ATE495739T1 - Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa - Google Patents
Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopaInfo
- Publication number
- ATE495739T1 ATE495739T1 AT04782161T AT04782161T ATE495739T1 AT E495739 T1 ATE495739 T1 AT E495739T1 AT 04782161 T AT04782161 T AT 04782161T AT 04782161 T AT04782161 T AT 04782161T AT E495739 T1 ATE495739 T1 AT E495739T1
- Authority
- AT
- Austria
- Prior art keywords
- methods
- carbidopa
- levodopa
- pharmaceutical compositions
- compositions
- Prior art date
Links
- IVTMXOXVAHXCHI-YXLMWLKOSA-N (2s)-2-amino-3-(3,4-dihydroxyphenyl)propanoic acid;(2s)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1.NN[C@@](C(O)=O)(C)CC1=CC=C(O)C(O)=C1 IVTMXOXVAHXCHI-YXLMWLKOSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49925603P | 2003-08-29 | 2003-08-29 | |
| US50555103P | 2003-09-24 | 2003-09-24 | |
| US55986404P | 2004-04-06 | 2004-04-06 | |
| US58644204P | 2004-07-08 | 2004-07-08 | |
| PCT/US2004/027607 WO2005023185A2 (en) | 2003-08-29 | 2004-08-26 | Pharmaceutical compositions and method of using levodopa and carbidopa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE495739T1 true ATE495739T1 (de) | 2011-02-15 |
Family
ID=34280054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04782161T ATE495739T1 (de) | 2003-08-29 | 2004-08-26 | Pharmazeutische zusammensetzungen und verfahren zur verwendung von levodopa und carbidopa |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20050070608A1 (de) |
| EP (1) | EP1670450B8 (de) |
| JP (1) | JP5160786B2 (de) |
| AT (1) | ATE495739T1 (de) |
| AU (1) | AU2004270174B2 (de) |
| CA (1) | CA2536175C (de) |
| DE (1) | DE602004031134D1 (de) |
| MX (1) | MXPA06002344A (de) |
| WO (1) | WO2005023185A2 (de) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8815950B2 (en) | 2003-08-29 | 2014-08-26 | Janssen Biotech, Inc. | Pharmaceutical compositions and method of using levodopa and carbidopa |
| SE0401842D0 (sv) | 2004-07-12 | 2004-07-12 | Dizlin Medical Design Ab | Infusion and injection solution of levodopa |
| CA2613631A1 (en) * | 2005-06-23 | 2007-01-04 | Spherics, Inc. | Improved dosage forms for movement disorder treatment |
| US20070027216A1 (en) * | 2005-07-15 | 2007-02-01 | Bridget Larson | Novel hydrochloride salts of levodopa |
| EA200801540A1 (ru) * | 2005-12-20 | 2008-12-30 | Сириусайенс Аб | Способ и композиция для лечения и диагностики синдрома усталых ног |
| AU2007338631A1 (en) * | 2006-12-22 | 2008-07-03 | Combinatorx, Incorporated | Pharmaceutical compositions for treatment of parkinson's disease and related disorders |
| JP5631734B2 (ja) * | 2007-04-06 | 2014-11-26 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | 流体薬物を供給するためのシステム及び方法 |
| AU2014202306B2 (en) * | 2007-12-28 | 2016-09-08 | Impax Laboratories, Llc | Controlled release formulations of levodopa and uses thereof |
| CN101910113A (zh) | 2007-12-28 | 2010-12-08 | 怡百克制药公司 | 左旋多巴控释制剂及其用途 |
| PL2432454T3 (pl) * | 2009-05-19 | 2017-10-31 | Neuroderm Ltd | Kompozycje do ciągłego podawania inhibitorów dopa-dekarboksylazy |
| NZ598744A (en) * | 2009-09-18 | 2013-11-29 | Sanofi Sa | (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluormethylphenyl)-amide tablet formulations with improved stability |
| WO2013035053A2 (en) * | 2011-09-09 | 2013-03-14 | Kareus Therapeutics, Sa | Novel conjugation-facilitated transport of drugs across blood brain barrier |
| US10987313B2 (en) | 2013-10-07 | 2021-04-27 | Impax Laboratories, Llc | Muco-adhesive, controlled release formulations of levodopa and/or esters of levodopa and uses thereof |
| CN105658211A (zh) | 2013-10-07 | 2016-06-08 | 怡百克制药公司 | 左旋多巴和/或左旋多巴的酯的粘膜粘附性、控制释放调配物和其用途 |
| DK3116475T3 (da) * | 2014-03-13 | 2020-12-07 | Neuroderm Ltd | Dopa-decarboxylasehæmmersammensætninger |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| JP6622310B2 (ja) | 2014-09-04 | 2019-12-18 | ロブソル・ファーマシューティカルズ・アクチボラグＬｏｂｓｏｒ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ａｋｔｉｅｂｏｌａｇ | レボドパ、ドーパミン脱炭酸酵素阻害薬およびｃｏｍｔ阻害薬を含む医薬組成物ならびにその投与方法 |
| RU2021103000A (ru) | 2014-10-21 | 2021-03-01 | Эббви Инк. | Пролекарства карбидопа и l-dopa и их применение для лечения болезни паркинсона |
| CN113197851A (zh) | 2015-05-06 | 2021-08-03 | 辛纳吉勒公司 | 包含药物粒子的药用悬浮液、用于其配给的装置、以及其使用方法 |
| US10555922B2 (en) | 2015-09-04 | 2020-02-11 | Lobsor Pharmaceuticals Aktiebolag | Method of treating a dopamine related disorder in a subject by administering levodopa, in combination with a dopamine decarboxylase inhibitor and a catechol-o-methyltransferase inhibitor |
| WO2017177262A1 (en) * | 2016-04-11 | 2017-10-19 | University Of Canberra | Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier |
| EP4295909A3 (de) * | 2016-04-20 | 2024-07-17 | AbbVie Inc. | Carbidopa und l-dopa-prodrugs und verfahren zur verwendung |
| CA3065990A1 (en) | 2017-06-05 | 2018-12-13 | Dizlin Pharmaceuticals Ab | Levodopa infusion solution |
| BR112020013749A2 (pt) * | 2018-01-05 | 2020-12-01 | Impel Neuropharma, Inc. | dispensação intranasal de pó de levodopa por dispositivo olfativo de precisão |
| EP3768263B1 (de) | 2018-03-23 | 2025-10-29 | LobSor Pharmaceuticals Aktiebolag | Kontinuierliche verabreichung einer pharmazeutischen zusammensetzung zur behandlung von neurodegenerativen erkrankungen |
| US11517548B2 (en) | 2018-07-19 | 2022-12-06 | Impel Pharmaceuticals Inc. | Respiratory tract delivery of levodopa and DOPA decarboxylase inhibitor for treatment of Parkinson's Disease |
| BR112021009353A2 (pt) | 2018-11-15 | 2021-11-23 | Abbvie Inc | Formulações farmacêuticas para administração subcutânea |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| KR20230124622A (ko) | 2020-12-22 | 2023-08-25 | 암닐 파마슈티컬스 엘엘씨 | 레보도파 투여 요법 |
| US11986449B2 (en) | 2020-12-22 | 2024-05-21 | Amneal Pharmaceuticals Llc | Levodopa dosing regimen |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3928431A (en) * | 1972-07-14 | 1975-12-23 | Medica Ab Oy | Method of isolating L-dopa from a aqueous solution thereof |
| US4771073A (en) | 1985-12-30 | 1988-09-13 | Merck & Co., Inc. | Rectally absorbable form of L-dopa |
| DE252290T1 (de) * | 1986-06-10 | 1988-06-09 | Chiesi Farmaceutici S.P.A., Parma | Levodopa-methyl-ester enthaltende pharmazeutische zusammensetzungen, ihre herstellung und therapeutische verwendungen. |
| US4829875A (en) * | 1988-09-12 | 1989-05-16 | Queen's University At Kingston | Over-centre locking tool |
| US5190763A (en) | 1990-05-07 | 1993-03-02 | Alza Corporation | Dosage form indicated for the management of abnormal posture, tremor and involuntary movement |
| DE4101873C2 (de) * | 1991-01-23 | 1993-12-09 | Isis Pharma Gmbh | Peroral applizierbare Arzneiform zur Behandlung zentraler Dopaminmangelzustände |
| US5607969A (en) * | 1992-12-24 | 1997-03-04 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | L-DOPA ethyl ester to treat Parkinson's disease |
| US5354885A (en) * | 1992-12-24 | 1994-10-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Process for preparing ethyl ester of L-DOPA |
| US5881926A (en) * | 1993-03-11 | 1999-03-16 | Taro Pharmaceutical Industries, Ltd. | Pharmaceutical compositions in semisolid form and a device for administration thereof |
| US6166081A (en) * | 1997-10-09 | 2000-12-26 | Kushnir; Moshe | Methods and apparatus for treatment of Parkinson's disease |
| NZ512027A (en) * | 1998-11-10 | 2004-04-30 | Teva Pharma | Dispersible compositions containing L-dopa ethyl ester |
| US6531153B2 (en) * | 2001-05-29 | 2003-03-11 | Drugtech Corporation | Composition with sustained release of levodopa and carbidopa |
| CA2471081A1 (en) * | 2001-12-19 | 2003-07-03 | Alza Corporation | Formulation & dosage form for the controlled delivery of therapeutic agents |
-
2004
- 2004-08-26 DE DE602004031134T patent/DE602004031134D1/de not_active Expired - Lifetime
- 2004-08-26 WO PCT/US2004/027607 patent/WO2005023185A2/en not_active Ceased
- 2004-08-26 US US10/926,702 patent/US20050070608A1/en not_active Abandoned
- 2004-08-26 MX MXPA06002344A patent/MXPA06002344A/es active IP Right Grant
- 2004-08-26 EP EP04782161A patent/EP1670450B8/de not_active Expired - Lifetime
- 2004-08-26 AU AU2004270174A patent/AU2004270174B2/en not_active Ceased
- 2004-08-26 AT AT04782161T patent/ATE495739T1/de active
- 2004-08-26 JP JP2006524820A patent/JP5160786B2/ja not_active Expired - Fee Related
- 2004-08-26 CA CA2536175A patent/CA2536175C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HK1085140A1 (en) | 2006-08-18 |
| WO2005023185A3 (en) | 2005-05-19 |
| WO2005023185A2 (en) | 2005-03-17 |
| EP1670450B1 (de) | 2011-01-19 |
| EP1670450A2 (de) | 2006-06-21 |
| CA2536175A1 (en) | 2005-03-17 |
| AU2004270174A1 (en) | 2005-03-17 |
| JP2007504143A (ja) | 2007-03-01 |
| JP5160786B2 (ja) | 2013-03-13 |
| MXPA06002344A (es) | 2006-05-19 |
| US20050070608A1 (en) | 2005-03-31 |
| AU2004270174B2 (en) | 2010-05-20 |
| CA2536175C (en) | 2013-05-28 |
| EP1670450B8 (de) | 2011-03-23 |
| DE602004031134D1 (de) | 2011-03-03 |
| EP1670450A4 (de) | 2008-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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