BRPI0514030A - derivados de ácido hidroxámico substituìdo por arilssulfonamida, como inibidores de metaloproteinases de matrizes - Google Patents
derivados de ácido hidroxámico substituìdo por arilssulfonamida, como inibidores de metaloproteinases de matrizesInfo
- Publication number
- BRPI0514030A BRPI0514030A BRPI0514030-7A BRPI0514030A BRPI0514030A BR PI0514030 A BRPI0514030 A BR PI0514030A BR PI0514030 A BRPI0514030 A BR PI0514030A BR PI0514030 A BRPI0514030 A BR PI0514030A
- Authority
- BR
- Brazil
- Prior art keywords
- hydroxamic acid
- arylsulfonamide
- matrix metalloproteinases
- acid derivatives
- substituted hydroxamic
- Prior art date
Links
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical class C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
- 102000002274 Matrix Metalloproteinases Human genes 0.000 title abstract 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 abstract 2
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 230000003712 anti-aging effect Effects 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002018 overexpression Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/02—Monosaccharides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrane Compounds (AREA)
- Lubricants (AREA)
Abstract
DERIVADOS DE áCIDO HIDROXáMICO SUBSTITUìDO POR ARILSSULFONAMIDA, COMO INIBIDORES DE METALOPROTEINASES DE MATRIZES A presente invenção descreve derivados de ácido hidroxâmico substituído por arilssulfonamida de fórmula (I): os quais apresentam satisfatória solubilidade em água e atividade inibitória de metaloproteinases de matrizes, que são de utilidade para a preparação de composições farmacêuticas destinadas ao tratamento de doenças associadas à atividade patológica e/ou superexpressão de metaloproteinases, assim como, de preparações cosméticas que apresentam propriedades antienvelhecimento, em particular, para o cabelo e a pele.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000174A ITFI20040174A1 (it) | 2004-08-03 | 2004-08-03 | Derivati arilsolfonammidici dell'acido idrossammico ad azione inibitoria di metalloproteinasi |
| PCT/EP2005/053722 WO2006013193A2 (en) | 2004-08-03 | 2005-07-29 | Derivatives of arylsulfonamido-substituted hydroxamic acid as matrix metalloproteinases inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0514030A true BRPI0514030A (pt) | 2008-05-27 |
Family
ID=35787488
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0514030-7A BRPI0514030A (pt) | 2004-08-03 | 2005-07-29 | derivados de ácido hidroxámico substituìdo por arilssulfonamida, como inibidores de metaloproteinases de matrizes |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7772430B2 (pt) |
| EP (2) | EP2308837A3 (pt) |
| JP (1) | JP2008509108A (pt) |
| CN (1) | CN101076514A (pt) |
| AT (1) | ATE492530T1 (pt) |
| AU (1) | AU2005268765B2 (pt) |
| BR (1) | BRPI0514030A (pt) |
| CA (1) | CA2580235A1 (pt) |
| DE (1) | DE602005025495D1 (pt) |
| IT (1) | ITFI20040174A1 (pt) |
| MX (1) | MX2007001269A (pt) |
| RU (2) | RU2406721C2 (pt) |
| WO (1) | WO2006013193A2 (pt) |
| ZA (1) | ZA200701798B (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20110040911A (ko) * | 2008-07-14 | 2011-04-20 | 노파르티스 아게 | 선택적 히드록삼산계 ｍｍｐ-12 및 ｍｍｐ-13 억제제 |
