ATE496021T1 - Kristalline formen von (-)-(1r,2r)-3-(3- dimethylamino-1-ethyl-2-methylpropyl)- phenolhydrochlorid zur verwendung als aktivstoff in pharmazeutischen zubereitungen - Google Patents

Kristalline formen von (-)-(1r,2r)-3-(3- dimethylamino-1-ethyl-2-methylpropyl)- phenolhydrochlorid zur verwendung als aktivstoff in pharmazeutischen zubereitungen

Info

Publication number: ATE496021T1
Authority: AT; Austria
Prior art keywords: methylpropyl; dimethylamino; ethyl; active ingredients; pharmaceutical preparations
Prior art date: 2004-06-28

Application number

AT05770026T

Other languages

English (en)

Inventor

Andreas Fischer

Helmut Buschmann

Michael Gruss

Dagmar Lischke

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-28

Filing date

2005-06-27

Publication date

2011-02-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34925507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE496021(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2005-06-27 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE496021T1 publication Critical patent/ATE496021T1/de

Links

ZELFLGGRLLOERW-YECZQDJWSA-N 3-[(2r,3r)-1-(dimethylamino)-2-methylpentan-3-yl]phenol;hydrochloride Chemical compound Cl.CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 ZELFLGGRLLOERW-YECZQDJWSA-N 0.000 title 1
239000004480 active ingredient Substances 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT05770026T 2004-06-28 2005-06-27 Kristalline formen von (-)-(1r,2r)-3-(3- dimethylamino-1-ethyl-2-methylpropyl)- phenolhydrochlorid zur verwendung als aktivstoff in pharmazeutischen zubereitungen ATE496021T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP04015091A EP1612203B1 (de)	2004-06-28	2004-06-28	Kristalline Formen von (-)-(1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochlorid
PCT/EP2005/006884 WO2006000441A2 (en)	2004-06-28	2005-06-27	Crystalline forms of (-)-(1r,2r)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride

Publications (1)

Publication Number	Publication Date
ATE496021T1 true ATE496021T1 (de)	2011-02-15

Family

ID=34925507

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT04015091T ATE368639T1 (de)	2004-06-28	2004-06-28	Kristalline formen von (-)-(1r,2r)-3-(3- dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochlorid
AT05770026T ATE496021T1 (de)	2004-06-28	2005-06-27	Kristalline formen von (-)-(1r,2r)-3-(3- dimethylamino-1-ethyl-2-methylpropyl)- phenolhydrochlorid zur verwendung als aktivstoff in pharmazeutischen zubereitungen

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT04015091T ATE368639T1 (de)	2004-06-28	2004-06-28	Kristalline formen von (-)-(1r,2r)-3-(3- dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochlorid

Country Status (27)

Country	Link
US (16)	US20070213405A1 (de)
EP (2)	EP1612203B1 (de)
JP (1)	JP4990764B2 (de)
KR (1)	KR101096501B1 (de)
CN (1)	CN1997621B (de)
AR (2)	AR049949A1 (de)
AT (2)	ATE368639T1 (de)
AU (1)	AU2005256512B2 (de)
BR (2)	BRPI0512792A (de)
CA (1)	CA2572147C (de)
CY (2)	CY1106929T1 (de)
DE (2)	DE602004007905T2 (de)
DK (2)	DK1612203T3 (de)
EC (1)	ECSP17046065A (de)
ES (2)	ES2291780T3 (de)
HR (1)	HRP20110050T8 (de)
IL (1)	IL180373A (de)
MX (1)	MXPA06014741A (de)
NO (3)	NO338605B1 (de)
NZ (1)	NZ551605A (de)
PE (1)	PE20060372A1 (de)
PL (2)	PL1612203T3 (de)
PT (2)	PT1612203E (de)
RU (1)	RU2423345C2 (de)
SI (2)	SI1612203T1 (de)
WO (1)	WO2006000441A2 (de)
ZA (1)	ZA200700774B (de)

