ATE493417T1 - Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga - Google Patents

Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga

Info

Publication number
ATE493417T1
ATE493417T1 AT06770920T AT06770920T ATE493417T1 AT E493417 T1 ATE493417 T1 AT E493417T1 AT 06770920 T AT06770920 T AT 06770920T AT 06770920 T AT06770920 T AT 06770920T AT E493417 T1 ATE493417 T1 AT E493417T1
Authority
AT
Austria
Prior art keywords
hydroxylopiates
halogenethebain
analogs
synthetic route
novel
Prior art date
Application number
AT06770920T
Other languages
English (en)
Inventor
Peter Wang
Frank Moser
Gary Cantrell
Daniel Magparangalan
Jian Bao
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of ATE493417T1 publication Critical patent/ATE493417T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
AT06770920T 2005-06-16 2006-05-22 Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga ATE493417T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69118405P 2005-06-16 2005-06-16
PCT/US2006/019867 WO2006138020A2 (en) 2005-06-16 2006-05-22 A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs

Publications (1)

Publication Number Publication Date
ATE493417T1 true ATE493417T1 (de) 2011-01-15

Family

ID=36955060

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06770920T ATE493417T1 (de) 2005-06-16 2006-05-22 Synthetische route zu 14-hydroxylopiaten über 1- halogenthebain oder analoga

Country Status (11)

Country Link
US (1) US8067597B2 (de)
EP (1) EP1893616B1 (de)
JP (1) JP2008546688A (de)
CN (1) CN101198612A (de)
AT (1) ATE493417T1 (de)
AU (1) AU2006259780B2 (de)
CA (1) CA2610859C (de)
DE (1) DE602006019246D1 (de)
ES (1) ES2357216T3 (de)
MX (1) MX2007015789A (de)
WO (1) WO2006138020A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201509943A (zh) 2004-03-30 2015-03-16 Euro Celtique Sa 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝
US20100022774A1 (en) * 2006-05-25 2010-01-28 Ole Heine Kvernenes Process useful in the preparation of morphinan antagonists
KR100780932B1 (ko) * 2006-05-30 2007-11-30 엠텍비젼 주식회사 컬러 보간 방법 및 장치
JP2010504325A (ja) * 2006-09-20 2010-02-12 マリンクロット インコーポレイテッド 置換モルフィナン−６−オン、並びにその塩および中間体の調製
EP2131841B1 (de) * 2007-01-30 2012-08-01 Avigen, Inc. Verfahren zur behandlung von akuten schmerzen
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
WO2008109156A2 (en) * 2007-03-06 2008-09-12 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
US7928234B2 (en) 2007-06-29 2011-04-19 Brock University Conversion of thebaine to morphine derivatives
GB2450691A (en) * 2007-07-02 2009-01-07 Alpharma Aps One-pot preparation of oxycodone from thebaine
PL2222678T3 (pl) * 2007-12-17 2016-09-30 Sposoby wytwarzania związków morfinanowych (+)-'nal'
US8148528B2 (en) * 2008-05-27 2012-04-03 Mallinckrodt Llc Processes and compounds for the preparation of normorphinans
AU2014200890B2 (en) * 2008-05-27 2016-02-04 SpecGx LLC Processes and compounds for the preparation of normorphinans
EP2331508B1 (de) 2008-09-03 2014-11-12 Mallinckrodt LLC Substituierte berbine und verfahren zu ihrer synthese
AU2011263416B2 (en) 2010-06-11 2014-04-10 Rhodes Technologies Process for N-dealkylation of tertiary amines
EP2995614B8 (de) 2010-06-11 2018-03-28 Rhodes Technologies Inc. Übergangsmetallkatalysierte verfahren zur herstellung von n-allyl-verbindungen und verwendung davon
US8703950B2 (en) 2010-07-02 2014-04-22 Johnson Matthey Public Limited Co. Low ABUK oxycodone, its salts and methods of making same
TWI643859B (zh) 2012-07-16 2018-12-11 羅德科技公司 改良之類鴉片合成方法
TW201639855A (zh) 2012-07-16 2016-11-16 羅德科技公司 改良之類鴉片合成方法
US10227354B2 (en) 2013-12-18 2019-03-12 Cody Laboratories, Inc. Conversion of oxycodone base to oxycodone hydrochloride
US9062062B1 (en) 2013-12-18 2015-06-23 Cody Laboratories, Inc. Synthesis of oxycodone hydrochloride
WO2015095585A2 (en) 2013-12-18 2015-06-25 Cody Laboratories, Inc. Sysnthesis of oxycodone hydrochloride
US8846923B1 (en) 2013-12-18 2014-09-30 Cody Laboratories, Inc. Preparation of 14-hydroxycodeinone sulfate
TWI539952B (zh) 2014-01-15 2016-07-01 羅德科技公司 改良氧化嗎啡酮合成之方法
WO2015107471A1 (en) * 2014-01-15 2015-07-23 Rhodes Technologies Process for improved oxycodone synthesis

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2797223A (en) * 1957-06-25 Preparation of ix-bromocodeinone
US3112323A (en) * 1963-11-26 Method for the preparation of
FR1602610A (en) * 1962-10-10 1971-01-04 10.10.62.-17.4.63. 38445-15209 thebaine derivs
BE638369A (de) * 1962-10-10
US3884898A (en) 1972-08-18 1975-05-20 Syva Co Normorphine derivatives bonded to proteins
US3881898A (en) * 1973-01-18 1975-05-06 Lodge Cottrell Ltd Gas treatment
GB1495271A (en) * 1974-04-10 1977-12-14 Macfarlan Smith Ltd Dehydrohalogenation of codeinone derivatives
US4110329A (en) * 1976-03-10 1978-08-29 The Regents Of The University Of California Metallic derivatives of neopinone ketal
US4054566A (en) * 1976-03-10 1977-10-18 The Regents Of The University Of California Process for converting neopinone to codeinone
US4052402A (en) * 1976-03-15 1977-10-04 Fabrica De Productos Quimicos Y Farmaceuticos Abello, S.A. Process for synthesizing codeinone from thebaine
GB1582234A (en) * 1976-08-17 1981-01-07 Macfarlan Smith Ltd Morphine derivatives
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives
GB1587831A (en) 1977-03-23 1981-04-08 Reckitt & Colmann Prod Ltd Morphine derivatives
GB1593191A (en) 1977-03-23 1981-07-15 Reckitt & Colmann Prod Ltd Derivatives of morphine
US4141895A (en) * 1977-06-16 1979-02-27 E. I. Du Pont De Nemours And Company Hydroxyquinazolines and their use as intermediates for pharmaceutical agents
US4272541A (en) 1978-06-02 1981-06-09 Miles Laboratories, Inc. 7,8 and 7-8 Substituted 4,5α-epoxymorphinan-6-one compounds, and methods of treating pain and drug dependence with them
US4236008A (en) * 1978-09-19 1980-11-25 E. I. Du Pont De Nemours And Company Fluorination of precursors for fluorine analogs of hydrocodone and oxycodone
US4241065A (en) * 1979-07-02 1980-12-23 E. I. Du Pont De Nemours And Company Fluoro analogs of hydrocodone and oxycodone useful as analgesics, narcotic antagonists or both
JPS5828633B2 (ja) * 1978-12-22 1983-06-17 ロ−レルバンクマシン株式会社 紙葉類計数機における紙葉類束保持装置
US4277604A (en) * 1980-01-25 1981-07-07 The United States Of America As Represented By The Department Of Health And Human Services Facile synthesis of codeine precursors from thebaine
US4410700A (en) * 1980-07-03 1983-10-18 The United States Of America As Represented By The Department Of Health And Human Services Preparation of chiral 1-benzyl-1,2,3,4-tetrahydroisoquinolines by optical resolution
US4368326A (en) * 1980-07-03 1983-01-11 Rice Kenner C Short total synthesis of dihydrothebainone, dihydrocodeinone, and nordihydroccodeinone
US4521601A (en) * 1981-05-20 1985-06-04 The United States Of America As Represented By The Department Of Health & Human Services Practical total synthesis unnatural enantiomers of opium-derived morphinans
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US4613668A (en) * 1983-12-22 1986-09-23 The United States Of America As Represented By The Department Of Health And Human Services Short total synthesis or morphinan compounds which uses cyclization of a cycloalkylcarbonyl compound selected from cyclopropylcarbonyl and cyclobutylcarbonyl
US4639520A (en) * 1984-03-27 1987-01-27 Mallinckrodt, Inc. Preparation of 14-hydroxy-N-ethoxy-carbonyl-norcodeinone
EP0158476B1 (de) * 1984-03-27 1991-01-23 Mallinckrodt, Inc. (a Delaware corporation) Herstellung von Noroxymorphon aus Morphin
US5112975A (en) * 1984-03-27 1992-05-12 Mallinckrodt Specialty Chemicals Company Preparation of noroxymorphone from morphine
US4667037A (en) * 1985-06-06 1987-05-19 E. I. Du Pont De Nemours And Company Dealkylation of opioid ethers
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
AU642447B2 (en) * 1989-10-16 1993-10-21 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Total synthesis of northebaine, normorphine, noroxymorphone enantiomers and derivatives via N-nor intermediates
US5208338A (en) * 1991-06-14 1993-05-04 The United States Of America As Represented By The Department Of Health & Human Services. Radiolabeled N-substituted-6-iodo-3,14-dihydroxy-4,5α-epoxymorphinans
US5300499A (en) * 1992-09-02 1994-04-05 Allergan, Inc. 5-substituted 3-thiophene sulfonamides as antiglaucoma agents
US6121296A (en) * 1992-11-04 2000-09-19 Albert Einstein College Of Medicine Of Yeshiva University Transition-state inhibitors for nucleoside hydrolase and transferase reactions
NZ287243A (en) * 1994-05-31 1997-12-19 Mallinckrodt Chemical Inc Process for production of nalbuphine form alpha-noroxymorphol
US6291675B1 (en) * 1996-05-21 2001-09-18 The United States As Represented By The Department Of Health And Human Services Methods of o-demethylation and n-deprotection
US6067749A (en) * 1996-07-11 2000-05-30 Tasmanian Alkaloids Pty. Ltd. Papaver somniferum strain with high concentration of thebaine and oripavine
US5869669A (en) * 1996-07-26 1999-02-09 Penick Corporation Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates
GB9616253D0 (en) * 1996-08-01 1996-09-11 Johnson Matthey Plc Preparation of narcotic analgesics
GB9713703D0 (en) * 1997-06-30 1997-09-03 Johnson Matthey Plc Preparation of opiates
JP3980801B2 (ja) * 1999-09-16 2007-09-26 株式会社東芝 三次元構造体およびその製造方法
US6177567B1 (en) 1999-10-15 2001-01-23 Boehringer Ingelheim Chemicals, Inc. Method for preparing oxycodone
MXPA04001647A (es) 2001-08-23 2004-05-31 Akzo Nobel Nv Proceso para la preparacion de un derivado de 14-hidroxinormorfinona.
GB2392670A (en) 2002-09-03 2004-03-10 Stylacats Ltd (+)-Morphine production
US7323565B2 (en) * 2002-11-11 2008-01-29 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7321038B2 (en) * 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
EP1562952B1 (de) * 2002-11-11 2007-10-24 Mallinckrodt Inc. Katalytisches verfahren zur herstellung von hydromorphone und hydrocodone
US6864370B1 (en) 2003-06-05 2005-03-08 Zhaiwei Lin Process for manufacturing oxycodone

Also Published As

Publication number Publication date
JP2008546688A (ja) 2008-12-25
WO2006138020A3 (en) 2007-03-22
EP1893616B1 (de) 2010-12-29
ES2357216T3 (es) 2011-04-20
CA2610859A1 (en) 2006-12-28
US20080207906A1 (en) 2008-08-28
EP1893616A2 (de) 2008-03-05
AU2006259780B2 (en) 2012-04-12
AU2006259780A1 (en) 2006-12-28
US8067597B2 (en) 2011-11-29
CA2610859C (en) 2013-11-12
MX2007015789A (es) 2008-02-15
WO2006138020A2 (en) 2006-12-28
CN101198612A (zh) 2008-06-11
DE602006019246D1 (de) 2011-02-10

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