ATE498614T1 - (chinazolin-4-yl)piperazin-4-ylüthiocarboxamide als hemmer der phosphorylierung eines pdgf- rezeptors - Google Patents
(chinazolin-4-yl)piperazin-4-ylüthiocarboxamide als hemmer der phosphorylierung eines pdgf- rezeptorsInfo
- Publication number
- ATE498614T1 ATE498614T1 AT01973653T AT01973653T ATE498614T1 AT E498614 T1 ATE498614 T1 AT E498614T1 AT 01973653 T AT01973653 T AT 01973653T AT 01973653 T AT01973653 T AT 01973653T AT E498614 T1 ATE498614 T1 AT E498614T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphorylation
- kinases
- pdgf receptor
- yluthiocarboxamide
- chinazoline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22612100P | 2000-08-18 | 2000-08-18 | |
| PCT/US2001/041750 WO2002016361A2 (en) | 2000-08-18 | 2001-08-17 | Nitrogenous heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE498614T1 true ATE498614T1 (de) | 2011-03-15 |
Family
ID=22847635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01973653T ATE498614T1 (de) | 2000-08-18 | 2001-08-17 | (chinazolin-4-yl)piperazin-4-ylüthiocarboxamide als hemmer der phosphorylierung eines pdgf- rezeptors |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7329655B2 (de) |
| EP (1) | EP1309568B1 (de) |
| AT (1) | ATE498614T1 (de) |
| AU (1) | AU2001293208A1 (de) |
| DE (1) | DE60144050D1 (de) |
| ES (1) | ES2361582T3 (de) |
| WO (1) | WO2002016361A2 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03001359A (es) | 2000-08-18 | 2004-12-13 | Millennium Pharm Inc | Derivados de quinazolina como inhibidores de cinasa. |
| ES2354039T3 (es) | 2000-08-18 | 2011-03-09 | Millennium Pharmaceuticals, Inc. | Derivados de n-aril-{4-[7-(alcoxi)quinazolin-4-il]piperazinil}carboxamida como inhibidores de pdgfr. |
| DE60144284D1 (de) | 2000-11-01 | 2011-05-05 | Millennium Pharm Inc | Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung |
| US6960580B2 (en) | 2001-03-08 | 2005-11-01 | Millennium Pharmaceuticals, Inc. | Nitrogenous heterocyclic substituted quinoline compounds |
| EP1575575B1 (de) * | 2002-11-08 | 2010-05-19 | High Point Pharmaceuticals, LLC | Sichere chemische entkuppler zur behandlung von fettsucht |
| US20100179162A1 (en) * | 2005-07-20 | 2010-07-15 | Millennium Pharmaceuticals , Inc. | Crystal forms of 4-[6-methoxy-7(3-piperidin-1-yl-propoxy) quinazoline-4yl) piperazine-1-carboxylic acid (4-isopropoxyphenyl)-amide |
| MX2008010953A (es) * | 2006-02-28 | 2008-09-08 | Amgen Inc | Derivados de cinolina y quinoxalina como inhibidores de la fosfodiesterasa 10. |
| JP2012509321A (ja) * | 2008-11-21 | 2012-04-19 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | 癌および他の疾患または障害の処置のための、４−［６−メトキシ−７−（３−ピペリジン−１−イル−プロポキシ）キナゾリン−４−イル］ピペラジン−１−カルボン酸（４−イソプロポキシフェニル）−アミドの乳酸塩およびその薬学的組成物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4073961B2 (ja) * | 1996-10-01 | 2008-04-09 | 協和醗酵工業株式会社 | 含窒素複素環化合物 |
| ATE496035T1 (de) | 1998-03-31 | 2011-02-15 | Kyowa Hakko Kirin Co Ltd | Stickstoffenthaltende heterocyclische verbindungen |
| MXPA03001359A (es) | 2000-08-18 | 2004-12-13 | Millennium Pharm Inc | Derivados de quinazolina como inhibidores de cinasa. |
| EP1309567A2 (de) | 2000-08-18 | 2003-05-14 | Millennium Pharmaceuticals, Inc. | Stickstoffhaltige heterozyklische verbindungen |
| ES2354039T3 (es) | 2000-08-18 | 2011-03-09 | Millennium Pharmaceuticals, Inc. | Derivados de n-aril-{4-[7-(alcoxi)quinazolin-4-il]piperazinil}carboxamida como inhibidores de pdgfr. |
| US6960580B2 (en) * | 2001-03-08 | 2005-11-01 | Millennium Pharmaceuticals, Inc. | Nitrogenous heterocyclic substituted quinoline compounds |
-
2001
- 2001-08-17 AT AT01973653T patent/ATE498614T1/de not_active IP Right Cessation
- 2001-08-17 ES ES01973653T patent/ES2361582T3/es not_active Expired - Lifetime
- 2001-08-17 US US10/344,625 patent/US7329655B2/en not_active Expired - Fee Related
- 2001-08-17 DE DE60144050T patent/DE60144050D1/de not_active Expired - Lifetime
- 2001-08-17 AU AU2001293208A patent/AU2001293208A1/en not_active Abandoned
- 2001-08-17 WO PCT/US2001/041750 patent/WO2002016361A2/en not_active Ceased
- 2001-08-17 EP EP01973653A patent/EP1309568B1/de not_active Expired - Lifetime
-
2007
- 2007-12-18 US US11/959,341 patent/US8022071B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ES2361582T3 (es) | 2011-06-20 |
| US7329655B2 (en) | 2008-02-12 |
| US20090176780A1 (en) | 2009-07-09 |
| EP1309568A2 (de) | 2003-05-14 |
| AU2001293208A1 (en) | 2002-03-04 |
| US20040176594A1 (en) | 2004-09-09 |
| WO2002016361A2 (en) | 2002-02-28 |
| DE60144050D1 (de) | 2011-03-31 |
| EP1309568B1 (de) | 2011-02-16 |
| WO2002016361A3 (en) | 2002-06-13 |
| US8022071B2 (en) | 2011-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |