ATE493412T1 - Spirohydantoin-aryl-cgrp-rezeptorantagonisten - Google Patents

Spirohydantoin-aryl-cgrp-rezeptorantagonisten

Info

Publication number
ATE493412T1
ATE493412T1 AT06844350T AT06844350T ATE493412T1 AT E493412 T1 ATE493412 T1 AT E493412T1 AT 06844350 T AT06844350 T AT 06844350T AT 06844350 T AT06844350 T AT 06844350T AT E493412 T1 ATE493412 T1 AT E493412T1
Authority
AT
Austria
Prior art keywords
spirohydantoin
aryl
receptor antagonists
cgrp receptor
cgrp
Prior art date
Application number
AT06844350T
Other languages
English (en)
Inventor
Ian Bell
Craig Stump
Cory Theberge
Michael Wood
C Blair Zartman
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Application granted granted Critical
Publication of ATE493412T1 publication Critical patent/ATE493412T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT06844350T 2005-11-18 2006-11-14 Spirohydantoin-aryl-cgrp-rezeptorantagonisten ATE493412T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73824105P 2005-11-18 2005-11-18
PCT/US2006/044086 WO2007061676A2 (en) 2005-11-18 2006-11-14 Spirohydantoin aryl cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
ATE493412T1 true ATE493412T1 (de) 2011-01-15

Family

ID=38067723

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06844350T ATE493412T1 (de) 2005-11-18 2006-11-14 Spirohydantoin-aryl-cgrp-rezeptorantagonisten

Country Status (8)

Country Link
US (1) US8071770B2 (de)
EP (1) EP1951251B1 (de)
JP (1) JP2009515971A (de)
AT (1) ATE493412T1 (de)
AU (1) AU2006316626A1 (de)
CA (1) CA2629406A1 (de)
DE (1) DE602006019304D1 (de)
WO (1) WO2007061676A2 (de)

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ES2433251T5 (es) 2005-11-14 2020-03-13 Teva Pharmaceuticals Int Gmbh Anticuerpos antagonistas dirigidos contra un péptido relacionado con el gen de la calcitonina y procedimientos que utilizan los mismos
WO2007061694A2 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin tricyclic cgrp receptor antagonists
WO2007061677A2 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirolactam aryl cgrp receptor antagonists
EP1951228B1 (de) * 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Bicyclische spirohydantoin cgrp-rezeptor-antagonisten
AU2006316646A1 (en) 2005-11-18 2007-05-31 Merck Sharp & Dohme Corp. Spirolactam bicyclic CGRP receptor antagonists
EP1951042B1 (de) 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Spirolactam tricyclische cgrp-rezeptor-antagonisten
WO2009109911A1 (en) * 2008-03-04 2009-09-11 Pfizer Limited Methods of treating chronic pain
ES2584907T3 (es) 2008-03-04 2016-09-30 Labrys Biologics Inc. Métodos para tratamiento del dolor inflamatorio
WO2009144554A1 (en) 2008-05-28 2009-12-03 Pfizer, Inc. Pyrazolospiroketone acetyl-c0a carboxylase inhibitors
EP2299813B1 (de) * 2008-06-12 2015-12-16 Merck Sharp & Dohme Corp. Verzweigte 3- und 6-substituierte chinoline als cgrp-rezeptorantagonisten
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
AU2009282963A1 (en) * 2008-08-18 2010-02-25 Merck Sharp & Dohme Corp. 3- and 6-quinolines with N-attached heterocyclic CGRP receptor antagonists
ES2912569T3 (es) 2009-08-28 2022-05-26 Teva Pharmaceuticals Int Gmbh Métodos para tratar el dolor visceral administrando anticuerpos antagonistas dirigidos contra el péptido relacionado con el gen de la calcitonina
PT2499139E (pt) 2009-11-10 2014-02-10 Pfizer Inibidores de n1-pirazolospirocetona acetil-coa carboxilase
HRP20161178T1 (hr) 2010-09-30 2016-11-04 Pfizer Inc. N1-PIRAZOLOSPIROKETONSKI INHIBITORI ACETIL-CoA-KARBOKSILAZE
HUE025078T2 (en) 2010-10-29 2016-01-28 Pfizer N1 / N2-lactam-acetyl-CoA carboxylase inhibitors
PE20141187A1 (es) 2011-04-22 2014-09-18 Pfizer Inhibidores sustituidos de aeitl-coa carboxilasa
NZ732875A (en) 2011-05-20 2022-08-26 H Lundbeck As Use of anti-cgrp or anti-cgrp-r antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea
SG10201604040PA (en) 2011-05-20 2016-07-28 Alderbio Holdings Llc Anti-cgrp compositions and use thereof
RS66303B1 (sr) 2011-05-20 2025-01-31 H Lundbeck As Upotreba anti-cgrp antitela i fragmenata antitela za sprečavanje ili inhibiranje fotofobije ili odbojnosti prema svetlu kod subjekata kojima je to potrebno, naročito kod subjekata koji pate od migrene
US20170114122A1 (en) 2015-10-23 2017-04-27 Alderbio Holdings Llc Regulation of glucose metabolism using anti-cgrp antibodies
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
MX378344B (es) 2014-03-21 2025-03-10 Teva Pharmaceuticals Int Gmbh Anticuerpos antagonistas dirigidos contra el peptido relacionado con el gen de calcitonina y metodos que usan los mismos.
AU2017331593B2 (en) 2016-09-23 2022-04-28 Teva Pharmaceuticals International Gmbh Treating refractory migraine
GB201707938D0 (en) 2017-05-17 2017-06-28 Univ Sheffield Compounds
PE20211707A1 (es) 2019-01-08 2021-09-01 H Lundbeck As Tratamiento agudo y tratamiento rapido de la cefalea usando anticuerpos anticgrp
KR20210124867A (ko) 2020-04-06 2021-10-15 하. 룬드벡 아크티에셀스카브 항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3561198D1 (en) 1984-03-23 1988-01-28 Pfizer Spiro-indenes and spiro-1,2-dihydro-naphthalenes for treatment of diabetic complications
US4722632A (en) 1984-05-21 1988-02-02 Oerlikron-Buehrle Ag Tensilely stressed window usable with infrared detector
FR2709306B1 (fr) 1993-07-20 1995-10-20 Adir Nouveaux dérivés de benzospiroalcène, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
ATE516803T1 (de) 2003-03-14 2011-08-15 Merck Sharp & Dohme Aryl-spirohydantoin-cgrp-rezeptor-antagonisten
US7205293B2 (en) 2003-03-14 2007-04-17 Merck & Co., Inc. Benodiazepine spirohydantoin CGRP receptor antagonists
WO2004082605A2 (en) * 2003-03-14 2004-09-30 Merck & Co. Inc. Bicyclic anilide spirohydantoin cgrp receptor antagonists
AU2004222378B2 (en) * 2003-03-14 2008-08-14 Merck Sharp & Dohme Corp. Carboxamide spirohydantoin CGRP receptor antagonists
US7192954B2 (en) 2003-03-14 2007-03-20 Merck & Co., Inc. Monocyclic anilide spirohydantoin CGRP receptor antagonists
US7659300B2 (en) 2004-09-08 2010-02-09 Merck Sharp & Dohme Corp. Monocyclic anilide spirolactam CGRP receptor antagonists
ATE537153T1 (de) * 2004-09-09 2011-12-15 Merck Sharp & Dohme Arylspirolactamverbindungen als antagonisten des cgrp-rezeptors
JP2008512456A (ja) 2004-09-09 2008-04-24 メルク エンド カムパニー インコーポレーテッド 三環式アニリドスピロラクタムｃｇｒｐ受容体拮抗薬
ATE464305T1 (de) * 2004-09-13 2010-04-15 Merck Sharp & Dohme Bicyclische anilidspirolactame als antagonisten des cgrp-rezeptors
US7390798B2 (en) 2004-09-13 2008-06-24 Merck & Co., Inc. Carboxamide spirolactam CGRP receptor antagonists
ATE518852T1 (de) 2004-09-13 2011-08-15 Merck Sharp & Dohme Tricyclische anilid-spirohydantoin-cgrp- rezeptorantagonisten
US7384930B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
US7384931B2 (en) 2004-11-03 2008-06-10 Bristol-Myers Squibb Company Constrained compounds as CGRP-receptor antagonists
EP1951042B1 (de) 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Spirolactam tricyclische cgrp-rezeptor-antagonisten
WO2007061694A2 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirohydantoin tricyclic cgrp receptor antagonists
AU2006316646A1 (en) 2005-11-18 2007-05-31 Merck Sharp & Dohme Corp. Spirolactam bicyclic CGRP receptor antagonists
EP1951228B1 (de) 2005-11-18 2012-10-10 Merck Sharp & Dohme Corp. Bicyclische spirohydantoin cgrp-rezeptor-antagonisten
WO2007061677A2 (en) 2005-11-18 2007-05-31 Merck & Co., Inc. Spirolactam aryl cgrp receptor antagonists

Also Published As

Publication number Publication date
US8071770B2 (en) 2011-12-06
EP1951251A2 (de) 2008-08-06
WO2007061676A2 (en) 2007-05-31
AU2006316626A1 (en) 2007-05-31
CA2629406A1 (en) 2007-05-31
EP1951251A4 (de) 2009-05-27
JP2009515971A (ja) 2009-04-16
US20090239870A1 (en) 2009-09-24
DE602006019304D1 (de) 2011-02-10
EP1951251B1 (de) 2010-12-29
WO2007061676A3 (en) 2007-12-21

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