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DE102005005446A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Bruchfeste Darreichungsformen mit retardierter Freisetzung
US20070048228A1 (en)	2003-08-06	2007-03-01	Elisabeth Arkenau-Maric	Abuse-proofed dosage form
DE10336400A1 (de)	2003-08-06	2005-03-24	Grünenthal GmbH	Gegen Missbrauch gesicherte Darreichungsform
DE10361596A1 (de)	2003-12-24	2005-09-29	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
PT1612203E (pt) *	2004-06-28	2007-08-20	Gruenenthal Gmbh	''formas cristalinas de cloridrato de (-) - (1r,2r) - 3 -(3-dimetilamino-l-etil - 2 - metilpropil) fenol''
DE102004032049A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de)	2007-03-07	2008-09-11	Grünenthal GmbH	Darreichungsform mit erschwertem Missbrauch
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CN104447360B (zh) *	2007-12-07	2017-04-12	格吕伦塔尔有限公司	(1r,2r)‑3‑(3‑二甲基氨基‑1‑乙基‑2‑甲基‑丙基)‑苯酚的结晶变体
CA2713128C (en)	2008-01-25	2016-04-05	Gruenenthal Gmbh	Pharmaceutical dosage form
AU2009243681B2 (en)	2008-05-09	2013-12-19	Grunenthal Gmbh	Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
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KR101738369B1 (ko)	2009-07-22	2017-05-22	그뤼넨탈 게엠베하	핫 멜트 압출된 제어 방출 투여형
CN102639118B (zh)	2009-07-22	2015-07-29	格吕伦塔尔有限公司	氧化稳定的抗干扰剂型
US8288592B2 (en)	2009-09-22	2012-10-16	Actavis Group Ptc Ehf	Solid state forms of tapentadol salts
EP2566461A2 (de)	2010-05-05	2013-03-13	Ratiopharm GmbH	Festes tapentadol in nicht-kristalliner form
CN110015955A (zh)	2010-07-23	2019-07-16	格吕伦塔尔有限公司	3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚的盐或共晶体
BR112013005194A2 (pt)	2010-09-02	2016-05-03	Gruenenthal Gmbh	forma de dosagem resistente à violação compreendendo sal inorgânico
TWI516286B (zh)	2010-09-02	2016-01-11	歌林達股份有限公司	含陰離子聚合物之抗破碎劑型
WO2012051246A1 (en)	2010-10-12	2012-04-19	Ratiopharm Gmbh	Tapentadol hydrobromide and crystalline forms thereof
CN103501775A (zh) *	2011-03-04	2014-01-08	格吕伦塔尔有限公司	他喷他多的胃肠外给药
MX388963B (es)	2011-03-04	2025-03-20	Gruenenthal Gmbh	Formulacion farmaceutica acuosa de tapentadol para administracion oral
ES2910085T3 (es)	2011-03-04	2022-05-11	Gruenenthal Gmbh	Composición farmacéutica acuosa semisólida que contiene tapentadol
BR112014001091A2 (pt)	2011-07-29	2017-02-14	Gruenenthal Gmbh	comprimido resistente à adulteração que fornece liberação imediata do fármaco
EA201400172A1 (ru)	2011-07-29	2014-06-30	Грюненталь Гмбх	Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
WO2013111161A2 (en) *	2012-01-10	2013-08-01	Msn Laboratories Limited	Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof
WO2013120466A1 (en)	2012-02-17	2013-08-22	Zentiva, K.S.	A new solid form of tapentadol and a method of its preparation
MX356421B (es)	2012-02-28	2018-05-29	Gruenenthal Gmbh	Forma de dosificacion resistente a la manipulacion indebida que comprende un compuesto farmacologicamente activo y un polimero anionico.
EP2838512B1 (de)	2012-04-18	2018-08-22	Grünenthal GmbH	Fälschungssichere und dose dumping sichere pharmazeutische darreichungsform
US10064945B2 (en)	2012-05-11	2018-09-04	Gruenenthal Gmbh	Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CZ304576B6 (cs) *	2012-07-24	2014-07-16	Zentiva, K.S.	Oxalát TAPENTADOLU a způsob jeho přípravy
CN102924303B (zh) *	2012-10-31	2013-11-20	合肥市新星医药化工有限公司	盐酸他喷他多晶型c及其制备方法和应用
US9737490B2 (en)	2013-05-29	2017-08-22	Grünenthal GmbH	Tamper resistant dosage form with bimodal release profile
EP3003279A1 (de)	2013-05-29	2016-04-13	Grünenthal GmbH	Manipulationssichere darreichungsform mit einem oder mehreren partikeln
EP2808319A1 (de)	2013-05-31	2014-12-03	Arevipharma GmbH	3-[3-(dimethylamin)-1-ethyl-2-methylpropyl]phenolharzkomplex
BR112016000194A8 (pt)	2013-07-12	2019-12-31	Gruenenthal Gmbh	forma de dosagem resistente à violação contendo o polímero de acetato de etileno-vinila
EP2845625A1 (de) *	2013-09-04	2015-03-11	Grünenthal GmbH	Tepentadol zur Verwendung bei der Behandlung von Fibromyalgie und chronischem Ermüdungssyndrom
USD730877S1 (en)	2013-09-06	2015-06-02	Plantronics, Inc.	Communications headset
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WO2015071248A1 (en)	2013-11-15	2015-05-21	Synthon B.V.	Abuse-proofed extended release pharmaceutical composition comprising tapentadol
EP3073994A1 (de)	2013-11-26	2016-10-05	Grünenthal GmbH	Herstellung einer pulverförmigen pharmazeutischen zusammensetzung mittels kryogenen mahlens
CZ307492B6 (cs)	2014-02-04	2018-10-17	Zentiva, K.S.	Pevná forma maleátu tapentadolu a způsob její přípravy
GB2523089A (en) *	2014-02-12	2015-08-19	Azad Pharmaceutical Ingredients Ag	Stable polymorph form B of tapentadol hydrochloride
WO2015173195A1 (en)	2014-05-12	2015-11-19	Grünenthal GmbH	Tamper resistant immediate release capsule formulation comprising tapentadol
EA201692388A1 (ru)	2014-05-26	2017-05-31	Грюненталь Гмбх	Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
PE20171651A1 (es)	2015-03-27	2017-11-13	Gruenenthal Chemie	Formulacion estable para administracion parenteral de tapentadol
WO2016170097A1 (en)	2015-04-24	2016-10-27	Grünenthal GmbH	Tamper-resistant dosage form with immediate release and resistance against solvent extraction
JP2018526414A (ja)	2015-09-10	2018-09-13	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	乱用抑止性の即放性製剤を用いた経口過剰摂取に対する保護
PL3445742T3 (pl)	2016-04-19	2020-05-18	Ratiopharm Gmbh	Krystaliczny fosforan tapentadolu
EP3515412B1 (de)	2016-09-23	2025-04-23	Grünenthal GmbH	Stabile formulierungen zur parenteralen verabreichung von tapentadol
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PT1612203E (pt) *	2004-06-28	2007-08-20	Gruenenthal Gmbh	''formas cristalinas de cloridrato de (-) - (1r,2r) - 3 -(3-dimetilamino-l-etil - 2 - metilpropil) fenol''
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2004
- 2004-06-28 PT PT04015091T patent/PT1612203E/pt unknown
- 2004-06-28 PL PL04015091T patent/PL1612203T3/pl unknown
- 2004-06-28 DE DE602004007905T patent/DE602004007905T2/de not_active Expired - Lifetime
- 2004-06-28 EP EP04015091A patent/EP1612203B1/de not_active Expired - Lifetime
- 2004-06-28 AT AT04015091T patent/ATE368639T1/de active
- 2004-06-28 SI SI200430461T patent/SI1612203T1/sl unknown
- 2004-06-28 DK DK04015091T patent/DK1612203T3/da active
- 2004-06-28 ES ES04015091T patent/ES2291780T3/es not_active Expired - Lifetime
2005
- 2005-06-27 AU AU2005256512A patent/AU2005256512B2/en not_active Expired
- 2005-06-27 PL PL05770026T patent/PL1799633T3/pl unknown
- 2005-06-27 EP EP05770026A patent/EP1799633B1/de not_active Expired - Lifetime
