ATE496934T1 - Makrocyclische inhibitoren des hepatitis-c-virus - Google Patents

Makrocyclische inhibitoren des hepatitis-c-virus

Info

Publication number
ATE496934T1
ATE496934T1 AT06764263T AT06764263T ATE496934T1 AT E496934 T1 ATE496934 T1 AT E496934T1 AT 06764263 T AT06764263 T AT 06764263T AT 06764263 T AT06764263 T AT 06764263T AT E496934 T1 ATE496934 T1 AT E496934T1
Authority
AT
Austria
Prior art keywords
hepatitis
virus
macrocyclic inhibitors
macrocyclic
inhibitors
Prior art date
Application number
AT06764263T
Other languages
English (en)
Inventor
Kock Herman De
Pierre Raboisson
Kenneth Simmen
Mats Stefan Lindstroem
Pia Cecilia Kahnberg
Dmitry Antonov
Karl Magnus Nilsson
Bengt Bertil Samuelsson
Asa Annica Rosenquist
Original Assignee
Tibotec Pharm Ltd
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd, Medivir Ab filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of ATE496934T1 publication Critical patent/ATE496934T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT06764263T 2005-07-29 2006-07-28 Makrocyclische inhibitoren des hepatitis-c-virus ATE496934T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05107066 2005-07-29
EP06101278 2006-02-03
PCT/EP2006/064812 WO2007014918A1 (en) 2005-07-29 2006-07-28 Macrocyclic inhibitors of hepatitis c virus

Publications (1)

Publication Number Publication Date
ATE496934T1 true ATE496934T1 (de) 2011-02-15

Family

ID=37102945

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06764263T ATE496934T1 (de) 2005-07-29 2006-07-28 Makrocyclische inhibitoren des hepatitis-c-virus

Country Status (31)

Country Link
US (1) US8008251B2 (de)
EP (1) EP1913014B1 (de)
JP (1) JP5508713B2 (de)
KR (1) KR101321392B1 (de)
CN (1) CN101233147B (de)
AR (1) AR054881A1 (de)
AT (1) ATE496934T1 (de)
AU (1) AU2006274857B2 (de)
BR (1) BRPI0614515A2 (de)
CA (1) CA2616954C (de)
CY (1) CY1112001T1 (de)
DE (1) DE602006019879D1 (de)
DK (1) DK1913014T3 (de)
EA (1) EA200800485A1 (de)
GT (1) GT200600340A (de)
HR (1) HRP20110289T1 (de)
IL (1) IL188281A (de)
ME (1) ME01233B (de)
MX (1) MX2008001394A (de)
MY (1) MY139987A (de)
NO (1) NO20081074L (de)
NZ (1) NZ564542A (de)
PE (1) PE20070210A1 (de)
PL (1) PL1913014T3 (de)
PT (1) PT1913014E (de)
RS (1) RS51776B (de)
SG (1) SG163610A1 (de)
SI (1) SI1913014T1 (de)
TW (1) TWI437993B (de)
UY (1) UY29702A1 (de)
WO (1) WO2007014918A1 (de)

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MY140680A (en) 2002-05-20 2010-01-15 Bristol Myers Squibb Co Hepatitis c virus inhibitors
PL1713822T3 (pl) 2004-01-30 2010-08-31 Medivir Ab Inhibitory proteazy serynowej HCV NS-3
WO2006116053A1 (en) * 2005-04-22 2006-11-02 Sciclone Pharmaceuticals, Inc. Immunomodulator compounds as vaccine enhancers
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
US7741281B2 (en) 2005-11-03 2010-06-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7935670B2 (en) 2006-07-11 2011-05-03 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8343477B2 (en) 2006-11-01 2013-01-01 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
US7772180B2 (en) 2006-11-09 2010-08-10 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7763584B2 (en) 2006-11-16 2010-07-27 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8003604B2 (en) 2006-11-16 2011-08-23 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
BRPI0718798A2 (pt) * 2006-11-17 2013-12-03 Tibotec Pharm Ltd Inibidores macrocíclicos de vírus da hepatite c
US8383583B2 (en) 2007-10-26 2013-02-26 Enanta Pharmaceuticals, Inc. Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
US8202996B2 (en) 2007-12-21 2012-06-19 Bristol-Myers Squibb Company Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
ES2437147T3 (es) 2008-02-04 2014-01-09 Idenix Pharmaceuticals, Inc. Inhibidores de serina proteasa macrocíclicos
CN102015652A (zh) 2008-03-20 2011-04-13 益安药业 作为丙型肝炎病毒抑制剂的氟化大环化合物
US8163921B2 (en) 2008-04-16 2012-04-24 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
EP2300491B1 (de) 2008-05-29 2016-01-06 Bristol-Myers Squibb Company Inhibitoren des hepatitis-c-virus
US7964560B2 (en) 2008-05-29 2011-06-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8207341B2 (en) 2008-09-04 2012-06-26 Bristol-Myers Squibb Company Process or synthesizing substituted isoquinolines
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8563505B2 (en) 2008-09-29 2013-10-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
TW201040181A (en) 2009-04-08 2010-11-16 Idenix Pharmaceuticals Inc Macrocyclic serine protease inhibitors
EP2461811B1 (de) 2009-08-05 2016-04-20 Idenix Pharmaceuticals LLC. Makrocyclische serinproteasehemmer gegen virale infektionen, im besonderen hvc
AR085352A1 (es) 2011-02-10 2013-09-25 Idenix Pharmaceuticals Inc Inhibidores macrociclicos de serina proteasa, sus composiciones farmaceuticas y su uso para tratar infecciones por hcv
US8957203B2 (en) 2011-05-05 2015-02-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8691757B2 (en) 2011-06-15 2014-04-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9207002B2 (en) 2011-10-12 2015-12-08 International Business Machines Corporation Contaminant separator for a vapor-compression refrigeration apparatus
EA025560B1 (ru) 2012-10-19 2017-01-30 Бристол-Майерс Сквибб Компани Ингибиторы вируса гепатита с
US9643999B2 (en) 2012-11-02 2017-05-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
WO2014070964A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
WO2014071007A1 (en) 2012-11-02 2014-05-08 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
EP2914614B1 (de) 2012-11-05 2017-08-16 Bristol-Myers Squibb Company Inhibitoren des hepatitis-c-virus
WO2014137869A1 (en) 2013-03-07 2014-09-12 Bristol-Myers Squibb Company Hepatitis c virus inhibitors
CN117186000A (zh) * 2023-08-16 2023-12-08 上海凌凯医药科技有限公司 一种喹啉类化合物的制备方法

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IL110752A (en) 1993-09-13 2000-07-26 Abbott Lab Liquid semi-solid or solid pharmaceutical composition for an HIV protease inhibitor
US5559158A (en) 1993-10-01 1996-09-24 Abbott Laboratories Pharmaceutical composition
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Also Published As

Publication number Publication date
SG163610A1 (en) 2010-08-30
HRP20110289T1 (hr) 2011-05-31
WO2007014918A1 (en) 2007-02-08
NO20081074L (no) 2008-04-29
DE602006019879D1 (de) 2011-03-10
US20080200503A1 (en) 2008-08-21
JP5508713B2 (ja) 2014-06-04
CY1112001T1 (el) 2015-11-04
MY139987A (en) 2009-11-30
GT200600340A (es) 2007-02-26
SI1913014T1 (sl) 2011-06-30
AU2006274857A1 (en) 2007-02-08
CA2616954A1 (en) 2007-02-08
CA2616954C (en) 2013-12-24
KR20080039430A (ko) 2008-05-07
CN101233147B (zh) 2012-06-20
IL188281A (en) 2015-01-29
AU2006274857B2 (en) 2012-11-29
HK1116503A1 (en) 2008-12-24
EP1913014B1 (de) 2011-01-26
BRPI0614515A2 (pt) 2011-03-29
EP1913014A1 (de) 2008-04-23
IL188281A0 (en) 2008-04-13
RS51776B (sr) 2011-12-31
US8008251B2 (en) 2011-08-30
TWI437993B (zh) 2014-05-21
UY29702A1 (es) 2007-05-31
PT1913014E (pt) 2011-04-20
AR054881A1 (es) 2007-07-25
KR101321392B1 (ko) 2013-10-30
CN101233147A (zh) 2008-07-30
JP2009502881A (ja) 2009-01-29
DK1913014T3 (da) 2011-08-01
PL1913014T3 (pl) 2011-06-30
TW200801044A (en) 2008-01-01
MX2008001394A (es) 2008-04-08
PE20070210A1 (es) 2007-04-16
ME01233B (me) 2013-06-20
EA200800485A1 (ru) 2009-04-28
NZ564542A (en) 2010-03-26

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