ATE495174T1 - 2-oxo-2-(2-phenyl-5,6,7,8-tetrahydroindolizin-3 yl)acetamidderivate und verwandte verbindungen als antipilzmittel - Google Patents
2-oxo-2-(2-phenyl-5,6,7,8-tetrahydroindolizin-3 yl)acetamidderivate und verwandte verbindungen als antipilzmittelInfo
- Publication number
- ATE495174T1 ATE495174T1 AT08750663T AT08750663T ATE495174T1 AT E495174 T1 ATE495174 T1 AT E495174T1 AT 08750663 T AT08750663 T AT 08750663T AT 08750663 T AT08750663 T AT 08750663T AT E495174 T1 ATE495174 T1 AT E495174T1
- Authority
- AT
- Austria
- Prior art keywords
- tetrahydroindolizin
- oxo
- phenyl
- antifungal agents
- related compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- KIYBKFLPHZZLSB-UHFFFAOYSA-N 2-oxo-2-(2-phenyl-5,6,7,8-tetrahydroindolizin-3-yl)acetamide Chemical class C1=C2CCCCN2C(C(=O)C(=O)N)=C1C1=CC=CC=C1 KIYBKFLPHZZLSB-UHFFFAOYSA-N 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- 239000003429 antifungal agent Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 abstract 3
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000000417 fungicide Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Environmental Sciences (AREA)
- Epidemiology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Communicable Diseases (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0710121.5A GB0710121D0 (en) | 2007-05-25 | 2007-05-25 | Antifungal agents |
| PCT/GB2008/001738 WO2008145963A1 (en) | 2007-05-25 | 2008-05-21 | 2-oxo-2- (2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl) -acetamide derivatives and related compounds as antifungal agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE495174T1 true ATE495174T1 (de) | 2011-01-15 |
Family
ID=38265404
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08750663T ATE495174T1 (de) | 2007-05-25 | 2008-05-21 | 2-oxo-2-(2-phenyl-5,6,7,8-tetrahydroindolizin-3 yl)acetamidderivate und verwandte verbindungen als antipilzmittel |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8524705B2 (de) |
| EP (1) | EP2173749B1 (de) |
| JP (1) | JP5409610B2 (de) |
| KR (1) | KR101595579B1 (de) |
| CN (1) | CN101743246B (de) |
| AT (1) | ATE495174T1 (de) |
| AU (1) | AU2008257196B2 (de) |
| CA (1) | CA2687790C (de) |
| DE (1) | DE602008004540D1 (de) |
| DK (1) | DK2173749T3 (de) |
| ES (1) | ES2359187T3 (de) |
| GB (1) | GB0710121D0 (de) |
| NZ (1) | NZ581143A (de) |
| WO (1) | WO2008145963A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2626361T3 (en) * | 2008-04-24 | 2015-01-19 | F2G Ltd | Pyrrol-Antimycotics |
| GB0809773D0 (en) * | 2008-05-29 | 2008-07-09 | F2G Ltd | Antifungal combination therapy |
| BR112012004513A2 (pt) * | 2009-08-31 | 2015-09-08 | Ihara Chemical Ind Co | processo para a preparação de derivados de pirimidinilacetonitrila e intermediários para a síntese dos mesmos |
| US10300055B2 (en) | 2014-04-10 | 2019-05-28 | Dalhousie University | Treatment of parkinson's disease through ARFGAP1 inhibition |
| CA2982660C (en) * | 2014-11-21 | 2023-01-24 | F2G Limited | 2-(1,5-dimethyl-3-phenyl-1h-pyrrol-2-yl)-n-(4-(4-(5-fluoropyrimidin-2-yl)piperazine-1-yl)phenyl)-2-oxoacetamide and derivatives thereof for use as antifungal agents |
| CN104910116B (zh) * | 2015-05-19 | 2017-03-22 | 中节能万润股份有限公司 | 一种制备4,4‑吡喃二甲酸二乙酯衍生物的方法 |
| CN106412680B (zh) * | 2015-07-31 | 2021-01-22 | 中兴通讯股份有限公司 | 多屏控制方法及装置 |
| GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
| KR102752886B1 (ko) * | 2018-05-25 | 2025-01-09 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | 2,3-디히드로-1h-피롤리진-7-포름아미드 유도체 및 그 사용 |
| WO2020156494A1 (zh) * | 2019-01-31 | 2020-08-06 | 正大天晴药业集团股份有限公司 | 含有吡咯并杂环的衣壳蛋白装配抑制剂 |
| US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
| CN112898316A (zh) * | 2019-12-03 | 2021-06-04 | 微境生物医药科技(上海)有限公司 | 新型吡咯化合物 |
| CN114644634B (zh) * | 2020-12-21 | 2023-06-20 | 深圳市祥根生物医药有限公司 | 一种吡咯衍生物及其制备方法和用途 |
| TW202521521A (zh) * | 2023-08-08 | 2025-06-01 | 大陸商上海森輝醫藥有限公司 | 一種４－苯基哌啶衍生物及其應用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2601368B1 (fr) | 1986-07-08 | 1989-04-07 | Synthelabo | Derives de nitrofuranne, leur preparation et leur application en therapeutique. |
| JPH09249669A (ja) | 1996-03-13 | 1997-09-22 | Ono Pharmaceut Co Ltd | 縮合ピロール誘導体、およびそれらを有効成分として含有する薬剤 |
| EP1399442B1 (de) | 2001-06-06 | 2006-08-09 | Vertex Pharmaceuticals Incorporated | Cak inhibitoren und deren verwendungen |
| ATE420639T1 (de) * | 2005-05-18 | 2009-01-15 | F2G Ltd | Antimykotische mittel |
| GB0623209D0 (en) | 2006-11-21 | 2007-01-03 | F2G Ltd | Antifungal agents |
-
2007
- 2007-05-25 GB GBGB0710121.5A patent/GB0710121D0/en not_active Ceased
-
2008
- 2008-05-21 AU AU2008257196A patent/AU2008257196B2/en not_active Ceased
- 2008-05-21 ES ES08750663T patent/ES2359187T3/es active Active
- 2008-05-21 US US12/601,284 patent/US8524705B2/en active Active
- 2008-05-21 EP EP08750663A patent/EP2173749B1/de active Active
- 2008-05-21 CA CA2687790A patent/CA2687790C/en active Active
- 2008-05-21 WO PCT/GB2008/001738 patent/WO2008145963A1/en not_active Ceased
- 2008-05-21 NZ NZ581143A patent/NZ581143A/en not_active IP Right Cessation
- 2008-05-21 AT AT08750663T patent/ATE495174T1/de not_active IP Right Cessation
- 2008-05-21 JP JP2010508902A patent/JP5409610B2/ja not_active Expired - Fee Related
- 2008-05-21 DE DE602008004540T patent/DE602008004540D1/de active Active
- 2008-05-21 KR KR1020097026994A patent/KR101595579B1/ko not_active Expired - Fee Related
- 2008-05-21 CN CN2008800230773A patent/CN101743246B/zh active Active
- 2008-05-21 DK DK08750663.0T patent/DK2173749T3/da active
Also Published As
| Publication number | Publication date |
|---|---|
| KR101595579B1 (ko) | 2016-02-18 |
| CN101743246A (zh) | 2010-06-16 |
| AU2008257196B2 (en) | 2013-06-20 |
| CA2687790A1 (en) | 2008-12-04 |
| EP2173749A1 (de) | 2010-04-14 |
| US8524705B2 (en) | 2013-09-03 |
| CN101743246B (zh) | 2013-07-17 |
| DK2173749T3 (da) | 2011-05-02 |
| EP2173749B1 (de) | 2011-01-12 |
| JP2010527979A (ja) | 2010-08-19 |
| GB0710121D0 (en) | 2007-07-04 |
| DE602008004540D1 (de) | 2011-02-24 |
| CA2687790C (en) | 2014-11-18 |
| AU2008257196A1 (en) | 2008-12-04 |
| KR20100033383A (ko) | 2010-03-29 |
| NZ581143A (en) | 2011-07-29 |
| WO2008145963A1 (en) | 2008-12-04 |
| US20110009390A1 (en) | 2011-01-13 |
| JP5409610B2 (ja) | 2014-02-05 |
| ES2359187T3 (es) | 2011-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |