ATE497501T1 - Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90 - Google Patents

Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90

Info

Publication number
ATE497501T1
ATE497501T1 AT06743635T AT06743635T ATE497501T1 AT E497501 T1 ATE497501 T1 AT E497501T1 AT 06743635 T AT06743635 T AT 06743635T AT 06743635 T AT06743635 T AT 06743635T AT E497501 T1 ATE497501 T1 AT E497501T1
Authority
AT
Austria
Prior art keywords
inhibiters
compositions
activity
preparation
pharmaceutical use
Prior art date
Application number
AT06743635T
Other languages
English (en)
Inventor
Patrick Mailliet
Luc Bertin
Didier Benard
Chantal Carrez
Francois Vallee
Eric Bacque
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE497501T1 publication Critical patent/ATE497501T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
AT06743635T 2005-04-08 2006-04-05 Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90 ATE497501T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0503511A FR2884252B1 (fr) 2005-04-08 2005-04-08 Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90
PCT/FR2006/000750 WO2006108948A2 (fr) 2005-04-08 2006-04-05 Nouveaux derives d'isoindoles, compositions les contenant, leur preparation et leurs utilisations pharmaceutiques notamment en tant qu'inhibiteurs d'activites de la proteine chaperone hsp90

Publications (1)

Publication Number Publication Date
ATE497501T1 true ATE497501T1 (de) 2011-02-15

Family

ID=35539484

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06743635T ATE497501T1 (de) 2005-04-08 2006-04-05 Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90

Country Status (17)

Country Link
US (1) US8034939B2 (de)
EP (1) EP1869042B1 (de)
JP (1) JP5124443B2 (de)
KR (1) KR20080002809A (de)
CN (1) CN101287733A (de)
AR (1) AR053206A1 (de)
AT (1) ATE497501T1 (de)
AU (1) AU2006234396A1 (de)
BR (1) BRPI0609734A2 (de)
CA (1) CA2603634A1 (de)
DE (1) DE602006019953D1 (de)
FR (1) FR2884252B1 (de)
IL (1) IL186050A0 (de)
RU (1) RU2375361C2 (de)
TW (1) TW200718700A (de)
UY (1) UY29468A1 (de)
WO (1) WO2006108948A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2885904B1 (fr) * 2005-05-19 2007-07-06 Aventis Pharma Sa Nouveaux derives du fluorene, compositions les contenant et utilisation
WO2008045529A1 (en) * 2006-10-12 2008-04-17 Serenex, Inc. Purine and pyrimidine derivatives for treatment of cancer and inflammatory diseases
FR2932484B1 (fr) * 2008-06-16 2010-06-18 Sanofi Aventis Nouveaux derives de pyrroloindole inhibiteurs d'hsp90, compositions les contenant et utilisation
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
CA2956934C (en) * 2010-04-21 2019-07-09 Syntarga B.V. Novel conjugates of cc-1065 analogs and bifunctional linkers
UY36630A (es) 2015-04-17 2016-11-30 Abbvie Inc Moduladores tricíclicos de la señalización por tnf
WO2016168633A1 (en) 2015-04-17 2016-10-20 Abbvie Inc. Indazolones as modulators of tnf signaling
US9879016B2 (en) 2015-04-17 2018-01-30 Abbvie Inc. Indazolones as modulators of TNF signaling
KR101925395B1 (ko) 2016-01-29 2019-02-27 계명대학교 산학협력단 Ｈｓｐ９０ 억제 활성을 갖는 신규 디히드록시페닐계 화합물 또는 이의 약제학적으로 허용가능한 염 및 이의 의학적 용도
JOP20190090B1 (ar) 2016-10-24 2023-03-28 Astrazeneca Ab مشتقات 9،8،7،6-رابع هيدرو-3h-بيرازولو [4،3-f]أيزوكينولين مفيدة في علاج السرطان
EP3689873B1 (de) 2017-01-30 2022-09-14 Astrazeneca AB Östrogen-rezeptor-modulatoren
KR20190014474A (ko) 2017-08-02 2019-02-12 계명대학교 산학협력단 Ｈｓｐ９０ 억제 활성을 갖는 디히드록시페닐계 입체이성질체 및 이의 의학적 용도
JP7712955B2 (ja) 2020-04-24 2025-07-24 アストラゼネカ・アクチエボラーグ 癌の治療のための投薬レジメン
MX2022013258A (es) 2020-04-24 2022-11-14 Astrazeneca Ab Formulaciones farmaceuticas.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA62972C2 (en) * 1997-07-03 2004-01-15 Application of imidazopyrimidins and imidazopyridins for the treatment of neural disorders
GB9819035D0 (en) * 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
JP2001106673A (ja) * 1999-07-26 2001-04-17 Banyu Pharmaceut Co Ltd ビアリールウレア誘導体
GB0228417D0 (en) 2002-12-05 2003-01-08 Cancer Rec Tech Ltd Pyrazole compounds
GB0229618D0 (en) * 2002-12-19 2003-01-22 Cancer Rec Tech Ltd Pyrazole compounds
US7160885B2 (en) * 2003-02-10 2007-01-09 Cgi Pharmaceuticals, Inc. Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity
SI1611112T1 (sl) 2003-02-11 2012-12-31 Vernalis (R&D) Limited Izoksazolne spojine kot inhibitorji vroäśinskih ĺ ok proteinov
GB0309637D0 (en) * 2003-04-28 2003-06-04 Cancer Rec Tech Ltd Pyrazole compounds
ES2432747T3 (es) 2003-06-27 2013-12-05 Kyowa Hakko Kirin Co., Ltd. Inhibidores de proteínas de la familia HSP90
GB0315111D0 (en) 2003-06-27 2003-07-30 Cancer Rec Tech Ltd Substituted 5-membered ring compounds and their use

Also Published As

Publication number Publication date
IL186050A0 (en) 2008-06-05
WO2006108948A2 (fr) 2006-10-19
CA2603634A1 (fr) 2006-10-19
TW200718700A (en) 2007-05-16
KR20080002809A (ko) 2008-01-04
FR2884252B1 (fr) 2007-05-18
US20080119507A1 (en) 2008-05-22
UY29468A1 (es) 2006-11-30
AR053206A1 (es) 2007-04-25
RU2375361C2 (ru) 2009-12-10
EP1869042B1 (de) 2011-02-02
EP1869042A2 (de) 2007-12-26
FR2884252A1 (fr) 2006-10-13
CN101287733A (zh) 2008-10-15
AU2006234396A1 (en) 2006-10-19
BRPI0609734A2 (pt) 2010-04-27
WO2006108948A3 (fr) 2007-10-11
JP5124443B2 (ja) 2013-01-23
DE602006019953D1 (de) 2011-03-17
JP2008534660A (ja) 2008-08-28
RU2007141398A (ru) 2009-05-20
US8034939B2 (en) 2011-10-11

Similar Documents

Publication Publication Date Title
ATE425979T1 (de) Neue substituierte imidazo-pyridinone und imidazo-pyridazinone, ihre herstellung und ihre verwendung als arzneimittel
DE50312295D1 (de) 8-ä3-amino-piperidin-1-ylü -xanthine, deren herstellung und deren verwendung als arzneimittel
EP2030974A4 (de) Heterozyklische nichtnukleosidverbindungen, ihre herstellung, pharmazeutische zusammensetzung und ihre verwendung als antivirale mittel
DE502005006424D1 (de) Neue alkyl-haltige 5-acylindolinone, deren herstellung und deren verwendung als arzneimittel
DE50312747D1 (de) Neue xanthinderivate, deren herstellung und deren verwendung als arzneimittel
BRPI0614205A2 (pt) composto, composição farmacêutica, e, uso de composto
DE602006019953D1 (de) Neue isoindolderivate, zusammensetzungen damit, ihre herstellung und pharmazeutische verwendung, insbesondere als hemmer der aktivität des chaperonproteins hsp90
ATE529420T1 (de) 3-ä(2-ää4-hexyloxycarbonylamino-imino-methyl)- phenylaminoü-methylü-1-methyl-1h-benzimidazol-5 carbonyl)-pyridin-2-yl-aminoü-propionsäure- ethylester-methansulfonat-hemihydrat und dessen verwendung als arzneimittel
DE502005002105D1 (de) 4-benzimidazol-2-yl-pyridazin-3-on-derivative, ihre herstellung und verwendung in arzneimitteln
CL2007002017A1 (es) Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple.
ATE489382T1 (de) Benzoxazinonderivate, deren herstellung und verwendung als arzneimittel
DE602005006815D1 (de) 2-carbamid-4-phenylthiazol-derivate, deren herstellung und therapeutische verwendung
DE602006013878D1 (de) Heterocyclische verbindungen, ihre herstellung und ihre verwendung als antibakterielle mittel
CL2008002353A1 (es) Compuestos derivados de 7h-indolo[2,1-a][2]benzazepina; composicion farmaceutica; y uso en el tratamiento de la hepatitis c.
CL2007002619A1 (es) Compuestos derivados de 3-aza-biciclo[4.1.0]heptano; composicion farmaceutica; y uso en el tratamiento de la depresion.
DE602005005456D1 (de) Neue azabicyclische derivate, herstellungsverfahren dafür und sie enthaltende pharmazeutische zusammensetzungen
DE602005011593D1 (de) Substituierte diazaspiroä5.5üundecanderivate und deren verwendung als neurokininantagonisten
ATE517105T1 (de) Neue imidazolon-derivate, wirkstoffpräparat daraus, pharmazeutische zusammensetzungen und ihre verwendung als hemmer von proteinkinasen, insbesondere cdc7
CL2007002769A1 (es) Compuestos derivados de sulfonamida; procedimiento de obtencion; composicion farmaceutica; y uso en el tratamiento de la diabetes.
ITRM20030363A1 (it) Composizioni comprendenti la 3, 5diiodotironina e uso farmaceutico di esse.
DE602004015600D1 (de) Neue imidazolderivative, deren herstellung und deren verwendung als medikament
ATE538125T1 (de) Neue 2-azaindol-derivate, deren herstellung und pharmazeutische verwendung als kinase-inhibitoren
ATE312828T1 (de) Acylaminothiazolderivate, deren herstellung und deren therapeutische verwendung
DE602006002887D1 (de) Tricyclische azolderivate, ihre herstellung und ihre verwendung als pharmazeutische mittel
ATE417846T1 (de) Aminotropanderivate, deren herstellung und deren therapeutische verwendung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties