ATE496940T1 - Ghrelin-analoga - Google Patents

Ghrelin-analoga

Info

Publication number: ATE496940T1
Authority: AT; Austria
Prior art keywords: ghrelin analogue; ghrelin; analogue
Prior art date: 2002-07-23

Application number

AT03765930T

Other languages

English (en)

Inventor

Zheng Dong

Yeelana Shen

Original Assignee

Ipsen Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-23

Filing date

2003-07-23

Publication date

2011-02-15

2003-07-23 Application filed by Ipsen Pharma filed Critical Ipsen Pharma

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE496940T1 publication Critical patent/ATE496940T1/de

Links

GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical class C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title 1
229940121382 ghrelin analogues Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
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- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
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- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Cardiology (AREA)
Obesity (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Virology (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Neurology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)

AT03765930T 2002-07-23 2003-07-23 Ghrelin-analoga ATE496940T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US39783402P	2002-07-23	2002-07-23
US42748802P	2002-11-19	2002-11-19
PCT/US2003/022925 WO2004009616A2 (en)	2002-07-23	2003-07-23	Ghrelin analogs

Publications (1)

Publication Number	Publication Date
ATE496940T1 true ATE496940T1 (de)	2011-02-15

Family

ID=34278194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03765930T ATE496940T1 (de)	2002-07-23	2003-07-23	Ghrelin-analoga

Country Status (18)

Country	Link
US (3)	US7589058B2 (de)
EP (2)	EP2258381A3 (de)
JP (2)	JP2006515271A (de)
KR (1)	KR101065471B1 (de)
AR (2)	AR040955A1 (de)
AT (1)	ATE496940T1 (de)
AU (1)	AU2003254119B2 (de)
BR (1)	BR0312871A (de)
CA (1)	CA2491946C (de)
DE (1)	DE60335913D1 (de)
IL (1)	IL166170A (de)
MX (1)	MXPA05000908A (de)
NO (1)	NO334857B1 (de)
PL (1)	PL212106B1 (de)
PT (1)	PT1578778E (de)
RU (3)	RU2315059C2 (de)
TW (1)	TWI325003B (de)
WO (1)	WO2004009616A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2491946C (en)	2002-07-23	2013-05-28	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R	Ghrelin analogs
WO2005110463A1 (en) *	2004-05-11	2005-11-24	The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, National Institutes Of Health	Methods of inhibiting proinflammatory cytokine expression using ghrelin
RU2427587C2 (ru) *	2005-09-28	2011-08-27	Ипсен Фарма С.А.С.	Аналоги грелина
CA2625920C (en)	2005-09-28	2014-12-23	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R	Analogs of ghrelin
CA2625447C (en) *	2005-09-29	2015-06-09	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Compositions and methods for stimulating gastrointestinal motility
US8992928B2 (en) *	2006-02-11	2015-03-31	Victor Raso	Isolated monoclonal antibody or antigen-binding fragment that cleaves octanoylated native ghrelin
WO2007106385A2 (en) *	2006-03-10	2007-09-20	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment
NZ571183A (en) *	2006-03-13	2010-09-30	Liat Mintz	Use of ghrelin splice variant for treating cachexia and/or anorexia and/or anorexia-cachexia and/or malnutrition and/or lipodystrophy and/or muscle wasting and/or appetite stimulation
US8299022B2 (en) *	2006-09-27	2012-10-30	Ipsen Pharma S.A.S.	Analogs of ghrelin substituted at the N-terminal
WO2008067831A2 (en) *	2006-12-05	2008-06-12	Charite Universitätsmedizin - Berlin	Use of ghrelin, an analogue thereof or a pharmaceutically acceptable salt thereof
TW200916113A (en) *	2007-08-08	2009-04-16	Sod Conseils Rech Applic	Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue
US9724381B2 (en)	2009-05-12	2017-08-08	The Administrators Of The Tulane Educational Fund	Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
US8883721B2 (en) *	2009-05-12	2014-11-11	Mcgill University	Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
EP2493910A1 (de)	2009-10-30	2012-09-05	Tranzyme Pharma, Inc.	Makrozyklische ghrelin-rezeptorantagonisten und gegenagonisten sowie verwendungsverfahren dafür
AU2011268256B8 (en) *	2010-06-16	2016-12-22	Mcgill University	Growth hormone secretatogue receptor antagonists and uses thereof
JP5560248B2 (ja) *	2011-09-07	2014-07-23	花王株式会社	ジペプチド誘導体及びその製造方法
WO2013113916A2 (en) *	2012-02-03	2013-08-08	Zealand Pharma A/S	Ghrelin analogues
AU2013263349B2 (en)	2012-05-17	2016-09-08	Extend Biosciences, Inc	Carriers for improved drug delivery
US9119832B2 (en)	2014-02-05	2015-09-01	The Regents Of The University Of California	Methods of treating mild brain injury
US9616109B2 (en)	2014-10-22	2017-04-11	Extend Biosciences, Inc.	Insulin vitamin D conjugates
WO2016065042A1 (en)	2014-10-22	2016-04-28	Extend Biosciences, Inc.	Therapeutic vitamin d conjugates
US9789197B2 (en)	2014-10-22	2017-10-17	Extend Biosciences, Inc.	RNAi vitamin D conjugates
WO2017075535A1 (en)	2015-10-28	2017-05-04	Oxeia Biopharmaceuticals, Inc.	Methods of treating neurodegenerative conditions
CN108029863B (zh) *	2018-01-19	2021-07-27	广州英赛特生物技术有限公司	丁酰甘氨酸及其衍生物在制备动物饲料添加剂中的应用
KR20250075704A (ko)	2022-09-30	2025-05-28	익스텐드 바이오사이언시즈, 인크.	장기-지속형 부갑상선 호르몬

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GB8821785D0 (en) *	1988-09-16	1988-10-19	Nycomed As	Peptide compounds
US5264565A (en)	1991-01-22	1993-11-23	Affymax Technologies, N.V.	Nucleic acid encoding the D2 /Ml chimeric receptor
ATE225806T1 (de) *	1994-09-27	2002-10-15	Bioscience Limited Ardana	D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
ES2308779T3 (es)	1995-07-26	2008-12-01	Astrazeneca Ab	Receptores quimericos y metodos para identificar compuestos activos en los receptores de glutamato metabotropico y el uso de tales compuestos en el tratamiento de trastornos y enfermedades neurologicas.
JP3754084B2 (ja)	1995-12-13	2006-03-08	メルクエンドカンパニーインコーポレーテッド	成長ホルモン分泌促進薬受容体ファミリー
EP1992641A3 (de) *	1998-12-07	2009-07-29	Ipsen Pharma	GLP-1-Analoge
ES2401939T3 (es)	1999-07-23	2013-04-25	Kenji Kangawa	Nuevos péptidos
US6967237B2 (en) *	2000-05-30	2005-11-22	Merck & Co., Inc.	Ghrelin analogs
CN1443198A (zh) *	2000-07-24	2003-09-17	阿达纳生物科学有限公司	Ghrelin拮抗剂
PT1573022E (pt) *	2001-04-10	2011-08-23	Agensys Inc	Ácido nucleico e proteína correspondente intitulada 184p1e2, utilizadas para o tratamento e detecção de cancro
CA2491946C (en)	2002-07-23	2013-05-28	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R	Ghrelin analogs

2003
- 2003-07-23 CA CA2491946A patent/CA2491946C/en not_active Expired - Fee Related
- 2003-07-23 WO PCT/US2003/022925 patent/WO2004009616A2/en not_active Ceased
- 2003-07-23 JP JP2004523304A patent/JP2006515271A/ja active Pending
- 2003-07-23 PL PL377075A patent/PL212106B1/pl unknown
- 2003-07-23 PT PT03765930T patent/PT1578778E/pt unknown
- 2003-07-23 AT AT03765930T patent/ATE496940T1/de not_active IP Right Cessation
- 2003-07-23 RU RU2005104841/04A patent/RU2315059C2/ru not_active IP Right Cessation
- 2003-07-23 AR ARP030102647A patent/AR040955A1/es not_active Application Discontinuation
- 2003-07-23 MX MXPA05000908A patent/MXPA05000908A/es active IP Right Grant
- 2003-07-23 EP EP10181462A patent/EP2258381A3/de not_active Withdrawn
- 2003-07-23 DE DE60335913T patent/DE60335913D1/de not_active Expired - Lifetime
- 2003-07-23 KR KR1020057001095A patent/KR101065471B1/ko not_active Expired - Fee Related
- 2003-07-23 AU AU2003254119A patent/AU2003254119B2/en not_active Ceased
- 2003-07-23 BR BRPI0312871-7A patent/BR0312871A/pt not_active IP Right Cessation
- 2003-07-23 TW TW092120152A patent/TWI325003B/zh not_active IP Right Cessation
- 2003-07-23 US US10/522,398 patent/US7589058B2/en not_active Expired - Fee Related
- 2003-07-23 RU RU2007124275/04A patent/RU2373220C2/ru not_active IP Right Cessation
- 2003-07-23 EP EP03765930A patent/EP1578778B1/de not_active Expired - Lifetime
2005
- 2005-01-06 NO NO20050083A patent/NO334857B1/no not_active IP Right Cessation
- 2005-01-06 IL IL166170A patent/IL166170A/en active IP Right Grant
2009
- 2009-02-27 JP JP2009046345A patent/JP2009161546A/ja active Pending
- 2009-06-16 US US12/456,429 patent/US8633151B2/en not_active Expired - Fee Related
- 2009-07-14 RU RU2009127162/04A patent/RU2009127162A/ru not_active Application Discontinuation
- 2009-08-20 AR ARP090103204A patent/AR073099A2/es not_active Application Discontinuation
2014
- 2014-01-17 US US14/157,770 patent/US9133261B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RU2005104841A (ru)	2005-09-10
AU2003254119B2 (en)	2007-11-29
US20140135260A1 (en)	2014-05-15
TWI325003B (en)	2010-05-21
US8633151B2 (en)	2014-01-21
WO2004009616A3 (en)	2006-02-09
NO20050083L (no)	2005-03-23
WO2004009616A2 (en)	2004-01-29
AR040955A1 (es)	2005-04-27
TW200403253A (en)	2004-03-01
EP2258381A3 (de)	2011-11-02
CA2491946A1 (en)	2004-01-29
JP2009161546A (ja)	2009-07-23
EP1578778B1 (de)	2011-01-26
RU2007124275A (ru)	2009-01-10
EP1578778A4 (de)	2007-02-28
KR101065471B1 (ko)	2011-09-16
AU2003254119A1 (en)	2004-02-09
RU2315059C2 (ru)	2008-01-20
KR20050026503A (ko)	2005-03-15
PL212106B1 (pl)	2012-08-31
BR0312871A (pt)	2007-07-10
DE60335913D1 (de)	2011-03-10
EP1578778A2 (de)	2005-09-28
CA2491946C (en)	2013-05-28
IL166170A0 (en)	2006-01-15
RU2373220C2 (ru)	2009-11-20
US20050272648A1 (en)	2005-12-08
EP2258381A2 (de)	2010-12-08
US9133261B2 (en)	2015-09-15
US7589058B2 (en)	2009-09-15
IL166170A (en)	2011-01-31
AR073099A2 (es)	2010-10-13
US20100069299A1 (en)	2010-03-18
NO334857B1 (no)	2014-06-23
JP2006515271A (ja)	2006-05-25
MXPA05000908A (es)	2005-07-22
PL377075A1 (pl)	2006-01-23
RU2009127162A (ru)	2011-01-20
PT1578778E (pt)	2011-03-07

Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE496940T1 (de)	2011-02-15	Ghrelin-analoga
ATE390898T1 (de)	2008-04-15	Zwischenwirbelimplantat
ATE394087T1 (de)	2008-05-15	Zwischenwirbelimplantat
ATE394086T1 (de)	2008-05-15	Zwischenwirbelimplantat
DE60328309D1 (de)	2009-08-20	Ssigkeiten
DE60332534D1 (de)	2010-06-24	Chinuclidinamidderivate
EP1489376A4 (de)	2005-12-28	Zünder
DE60300967D1 (de)	2005-08-11	Seilantriebsanordung
DE60207371D1 (de)	2005-12-22	Stumpfvermahlungsgerät
DE60305663D1 (de)	2006-07-06	Kippschirm
DE60315105D1 (de)	2007-09-06	Ozonisator
DE50311715D1 (de)	2009-08-27	Weltzeituhr
DE60336494D1 (de)	2011-05-05	Kompaktlader
DK1513861T3 (da)	2007-04-10	Etonogestrelestere
DE60330661D1 (de)	2010-02-04	Einführdichtungsanordnung
DE60309990D1 (de)	2007-01-11	Schraubbefestigungsstruktur
DE60228135D1 (de)	2008-09-18	Eifen
DE60326562D1 (de)	2009-04-23	Seinhibitoren
FR2843017B1 (fr)	2004-09-10	Implant inter-somatique
DE50309499D1 (de)	2008-05-08	Librierwerkzeugen
DE60328497D1 (de)	2009-09-03	Zugschiffspropeller
FI5303U1 (fi)	2002-03-22	Ammesovitelma
DE60336661D1 (de)	2011-05-19	Molsieb ssz-64
DE50305973D1 (de)	2007-01-25	Auffangwanne
DE60205924T2 (de)	2006-06-14	Mikrogreifer