PL1612203T3 - Krystaliczne postacie chlorowodorku (-)-(1R,2R)-3-(3-dimetyloamino-1-etylo-2-metylo-propylo)fenolu - Google Patents

Krystaliczne postacie chlorowodorku (-)-(1R,2R)-3-(3-dimetyloamino-1-etylo-2-metylo-propylo)fenolu

Info

Publication number: PL1612203T3
Authority: PL; Poland
Prior art keywords: methylpropyl; dimethylamino; ethyl; crystalline forms; phenol hydrochloride
Prior art date: 2004-06-28

Application number

PL04015091T

Other languages

English (en)

Inventor

Andreas Fischer

Helmut Buschmann

Michael Gruss

Dagmar Lischke

Original Assignee

Gruenenthal Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-06-28

Filing date

2004-06-28

Publication date

2007-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34925507&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1612203(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2004-06-28 Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh

2007-12-31 Publication of PL1612203T3 publication Critical patent/PL1612203T3/pl

Links

ZELFLGGRLLOERW-YECZQDJWSA-N 3-[(2r,3r)-1-(dimethylamino)-2-methylpentan-3-yl]phenol;hydrochloride Chemical compound Cl.CN(C)C[C@H](C)[C@@H](CC)C1=CC=CC(O)=C1 ZELFLGGRLLOERW-YECZQDJWSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/62—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Hematology (AREA)
Rheumatology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

PL04015091T 2004-06-28 2004-06-28 Krystaliczne postacie chlorowodorku (-)-(1R,2R)-3-(3-dimetyloamino-1-etylo-2-metylo-propylo)fenolu PL1612203T3 (pl)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP04015091A EP1612203B1 (en)	2004-06-28	2004-06-28	Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride

Publications (1)

Publication Number	Publication Date
PL1612203T3 true PL1612203T3 (pl)	2007-12-31

Family

ID=34925507

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PL04015091T PL1612203T3 (pl)	2004-06-28	2004-06-28	Krystaliczne postacie chlorowodorku (-)-(1R,2R)-3-(3-dimetyloamino-1-etylo-2-metylo-propylo)fenolu
PL05770026T PL1799633T3 (pl)	2004-06-28	2005-06-27	Krystaliczne postacie chlorowodorku (-)-(1R,2R)-3-(3-dimetyloamino-1-etylo-2-metylopropylo)-fenolu do stosowania jako składnik aktywny w kompozycjach farmaceutycznych

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
PL05770026T PL1799633T3 (pl)	2004-06-28	2005-06-27	Krystaliczne postacie chlorowodorku (-)-(1R,2R)-3-(3-dimetyloamino-1-etylo-2-metylopropylo)-fenolu do stosowania jako składnik aktywny w kompozycjach farmaceutycznych

Country Status (27)

Country	Link
US (16)	US20070213405A1 (pl)
EP (2)	EP1612203B1 (pl)
JP (1)	JP4990764B2 (pl)
KR (1)	KR101096501B1 (pl)
CN (1)	CN1997621B (pl)
AR (2)	AR049949A1 (pl)
AT (2)	ATE368639T1 (pl)
AU (1)	AU2005256512B2 (pl)
BR (2)	BRPI0512792A (pl)
CA (1)	CA2572147C (pl)
CY (2)	CY1106929T1 (pl)
DE (2)	DE602004007905T2 (pl)
DK (2)	DK1612203T3 (pl)
EC (1)	ECSP17046065A (pl)
ES (2)	ES2291780T3 (pl)
HR (1)	HRP20110050T8 (pl)
IL (1)	IL180373A (pl)
MX (1)	MXPA06014741A (pl)
NO (3)	NO338605B1 (pl)
NZ (1)	NZ551605A (pl)
PE (1)	PE20060372A1 (pl)
PL (2)	PL1612203T3 (pl)
PT (2)	PT1612203E (pl)
RU (1)	RU2423345C2 (pl)
SI (2)	SI1612203T1 (pl)
WO (1)	WO2006000441A2 (pl)
ZA (1)	ZA200700774B (pl)

