ATE499345T1 - Verfahren zur aufreinigung von montelukast - Google Patents

Verfahren zur aufreinigung von montelukast

Info

Publication number: ATE499345T1
Authority: AT; Austria
Prior art keywords: montelukast; comprised; organic solvent; impurities; mixture
Prior art date: 2006-08-09

Application number

AT07788278T

Other languages

English (en)

Inventor

Guillen Yolanda Gasanz

Llagostera Montserrat Monsalvatje

Escasany Pedro Talavera

Original Assignee

Esteve Quimica Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-09

Filing date

2007-08-07

Publication date

2011-03-15

2007-08-07 Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa

2011-03-15 Application granted granted Critical

2011-03-15 Publication of ATE499345T1 publication Critical patent/ATE499345T1/de

Links

UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 title abstract 5
229960005127 montelukast Drugs 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 2
239000003960 organic solvent Substances 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
239000008346 aqueous phase Substances 0.000 abstract 2
239000012535 impurity Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
238000000638 solvent extraction Methods 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
230000020477 pH reduction Effects 0.000 abstract 1
238000000746 purification Methods 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Quinoline Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT07788278T 2006-08-09 2007-08-07 Verfahren zur aufreinigung von montelukast ATE499345T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US83687306P	2006-08-09	2006-08-09
EP06118689A EP1886997A1 (de)	2006-08-09	2006-08-09	Verfahren zur Aufreinigung von Montelukast
PCT/EP2007/058176 WO2008017667A1 (en)	2006-08-09	2007-08-07	Process for the purification of montelukast

Publications (1)

Publication Number	Publication Date
ATE499345T1 true ATE499345T1 (de)	2011-03-15

Family

ID=37667497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07788278T ATE499345T1 (de)	2006-08-09	2007-08-07	Verfahren zur aufreinigung von montelukast

Country Status (19)

Country	Link
US (1)	US20100029945A1 (de)
EP (2)	EP1886997A1 (de)
JP (1)	JP2010500324A (de)
KR (1)	KR20090037445A (de)
CN (1)	CN101490005B (de)
AT (1)	ATE499345T1 (de)
AU (1)	AU2007283613A1 (de)
CA (1)	CA2657017A1 (de)
DE (1)	DE602007012728D1 (de)
ES (1)	ES2361239T3 (de)
HR (1)	HRP20110322T1 (de)
IL (1)	IL195622A (de)
MX (1)	MX2008015135A (de)
NO (1)	NO20090748L (de)
PL (1)	PL2066638T3 (de)
PT (1)	PT2066638E (de)
RU (1)	RU2009108271A (de)
SI (1)	SI2066638T1 (de)
WO (1)	WO2008017667A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2005003885A2 (en)	2003-07-07	2005-01-13	Sensomatix Ltd.	Traffic information system
EP1904448B1 (de)	2005-07-05	2011-02-02	Teva Pharmaceutical Industries, Ltd.	Reinigung von montelukast
EP2552892A1 (de)	2010-03-31	2013-02-06	KRKA, D.D., Novo Mesto	Effiziente synthese zur herstellung von montelukast und neue kristalline form von zwischenprodukten darin
JP5553096B2 (ja) *	2012-08-29	2014-07-16	大日本印刷株式会社	高純度モンテルカストの製造法
CN103570619B (zh) *	2013-11-08	2015-12-09	南京靖龙药物研发有限公司	一种孟鲁司特钠衍生物的制备方法
CN105646344B (zh) *	2016-02-29	2018-08-14	山东新时代药业有限公司	一种孟鲁司特的纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050107612A1 (en) *	2002-12-30	2005-05-19	Dr. Reddy's Laboratories Limited	Process for preparation of montelukast and its salts
KR20060117356A (ko) *	2004-01-30	2006-11-16	테바 파마슈티컬 인더스트리즈 리미티드	몬테루카스트 유리산 다형체
WO2005074893A1 (en) *	2004-02-03	2005-08-18	Chemagis Ltd.	Stable amorphous forms of montelukast sodium
US7189853B2 (en) *	2004-04-15	2007-03-13	Dr. Reddy's Laboratories Limited	Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts
US20080214822A1 (en) *	2004-11-30	2008-09-04	Medichem, S.A.	Process For the Preparation of a Leukotriene Antagonist
WO2006064269A2 (en) *	2004-12-17	2006-06-22	Cipla Limited	Salts of leukotriene antagonist montelukast

2006
- 2006-08-09 EP EP06118689A patent/EP1886997A1/de not_active Withdrawn
2007
- 2007-08-07 AT AT07788278T patent/ATE499345T1/de not_active IP Right Cessation
- 2007-08-07 CN CN2007800263787A patent/CN101490005B/zh not_active Expired - Fee Related
- 2007-08-07 EP EP07788278A patent/EP2066638B8/de active Active
- 2007-08-07 SI SI200730588T patent/SI2066638T1/sl unknown
- 2007-08-07 WO PCT/EP2007/058176 patent/WO2008017667A1/en not_active Ceased
- 2007-08-07 MX MX2008015135A patent/MX2008015135A/es active IP Right Grant
- 2007-08-07 HR HR20110322T patent/HRP20110322T1/hr unknown
- 2007-08-07 CA CA002657017A patent/CA2657017A1/en not_active Abandoned
- 2007-08-07 PL PL07788278T patent/PL2066638T3/pl unknown
- 2007-08-07 ES ES07788278T patent/ES2361239T3/es active Active
- 2007-08-07 KR KR1020097002300A patent/KR20090037445A/ko not_active Withdrawn
- 2007-08-07 RU RU2009108271/04A patent/RU2009108271A/ru not_active Application Discontinuation
- 2007-08-07 JP JP2009523275A patent/JP2010500324A/ja active Pending
- 2007-08-07 DE DE602007012728T patent/DE602007012728D1/de active Active
- 2007-08-07 AU AU2007283613A patent/AU2007283613A1/en not_active Abandoned
- 2007-08-07 US US12/376,773 patent/US20100029945A1/en not_active Abandoned
- 2007-08-07 PT PT07788278T patent/PT2066638E/pt unknown
2008
- 2008-12-01 IL IL195622A patent/IL195622A/en not_active IP Right Cessation
2009
- 2009-02-17 NO NO20090748A patent/NO20090748L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
MX2008015135A (es)	2008-12-15
EP2066638B8 (de)	2011-10-12
ES2361239T3 (es)	2011-06-15
PT2066638E (pt)	2011-05-16
KR20090037445A (ko)	2009-04-15
WO2008017667A1 (en)	2008-02-14
AU2007283613A1 (en)	2008-02-14
RU2009108271A (ru)	2010-09-20
IL195622A0 (en)	2009-09-01
EP2066638B1 (de)	2011-02-23
IL195622A (en)	2011-03-31
EP1886997A1 (de)	2008-02-13
EP2066638A1 (de)	2009-06-10
CN101490005B (zh)	2011-08-31
JP2010500324A (ja)	2010-01-07
NO20090748L (no)	2009-03-09
US20100029945A1 (en)	2010-02-04
HRP20110322T1 (hr)	2011-06-30
CN101490005A (zh)	2009-07-22
DE602007012728D1 (de)	2011-04-07
PL2066638T3 (pl)	2011-07-29
SI2066638T1 (sl)	2011-06-30
AU2007283613A8 (en)	2009-01-22
CA2657017A1 (en)	2008-02-14

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Legal Events

Date	Code	Title	Description
2011-08-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties