ATE493429T1 - Verbessertes verfahren zur gewinnung von betulinsäure - Google Patents

Verbessertes verfahren zur gewinnung von betulinsäure

Info

Publication number: ATE493429T1
Authority: AT; Austria
Prior art keywords: improved method; betulinic acid; obtaining; obtaining betulinic; acid
Prior art date: 2005-10-12

Application number

AT06807177T

Other languages

German (de)

English (en)

Inventor

Carsten H Puder

Herbert Graef

Markus J Thumerer

Markus Heitzmann

Original Assignee

Boehringer Ingelheim Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-10-12

Filing date

2006-10-12

Publication date

2011-01-15

2006-10-12 Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma

2011-01-15 Application granted granted Critical

2011-01-15 Publication of ATE493429T1 publication Critical patent/ATE493429T1/de

Links

QGJZLNKBHJESQX-UHFFFAOYSA-N 3-Epi-Betulin-Saeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(=C)C)C5C4CCC3C21C QGJZLNKBHJESQX-UHFFFAOYSA-N 0.000 title 1
CLOUCVRNYSHRCF-UHFFFAOYSA-N 3beta-Hydroxy-20(29)-Lupen-3,27-oic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C(O)=O)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C CLOUCVRNYSHRCF-UHFFFAOYSA-N 0.000 title 1
DIZWSDNSTNAYHK-XGWVBXMLSA-N Betulinic acid Natural products CC(=C)[C@@H]1C[C@H]([C@H]2CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]12)C(=O)O DIZWSDNSTNAYHK-XGWVBXMLSA-N 0.000 title 1
QGJZLNKBHJESQX-FZFNOLFKSA-N betulinic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C QGJZLNKBHJESQX-FZFNOLFKSA-N 0.000 title 1
PZXJOHSZQAEJFE-UHFFFAOYSA-N dihydrobetulinic acid Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C(C)C)C5C4CCC3C21C PZXJOHSZQAEJFE-UHFFFAOYSA-N 0.000 title 1
MQYXUWHLBZFQQO-UHFFFAOYSA-N nepehinol Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C)CCC(C(=C)C)C5C4CCC3C21C MQYXUWHLBZFQQO-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Extraction Or Liquid Replacement (AREA)

AT06807177T 2005-10-12 2006-10-12 Verbessertes verfahren zur gewinnung von betulinsäure ATE493429T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05109482		2005-10-12
PCT/EP2006/067309 WO2007042542A1 (de)	2005-10-12	2006-10-12	Verbessertes verfahren zur gewinnung von betulinsäure

Publications (1)

Publication Number	Publication Date
ATE493429T1 true ATE493429T1 (de)	2011-01-15

Family

ID=36046978

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT06807177T ATE493429T1 (de)	2005-10-12	2006-10-12	Verbessertes verfahren zur gewinnung von betulinsäure

Country Status (15)

Country	Link
US (1)	US20070149490A1 (es)
EP (1)	EP1937707B1 (es)
JP (1)	JP5203950B2 (es)
KR (1)	KR20080059434A (es)
CN (1)	CN101287745A (es)
AR (1)	AR057545A1 (es)
AT (1)	ATE493429T1 (es)
BR (1)	BRPI0617226A2 (es)
CA (1)	CA2624996A1 (es)
DE (1)	DE502006008620D1 (es)
ES (1)	ES2358752T3 (es)
IL (1)	IL190743A0 (es)
RU (1)	RU2008118419A (es)
TW (1)	TW200720287A (es)
WO (1)	WO2007042542A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102206244B (zh) *	2011-04-02	2012-07-04	南京林业大学	从梧桐树科树皮中提取桦木酸的方法
CN102527066B (zh) *	2012-02-23	2014-09-17	李晓云	多功能热回流提取浓缩机组
CN111333693B (zh) *	2020-04-22	2021-02-12	南京林业大学	一种桦木酸的提取方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19713768B4 (de) *	1997-04-03	2006-07-13	Martin-Luther-Universität Halle-Wittenberg	Herstellung von Betulinsäure
US6048847A (en) *	1997-09-30	2000-04-11	Dabur Research Foundation	Use of betulinic acid and its derivatives for inhibiting cancer growth and a method of monitoring this
US6264998B1 (en) *	2000-03-01	2001-07-24	Dabur Research Foundation	Extracting betulinic acid from Ziziphus jujuba
US20020155177A1 (en) *	2000-09-29	2002-10-24	Krasutsky Pavel A.	Process for extracting compounds from plants
WO2002026343A2 (en) *	2000-09-29	2002-04-04	Regents Of The University Of Minnesota	Process for extracting compounds from plants
EP2567625A1 (en) *	2001-05-11	2013-03-13	University Of Ottawa	Preparation containing betulinic acid, obtained from a plant of the family Marcgraviaceae
US6943260B2 (en) *	2002-02-02	2005-09-13	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Process for obtaining betulinic acid
DE10204271B4 (de) *	2002-02-02	2004-01-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Verfahren zur Gewinnung von Betulinsäure-Monoethanolat
CN1634972A (zh) *	2004-11-12	2005-07-06	张梅	白桦脂醇和白桦酯酸的提取纯化方法

2006
- 2006-10-03 US US11/538,124 patent/US20070149490A1/en not_active Abandoned
- 2006-10-11 TW TW095137374A patent/TW200720287A/zh unknown
- 2006-10-11 AR ARP060104454A patent/AR057545A1/es not_active Application Discontinuation
- 2006-10-12 KR KR1020087011036A patent/KR20080059434A/ko not_active Withdrawn
- 2006-10-12 RU RU2008118419/04A patent/RU2008118419A/ru not_active Application Discontinuation
- 2006-10-12 DE DE502006008620T patent/DE502006008620D1/de active Active
- 2006-10-12 ES ES06807177T patent/ES2358752T3/es active Active
- 2006-10-12 EP EP06807177A patent/EP1937707B1/de not_active Not-in-force
- 2006-10-12 CN CNA2006800381789A patent/CN101287745A/zh active Pending
- 2006-10-12 AT AT06807177T patent/ATE493429T1/de active
- 2006-10-12 WO PCT/EP2006/067309 patent/WO2007042542A1/de not_active Ceased
- 2006-10-12 JP JP2008535025A patent/JP5203950B2/ja not_active Expired - Fee Related
- 2006-10-12 BR BRPI0617226-1A patent/BRPI0617226A2/pt not_active IP Right Cessation
- 2006-10-12 CA CA002624996A patent/CA2624996A1/en not_active Abandoned
2008
- 2008-04-09 IL IL190743A patent/IL190743A0/en unknown

Also Published As

Publication number	Publication date
EP1937707A1 (de)	2008-07-02
ES2358752T3 (es)	2011-05-13
WO2007042542A1 (de)	2007-04-19
EP1937707B1 (de)	2010-12-29
AR057545A1 (es)	2007-12-05
KR20080059434A (ko)	2008-06-27
JP5203950B2 (ja)	2013-06-05
JP2009511546A (ja)	2009-03-19
CA2624996A1 (en)	2007-04-19
IL190743A0 (en)	2009-09-22
RU2008118419A (ru)	2009-11-20
CN101287745A (zh)	2008-10-15
TW200720287A (en)	2007-06-01
BRPI0617226A2 (pt)	2011-07-19
DE502006008620D1 (de)	2011-02-10
US20070149490A1 (en)	2007-06-28

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