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DE10361596A1 (de)	2003-12-24	2005-09-29	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE602004007905T2 (de) *	2004-06-28	2008-05-08	Grünenthal GmbH	Kristalline Formen von (-)-(1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochlorid
DE102004032049A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Gegen Missbrauch gesicherte, orale Darreichungsform
DE102005005449A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102007011485A1 (de)	2007-03-07	2008-09-11	Grünenthal GmbH	Darreichungsform mit erschwertem Missbrauch
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WO2009071310A1 (de) *	2007-12-07	2009-06-11	Grünenthal GmbH	Kristalline modifikationen von (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
KR101616246B1 (ko)	2008-01-25	2016-05-02	그뤼넨탈 게엠베하	약제학적 투여형
AU2009243681B2 (en)	2008-05-09	2013-12-19	Grunenthal Gmbh	Process for the preparation of an intermediate powder formulation and a final solid dosage form under usage of a spray congealing step
US20100272815A1 (en) *	2009-04-28	2010-10-28	Actavis Group Ptc Ehf	Amorphous form of tapentadol hydrochloride
TWI473628B (zh)	2009-07-22	2015-02-21		用於對氧化敏感之類鴉片藥劑之抗破壞劑型
WO2011009602A1 (en)	2009-07-22	2011-01-27	Grünenthal GmbH	Hot-melt extruded controlled release dosage form
US8288592B2 (en)	2009-09-22	2012-10-16	Actavis Group Ptc Ehf	Solid state forms of tapentadol salts
EP2566461A2 (de)	2010-05-05	2013-03-13	Ratiopharm GmbH	Festes tapentadol in nicht-kristalliner form
EP3597628A1 (en)	2010-07-23	2020-01-22	Grünenthal GmbH	Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
WO2012028318A1 (en)	2010-09-02	2012-03-08	Grünenthal GmbH	Tamper resistant dosage form comprising an anionic polymer
CA2808219C (en)	2010-09-02	2019-05-14	Gruenenthal Gmbh	Tamper resistant dosage form comprising inorganic salt
WO2012051246A1 (en)	2010-10-12	2012-04-19	Ratiopharm Gmbh	Tapentadol hydrobromide and crystalline forms thereof
KR101946790B1 (ko)	2011-03-04	2019-02-13	그뤼넨탈 게엠베하	경구 투여를 위한 타펜타돌의 수성 약제학적 제형
RS56692B1 (sr)	2011-03-04	2018-03-30	Gruenenthal Gmbh	Polučvrsta vodena farmaceutska kompozicija koja sadrži tapentadol
CA2828635C (en) *	2011-03-04	2020-01-14	Grunenthal Gmbh	Parenteral administration of tapentadol
ES2648129T3 (es)	2011-07-29	2017-12-28	Grünenthal GmbH	Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento
AU2012289764B2 (en)	2011-07-29	2017-03-02	Grünenthal GmbH	Tamper-resistant tablet providing immediate drug release
WO2013111161A2 (en) *	2012-01-10	2013-08-01	Msn Laboratories Limited	Process for the preparation of 3-aryl-2-methyl-propanamine derivatives and polymorphs thereof
WO2013120466A1 (en)	2012-02-17	2013-08-22	Zentiva, K.S.	A new solid form of tapentadol and a method of its preparation
US20130225697A1 (en)	2012-02-28	2013-08-29	Grunenthal Gmbh	Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer
PL2838512T3 (pl)	2012-04-18	2018-12-31	Grünenthal GmbH	Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki
US10064945B2 (en)	2012-05-11	2018-09-04	Gruenenthal Gmbh	Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc
CZ304576B6 (cs) *	2012-07-24	2014-07-16	Zentiva, K.S.	Oxalát TAPENTADOLU a způsob jeho přípravy
CN102924303B (zh) *	2012-10-31	2013-11-20	合肥市新星医药化工有限公司	盐酸他喷他多晶型c及其制备方法和应用
AU2014273227B2 (en)	2013-05-29	2019-08-15	Grunenthal Gmbh	Tamper-resistant dosage form containing one or more particles
JP6466417B2 (ja)	2013-05-29	2019-02-06	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形
EP2808319A1 (en)	2013-05-31	2014-12-03	Arevipharma GmbH	3-[3-(Dimethylamino)-1-ethyl-2-methylpropyl]phenol resin complex
JP6449871B2 (ja)	2013-07-12	2019-01-09	グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング	エチレン−酢酸ビニルポリマーを含有する改変防止剤形
EP2845625A1 (en) *	2013-09-04	2015-03-11	Grünenthal GmbH	Tapentadol for use in the treatment of fibromyalgia and chronic fatigue syndrome
USD730877S1 (en)	2013-09-06	2015-06-02	Plantronics, Inc.	Communications headset
US9599565B1 (en) *	2013-10-02	2017-03-21	Ondax, Inc.	Identification and analysis of materials and molecular structures
WO2015071248A1 (en)	2013-11-15	2015-05-21	Synthon B.V.	Abuse-proofed extended release pharmaceutical composition comprising tapentadol
EP3073994A1 (en)	2013-11-26	2016-10-05	Grünenthal GmbH	Preparation of a powdery pharmaceutical composition by means of cryo-milling
CZ307492B6 (cs)	2014-02-04	2018-10-17	Zentiva, K.S.	Pevná forma maleátu tapentadolu a způsob její přípravy
GB2523089A (en) *	2014-02-12	2015-08-19	Azad Pharmaceutical Ingredients Ag	Stable polymorph form B of tapentadol hydrochloride
EP3142646A1 (en)	2014-05-12	2017-03-22	Grünenthal GmbH	Tamper resistant immediate release capsule formulation comprising tapentadol
EA201692388A1 (ru)	2014-05-26	2017-05-31	Грюненталь Гмбх	Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
EP3273953B1 (en)	2015-03-27	2019-01-02	Grünenthal GmbH	Stable formulation for parenteral administration of tapentadol
BR112017021475A2 (pt)	2015-04-24	2018-07-10	Gruenenthal Gmbh	forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
WO2017042325A1 (en)	2015-09-10	2017-03-16	Grünenthal GmbH	Protecting oral overdose with abuse deterrent immediate release formulations
PT3445742T (pt)	2016-04-19	2020-02-19	Ratiopharm Gmbh	Fosfato de tapentadol cristalino
CN109996533A (zh)	2016-09-23	2019-07-09	格吕伦塔尔有限公司	用于肠胃外施用他喷他多的稳定制剂
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DE4426245A1 (de)	1994-07-23	1996-02-22	Gruenenthal Gmbh	1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
TR199900298T2 (xx) *	1996-08-14	1999-05-21	G.D. Searle &Co.	4-(5-Metil-3-fenilizoksazol-4-il) BenzenS�lfonamidin kristal halinde bi�imi.
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PE20030527A1 (es) *	2001-10-24	2003-07-26	Gruenenthal Chemie	Formulacion farmaceutica con liberacion retardada que contiene 3-(3-dimetilamino-1-etil-2-metil-propil) fenol o una sal farmaceuticamente aceptable del mismo y tabletas para administracion oral que la contienen
DE602004007905T2 (de) *	2004-06-28	2008-05-08	Grünenthal GmbH	Kristalline Formen von (-)-(1R,2R)-3-(3-Dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochlorid
WO2009071310A1 (de) *	2007-12-07	2009-06-11	Grünenthal GmbH	Kristalline modifikationen von (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol

2004
- 2004-06-28 DE DE602004007905T patent/DE602004007905T2/de not_active Expired - Lifetime
- 2004-06-28 AT AT04015091T patent/ATE368639T1/de active
- 2004-06-28 SI SI200430461T patent/SI1612203T1/sl unknown
- 2004-06-28 ES ES04015091T patent/ES2291780T3/es not_active Expired - Lifetime
- 2004-06-28 DK DK04015091T patent/DK1612203T3/da active
- 2004-06-28 PL PL04015091T patent/PL1612203T3/pl unknown
- 2004-06-28 PT PT04015091T patent/PT1612203E/pt unknown
- 2004-06-28 EP EP04015091A patent/EP1612203B1/en not_active Expired - Lifetime
2005
- 2005-06-27 EP EP05770026A patent/EP1799633B1/en not_active Expired - Lifetime
- 2005-06-27 MX MXPA06014741A patent/MXPA06014741A/es active IP Right Grant
- 2005-06-27 JP JP2007518520A patent/JP4990764B2/ja not_active Expired - Lifetime
- 2005-06-27 BR BRPI0512792-0A patent/BRPI0512792A/pt not_active Application Discontinuation
- 2005-06-27 CA CA2572147A patent/CA2572147C/en not_active Expired - Lifetime
- 2005-06-27 AT AT05770026T patent/ATE496021T1/de active
- 2005-06-27 PL PL05770026T patent/PL1799633T3/pl unknown
- 2005-06-27 AU AU2005256512A patent/AU2005256512B2/en not_active Expired
- 2005-06-27 RU RU2007103297/04A patent/RU2423345C2/ru active
- 2005-06-27 DK DK05770026.2T patent/DK1799633T3/da active
- 2005-06-27 HR HR20110050T patent/HRP20110050T8/xx unknown
- 2005-06-27 BR BR122018014454A patent/BR122018014454B8/pt active IP Right Grant
- 2005-06-27 NZ NZ551605A patent/NZ551605A/en not_active IP Right Cessation
- 2005-06-27 PT PT05770026T patent/PT1799633E/pt unknown
- 2005-06-27 KR KR1020077002099A patent/KR101096501B1/ko not_active Expired - Lifetime
- 2005-06-27 PE PE2005000742A patent/PE20060372A1/es active IP Right Grant
- 2005-06-27 CN CN2005800216611A patent/CN1997621B/zh not_active Expired - Fee Related
- 2005-06-27 ES ES05770026T patent/ES2359504T3/es not_active Expired - Lifetime
- 2005-06-27 SI SI200531252T patent/SI1799633T1/sl unknown
- 2005-06-27 DE DE602005026031T patent/DE602005026031D1/de not_active Expired - Lifetime
- 2005-06-27 WO PCT/EP2005/006884 patent/WO2006000441A2/en not_active Ceased
- 2005-06-28 AR ARP050102663A patent/AR049949A1/es not_active Application Discontinuation
2006
- 2006-12-26 IL IL180373A patent/IL180373A/en active IP Right Grant
- 2006-12-28 US US11/646,232 patent/US20070213405A1/en not_active Abandoned
2007
- 2007-01-09 NO NO20070162A patent/NO338605B1/no unknown
- 2007-01-26 ZA ZA200700774A patent/ZA200700774B/xx unknown
- 2007-10-11 CY CY20071101312T patent/CY1106929T1/el unknown
2008
- 2008-11-20 US US12/274,747 patent/US20090186947A1/en not_active Abandoned
2009
- 2009-12-10 US US12/634,777 patent/US7994364B2/en not_active Expired - Lifetime
2011
- 2011-02-16 CY CY20111100192T patent/CY1111530T1/el unknown
- 2011-06-29 US US13/172,009 patent/US20110294898A1/en not_active Abandoned
2012
- 2012-08-03 US US13/565,867 patent/US20120302643A1/en not_active Abandoned
2013
- 2013-06-21 US US13/923,891 patent/US20140011886A1/en not_active Abandoned
2014
- 2014-06-13 US US14/304,313 patent/US20140296346A1/en not_active Abandoned
2015
- 2015-11-02 US US14/930,337 patent/US20160122287A1/en not_active Abandoned
2016
- 2016-05-30 NO NO20160914A patent/NO341239B1/no unknown
2017
- 2017-02-09 US US15/428,613 patent/US20170166515A1/en not_active Abandoned
- 2017-07-04 NO NO20171103A patent/NO343922B1/no unknown
- 2017-07-17 EC ECIEPI201746065A patent/ECSP17046065A/es unknown
- 2017-10-05 US US15/725,967 patent/US20180029976A1/en not_active Abandoned
2018
- 2018-04-12 US US15/951,838 patent/US20180230082A1/en not_active Abandoned
- 2018-10-26 US US16/172,100 patent/US20190062263A1/en not_active Abandoned
2019
- 2019-09-02 AR ARP190102495A patent/AR116052A2/es not_active Application Discontinuation
- 2019-10-14 US US16/600,884 patent/US20200102261A1/en not_active Abandoned
2020
- 2020-06-23 US US16/909,123 patent/US20200385334A1/en not_active Abandoned
2021
- 2021-03-08 US US17/194,717 patent/US20210261492A1/en not_active Abandoned
2023
- 2023-01-30 US US18/103,410 patent/US20230174458A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1612203B1 (en)	2007-08-01
CY1106929T1 (el)	2012-09-26
US20180029976A1 (en)	2018-02-01
US20210261492A1 (en)	2021-08-26
AR049949A1 (es)	2006-09-20
NZ551605A (en)	2010-01-29
PE20060372A1 (es)	2006-05-08
EP1799633B1 (en)	2011-01-19
US7994364B2 (en)	2011-08-09
WO2006000441A3 (en)	2006-05-04
NO20070162L (no)	2007-01-24
KR101096501B1 (ko)	2011-12-20
HRP20110050T1 (hr)	2011-02-28
NO343922B1 (no)	2019-07-08
ES2359504T3 (es)	2011-05-24
ECSP17046065A (es)	2018-11-30
MXPA06014741A (es)	2007-02-12
JP2008504326A (ja)	2008-02-14
US20230174458A1 (en)	2023-06-08
SI1612203T1 (sl)	2007-12-31
KR20070039929A (ko)	2007-04-13
US20180230082A1 (en)	2018-08-16
AU2005256512B2 (en)	2011-05-19
US20090186947A1 (en)	2009-07-23
RU2423345C2 (ru)	2011-07-10
PL1799633T3 (pl)	2011-06-30
ES2291780T3 (es)	2008-03-01
CY1111530T1 (el)	2015-08-05
BRPI0512792A (pt)	2008-04-08
DK1799633T3 (da)	2011-03-28
CN1997621A (zh)	2007-07-11
DK1612203T3 (da)	2007-12-03
US20160122287A1 (en)	2016-05-05
HRP20110050T8 (en)	2011-03-31
ATE496021T1 (de)	2011-02-15
US20200102261A1 (en)	2020-04-02
US20200385334A1 (en)	2020-12-10
IL180373A (en)	2012-05-31
US20120302643A1 (en)	2012-11-29
EP1612203A1 (en)	2006-01-04
DE602004007905D1 (de)	2007-09-13
NO338605B1 (no)	2016-09-12
SI1799633T1 (sl)	2011-05-31
US20190062263A1 (en)	2019-02-28
WO2006000441A2 (en)	2006-01-05
US20140296346A1 (en)	2014-10-02
IL180373A0 (en)	2007-06-03
AU2005256512A1 (en)	2006-01-05
CA2572147A1 (en)	2006-01-05
PT1799633E (pt)	2011-03-07
ZA200700774B (en)	2008-09-25
CN1997621B (zh)	2011-06-15
US20170166515A1 (en)	2017-06-15
PT1612203E (pt)	2007-08-20
US20110294898A1 (en)	2011-12-01
CA2572147C (en)	2012-10-30
ATE368639T1 (de)	2007-08-15
US20140011886A1 (en)	2014-01-09
DE602004007905T2 (de)	2008-05-08
NO341239B1 (no)	2017-09-25
BR122018014454B8 (pt)	2021-07-27
NO20171103A1 (no)	2007-01-24
JP4990764B2 (ja)	2012-08-01
RU2007103297A (ru)	2008-08-10
US20100160447A1 (en)	2010-06-24
US20070213405A1 (en)	2007-09-13
AR116052A2 (es)	2021-03-25
BR122018014454B1 (pt)	2019-09-03
EP1799633A2 (en)	2007-06-27
NO20160914A1 (no)	2007-01-24
DE602005026031D1 (de)	2011-03-03

Publication	Publication Date	Title
ZA200700774B (en)	2008-09-25	Crystalline forms of (-)-(1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropyl)-phenol hydrochloride
IL255201A0 (en)	2017-12-31	Process for the preparation of (r2, 1r)-3-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
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HK1105644A (en)	2008-02-22	Polymorph of n,n-diethyl-4-(3-fluorophenyl-piperidin-4-ylidene-methyl)-benzamide hydrochloride salt