSTEMS
US11099202B2 (en) 2017-10-20 2021-08-24 Tecan Genomics, Inc. Reagent delivery system
CN107589193B (zh) * 2017-10-25 2020-05-05 南京工业大学 一种利用微反应装置筛选蛋白抑制剂的方法
AU2018366213B2 (en) 2017-11-08 2025-05-15 Twinstrand Biosciences, Inc. Reagents and adapters for nucleic acid sequencing and methods for making such reagents and adapters
WO2019121603A1 (en) 2017-12-18 2019-06-27 Keygene N.V. Chemical mutagenesis of cassava
JP7047373B2 (ja) 2017-12-25 2022-04-05 トヨタ自動車株式会社 次世代シーケンサー用プライマー並びにその製造方法、次世代シーケンサー用プライマーを用いたｄｎａライブラリー並びにその製造方法、及びｄｎａライブラリーを用いたゲノムｄｎａ解析方法
EP3759118A4 (de) * 2018-02-20 2022-03-23 William Marsh Rice University Systeme und verfahren zur allelanreicherung mittels multiplex-blocker-verdrängungsamplifikation
US11814750B2 (en) 2018-05-31 2023-11-14 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
US10801064B2 (en) 2018-05-31 2020-10-13 Personalis, Inc. Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples
BR112021000409A2 (pt) 2018-07-12 2021-04-06 Twinstrand Biosciences, Inc. Métodos e reagentes para caracterizar edição genômica, expansão clonal e aplicações associadas
AU2019309870A1 (en) 2018-07-26 2021-02-18 Lexent Bio, Inc. Multiple sequencing using a single flow cell
US11519033B2 (en) 2018-08-28 2022-12-06 10X Genomics, Inc. Method for transposase-mediated spatial tagging and analyzing genomic DNA in a biological sample
WO2020109412A1 (en) 2018-11-28 2020-06-04 Keygene N.V. Targeted enrichment by endonuclease protection
WO2020123316A2 (en) 2018-12-10 2020-06-18 10X Genomics, Inc. Methods for determining a location of a biological analyte in a biological sample
US12529094B2 (en) 2018-12-10 2026-01-20 10X Genomics, Inc. Imaging system hardware
CN112867800B (zh) * 2018-12-17 2024-07-12 Illumina公司 用于制备测序文库的方法和手段
TWI725686B (zh) 2018-12-26 2021-04-21 財團法人工業技術研究院 用於產生液珠的管狀結構及液珠產生方法
US11926867B2 (en) 2019-01-06 2024-03-12 10X Genomics, Inc. Generating capture probes for spatial analysis
US11649485B2 (en) 2019-01-06 2023-05-16 10X Genomics, Inc. Generating capture probes for spatial analysis
CA3127572A1 (en) 2019-02-21 2020-08-27 Keygene N.V. Genotyping of polyploids
WO2020243579A1 (en) 2019-05-30 2020-12-03 10X Genomics, Inc. Methods of detecting spatial heterogeneity of a biological sample
KR20220015367A (ko) 2019-05-31 2022-02-08 프리놈 홀딩스, 인크. 메틸화된 핵산의 고심도 시퀀싱 방법 및 시스템
US10927409B1 (en) 2019-10-14 2021-02-23 Pioneer Hi-Bred International, Inc. Detection of sequences uniquely associated with a dna target region
JP7470787B2 (ja) 2019-11-05 2024-04-18 パーソナリス，インコーポレイティド 単一試料からの腫瘍純度の推定
WO2021092433A2 (en) 2019-11-08 2021-05-14 10X Genomics, Inc. Enhancing specificity of analyte binding
WO2021116371A1 (en) 2019-12-12 2021-06-17 Keygene N.V. Semi-solid state nucleic acid manipulation
EP4077661A1 (de) 2019-12-20 2022-10-26 Keygene N.V. Herstellung von ngs-bibliotheken unter verwendung von kovalent verschlossenen nukleinsäuremolekül-enden.
CN115135984B (zh) 2019-12-23 2025-12-23 10X基因组学有限公司 可逆固定试剂及其使用方法
ES2982420T3 (es) 2019-12-23 2024-10-16 10X Genomics Inc Métodos para el análisis espacial mediante el uso de la ligazón con plantilla de ARN
EP4081656A1 (de) 2019-12-23 2022-11-02 10X Genomics, Inc. Zusammensetzungen und verfahren zur verwendung von fixierten biologischen proben bei partitionsbasierten tests
US12365942B2 (en) 2020-01-13 2025-07-22 10X Genomics, Inc. Methods of decreasing background on a spatial array
US12405264B2 (en) 2020-01-17 2025-09-02 10X Genomics, Inc. Electrophoretic system and method for analyte capture
EP3851542A1 (de) 2020-01-20 2021-07-21 Tecan Genomics, Inc. Verarmung von reichlich uninformativen sequenzen
US11702693B2 (en) 2020-01-21 2023-07-18 10X Genomics, Inc. Methods for printing cells and generating arrays of barcoded cells
US11732299B2 (en) 2020-01-21 2023-08-22 10X Genomics, Inc. Spatial assays with perturbed cells
US20210230681A1 (en) 2020-01-24 2021-07-29 10X Genomics, Inc. Methods for spatial analysis using proximity ligation
US11821035B1 (en) 2020-01-29 2023-11-21 10X Genomics, Inc. Compositions and methods of making gene expression libraries
US12076701B2 (en) 2020-01-31 2024-09-03 10X Genomics, Inc. Capturing oligonucleotides in spatial transcriptomics
US12059674B2 (en) 2020-02-03 2024-08-13 Tecan Genomics, Inc. Reagent storage system
US12110541B2 (en) 2020-02-03 2024-10-08 10X Genomics, Inc. Methods for preparing high-resolution spatial arrays
US11898205B2 (en) 2020-02-03 2024-02-13 10X Genomics, Inc. Increasing capture efficiency of spatial assays
US11732300B2 (en) 2020-02-05 2023-08-22 10X Genomics, Inc. Increasing efficiency of spatial analysis in a biological sample
WO2021158925A1 (en) 2020-02-07 2021-08-12 10X Genomics, Inc. Quantitative and automated permeabilization performance evaluation for spatial transcriptomics
US12281357B1 (en) 2020-02-14 2025-04-22 10X Genomics, Inc. In situ spatial barcoding
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11891654B2 (en) 2020-02-24 2024-02-06 10X Genomics, Inc. Methods of making gene expression libraries
AU2021245992A1 (en) 2020-03-31 2022-11-10 Freenome Holdings, Inc. Methods and systems for detecting colorectal cancer via nucleic acid methylation analysis
EP4139485B1 (de) 2020-04-22 2023-09-06 10X Genomics, Inc. Verfahren zur räumlichen analyse unter verwendung von gezieltem rna-abbau
EP4414459B1 (de) 2020-05-22 2025-09-03 10X Genomics, Inc. Simultane räumlich-zeitliche messung der genexpression und der zellaktivität
EP4153776B1 (de) 2020-05-22 2025-03-05 10X Genomics, Inc. Räumliche analyse zur erkennung von sequenzvarianten
WO2021242834A1 (en) 2020-05-26 2021-12-02 10X Genomics, Inc. Method for resetting an array
EP4600376A3 (de) 2020-06-02 2025-10-22 10X Genomics, Inc. Räumliche transkriptomik für antigenrezeptoren
AU2021283174A1 (en) 2020-06-02 2023-01-05 10X Genomics, Inc. Nucleic acid library methods
US12031177B1 (en) 2020-06-04 2024-07-09 10X Genomics, Inc. Methods of enhancing spatial resolution of transcripts
EP4421186B1 (de) 2020-06-08 2025-08-13 10X Genomics, Inc. Verfahren zur bestimmung eines chirurgischen randes und verfahren zur verwendung davon
