ATE492547T1 - Verfahren zur herstellung lipophiler pharmazeutisch akzeptabler salze aus pemetrexed- disäure - Google Patents

Verfahren zur herstellung lipophiler pharmazeutisch akzeptabler salze aus pemetrexed- disäure

Info

Publication number
ATE492547T1
ATE492547T1 AT07836879T AT07836879T ATE492547T1 AT E492547 T1 ATE492547 T1 AT E492547T1 AT 07836879 T AT07836879 T AT 07836879T AT 07836879 T AT07836879 T AT 07836879T AT E492547 T1 ATE492547 T1 AT E492547T1
Authority
AT
Austria
Prior art keywords
pemetrexed
pharmaceutically acceptable
acceptable salts
disacid
lipophilic pharmaceutically
Prior art date
Application number
AT07836879T
Other languages
English (en)
Inventor
Jonathan Busolli
Nicola Diulgheroff
Racz Csilla Nemethne
Moran Pirkes
Alessandro Pontiroli
Marco Villa
Zvi Harel
Original Assignee
Sicor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Inc filed Critical Sicor Inc
Application granted granted Critical
Publication of ATE492547T1 publication Critical patent/ATE492547T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT07836879T 2006-08-14 2007-08-14 Verfahren zur herstellung lipophiler pharmazeutisch akzeptabler salze aus pemetrexed- disäure ATE492547T1 (de)

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US83730306P 2006-08-14 2006-08-14
US83763706P 2006-08-15 2006-08-15
US83955106P 2006-08-22 2006-08-22
US84503106P 2006-09-14 2006-09-14
US84729106P 2006-09-25 2006-09-25
US85513906P 2006-10-30 2006-10-30
US86055406P 2006-11-21 2006-11-21
US86055706P 2006-11-21 2006-11-21
US88017807P 2007-01-11 2007-01-11
US88017907P 2007-01-11 2007-01-11
US89992807P 2007-02-06 2007-02-06
US93655307P 2007-06-20 2007-06-20
US95832607P 2007-07-02 2007-07-02
US95821307P 2007-07-03 2007-07-03
US95841307P 2007-07-05 2007-07-05
PCT/US2007/018098 WO2008021411A2 (en) 2006-08-14 2007-08-14 Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid

Publications (1)

Publication Number Publication Date
ATE492547T1 true ATE492547T1 (de) 2011-01-15

Family

ID=49584971

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07836879T ATE492547T1 (de) 2006-08-14 2007-08-14 Verfahren zur herstellung lipophiler pharmazeutisch akzeptabler salze aus pemetrexed- disäure

Country Status (9)

Country Link
US (1) US8629152B2 (de)
EP (1) EP1943252B1 (de)
JP (1) JP2008543976A (de)
KR (1) KR101083230B1 (de)
AT (1) ATE492547T1 (de)
DE (1) DE602007011384D1 (de)
ES (1) ES2356792T3 (de)
TW (1) TWI377955B (de)
WO (1) WO2008021411A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008124485A2 (en) 2007-04-03 2008-10-16 Dr. Reddy's Laboratories Ltd. Solid forms of pemetrexed
CN101684121B (zh) * 2008-09-22 2013-04-03 重庆医药工业研究院有限责任公司 培美曲塞二酸的新晶型及其制备方法
CN102838602B (zh) * 2011-06-21 2016-08-03 重庆医药工业研究院有限责任公司 培美曲塞氧化物及其制备方法
WO2013179248A1 (en) 2012-05-30 2013-12-05 Fresenius Kabi Oncology Ltd. Pharmaceutical compositions of pemetrexed
WO2014060953A1 (en) * 2012-10-17 2014-04-24 Shilpa Medicare Limited Process for preparing pemetrexed di potassium and its hydrates
KR101260636B1 (ko) * 2012-11-29 2013-05-13 씨제이제일제당 (주) 안정화된 페메트렉시드 제제
WO2014122460A2 (en) 2013-02-06 2014-08-14 Cipla House Pemetrexed complexes and pharmaceutical compositions containing pemetrexed complexes
WO2014185797A1 (en) 2013-05-17 2014-11-20 Instytut Farmaceutyczny Process for the preparation of high purity amorphous pemetrexed disodium and crystalline forms of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3- d] pyrimidin-5-yl)ethyl] benzoyl]-l-glutamic acid
WO2014198338A1 (en) 2013-06-14 2014-12-18 Synthon B.V. Stable pemetrexed arginine salt and compositions comprising it
KR101703980B1 (ko) 2013-12-30 2017-02-08 주식회사 삼양바이오팜 항산화제를 함유하지 않는 약학 조성물 및 그의 제조방법
NZ630299A (en) * 2014-06-30 2014-11-28 Shilpa Medicare Ltd Pemetrexed dipotassium formulations
MX2022009547A (es) * 2016-02-19 2022-09-09 Eagle Pharmaceuticals Inc Formulaciones de pemetrexed.
US20170239250A1 (en) 2016-02-19 2017-08-24 Eagle Pharmaceuticals, Inc. Pemetrexed formulations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
IL96531A (en) 1989-12-11 1995-08-31 Univ Princeton History of Acid N- (Diomeric-H1-Pyrolo] D-2,3 [Pyrimidine-3-Ilacyl (-glutamic, preparation and pharmaceutical preparations containing them)
CA2032695A1 (en) 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
US6262262B1 (en) * 1997-09-26 2001-07-17 Eli Lilly And Company Processes and intermediates useful to make antifolates
EP1212325A2 (de) 1999-08-23 2002-06-12 Eli Lilly And Company Neue kristalline form von disodium n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]benzoyl]-l-glutamic säuresalz und verfahren hierfür
EP1259513B1 (de) * 2000-02-25 2003-09-10 Eli Lilly And Company NEUE KRISTALLINE FORM VON N-[4-[2-(2-AMINO-4,7-DIHYDRO-4-OXO-3H-PYRROLO[2,3-d]-PYRIMIDIN-5-YL)ETHYL]BENZOYL]-L-GLUTAMINSÄURE UND VERFAHREN FÜR IHRE HERSTELLUNG
ATE518855T1 (de) * 2005-02-16 2011-08-15 Schering Corp Neue heterozyklische substituierte pyridin- oder phenylverbindungen mit cxcr3-antagonistischer aktivität
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
WO2008124485A2 (en) 2007-04-03 2008-10-16 Dr. Reddy's Laboratories Ltd. Solid forms of pemetrexed

Also Published As

Publication number Publication date
TWI377955B (en) 2012-12-01
WO2008021411A2 (en) 2008-02-21
DE602007011384D1 (de) 2011-02-03
EP1943252A2 (de) 2008-07-16
WO2008021411A3 (en) 2008-04-10
TW200824720A (en) 2008-06-16
US20080139810A1 (en) 2008-06-12
KR101083230B1 (ko) 2011-11-11
EP1943252B1 (de) 2010-12-22
ES2356792T3 (es) 2011-04-13
JP2008543976A (ja) 2008-12-04
US8629152B2 (en) 2014-01-14
KR20090035478A (ko) 2009-04-09

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Legal Events

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