NO20081005L - 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents - Google Patents

8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents

Info

Publication number
NO20081005L
NO20081005L NO20081005A NO20081005A NO20081005L NO 20081005 L NO20081005 L NO 20081005L NO 20081005 A NO20081005 A NO 20081005A NO 20081005 A NO20081005 A NO 20081005A NO 20081005 L NO20081005 L NO 20081005L
Authority
NO
Norway
Prior art keywords
formula
compounds
compound
isothiazolo
dione
Prior art date
Application number
NO20081005A
Other languages
English (en)
Other versions
NO343376B1 (no
Inventor
Milind Deshpande
Barton James Bradbury
Michael John Pucci
Jason Allan Wiles
Akihiro Hashimoto
Edlaine Lucien
Qiuping Wang
Godwin Clarence Gilroy Pais
Ha Young Kim
Original Assignee
Achillion Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Achillion Pharmaceuticals Inc filed Critical Achillion Pharmaceuticals Inc
Publication of NO20081005L publication Critical patent/NO20081005L/no
Publication of NO343376B1 publication Critical patent/NO343376B1/no

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Oppfinnelsen tilveiebringer forbindelse og salter med Formel I og II, beskrevet her, som innbefatter forbindelser med Formel A og Formel B: Slike forbindelser har anvendelig antimikrobiell aktivitet. Variablene R2, R3, R5, R6, R7 og R9 vist i Formel A og B er definert her. Visse forbindelser med Formel I og Formel II som er beskrevet her, er kraftige og/eller selektive inhibitorer av bakteriell DNA-syntese og bakteriell replikasjon. Oppfinnelsen tilveiebringer også antimikrobielle preparater, som omfatter farmasøytiske preparater, inneholdende én eller flere forbindelser med Formel I eller Formel II og én eller flere bærere, tilsetningsmidler eller fortynningsmidler. Slike preparater kan inneholde en forbindelse med Formel I eller Formel II som eneste aktive middel eller kan inneholde en kombinasjon av en forbindelse med Formel I eller Formel II og én eller flere andre aktive midler. Oppfinnelsen tilveiebringer også metoder for behandling av mikrobielle infeksjoner i dyr. Formel A Fo rmel B
NO20081005A 2005-07-27 2008-02-27 8-metoksy-9H-isotiazolo[5,4-b]kinolin-3,4-dioner, farmasøytisk preparater omfattende slike samt slike forbindelser og preparater for anvendelse ved behandling eller forhindring av infeksjoner NO343376B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70281105P 2005-07-27 2005-07-27
PCT/US2006/029302 WO2007014308A1 (en) 2005-07-27 2006-07-27 8-methoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones and related compounds as anti-infective agents

Publications (2)

Publication Number Publication Date
NO20081005L true NO20081005L (no) 2008-04-09
NO343376B1 NO343376B1 (no) 2019-02-11

Family

ID=37106335

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20081005A NO343376B1 (no) 2005-07-27 2008-02-27 8-metoksy-9H-isotiazolo[5,4-b]kinolin-3,4-dioner, farmasøytisk preparater omfattende slike samt slike forbindelser og preparater for anvendelse ved behandling eller forhindring av infeksjoner

Country Status (19)

Country Link
US (2) US8044204B2 (no)
EP (1) EP1913004B1 (no)
JP (1) JP5143000B2 (no)
KR (1) KR101272263B1 (no)
CN (1) CN101263146B (no)
AT (1) ATE482219T1 (no)
AU (1) AU2006272571B2 (no)
BR (1) BRPI0614456B8 (no)
CA (1) CA2616768C (no)
DE (1) DE602006017082D1 (no)
DK (1) DK1913004T3 (no)
EA (1) EA013244B1 (no)
ES (1) ES2352799T3 (no)
IL (1) IL189017A (no)
NO (1) NO343376B1 (no)
NZ (1) NZ566209A (no)
PL (1) PL1913004T3 (no)
PT (1) PT1913004E (no)
WO (1) WO2007014308A1 (no)

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WO2008021491A2 (en) * 2006-08-16 2008-02-21 Achillion Pharmaceuticals, Inc. Method for synthesis of 8-alkoxy-9h-isothiazolo[5,4-b]quinoline-3,4-diones
WO2010115184A2 (en) * 2009-04-03 2010-10-07 Achillion Pharmaceuticals, Inc. Hydroxythienoquinolones and related compounds as anti-infective agents
WO2011031745A1 (en) 2009-09-09 2011-03-17 Achaogen, Inc. Antibacterial fluoroquinolone analogs
BR112012008759A2 (pt) 2009-10-16 2020-08-25 Rib-X Pharmaceuticals, Inc. compostos antimicrobianos e métodos de fabricação e uso dos mesmos
WO2011047323A2 (en) 2009-10-16 2011-04-21 Rib-X Pharmaceuticals, Inc. Antimicrobial compounds and methods of making and using the same
CN105646370A (zh) * 2009-10-16 2016-06-08 梅琳塔治疗公司 抗微生物化合物和其制备和使用方法
TN2010000566A1 (en) * 2010-12-03 2012-05-24 Rekik Raouf Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs
CN103819401B (zh) * 2012-11-19 2016-04-13 浙江中欣氟材股份有限公司 1-环丙基-4-氧代-7-氟-8-甲氧基-1,4-二氢喹啉-3-羧酸的合成方法
EP3039025A4 (en) 2013-09-09 2017-05-31 Melinta Therapeutics, Inc. Antimicrobial compounds and methods of making and using the same
MX2016003046A (es) 2013-09-09 2016-09-08 Melinta Therapeutics Inc Compuestos antimicrobianos y métodos de fabricación y utilización de los mismos.
WO2015114317A1 (en) * 2014-01-28 2015-08-06 Redx Pharma Plc 5h-isothiazolo[4,5-c]pyridine-3,4-dione or 5h-pyrazolo[4,3-c]pyridin-3,4-dione as antibacterial compounds
CN107922418A (zh) 2015-03-11 2018-04-17 梅琳塔治疗公司 抗微生物化合物及制备和使用所述化合物的方法
JP2019515041A (ja) 2016-05-06 2019-06-06 メリンタ セラピューティクス、 インコーポレイテッドＭｅｌｉｎｔａ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 抗菌剤ならびにそれを作製および使用する方法
EP4483875A3 (en) 2016-05-10 2025-04-02 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN109562107A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的杂环降解决定子体
EP3455219A4 (en) 2016-05-10 2019-12-18 C4 Therapeutics, Inc. AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
EP3641762B1 (en) 2017-06-20 2026-02-18 C4 Therapeutics, Inc. N/o-linked degrons and degronimers for protein degradation
KR102534570B1 (ko) * 2019-02-01 2023-05-18 에어리 파마슈티컬즈, 인코포레이티드 근시의 치료를 위한 화합물, 조성물 및 방법

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Also Published As

Publication number Publication date
PT1913004E (pt) 2010-12-09
EA200800444A1 (ru) 2008-06-30
AU2006272571B2 (en) 2012-03-08
BRPI0614456B8 (pt) 2021-05-25
PL1913004T3 (pl) 2011-03-31
WO2007014308A1 (en) 2007-02-01
US20120040959A1 (en) 2012-02-16
NO343376B1 (no) 2019-02-11
US20070049586A1 (en) 2007-03-01
AU2006272571A1 (en) 2007-02-01
CA2616768C (en) 2014-05-06
EA013244B1 (ru) 2010-04-30
IL189017A (en) 2014-01-30
DE602006017082D1 (de) 2010-11-04
HK1122024A1 (en) 2009-05-08
CA2616768A1 (en) 2007-02-01
JP5143000B2 (ja) 2013-02-13
BRPI0614456B1 (pt) 2019-08-27
ATE482219T1 (de) 2010-10-15
NZ566209A (en) 2011-03-31
EP1913004A1 (en) 2008-04-23
KR101272263B1 (ko) 2013-06-13
KR20080035661A (ko) 2008-04-23
IL189017A0 (en) 2008-08-07
BRPI0614456A2 (pt) 2011-03-29
JP2009502953A (ja) 2009-01-29
DK1913004T3 (da) 2011-01-10
US8044204B2 (en) 2011-10-25
CN101263146A (zh) 2008-09-10
EP1913004B1 (en) 2010-09-22
US8946422B2 (en) 2015-02-03
CN101263146B (zh) 2012-12-05
ES2352799T3 (es) 2011-02-23

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