EP4165207B1 (de) 2020-06-10 2024-09-25 10X Genomics, Inc. Verfahren zur bestimmung der position eines analyten in einer biologischen probe
ES2994976T3 (en) 2020-06-25 2025-02-05 10X Genomics Inc Spatial analysis of dna methylation
US11761038B1 (en) 2020-07-06 2023-09-19 10X Genomics, Inc. Methods for identifying a location of an RNA in a biological sample
US11981960B1 (en) 2020-07-06 2024-05-14 10X Genomics, Inc. Spatial analysis utilizing degradable hydrogels
US12209280B1 (en) 2020-07-06 2025-01-28 10X Genomics, Inc. Methods of identifying abundance and location of an analyte in a biological sample using second strand synthesis
US20220017956A1 (en) * 2020-07-14 2022-01-20 Accugenomics, Inc. Endogenous complexity calibration ladder target
US11981958B1 (en) 2020-08-20 2024-05-14 10X Genomics, Inc. Methods for spatial analysis using DNA capture
US11926822B1 (en) 2020-09-23 2024-03-12 10X Genomics, Inc. Three-dimensional spatial analysis
CN116670510A (zh) 2020-10-05 2023-08-29 福瑞诺姆控股公司 用于结肠细胞增殖性病症的早期检测的标志物
WO2022074058A1 (en) 2020-10-06 2022-04-14 Keygene N.V. Targeted sequence addition
US11827935B1 (en) 2020-11-19 2023-11-28 10X Genomics, Inc. Methods for spatial analysis using rolling circle amplification and detection probes
WO2022112316A1 (en) 2020-11-24 2022-06-02 Keygene N.V. Targeted enrichment using nanopore selective sequencing
US20240093288A1 (en) 2020-11-25 2024-03-21 Koninklijke Nederlandse Akademie Van Wetenschappen Ribosomal profiling in single cells
EP4729631A2 (de) 2020-12-21 2026-04-22 10X Genomics, Inc. Verfahren, zusammensetzungen und systeme zur erfassung von sonden und/oder barcodes
CA3202255A1 (en) 2020-12-21 2022-06-30 Hayley WARSINSKE Markers for the early detection of colon cell proliferative disorders
CN112695125B (zh) * 2021-01-29 2021-08-27 广东省农业科学院环境园艺研究所 一种卡特兰属ssr分子标记引物组合物及其应用
EP4305196B1 (de) 2021-04-14 2025-04-02 10X Genomics, Inc. Verfahren zur messung der fehllokalisierung eines analyten
EP4320271B1 (de) 2021-05-06 2025-03-19 10X Genomics, Inc. Verfahren zur erhöhung der auflösung von räumlicher analyse
WO2022256503A1 (en) 2021-06-03 2022-12-08 10X Genomics, Inc. Methods, compositions, kits, and systems for enhancing analyte capture for spatial analysis
WO2023034489A1 (en) 2021-09-01 2023-03-09 10X Genomics, Inc. Methods, compositions, and kits for blocking a capture probe on a spatial array
CN113832250B (zh) * 2021-09-29 2024-06-07 石家庄博瑞迪生物技术有限公司 一种基于mSNP技术检测玉米种子纯度的混样检测方法
WO2023059654A1 (en) 2021-10-05 2023-04-13 Personalis, Inc. Customized assays for personalized cancer monitoring
WO2023086880A1 (en) 2021-11-10 2023-05-19 10X Genomics, Inc. Methods, compositions, and kits for determining the location of an analyte in a biological sample
WO2023102118A2 (en) 2021-12-01 2023-06-08 10X Genomics, Inc. Methods, compositions, and systems for improved in situ detection of analytes and spatial analysis
EP4482979B1 (de) 2022-11-09 2025-10-01 10X Genomics, Inc. Verfahren, zusammensetzungen und kits zur bestimmung der position mehrerer analyten in einer biologischen probe
WO2024121354A1 (en) 2022-12-08 2024-06-13 Keygene N.V. Duplex sequencing with covalently closed dna ends
EP4689157A1 (de) 2023-04-04 2026-02-11 Keygene N.V. Linker für duplexsequenzierung
WO2025257212A1 (en) 2024-06-11 2025-12-18 Keygene N.V. Screening and regeneration of protoplast callus

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US24939A (en) 1859-08-02 Improvement in sewing-machines
DE3465508D1 (en) 1983-04-28 1987-09-24 Flexible Steel Lacing Co Method and apparatus for riveting fasteners to a belt
EP0456721A4 (en) 1989-01-31 1992-06-03 University Of Miami Microdissection and amplification of chromosomal dna
AU672760B2 (en) 1991-09-24 1996-10-17 Keygene N.V. Selective restriction fragment amplification: a general method for DNA fingerprinting
US20100267023A1 (en) 1992-09-24 2010-10-21 Keygene N.V. Selective restriction fragment amplification: fingerprinting
WO1995019697A1 (en) 1994-01-21 1995-07-27 North Carolina State University Methods for within family selection in woody perennials using genetic markers
EG23907A (en) 1994-08-01 2007-12-30 Delta & Pine Land Co Control of plant gene expression
US6013445A (en) 1996-06-06 2000-01-11 Lynx Therapeutics, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
WO1996017082A2 (en) 1994-11-28 1996-06-06 E.I. Du Pont De Nemours And Company Compound microsatellite primers for the detection of genetic polymorphisms
US5565340A (en) 1995-01-27 1996-10-15 Clontech Laboratories, Inc. Method for suppressing DNA fragment amplification during PCR
AU6024598A (en) 1997-01-10 1998-08-03 Pioneer Hi-Bred International, Inc. Hybridization-based genetic amplification and analysis
US6090556A (en) 1997-04-07 2000-07-18 Japan Science & Technology Corporation Method for quantitatively determining the expression of a gene
JP2001515362A (ja) 1997-05-13 2001-09-18 ディスプレイ・システムズ・バイオテック・アクティーゼルスカブ ｍＲＮＡをクローニングする方法および差次的に発現された転写物のディスプレイ（ＤＯＤＥＴ）
EP0930370B1 (de) 1997-12-15 2007-08-08 CSL Behring GmbH Markierter Primer, geeignet für die Detektion von Nukleinsäuren
CA2273616A1 (en) 1998-06-08 1999-12-08 The Board Of Trustees Of The Leland Stanford Junior University Method for parallel screening of allelic variation
US6124201A (en) 1998-06-12 2000-09-26 Advanced Micro Devices, Inc. Method for manufacturing semiconductors with self-aligning vias
DE69813203T2 (de) 1998-07-21 2004-02-12 Keygene N.V. Verbesserte Primer zur AFLP Amplifizierung
EP0976835B1 (de) 1998-07-29 2003-07-09 Keygene N.V. Verfahren zur Erkennung von Nukleinsäuremethylierungen durch AFLP
US6232067B1 (en) * 1998-08-17 2001-05-15 The Perkin-Elmer Corporation Adapter directed expression analysis
US6703228B1 (en) 1998-09-25 2004-03-09 Massachusetts Institute Of Technology Methods and products related to genotyping and DNA analysis
EP1001037A3 (de) 1998-09-28 2003-10-01 Whitehead Institute For Biomedical Research Vorselektion und Isolierung eines Einzelnukleotidpolymorphismus
CA2345441A1 (en) * 1998-10-27 2000-05-04 Affymetrix, Inc. Complexity management and analysis of genomic dna
US6480791B1 (en) 1998-10-28 2002-11-12 Michael P. Strathmann Parallel methods for genomic analysis
US6534293B1 (en) 1999-01-06 2003-03-18 Cornell Research Foundation, Inc. Accelerating identification of single nucleotide polymorphisms and alignment of clones in genomic sequencing
US20040029155A1 (en) 1999-01-08 2004-02-12 Curagen Corporation Method for identifying a biomolecule
JP2002534461A (ja) 1999-01-12 2002-10-15 クアナム メディカル コーポレイション 水不溶性のパクリタキセル誘導体の投与のための組成物および方法
DE19911130A1 (de) 1999-03-12 2000-09-21 Hager Joerg Verfahren zur Identifikation chromosomaler Regionen und Gene
JP2002540802A (ja) 1999-04-06 2002-12-03 イェール ユニバーシティ 配列標識の固定されたアドレス分析
EP1173612B1 (de) 1999-04-09 2004-09-29 Keygene N.V. Verfahren zur erkennung und/oder analyse, unter verwendung von primertechniken, von einfachen nukleotidpolymorphismen in restriktionsfragmenten speziell aus amplifizierten restriktionsfragmenten generiert durch aflp
US20040031072A1 (en) 1999-05-06 2004-02-12 La Rosa Thomas J. Soy nucleic acid molecules and other molecules associated with transcription plants and uses thereof for plant improvement
US20020119448A1 (en) * 1999-06-23 2002-08-29 Joseph A. Sorge Methods of enriching for and identifying polymorphisms
US20030204075A9 (en) 1999-08-09 2003-10-30 The Snp Consortium Identification and mapping of single nucleotide polymorphisms in the human genome
WO2001021840A2 (en) 1999-09-23 2001-03-29 Gene Logic, Inc. Indexing populations
US6287778B1 (en) 1999-10-19 2001-09-11 Affymetrix, Inc. Allele detection using primer extension with sequence-coded identity tags
US6958225B2 (en) * 1999-10-27 2005-10-25 Affymetrix, Inc. Complexity management of genomic DNA
AU1413601A (en) 1999-11-19 2001-06-04 Takara Bio Inc. Method of amplifying nucleic acids
WO2001075167A1 (en) 2000-03-31 2001-10-11 Fred Hutchinson Cancer Research Center Reverse genetic strategy for identifying functional mutations in genes of known sequence
US20110131679A2 (en) 2000-04-19 2011-06-02 Thomas La Rosa Rice Nucleic Acid Molecules and Other Molecules Associated with Plants and Uses Thereof for Plant Improvement
EP1282729A2 (de) 2000-05-15 2003-02-12 Keygene N.V. Mikrosatelliten-aflp
US7300751B2 (en) 2000-06-30 2007-11-27 Syngenta Participations Ag Method for identification of genetic markers
GB0016742D0 (en) 2000-07-10 2000-08-30 Simeg Limited Diagnostic method
DE60131903T2 (de) 2000-10-24 2008-11-27 The Board of Trustees of the Leland S. Stanford Junior University, Palo Alto Direkte multiplex charakterisierung von genomischer dna
EP1367136A4 (de) * 2001-02-15 2005-01-12 Takara Bio Inc Verfahren zum nachweis von nukleotidpolymorphismus
US7141364B1 (en) 2001-03-29 2006-11-28 Council Of Scientific And Industrial Research Universal primers for wildlife identification
US20040053236A1 (en) 2001-03-30 2004-03-18 Mccallum Claire M. Reverse genetic strategy for identifying functional mutations in genes of known sequences
WO2002083911A1 (en) 2001-04-12 2002-10-24 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Production of plants with increased tolerance to drought stress or with increased transpiration
US20050064406A1 (en) 2001-04-20 2005-03-24 Eugene Zabarovsky Methods for high throughput genome analysis using restriction site tagged microarrays
WO2003004690A2 (en) 2001-07-06 2003-01-16 454$m(3) CORPORATION Method for isolation of independent, parallel chemical micro-reactions using a porous filter
WO2003020015A2 (en) 2001-08-30 2003-03-13 Purdue Research Foundation Methods to produce transgenic plants resistant to osmotic stress
EP1288301A1 (de) 2001-08-31 2003-03-05 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin Resistanzgen von Pflanzen abstamend
US6902921B2 (en) 2001-10-30 2005-06-07 454 Corporation Sulfurylase-luciferase fusion proteins and thermostable sulfurylase
US7504222B2 (en) * 2001-10-31 2009-03-17 Millennium Pharmaceuticals, Inc. Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
AU2003224789B2 (en) 2002-03-27 2007-03-15 Agrinomics, Llc Generation of plants with improved drought tolerance
US6815167B2 (en) 2002-04-25 2004-11-09 Geneohm Sciences Amplification of DNA to produce single-stranded product of defined sequence and length
US20070065816A1 (en) 2002-05-17 2007-03-22 Affymetrix, Inc. Methods for genotyping
US7108976B2 (en) 2002-06-17 2006-09-19 Affymetrix, Inc. Complexity management of genomic DNA by locus specific amplification
WO2004001074A1 (en) 2002-06-21 2003-12-31 Lynx Therapeutics, Inc. Method for detecting foreign dna in a host genome
CA2496517A1 (en) * 2002-09-05 2004-03-18 Plant Bioscience Limited Genome partitioning
US20040157238A1 (en) 2002-09-20 2004-08-12 Quinn John J. Method for detection of multiple nucleic acid sequence variations
AU2003298095A1 (en) 2002-10-18 2004-05-04 Cropdesign N.V. Identification of e2f target genes and uses thereof
JP4230457B2 (ja) 2002-12-18 2009-02-25 サード・ウェーブ・テクノロジーズ・インク 低分子核酸の検出方法
JP2004208586A (ja) 2002-12-27 2004-07-29 Wakunaga Pharmaceut Co Ltd Ｈｌａの検出
JP4690307B2 (ja) 2003-01-10 2011-06-01 ケイヘーネ・エヌ・ブイ 物理的および遺伝的地図を統合するためのａｆｌｐに基づいた方法
CA2513899C (en) * 2003-01-29 2013-03-26 454 Corporation Methods of amplifying and sequencing nucleic acids
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
CN103396933B (zh) 2003-02-26 2016-04-20 凯利达基因组股份有限公司 通过杂交进行的随机阵列dna分析
JP4888876B2 (ja) * 2003-06-13 2012-02-29 田平 武 アルツハイマー病の治療のための組換えアデノ随伴ウィルスベクター
US7754945B2 (en) 2003-06-24 2010-07-13 Agrigenetics Inc. Generation of plants with improved drought tolerance
DE602004032374D1 (de) 2003-06-24 2011-06-01 Agrigenetics Inc Erzeugung von pflanzen mit verbesserter toleranz gegenüber trockenheit
US7051935B2 (en) 2003-07-28 2006-05-30 Imageid Ltd. Color calibration for color bar codes
WO2005026686A2 (en) 2003-09-09 2005-03-24 Compass Genetics, Llc Multiplexed analytical platform
US20050153317A1 (en) 2003-10-24 2005-07-14 Metamorphix, Inc. Methods and systems for inferring traits to breed and manage non-beef livestock
EP1701785A1 (de) 2004-01-07 2006-09-20 Solexa Ltd. Modifizierte molekülarrays
US20050233354A1 (en) 2004-01-22 2005-10-20 Affymetrix, Inc. Genotyping degraded or mitochandrial DNA samples
WO2005080604A2 (en) 2004-02-12 2005-09-01 Compass Genetics, Llc Genetic analysis by sequence-specific sorting
US7709262B2 (en) 2004-02-18 2010-05-04 Trustees Of Boston University Method for detecting and quantifying rare mutations/polymorphisms
EP1574585A1 (de) 2004-03-12 2005-09-14 Plant Research International B.V. Methode für die selektive Verfielfältigung von DNS-Fragmenten für genetische Fingerabdrücke
WO2006020147A2 (en) * 2004-07-28 2006-02-23 The Regents Of The University Of California Use of pcr-based techniques to analyze compositions of botanicals
JP4809594B2 (ja) 2004-08-02 2011-11-09 東京エレクトロン株式会社 検査装置
FR2876479B1 (fr) 2004-10-11 2006-12-15 Parkeon Machine a pieces a receptacle de pieces de monnaie amovible
US7220549B2 (en) 2004-12-30 2007-05-22 Helicos Biosciences Corporation Stabilizing a nucleic acid for nucleic acid sequencing
US7407757B2 (en) 2005-02-10 2008-08-05 Population Genetics Technologies Genetic analysis by sequence-specific sorting
US7393665B2 (en) 2005-02-10 2008-07-01 Population Genetics Technologies Ltd Methods and compositions for tagging and identifying polynucleotides
WO2006122215A2 (en) 2005-05-10 2006-11-16 State Of Oregon Acting By & Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods of mapping polymorphisms and polymorphism microarrays
EP3257949A1 (de) 2005-06-15 2017-12-20 Complete Genomics Inc. Nukleinsäureanalyse durch zufällige mischungen von nichtüberlappenden fragmenten
DK2302070T3 (da) 2005-06-23 2012-11-26 Keygene Nv Strategier til identifikation og detektion af polymorfismer med højt gennemløb
DE602006013831D1 (de) 2005-06-23 2010-06-02 Keygene Nv Verbesserte strategien zur sequenzierung komplexer genome unter verwendung von sequenziertechniken mit hohem durchsatz
US20070020640A1 (en) 2005-07-21 2007-01-25 Mccloskey Megan L Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis
WO2007037678A2 (en) 2005-09-29 2007-04-05 Keygene N.V. High throughput screening of mutagenized populations
US10316364B2 (en) 2005-09-29 2019-06-11 Keygene N.V. Method for identifying the source of an amplicon
JP5166276B2 (ja) 2005-11-14 2013-03-21 ケイヘーネ・エヌ・ブイ トランスポゾンタギング集団のハイスループットスクリーニングおよび挿入部位の大規模並行配列特定のための方法
CN103937899B (zh) 2005-12-22 2017-09-08 凯津公司 用于基于aflp的高通量多态性检测的方法
WO2007087312A2 (en) 2006-01-23 2007-08-02 Population Genetics Technologies Ltd. Molecular counting
EP3239304B1 (de) 2006-04-04 2020-08-19 Keygene N.V. Nachweis von molekularmarkern mit hohem durchsatz auf der basis von aflp und mit hoher durchsatzsequenzierung
US8362325B2 (en) 2007-10-03 2013-01-29 Ceres, Inc. Nucleotide sequences and corresponding polypeptides conferring modulated plant characteristics
US20090124758A1 (en) 2007-11-09 2009-05-14 Bridgestone Sports Co., Ltd. Golf ball
US20140051585A1 (en) * 2012-08-15 2014-02-20 Natera, Inc. Methods and compositions for reducing genetic library contamination
WO2014196863A1 (en) 2013-06-07 2014-12-11 Keygene N.V. Method for targeted sequencing

Also Published As

Publication number Publication date
DE602006018744D1 (de) 2011-01-20
US20090036323A1 (en) 2009-02-05
US9453256B2 (en) 2016-09-27
US20200185056A1 (en) 2020-06-11
US20180247017A1 (en) 2018-08-30
US9493820B2 (en) 2016-11-15
ES2393318T3 (es) 2012-12-20
EP2302070A2 (de) 2011-03-30
EP2292788A1 (de) 2011-03-09
EP2302070A3 (de) 2011-06-22
US9896721B2 (en) 2018-02-20
EP2292788B1 (de) 2012-05-09
EP1910562A1 (de) 2008-04-16
US9898577B2 (en) 2018-02-20
US20190147977A1 (en) 2019-05-16
JP2008546404A (ja) 2008-12-25
US20170206314A1 (en) 2017-07-20
US20160060686A1 (en) 2016-03-03
CN102925561B (zh) 2015-09-09
EP2302070B1 (de) 2012-08-22
CN101641449A (zh) 2010-02-03
US10095832B2 (en) 2018-10-09
US8785353B2 (en) 2014-07-22
CN101641449B (zh) 2014-01-29
US20120316073A1 (en) 2012-12-13
CN102925561A (zh) 2013-02-13
US9898576B2 (en) 2018-02-20
CN105039313B (zh) 2018-10-23
US20140213462A1 (en) 2014-07-31
ATE557105T1 (de) 2012-05-15
JP5220597B2 (ja) 2013-06-26