| DE102011088926A1 (de) * | 2011-12-19 | 2013-06-20 | Beiersdorf Ag | Haarstylingformulierung zur Erstellung eines flexiblen Haltes durch Einsatz von Octanohydroxamsäure |
| DK2797942T3 (en) * | 2011-12-28 | 2018-12-10 | Galectin Therapeutics Inc | Composition of Hitherto-Unknown Carbohydrate Drugs for the Treatment of Human Diseases |
| EP2907512A1 (en) | 2014-02-14 | 2015-08-19 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Inhibitors of MMP-12 as antiviral Agents |
| CN105728047B (zh) * | 2016-03-24 | 2017-12-26 | 万华化学集团股份有限公司 | 一种氢甲酰化催化剂及其制备方法和应用 |
| JP2017210442A (ja) * | 2016-05-26 | 2017-11-30 | イノレックス インベストメント コーポレイション | マトリックスメタロプロテイナーゼを阻害して皮膚の老化を軽減する方法及び関連の相乗的組成物 |
| IT201600083975A1 (it) * | 2016-08-09 | 2018-02-09 | Consorzio Interuniversitario Naz Per La Scienza E Tecnologia Dei Materiali | Acido ialuronico funzionalizzato |
| JP6541118B1 (ja) * | 2018-04-27 | 2019-07-10 | 株式会社成和化成 | 化粧品基材および該化粧品基材を含有する毛髪用化粧品、美白剤 |
| LV15485B (lv) * | 2018-09-13 | 2020-06-20 | Latvijas Organiskās Sintēzes Institūts | Selenofēnhromenonu hidroksāmskābes, to izgatavošana un izmantošana angioģenēzes inhibīcijā |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU68901A1 (pt) | 1973-11-30 | 1975-08-20 | ||
| US5506242A (en) * | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| US5455258A (en) * | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| DE69737605T2 (de) * | 1996-01-23 | 2008-04-03 | Shionogi & Co., Ltd. | Sulfonierte aminosäurederivate und metalloproteinase-inhibitoren, die diese enthalten |
| AU2792097A (en) * | 1996-05-24 | 1998-01-05 | Ono Pharmaceutical Co. Ltd. | Phenylsulfonamide derivatives |
| JP2000515153A (ja) * | 1996-07-22 | 2000-11-14 | モンサント カンパニー | チオールスルホンアミド メタロプロテアーゼインヒビター |
| US5804593A (en) * | 1996-10-22 | 1998-09-08 | Pharmacia & Upjohn Company | α-Amino sulfonyl hydroxamic acids as matrix metalloproteinase inhibitors |
| ES2202796T3 (es) * | 1997-02-03 | 2004-04-01 | Pfizer Products Inc. | Derivados de acidos arilsulfonilaminohidroxamicos. |
| WO1998050348A1 (en) * | 1997-05-09 | 1998-11-12 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| KR100352316B1 (ko) * | 1997-07-31 | 2002-09-12 | 더 프록터 앤드 갬블 캄파니 | 메탈로프로테아제억제제로서사용되는술포닐아미노치환히드록삼산유도체 |
| JPH11199512A (ja) * | 1997-10-24 | 1999-07-27 | Pfizer Prod Inc | 変形性関節症および他のｍｍｐ媒介疾患の治療のためのｍｍｐ−１３選択的阻害剤の使用 |
| PA8469601A1 (es) * | 1998-04-10 | 2000-09-29 | Pfizer Prod Inc | Procedimiento para alquilar sulfonamidas impedidas estericamente |
| EP1149072B1 (en) * | 1998-12-22 | 2004-06-30 | F. Hoffmann-La Roche Ag | Sulfonamide hydroxamates |
| JP2002533375A (ja) | 1998-12-28 | 2002-10-08 | セラニーズ ベンチャーズ ゲー・エム・ベー・ハー | 水不溶性線状ポリ−α−グルカンのＵＶフィルターとしての使用 |
| FR2799964B1 (fr) | 1999-10-22 | 2002-07-26 | Oreal | Emulsions contenant au moins un filtre uv organique insoluble et un polymere associatif |
| ES2264985T3 (es) | 2000-05-10 | 2007-02-01 | Ciba Specialty Chemicals Holding Inc. | Compuestos sililados como precursores para composiciones de autobronceado. |
| GB0028161D0 (en) | 2000-11-17 | 2001-01-03 | Natural Environment Res | Personal care compositions |
| FR2827860B1 (fr) * | 2001-07-24 | 2004-12-10 | Servier Lab | Nouveau procede de synthese de derives de l'acide (2s, 3as, 7as)-1-[(s)-alanyl]-octahydro-1h-indole-2-carboxyline et application a la synthese du perindopril |
| DE10155200A1 (de) | 2001-11-12 | 2003-05-28 | Skinlab Gmbh | Verwendung von Cholesterin, cholesterinhaltigen Substanzen oder von den Cholesteringehalt erhöhenden Substanzen in kosmetischen und dermatologischen Zubereitungen zum Zwecke der UV-Protektion |
| DE10155769A1 (de) | 2001-11-14 | 2003-05-22 | Cognis Deutschland Gmbh | Kosmetische und/oder pharmazeutische Emulsionen |
| SI1511472T1 (sl) * | 2002-05-29 | 2009-08-31 | Merck & Co Inc | Spojine uporabne pri zdravljenju antraksa in inhibiranju letalnega faktorja |
-
2004
- 2004-08-03 IT IT000174A patent/ITFI20040174A1/it unknown
-
2005
- 2005-07-29 RU RU2007107872/04A patent/RU2406721C2/ru not_active IP Right Cessation
- 2005-07-29 CA CA002580235A patent/CA2580235A1/en not_active Abandoned
- 2005-07-29 AT AT05769876T patent/ATE492530T1/de not_active IP Right Cessation
- 2005-07-29 MX MX2007001269A patent/MX2007001269A/es not_active Application Discontinuation
- 2005-07-29 AU AU2005268765A patent/AU2005268765B2/en not_active Ceased
- 2005-07-29 JP JP2007524333A patent/JP2008509108A/ja active Pending
- 2005-07-29 WO PCT/EP2005/053722 patent/WO2006013193A2/en not_active Ceased
- 2005-07-29 CN CNA2005800336789A patent/CN101076514A/zh active Pending
- 2005-07-29 DE DE602005025495T patent/DE602005025495D1/de not_active Expired - Lifetime
- 2005-07-29 EP EP10188800A patent/EP2308837A3/en not_active Withdrawn
- 2005-07-29 EP EP05769876A patent/EP1781601B1/en not_active Expired - Lifetime
- 2005-07-29 BR BRPI0514030-7A patent/BRPI0514030A/pt not_active IP Right Cessation
- 2005-07-29 US US11/659,431 patent/US7772430B2/en not_active Expired - Fee Related
-
2007
- 2007-02-28 ZA ZA200701798A patent/ZA200701798B/xx unknown
-
2010
- 2010-08-04 US US12/849,981 patent/US20100298439A1/en not_active Abandoned
- 2010-08-31 RU RU2010136061/04A patent/RU2010136061A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008509108A (ja) | 2008-03-27 |
| US20080249032A1 (en) | 2008-10-09 |
| RU2010136061A (ru) | 2012-03-10 |
| ATE492530T1 (de) | 2011-01-15 |
| WO2006013193A8 (en) | 2010-07-29 |
| EP1781601A2 (en) | 2007-05-09 |
| WO2006013193A3 (en) | 2006-08-31 |
| WO2006013193A2 (en) | 2006-02-09 |
| EP2308837A2 (en) | 2011-04-13 |
| AU2005268765B2 (en) | 2011-08-04 |
| US7772430B2 (en) | 2010-08-10 |
| MX2007001269A (es) | 2007-07-16 |
| CA2580235A1 (en) | 2006-02-09 |
| DE602005025495D1 (de) | 2011-02-03 |
| ITFI20040174A1 (it) | 2004-11-03 |
| ZA200701798B (en) | 2008-08-27 |
| RU2007107872A (ru) | 2008-09-10 |
| AU2005268765A1 (en) | 2006-02-09 |
| EP2308837A3 (en) | 2011-04-20 |
| CN101076514A (zh) | 2007-11-21 |
| EP1781601B1 (en) | 2010-12-22 |
| RU2406721C2 (ru) | 2010-12-20 |
| US20100298439A1 (en) | 2010-11-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: PROTERA S.R.L. (IT) Free format text: TRANSFERIDO DE: ABIOGEN PHARMA S.P.A. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2260 DE 29/04/2014. |