- 2005-06-27 PE PE2005000742A patent/PE20060372A1/es active IP Right Grant
- 2005-06-27 JP JP2007518520A patent/JP4990764B2/ja not_active Expired - Lifetime
- 2005-06-27 MX MXPA06014741A patent/MXPA06014741A/es active IP Right Grant
- 2005-06-27 DK DK05770026.2T patent/DK1799633T3/da active
- 2005-06-27 CN CN2005800216611A patent/CN1997621B/zh not_active Expired - Fee Related
- 2005-06-27 BR BRPI0512792-0A patent/BRPI0512792A/pt not_active Application Discontinuation
- 2005-06-27 NZ NZ551605A patent/NZ551605A/en not_active IP Right Cessation
- 2005-06-27 HR HR20110050T patent/HRP20110050T8/xx unknown
- 2005-06-27 WO PCT/EP2005/006884 patent/WO2006000441A2/en not_active Ceased
- 2005-06-27 CA CA2572147A patent/CA2572147C/en not_active Expired - Lifetime
- 2005-06-27 ES ES05770026T patent/ES2359504T3/es not_active Expired - Lifetime
- 2005-06-27 PT PT05770026T patent/PT1799633E/pt unknown
- 2005-06-27 KR KR1020077002099A patent/KR101096501B1/ko not_active Expired - Lifetime
- 2005-06-27 RU RU2007103297/04A patent/RU2423345C2/ru active
- 2005-06-27 DE DE602005026031T patent/DE602005026031D1/de not_active Expired - Lifetime
- 2005-06-27 BR BR122018014454A patent/BR122018014454B8/pt active IP Right Grant
- 2005-06-27 SI SI200531252T patent/SI1799633T1/sl unknown
- 2005-06-27 AT AT05770026T patent/ATE496021T1/de active
- 2005-06-28 AR ARP050102663A patent/AR049949A1/es not_active Application Discontinuation
2006
- 2006-12-26 IL IL180373A patent/IL180373A/en active IP Right Grant
- 2006-12-28 US US11/646,232 patent/US20070213405A1/en not_active Abandoned
2007
- 2007-01-09 NO NO20070162A patent/NO338605B1/no unknown
- 2007-01-26 ZA ZA200700774A patent/ZA200700774B/xx unknown
- 2007-10-11 CY CY20071101312T patent/CY1106929T1/el unknown
2008
- 2008-11-20 US US12/274,747 patent/US20090186947A1/en not_active Abandoned
2009
- 2009-12-10 US US12/634,777 patent/US7994364B2/en not_active Expired - Lifetime
2011
- 2011-02-16 CY CY20111100192T patent/CY1111530T1/el unknown
- 2011-06-29 US US13/172,009 patent/US20110294898A1/en not_active Abandoned
2012
- 2012-08-03 US US13/565,867 patent/US20120302643A1/en not_active Abandoned
2013
- 2013-06-21 US US13/923,891 patent/US20140011886A1/en not_active Abandoned
2014
- 2014-06-13 US US14/304,313 patent/US20140296346A1/en not_active Abandoned
2015
- 2015-11-02 US US14/930,337 patent/US20160122287A1/en not_active Abandoned
2016
- 2016-05-30 NO NO20160914A patent/NO341239B1/no unknown
2017
- 2017-02-09 US US15/428,613 patent/US20170166515A1/en not_active Abandoned
- 2017-07-04 NO NO20171103A patent/NO343922B1/no unknown
- 2017-07-17 EC ECIEPI201746065A patent/ECSP17046065A/es unknown
- 2017-10-05 US US15/725,967 patent/US20180029976A1/en not_active Abandoned
2018
- 2018-04-12 US US15/951,838 patent/US20180230082A1/en not_active Abandoned
- 2018-10-26 US US16/172,100 patent/US20190062263A1/en not_active Abandoned
2019
- 2019-09-02 AR ARP190102495A patent/AR116052A2/es not_active Application Discontinuation
- 2019-10-14 US US16/600,884 patent/US20200102261A1/en not_active Abandoned
2020
- 2020-06-23 US US16/909,123 patent/US20200385334A1/en not_active Abandoned
2021
- 2021-03-08 US US17/194,717 patent/US20210261492A1/en not_active Abandoned
2023
- 2023-01-30 US US18/103,410 patent/US20230174458A1/en not_active Abandoned

Also Published As

Publication number	Publication date
IL180373A0 (en)	2007-06-03
PL1799633T3 (pl)	2011-06-30
US20200102261A1 (en)	2020-04-02
NZ551605A (en)	2010-01-29
US20140296346A1 (en)	2014-10-02
NO20160914A1 (no)	2007-01-24
BR122018014454B8 (pt)	2021-07-27
BRPI0512792A (pt)	2008-04-08
HRP20110050T8 (en)	2011-03-31
CY1111530T1 (el)	2015-08-05
AU2005256512B2 (en)	2011-05-19
CN1997621A (zh)	2007-07-11
DE602004007905T2 (de)	2008-05-08
SI1799633T1 (sl)	2011-05-31
US20180029976A1 (en)	2018-02-01
US20100160447A1 (en)	2010-06-24
ES2359504T3 (es)	2011-05-24
DE602004007905D1 (de)	2007-09-13
US20170166515A1 (en)	2017-06-15
NO338605B1 (no)	2016-09-12
SI1612203T1 (sl)	2007-12-31
PL1612203T3 (pl)	2007-12-31
CA2572147C (en)	2012-10-30
PE20060372A1 (es)	2006-05-08
KR20070039929A (ko)	2007-04-13
ES2291780T3 (es)	2008-03-01
CY1106929T1 (el)	2012-09-26
US20210261492A1 (en)	2021-08-26
AU2005256512A1 (en)	2006-01-05
HRP20110050T1 (hr)	2011-02-28
US20110294898A1 (en)	2011-12-01
WO2006000441A2 (en)	2006-01-05
US20200385334A1 (en)	2020-12-10
NO20070162L (no)	2007-01-24
CN1997621B (zh)	2011-06-15
EP1612203A1 (de)	2006-01-04
WO2006000441A3 (en)	2006-05-04
EP1612203B1 (de)	2007-08-01
NO341239B1 (no)	2017-09-25
NO20171103A1 (no)	2007-01-24
JP2008504326A (ja)	2008-02-14
AR116052A2 (es)	2021-03-25
US7994364B2 (en)	2011-08-09
US20140011886A1 (en)	2014-01-09
US20160122287A1 (en)	2016-05-05
US20180230082A1 (en)	2018-08-16
JP4990764B2 (ja)	2012-08-01
US20070213405A1 (en)	2007-09-13
IL180373A (en)	2012-05-31
PT1612203E (pt)	2007-08-20
MXPA06014741A (es)	2007-02-12
DE602005026031D1 (de)	2011-03-03
EP1799633A2 (de)	2007-06-27
RU2007103297A (ru)	2008-08-10
AR049949A1 (es)	2006-09-20
EP1799633B1 (de)	2011-01-19
ATE368639T1 (de)	2007-08-15
CA2572147A1 (en)	2006-01-05
BR122018014454B1 (pt)	2019-09-03
PT1799633E (pt)	2011-03-07
US20230174458A1 (en)	2023-06-08
US20190062263A1 (en)	2019-02-28
ECSP17046065A (es)	2018-11-30
DK1799633T3 (da)	2011-03-28
ZA200700774B (en)	2008-09-25
RU2423345C2 (ru)	2011-07-10
KR101096501B1 (ko)	2011-12-20
US20090186947A1 (en)	2009-07-23
DK1612203T3 (da)	2007-12-03
NO343922B1 (no)	2019-07-08
US20120302643A1 (en)	2012-11-29

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