US9376716B2 (en) 2016-06-28
US20160145689A1 (en) 2016-05-26
US10235494B2 (en) 2019-03-19
EP1910562B1 (de) 2010-12-08
ES2387878T3 (es) 2012-10-03
US20180025111A1 (en) 2018-01-25
WO2006137733A1 (en) 2006-12-28
CN105039313A (zh) 2015-11-11
DK2302070T3 (da) 2012-11-26
US20210202035A1 (en) 2021-07-01
US9447459B2 (en) 2016-09-20
JP2013063095A (ja) 2013-04-11
US20180137241A1 (en) 2018-05-17
US20140274744A1 (en) 2014-09-18
JP5823994B2 (ja) 2015-11-25
US9023768B2 (en) 2015-05-05
US8685889B2 (en) 2014-04-01
DK2292788T3 (da) 2012-07-23
US20170137872A1 (en) 2017-05-18
US10978175B2 (en) 2021-04-13
US20150232924A1 (en) 2015-08-20

Similar Documents

Publication Publication Date Title
ATE491045T1 (de) Strategien mit hohem durchsatz zur identifizierung und zum nachweis von polymorphismen
DK1639130T3 (da) Prober, biblioteker og kits til analyse af blandinger af nukleinsyrer og metoder til opbygning af disse
GB0324456D0 (en) Parallel DNA sequencing methods
ATE538213T1 (de) Vorrichtung und verfahren zum identifizieren genomischer dna von organismen
WO2009038668A3 (en) Highly multiplexed confocal detection systems and methods of using same
ATE509274T1 (de) Biosensorvorrichtung und verfahren zu ihrer verwendung
DE60023539D1 (de) Immunologischer nachweis von rna:dna hybriden auf mikroarrays
WO2009113779A3 (ko) Ｓｎｐ 어레이를 이용한 염색체, 유전자, 또는 특정 뉴클레오티드 서열의 카피 수 측정방법
NZ630091A (en) Immunofluorescence and fluorescent-based nucleic acid analysis on a single sample
DE602004032125D1 (de) Einstufige oligochromatographische vorrichtung und verfahren zu ihrer verwendung
ATE426681T1 (de) Mittel und verfahren zum nachweis von zielnukleotidsequenzen unter verwendung von ligationstests mit verbesserten oligonukleotidsondenpaaren
ATE509273T1 (de) Verfahren, system und computerprogramm zum nachweis molekularer bindungswechselwirkungen mit reaktionskurven-qualitätskontrolle
ATE431854T1 (de) Auf bio-barcodes beruhender nachweis von zielanalyten
ATE359517T1 (de) Chemisches und biochemisches nachweisverfahren und vorrichtung
DE602004009716D1 (de) Verwendung von transthyretin als biomarker zum nachweis von kolorektalen adenomen; verfahren und nachweis-system
WO2013010134A3 (en) Systems, apparatus and methods for biochemical analysis
DE60315715D1 (de) Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs
ATE200108T1 (de) Verfahren zum nachweis von telomerase-aktivität
ATE378422T1 (de) Verfahren zum nachweis klinisch relevanter veränderungen der dns-sequenz des ki-ras-onkogens,seine verwendung und testkit zur früherkennung von tumoren
EP1794318A4 (de) Arzneistoff-screening und molekularer diagnosetest zum frühen nachweis von kolorektalkarzinom: reagentien, verfahren und kits dafür
ATE546550T1 (de) Verfahren zum nachweis von hpv sowie sonden, primer und kits
DK1360329T3 (da) Biokemisk fremgangsmåde og apparat til detektion af genetiske egenskaber
WO2007047149A3 (en) Susceptibility-matched multi-well sample holders for high-throughput screening by magnetic analysis
MY209857A (en) Compositions and methods for detecting plasmodium species nucleic acid
ATE335853T1 (de) Verfahren zum nachweis von hybridisierungsereignissen in nukleinsäuren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties