ATE496940T1 - Ghrelin-analoga - Google Patents

Ghrelin-analoga

Info

Publication number: ATE496940T1
Authority: AT; Austria
Prior art keywords: ghrelin analogue; ghrelin; analogue
Prior art date: 2002-07-23

Application number

AT03765930T

Other languages

English (en)

Inventor

Zheng Dong

Yeelana Shen

Original Assignee

Ipsen Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-07-23

Filing date

2003-07-23

Publication date

2011-02-15

2003-07-23 Application filed by Ipsen Pharma filed Critical Ipsen Pharma

2011-02-15 Application granted granted Critical

2011-02-15 Publication of ATE496940T1 publication Critical patent/ATE496940T1/de

Links

GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical class C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 title 1
229940121382 ghrelin analogues Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
- A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Cardiology (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Virology (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Gynecology & Obstetrics (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)

AT03765930T 2002-07-23 2003-07-23 Ghrelin-analoga ATE496940T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US39783402P	2002-07-23	2002-07-23
US42748802P	2002-11-19	2002-11-19
PCT/US2003/022925 WO2004009616A2 (en)	2002-07-23	2003-07-23	Ghrelin analogs

Publications (1)

Publication Number	Publication Date
ATE496940T1 true ATE496940T1 (de)	2011-02-15

Family

ID=34278194

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03765930T ATE496940T1 (de)	2002-07-23	2003-07-23	Ghrelin-analoga

Country Status (18)

Country	Link
US (3)	US7589058B2 (de)
EP (2)	EP2258381A3 (de)
JP (2)	JP2006515271A (de)
KR (1)	KR101065471B1 (de)
AR (2)	AR040955A1 (de)
AT (1)	ATE496940T1 (de)
AU (1)	AU2003254119B2 (de)
BR (1)	BR0312871A (de)
CA (1)	CA2491946C (de)
DE (1)	DE60335913D1 (de)
IL (1)	IL166170A (de)
MX (1)	MXPA05000908A (de)
NO (1)	NO334857B1 (de)
PL (1)	PL212106B1 (de)
PT (1)	PT1578778E (de)
RU (3)	RU2315059C2 (de)
TW (1)	TWI325003B (de)
WO (1)	WO2004009616A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2006515271A (ja)	2002-07-23	2006-05-25	ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス	グレリン類似体
CA2566703A1 (en) *	2004-05-11	2005-11-24	Vishwa Deep Dixit	Methods of inhibiting proinflammatory cytokine expression using ghrelin
RU2427587C2 (ru) *	2005-09-28	2011-08-27	Ипсен Фарма С.А.С.	Аналоги грелина
CN101282738B (zh) *	2005-09-28	2015-09-16	益普生制药股份有限公司	生长素释放肽类似物
DK1937262T3 (da)	2005-09-29	2019-07-15	Ipsen Pharma	Sammensætning til anvendelse i behandling af gastrointestinal dysmotilitet
US8992928B2 (en) *	2006-02-11	2015-03-31	Victor Raso	Isolated monoclonal antibody or antigen-binding fragment that cleaves octanoylated native ghrelin
ES2424970T3 (es) *	2006-03-10	2013-10-10	Ipsen Pharma	Uso de un agonista de la grelina para mejorar los efectos catabólicos del tratamiento con glucocorticoides
KR101201055B1 (ko) *	2006-03-13	2012-11-15	리아트 민쯔	악액질 및/또는 식욕감퇴 및/또는 식욕감퇴-악액질 및/또는영양장애 및/또는 지방이영양증 및/또는 근육 쇠약 및/또는 식욕-자극의 치료를 위한 그렐린 스플라이스 변이체의 용도
CN101541341B (zh) *	2006-09-27	2013-06-05	益普生制药两合公司	N末端取代的生长素释放肽类似物
WO2008067831A2 (en) *	2006-12-05	2008-06-12	Charite Universitätsmedizin - Berlin	Use of ghrelin, an analogue thereof or a pharmaceutically acceptable salt thereof
TW200916113A (en) *	2007-08-08	2009-04-16	Sod Conseils Rech Applic	Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue
US9724381B2 (en)	2009-05-12	2017-08-08	The Administrators Of The Tulane Educational Fund	Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
US8883721B2 (en) *	2009-05-12	2014-11-11	Mcgill University	Methods of inhibiting the ghrelin/growth hormone secretatogue receptor pathway and uses thereof
US20110105389A1 (en)	2009-10-30	2011-05-05	Hoveyda Hamid R	Macrocyclic Ghrelin Receptor Antagonists and Inverse Agonists and Methods of Using the Same
WO2011159917A2 (en) *	2010-06-16	2011-12-22	The Administrators Of The Tulane Educational Fund	Growth hormone secretatogue receptor antagonists and uses thereof
JP5560248B2 (ja) *	2011-09-07	2014-07-23	花王株式会社	ジペプチド誘導体及びその製造方法
JP2015510505A (ja) *	2012-02-03	2015-04-09	ジーランドファーマアクティーゼルスカブ	グレリン類似体
MX349035B (es)	2012-05-17	2017-07-07	Extend Biosciences Inc	Portadores para el suministro mejorado de farmaco.
US9119832B2 (en)	2014-02-05	2015-09-01	The Regents Of The University Of California	Methods of treating mild brain injury
WO2016065052A1 (en)	2014-10-22	2016-04-28	Extend Biosciences, Inc.	Insulin vitamin d conjugates
US9585934B2 (en)	2014-10-22	2017-03-07	Extend Biosciences, Inc.	Therapeutic vitamin D conjugates
US9789197B2 (en)	2014-10-22	2017-10-17	Extend Biosciences, Inc.	RNAi vitamin D conjugates
WO2017075535A1 (en)	2015-10-28	2017-05-04	Oxeia Biopharmaceuticals, Inc.	Methods of treating neurodegenerative conditions
CN108029863B (zh) *	2018-01-19	2021-07-27	广州英赛特生物技术有限公司	丁酰甘氨酸及其衍生物在制备动物饲料添加剂中的应用
US12233115B2 (en)	2022-09-30	2025-02-25	Extend Biosciences, Inc.	Long-acting parathyroid hormone

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8821785D0 (en) *	1988-09-16	1988-10-19	Nycomed As	Peptide compounds
US5264565A (en)	1991-01-22	1993-11-23	Affymax Technologies, N.V.	Nucleic acid encoding the D2 /Ml chimeric receptor
EP0783521B8 (de) *	1994-09-27	2003-04-09	Ardana Bioscience Limited	D-2-alkyltryptophan enthaltende polypeptide mit wachstumhormon freisetzender aktivitaet
WO1997005252A2 (en)	1995-07-26	1997-02-13	Nps Pharmaceuticals, Inc.	Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors and the use of such compounds in the treatment of neurological disorders and diseases
ES2229289T3 (es)	1995-12-13	2005-04-16	MERCK & CO., INC.	Familia de receptores de secretagogo de la hormona del crecimiento.
PL208751B1 (pl) *	1998-12-07	2011-06-30	Sod Conseils Rech Applic	Związki stanowiące analogi GLP-1, kompozycje zawierające takie związki oraz zastosowanie takich związków
CA2380058C (en)	1999-07-23	2011-08-09	Kenji Kangawa	Novel peptides
CA2411667A1 (en)	2000-05-30	2001-12-06	Merck & Co. Inc.	Ghrelin analogs
CN1443198A (zh)	2000-07-24	2003-09-17	阿达纳生物科学有限公司	Ghrelin拮抗剂
WO2002083860A2 (en) *	2001-04-10	2002-10-24	Agensys, Inc.	Nucleic acid and corresponding protein entitled 151p3d4 useful in treatment and detection of cancer
JP2006515271A (ja)	2002-07-23	2006-05-25	ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス	グレリン類似体

2003
- 2003-07-23 JP JP2004523304A patent/JP2006515271A/ja active Pending
- 2003-07-23 AR ARP030102647A patent/AR040955A1/es not_active Application Discontinuation
- 2003-07-23 RU RU2005104841/04A patent/RU2315059C2/ru not_active IP Right Cessation
- 2003-07-23 AT AT03765930T patent/ATE496940T1/de not_active IP Right Cessation
- 2003-07-23 PL PL377075A patent/PL212106B1/pl unknown
- 2003-07-23 KR KR1020057001095A patent/KR101065471B1/ko not_active Expired - Fee Related
- 2003-07-23 WO PCT/US2003/022925 patent/WO2004009616A2/en not_active Ceased
- 2003-07-23 DE DE60335913T patent/DE60335913D1/de not_active Expired - Lifetime
- 2003-07-23 PT PT03765930T patent/PT1578778E/pt unknown
- 2003-07-23 TW TW092120152A patent/TWI325003B/zh not_active IP Right Cessation
- 2003-07-23 MX MXPA05000908A patent/MXPA05000908A/es active IP Right Grant
- 2003-07-23 RU RU2007124275/04A patent/RU2373220C2/ru not_active IP Right Cessation
- 2003-07-23 EP EP10181462A patent/EP2258381A3/de not_active Withdrawn
- 2003-07-23 CA CA2491946A patent/CA2491946C/en not_active Expired - Fee Related
- 2003-07-23 BR BRPI0312871-7A patent/BR0312871A/pt not_active IP Right Cessation
- 2003-07-23 US US10/522,398 patent/US7589058B2/en not_active Expired - Fee Related
- 2003-07-23 AU AU2003254119A patent/AU2003254119B2/en not_active Ceased
- 2003-07-23 EP EP03765930A patent/EP1578778B1/de not_active Expired - Lifetime
2005
- 2005-01-06 NO NO20050083A patent/NO334857B1/no not_active IP Right Cessation
- 2005-01-06 IL IL166170A patent/IL166170A/en active IP Right Grant
2009
- 2009-02-27 JP JP2009046345A patent/JP2009161546A/ja active Pending
- 2009-06-16 US US12/456,429 patent/US8633151B2/en not_active Expired - Fee Related
- 2009-07-14 RU RU2009127162/04A patent/RU2009127162A/ru not_active Application Discontinuation
- 2009-08-20 AR ARP090103204A patent/AR073099A2/es not_active Application Discontinuation
2014
- 2014-01-17 US US14/157,770 patent/US9133261B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2491946A1 (en)	2004-01-29
US9133261B2 (en)	2015-09-15
AR040955A1 (es)	2005-04-27
PL212106B1 (pl)	2012-08-31
EP2258381A3 (de)	2011-11-02
US20140135260A1 (en)	2014-05-15
RU2315059C2 (ru)	2008-01-20
EP1578778A2 (de)	2005-09-28
WO2004009616A3 (en)	2006-02-09
US20100069299A1 (en)	2010-03-18
DE60335913D1 (de)	2011-03-10
WO2004009616A2 (en)	2004-01-29
PT1578778E (pt)	2011-03-07
JP2009161546A (ja)	2009-07-23
MXPA05000908A (es)	2005-07-22
RU2009127162A (ru)	2011-01-20
US8633151B2 (en)	2014-01-21
EP2258381A2 (de)	2010-12-08
US20050272648A1 (en)	2005-12-08
AR073099A2 (es)	2010-10-13
AU2003254119B2 (en)	2007-11-29
RU2373220C2 (ru)	2009-11-20
IL166170A0 (en)	2006-01-15
RU2005104841A (ru)	2005-09-10
RU2007124275A (ru)	2009-01-10
KR101065471B1 (ko)	2011-09-16
TW200403253A (en)	2004-03-01
KR20050026503A (ko)	2005-03-15
BR0312871A (pt)	2007-07-10
NO334857B1 (no)	2014-06-23
JP2006515271A (ja)	2006-05-25
EP1578778B1 (de)	2011-01-26
US7589058B2 (en)	2009-09-15
EP1578778A4 (de)	2007-02-28
CA2491946C (en)	2013-05-28
NO20050083L (no)	2005-03-23
TWI325003B (en)	2010-05-21
AU2003254119A1 (en)	2004-02-09
IL166170A (en)	2011-01-31
PL377075A1 (pl)	2006-01-23

Legal Events

Date	Code	Title	Description
2011-07-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE390898T1 (de)	2008-04-15	Zwischenwirbelimplantat
ATE394087T1 (de)	2008-05-15	Zwischenwirbelimplantat
ATE394086T1 (de)	2008-05-15	Zwischenwirbelimplantat
DE60323499D1 (de)	2008-10-23	Tastverhältnisschätzer
DE60328364D1 (de)	2009-08-27	Abdominalretraktor
DE50313647D1 (de)	2011-06-01	Knochenfixationseinrichtumg
DE60321537D1 (de)	2008-07-24	Schtrockner
ATE318817T1 (de)	2006-03-15	Aza-arylpiperazine
DE60320334D1 (de)	2008-05-29	Klebwalzereiniger
DE60231753D1 (de)	2009-05-07	Betonsteintexturiermaschine
DE50301200D1 (de)	2005-10-20	Wischblatt
DE50311715D1 (de)	2009-08-27	Weltzeituhr
DE60335913D1 (de)	2011-03-10	Ghrelin-analoga
DE60330661D1 (de)	2010-02-04	Einführdichtungsanordnung
DE60226008D1 (de)	2008-05-21	Sicherheitsgurtpresentiereinrichtung
DE50309536D1 (de)	2008-05-15	Fadenabsaugvorrichtung
DE60318029D1 (de)	2008-01-24	Zünder
DE60228135D1 (de)	2008-09-18	Eifen
FR2843017B1 (fr)	2004-09-10	Implant inter-somatique
DE60302827D1 (de)	2006-01-26	Hochgeschwindigheitfräsmaschine
FI20021957A0 (fi)	2002-11-01	Lipeäruisku
FI5303U1 (fi)	2002-03-22	Ammesovitelma
ATA19152002A (de)	2004-11-15	Hubkupplung
DE60205924D1 (de)	2005-10-06	Mikrogreifer
DE60304326D1 (de)	2006-05-18	Wärmeniet