ATE496940T1 - Ghrelin-analoga - Google Patents

Ghrelin-analoga

Info

Publication number: ATE496940T1
Authority: AT; Austria
Prior art keywords: ghrelin analogue; ghrelin; analogue
Prior art date: 2002-07-23

Application number

AT03765930T

Other languages

English (en)

Inventor

Zheng Dong

Yeelana Shen

Original Assignee

Ipsen Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-23

Filing date

2003-07-23

Publication date

2011-02-15

2003-07-23 Application filed by Ipsen Pharma filed Critical Ipsen Pharma

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE496940T1 publication Critical patent/ATE496940T1/de

Links

GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical class C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title 1
229940121382 ghrelin analogues Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Obesity (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Virology (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Hospice & Palliative Care (AREA)
Gynecology & Obstetrics (AREA)
Tropical Medicine & Parasitology (AREA)
Oncology (AREA)

AT03765930T 2002-07-23 2003-07-23 Ghrelin-analoga ATE496940T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US39783402P	2002-07-23	2002-07-23
US42748802P	2002-11-19	2002-11-19
PCT/US2003/022925 WO2004009616A2 (en)	2002-07-23	2003-07-23	Ghrelin analogs

Publications (1)

Publication Number	Publication Date
ATE496940T1 true ATE496940T1 (de)	2011-02-15

Family

ID=34278194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03765930T ATE496940T1 (de)	2002-07-23	2003-07-23	Ghrelin-analoga

Country Status (18)

Country	Link
US (3)	US7589058B2 (de)
EP (2)	EP1578778B1 (de)
JP (2)	JP2006515271A (de)
KR (1)	KR101065471B1 (de)
AR (2)	AR040955A1 (de)
AT (1)	ATE496940T1 (de)
AU (1)	AU2003254119B2 (de)
BR (1)	BR0312871A (de)
CA (1)	CA2491946C (de)
DE (1)	DE60335913D1 (de)
IL (1)	IL166170A (de)
MX (1)	MXPA05000908A (de)
NO (1)	NO334857B1 (de)
PL (1)	PL212106B1 (de)
PT (1)	PT1578778E (de)
RU (3)	RU2315059C2 (de)
TW (1)	TWI325003B (de)
WO (1)	WO2004009616A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1578778B1 (de)	2002-07-23	2011-01-26	Ipsen Pharma	Ghrelin-analoga
EP1750745A1 (de) *	2004-05-11	2007-02-14	The United States of America, represented by the Secretary, Department of Health and Human Services	Verfahren zur hemmung der expression von proinflammatorischem cytokin unter verwendung von ghrelin
RU2427587C2 (ru) *	2005-09-28	2011-08-27	Ипсен Фарма С.А.С.	Аналоги грелина
WO2007038678A2 (en)	2005-09-28	2007-04-05	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Analogs of ghrelin
CN105381453B9 (zh)	2005-09-29	2019-01-11	益普生制药股份有限公司	用于刺激胃肠运动性的组合物和方法
US8992928B2 (en) *	2006-02-11	2015-03-31	Victor Raso	Isolated monoclonal antibody or antigen-binding fragment that cleaves octanoylated native ghrelin
WO2007106385A2 (en)	2006-03-10	2007-09-20	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment
US7981860B2 (en) *	2006-03-13	2011-07-19	Liat Mintz	Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite-stimulation
WO2008039415A2 (en) *	2006-09-27	2008-04-03	Ipsen Pharma S.A.S.	Analogs of ghrelin substituted at the n-terminal
WO2008067831A2 (en) *	2006-12-05	2008-06-12	Charite Universitätsmedizin - Berlin	Use of ghrelin, an analogue thereof or a pharmaceutically acceptable salt thereof
TW200916113A (en) *	2007-08-08	2009-04-16	Sod Conseils Rech Applic	Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue
US8883721B2 (en) *	2009-05-12	2014-11-11	Mcgill University	Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
US9724381B2 (en)	2009-05-12	2017-08-08	The Administrators Of The Tulane Educational Fund	Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
JP2013509434A (ja)	2009-10-30	2013-03-14	トランザイム・ファーマ，インコーポレイテッド	大環状グレリン受容体アンタゴニストおよびインバースアゴニストならびにその使用方法
WO2011159917A2 (en) *	2010-06-16	2011-12-22	The Administrators Of The Tulane Educational Fund	Growth hormone secretatogue receptor antagonists and uses thereof
JP5560248B2 (ja) *	2011-09-07	2014-07-23	花王株式会社	ジペプチド誘導体及びその製造方法
WO2013113916A2 (en) *	2012-02-03	2013-08-08	Zealand Pharma A/S	Ghrelin analogues
KR20220051197A (ko)	2012-05-17	2022-04-26	익스텐드 바이오사이언시즈, 인크.	개선된 약물 전달용 캐리어
US9119832B2 (en)	2014-02-05	2015-09-01	The Regents Of The University Of California	Methods of treating mild brain injury
WO2016065052A1 (en)	2014-10-22	2016-04-28	Extend Biosciences, Inc.	Insulin vitamin d conjugates
US9789197B2 (en)	2014-10-22	2017-10-17	Extend Biosciences, Inc.	RNAi vitamin D conjugates
US9585934B2 (en)	2014-10-22	2017-03-07	Extend Biosciences, Inc.	Therapeutic vitamin D conjugates
WO2017075535A1 (en)	2015-10-28	2017-05-04	Oxeia Biopharmaceuticals, Inc.	Methods of treating neurodegenerative conditions
CN108029863B (zh) *	2018-01-19	2021-07-27	广州英赛特生物技术有限公司	丁酰甘氨酸及其衍生物在制备动物饲料添加剂中的应用
EP4593867A2 (de)	2022-09-30	2025-08-06	Extend Biosciences, Inc.	Langwirkendes parathormon

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8821785D0 (en) *	1988-09-16	1988-10-19	Nycomed As	Peptide compounds
US5264565A (en)	1991-01-22	1993-11-23	Affymax Technologies, N.V.	Nucleic acid encoding the D2 /Ml chimeric receptor
DE69528531T2 (de) *	1994-09-27	2003-06-05	Ardana Bioscience Ltd., Edinburgh	D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
JPH10507934A (ja)	1995-07-26	1998-08-04	エヌピーエス・ファーマシウティカルズ・インコーポレイテッド	代謝指向型グルタミン酸受容体に活性を示す化合物を同定するためのキメラ受容体および方法、ならびに神経学的障害および疾患の治療におけるそのような化合物の使用
WO1997021730A1 (en)	1995-12-13	1997-06-19	Merck & Co., Inc.	Growth hormone secretagogue receptor family
PL205713B1 (pl) *	1998-12-07	2010-05-31	Sod Conseils Rech Applic	Związki stanowiące analogi GLP-1, kompozycje farmaceutyczne zawierające takie związki oraz zastosowanie tych związków
CN100506844C (zh) *	1999-07-23	2009-07-01	寒川贤治	新的肽
US6967237B2 (en) *	2000-05-30	2005-11-22	Merck & Co., Inc.	Ghrelin analogs
AU2001283938A1 (en) *	2000-07-24	2002-02-05	Ardana Bioscience Limited	Ghrelin antagonists
DK1573022T3 (da)	2001-04-10	2011-09-12	Agensys Inc	Nukleinsyre og tilsvarende protein betegnet 184P1E2, der er egnede til behandling og påvisning af cancer
EP1578778B1 (de)	2002-07-23	2011-01-26	Ipsen Pharma	Ghrelin-analoga

2003
- 2003-07-23 EP EP03765930A patent/EP1578778B1/de not_active Expired - Lifetime
- 2003-07-23 EP EP10181462A patent/EP2258381A3/de not_active Withdrawn
- 2003-07-23 CA CA2491946A patent/CA2491946C/en not_active Expired - Fee Related
- 2003-07-23 RU RU2005104841/04A patent/RU2315059C2/ru not_active IP Right Cessation
- 2003-07-23 AU AU2003254119A patent/AU2003254119B2/en not_active Ceased
- 2003-07-23 PT PT03765930T patent/PT1578778E/pt unknown
- 2003-07-23 TW TW092120152A patent/TWI325003B/zh not_active IP Right Cessation
- 2003-07-23 AR ARP030102647A patent/AR040955A1/es not_active Application Discontinuation
- 2003-07-23 PL PL377075A patent/PL212106B1/pl unknown
- 2003-07-23 AT AT03765930T patent/ATE496940T1/de not_active IP Right Cessation
- 2003-07-23 US US10/522,398 patent/US7589058B2/en not_active Expired - Fee Related
- 2003-07-23 DE DE60335913T patent/DE60335913D1/de not_active Expired - Lifetime
- 2003-07-23 KR KR1020057001095A patent/KR101065471B1/ko not_active Expired - Fee Related
- 2003-07-23 RU RU2007124275/04A patent/RU2373220C2/ru not_active IP Right Cessation
- 2003-07-23 MX MXPA05000908A patent/MXPA05000908A/es active IP Right Grant
- 2003-07-23 WO PCT/US2003/022925 patent/WO2004009616A2/en not_active Ceased
- 2003-07-23 JP JP2004523304A patent/JP2006515271A/ja active Pending
- 2003-07-23 BR BRPI0312871-7A patent/BR0312871A/pt not_active IP Right Cessation
2005
- 2005-01-06 IL IL166170A patent/IL166170A/en active IP Right Grant
- 2005-01-06 NO NO20050083A patent/NO334857B1/no not_active IP Right Cessation
2009
- 2009-02-27 JP JP2009046345A patent/JP2009161546A/ja active Pending
- 2009-06-16 US US12/456,429 patent/US8633151B2/en not_active Expired - Fee Related
- 2009-07-14 RU RU2009127162/04A patent/RU2009127162A/ru not_active Application Discontinuation
- 2009-08-20 AR ARP090103204A patent/AR073099A2/es not_active Application Discontinuation
2014
- 2014-01-17 US US14/157,770 patent/US9133261B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL212106B1 (pl)	2012-08-31
RU2009127162A (ru)	2011-01-20
TWI325003B (en)	2010-05-21
MXPA05000908A (es)	2005-07-22
US20100069299A1 (en)	2010-03-18
JP2009161546A (ja)	2009-07-23
IL166170A (en)	2011-01-31
US20050272648A1 (en)	2005-12-08
WO2004009616A3 (en)	2006-02-09
PT1578778E (pt)	2011-03-07
AU2003254119A1 (en)	2004-02-09
US8633151B2 (en)	2014-01-21
BR0312871A (pt)	2007-07-10
US7589058B2 (en)	2009-09-15
JP2006515271A (ja)	2006-05-25
EP1578778B1 (de)	2011-01-26
DE60335913D1 (de)	2011-03-10
US20140135260A1 (en)	2014-05-15
NO20050083L (no)	2005-03-23
RU2007124275A (ru)	2009-01-10
CA2491946C (en)	2013-05-28
RU2315059C2 (ru)	2008-01-20
NO334857B1 (no)	2014-06-23
EP2258381A3 (de)	2011-11-02
AU2003254119B2 (en)	2007-11-29
EP1578778A2 (de)	2005-09-28
EP1578778A4 (de)	2007-02-28
RU2373220C2 (ru)	2009-11-20
CA2491946A1 (en)	2004-01-29
KR20050026503A (ko)	2005-03-15
AR040955A1 (es)	2005-04-27
US9133261B2 (en)	2015-09-15
IL166170A0 (en)	2006-01-15
EP2258381A2 (de)	2010-12-08
TW200403253A (en)	2004-03-01
WO2004009616A2 (en)	2004-01-29
PL377075A1 (pl)	2006-01-23
RU2005104841A (ru)	2005-09-10
AR073099A2 (es)	2010-10-13
KR101065471B1 (ko)	2011-09-16

Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE390898T1 (de)	2008-04-15	Zwischenwirbelimplantat
ATE394087T1 (de)	2008-05-15	Zwischenwirbelimplantat
ATE394086T1 (de)	2008-05-15	Zwischenwirbelimplantat
DE60323499D1 (de)	2008-10-23	Tastverhältnisschätzer
DE60328364D1 (de)	2009-08-27	Abdominalretraktor
DE50313647D1 (de)	2011-06-01	Knochenfixationseinrichtumg
DE60321537D1 (de)	2008-07-24	Schtrockner
ATE318817T1 (de)	2006-03-15	Aza-arylpiperazine
DE60320334D1 (de)	2008-05-29	Klebwalzereiniger
DE60231753D1 (de)	2009-05-07	Betonsteintexturiermaschine
DE50301200D1 (de)	2005-10-20	Wischblatt
DE50311715D1 (de)	2009-08-27	Weltzeituhr
DE60335913D1 (de)	2011-03-10	Ghrelin-analoga
DE60330661D1 (de)	2010-02-04	Einführdichtungsanordnung
DE60226008D1 (de)	2008-05-21	Sicherheitsgurtpresentiereinrichtung
DE50309536D1 (de)	2008-05-15	Fadenabsaugvorrichtung
DE60318029D1 (de)	2008-01-24	Zünder
DE60228135D1 (de)	2008-09-18	Eifen
FR2843017B1 (fr)	2004-09-10	Implant inter-somatique
DE60302827D1 (de)	2006-01-26	Hochgeschwindigheitfräsmaschine
FI20021957A0 (fi)	2002-11-01	Lipeäruisku
FI5303U1 (fi)	2002-03-22	Ammesovitelma
ATA19152002A (de)	2004-11-15	Hubkupplung
DE60205924D1 (de)	2005-10-06	Mikrogreifer
DE60304326D1 (de)	2006-05-18	Wärmeniet