PL2066638T3 - Sposób oczyszczania Montelukastu - Google Patents

Sposób oczyszczania Montelukastu

Info

Publication number: PL2066638T3
Authority: PL; Poland
Prior art keywords: montelukast; comprised; organic solvent; purification; impurities
Prior art date: 2006-08-09

Application number

PL07788278T

Other languages

English (en)

Inventor

Guillen Yolanda Gasanz

Llagostera Montserrat Monsalvatje

Escasany Pedro Talavera

Original Assignee

Esteve Quim S A

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-09

Filing date

2007-08-07

Publication date

2011-07-29

2007-08-07 Application filed by Esteve Quim S A filed Critical Esteve Quim S A

2011-07-29 Publication of PL2066638T3 publication Critical patent/PL2066638T3/pl

Links

UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 title abstract 5
229960005127 montelukast Drugs 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 2
238000000746 purification Methods 0.000 title abstract 2
239000003960 organic solvent Substances 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
239000008346 aqueous phase Substances 0.000 abstract 2
239000012535 impurity Substances 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
238000000638 solvent extraction Methods 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
230000020477 pH reduction Effects 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Quinoline Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

PL07788278T 2006-08-09 2007-08-07 Sposób oczyszczania Montelukastu PL2066638T3 (pl)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US83687306P	2006-08-09	2006-08-09
EP06118689A EP1886997A1 (en)	2006-08-09	2006-08-09	Process for the purification of montelukast
PCT/EP2007/058176 WO2008017667A1 (en)	2006-08-09	2007-08-07	Process for the purification of montelukast
EP07788278A EP2066638B8 (en)	2006-08-09	2007-08-07	Process for the purification of montelukast

Publications (1)

Publication Number	Publication Date
PL2066638T3 true PL2066638T3 (pl)	2011-07-29

Family

ID=37667497

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PL07788278T PL2066638T3 (pl)	2006-08-09	2007-08-07	Sposób oczyszczania Montelukastu

Country Status (19)

Country	Link
US (1)	US20100029945A1 (pl)
EP (2)	EP1886997A1 (pl)
JP (1)	JP2010500324A (pl)
KR (1)	KR20090037445A (pl)
CN (1)	CN101490005B (pl)
AT (1)	ATE499345T1 (pl)
AU (1)	AU2007283613A1 (pl)
CA (1)	CA2657017A1 (pl)
DE (1)	DE602007012728D1 (pl)
ES (1)	ES2361239T3 (pl)
HR (1)	HRP20110322T1 (pl)
IL (1)	IL195622A (pl)
MX (1)	MX2008015135A (pl)
NO (1)	NO20090748L (pl)
PL (1)	PL2066638T3 (pl)
PT (1)	PT2066638E (pl)
RU (1)	RU2009108271A (pl)
SI (1)	SI2066638T1 (pl)
WO (1)	WO2008017667A1 (pl)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7821421B2 (en)	2003-07-07	2010-10-26	Sensomatix Ltd.	Traffic information system
US7812168B2 (en)	2005-07-05	2010-10-12	Teva Pharmaceutical Industries Ltd.	Purification of montelukast
EP2552892A1 (en)	2010-03-31	2013-02-06	KRKA, D.D., Novo Mesto	Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
JP5553096B2 (ja) *	2012-08-29	2014-07-16	大日本印刷株式会社	高純度モンテルカストの製造法
CN103570619B (zh) *	2013-11-08	2015-12-09	南京靖龙药物研发有限公司	一种孟鲁司特钠衍生物的制备方法
CN105646344B (zh) *	2016-02-29	2018-08-14	山东新时代药业有限公司	一种孟鲁司特的纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050107612A1 (en) *	2002-12-30	2005-05-19	Dr. Reddy's Laboratories Limited	Process for preparation of montelukast and its salts
EP1708708A1 (en) *	2004-01-30	2006-10-11	Teva Pharmaceutical Industries Ltd.	Montelukast free acid polymorphs
EP1711166A1 (en) *	2004-02-03	2006-10-18	Chemagis Ltd.	Stable amorphous forms of montelukast sodium
US7189853B2 (en) *	2004-04-15	2007-03-13	Dr. Reddy's Laboratories Limited	Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts
US20080214822A1 (en) *	2004-11-30	2008-09-04	Medichem, S.A.	Process For the Preparation of a Leukotriene Antagonist
WO2006064269A2 (en) *	2004-12-17	2006-06-22	Cipla Limited	Salts of leukotriene antagonist montelukast

2006
- 2006-08-09 EP EP06118689A patent/EP1886997A1/en not_active Withdrawn
2007
- 2007-08-07 WO PCT/EP2007/058176 patent/WO2008017667A1/en not_active Ceased
- 2007-08-07 JP JP2009523275A patent/JP2010500324A/ja active Pending
- 2007-08-07 ES ES07788278T patent/ES2361239T3/es active Active
- 2007-08-07 AU AU2007283613A patent/AU2007283613A1/en not_active Abandoned
- 2007-08-07 DE DE602007012728T patent/DE602007012728D1/de active Active
- 2007-08-07 RU RU2009108271/04A patent/RU2009108271A/ru not_active Application Discontinuation
- 2007-08-07 CN CN2007800263787A patent/CN101490005B/zh not_active Expired - Fee Related
- 2007-08-07 KR KR1020097002300A patent/KR20090037445A/ko not_active Withdrawn
- 2007-08-07 PT PT07788278T patent/PT2066638E/pt unknown
- 2007-08-07 SI SI200730588T patent/SI2066638T1/sl unknown
- 2007-08-07 HR HR20110322T patent/HRP20110322T1/hr unknown
- 2007-08-07 AT AT07788278T patent/ATE499345T1/de not_active IP Right Cessation
- 2007-08-07 PL PL07788278T patent/PL2066638T3/pl unknown
- 2007-08-07 US US12/376,773 patent/US20100029945A1/en not_active Abandoned
- 2007-08-07 EP EP07788278A patent/EP2066638B8/en active Active
- 2007-08-07 CA CA002657017A patent/CA2657017A1/en not_active Abandoned
- 2007-08-07 MX MX2008015135A patent/MX2008015135A/es active IP Right Grant
2008
- 2008-12-01 IL IL195622A patent/IL195622A/en not_active IP Right Cessation
2009
- 2009-02-17 NO NO20090748A patent/NO20090748L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
US20100029945A1 (en)	2010-02-04
IL195622A (en)	2011-03-31
NO20090748L (no)	2009-03-09
EP2066638A1 (en)	2009-06-10
RU2009108271A (ru)	2010-09-20
EP2066638B1 (en)	2011-02-23
CN101490005A (zh)	2009-07-22
HRP20110322T1 (hr)	2011-06-30
EP2066638B8 (en)	2011-10-12
CA2657017A1 (en)	2008-02-14
DE602007012728D1 (de)	2011-04-07
JP2010500324A (ja)	2010-01-07
EP1886997A1 (en)	2008-02-13
CN101490005B (zh)	2011-08-31
AU2007283613A1 (en)	2008-02-14
PT2066638E (pt)	2011-05-16
WO2008017667A1 (en)	2008-02-14
ATE499345T1 (de)	2011-03-15
IL195622A0 (en)	2009-09-01
MX2008015135A (es)	2008-12-15
AU2007283613A8 (en)	2009-01-22
ES2361239T3 (es)	2011-06-15
SI2066638T1 (sl)	2011-06-30
KR20090037445A (ko)	2009-04-15

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