NO20090748L - Fremgangsmate for rensing av montelukast - Google Patents

Fremgangsmate for rensing av montelukast

Info

Publication number
NO20090748L
NO20090748L NO20090748A NO20090748A NO20090748L NO 20090748 L NO20090748 L NO 20090748L NO 20090748 A NO20090748 A NO 20090748A NO 20090748 A NO20090748 A NO 20090748A NO 20090748 L NO20090748 L NO 20090748L
Authority
NO
Norway
Prior art keywords
montelukast
comprised
organic solvent
impurities
mixture
Prior art date
Application number
NO20090748A
Other languages
English (en)
Inventor
Montserrat Monsalvatje Llagostera
Pedro Talavera Escasany
Yolanda Gasanz Guillen
Original Assignee
Esteve Quimica Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa
Publication of NO20090748L publication Critical patent/NO20090748L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Det er beskrevet en fremgangsmåte for rensing av montelukast, eller farmasøytiske salter derav, eller solvater derav, innbefattende stereoisomerer eller blandinger derav som omfatter utførelse av en spesifikk serie av selektive oppløsningsmiddel-ekstraksjoner av montelukast eller dets forurensninger i en blanding av et organisk oppløsningsmiddel og vann ved spesifikke områder av pH og temperatur som avhenger av typen av forurensninger som skal fjernes. Spesielt omfatter den minst én vasking av en vandig fase inneholdende rått montelukast i saltform med et organisk oppløsningsmiddel, ved en pH omfattet mellom 12,0 og 13,5; og eventuelt en eller flere vaskinger av den resulterende vandige fasen med et organisk oppløsningsmiddel ved en pH omfattet mellom 8,5 og 10,0. Montelukast utvinnes ved surgjøring ved en pH omfattet mellom 4,5 og 8,0 og oppløsningsmiddelekstraksjon, og isoleres enten som syre eller i saltform.
NO20090748A 2006-08-09 2009-02-17 Fremgangsmate for rensing av montelukast NO20090748L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83687306P 2006-08-09 2006-08-09
EP06118689A EP1886997A1 (en) 2006-08-09 2006-08-09 Process for the purification of montelukast
PCT/EP2007/058176 WO2008017667A1 (en) 2006-08-09 2007-08-07 Process for the purification of montelukast

Publications (1)

Publication Number Publication Date
NO20090748L true NO20090748L (no) 2009-03-09

Family

ID=37667497

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20090748A NO20090748L (no) 2006-08-09 2009-02-17 Fremgangsmate for rensing av montelukast

Country Status (19)

Country Link
US (1) US20100029945A1 (no)
EP (2) EP1886997A1 (no)
JP (1) JP2010500324A (no)
KR (1) KR20090037445A (no)
CN (1) CN101490005B (no)
AT (1) ATE499345T1 (no)
AU (1) AU2007283613A1 (no)
CA (1) CA2657017A1 (no)
DE (1) DE602007012728D1 (no)
ES (1) ES2361239T3 (no)
HR (1) HRP20110322T1 (no)
IL (1) IL195622A (no)
MX (1) MX2008015135A (no)
NO (1) NO20090748L (no)
PL (1) PL2066638T3 (no)
PT (1) PT2066638E (no)
RU (1) RU2009108271A (no)
SI (1) SI2066638T1 (no)
WO (1) WO2008017667A1 (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7821421B2 (en) 2003-07-07 2010-10-26 Sensomatix Ltd. Traffic information system
US7812168B2 (en) 2005-07-05 2010-10-12 Teva Pharmaceutical Industries Ltd. Purification of montelukast
EP2552892A1 (en) 2010-03-31 2013-02-06 KRKA, D.D., Novo Mesto Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
JP5553096B2 (ja) * 2012-08-29 2014-07-16 大日本印刷株式会社 高純度モンテルカストの製造法
CN103570619B (zh) * 2013-11-08 2015-12-09 南京靖龙药物研发有限公司 一种孟鲁司特钠衍生物的制备方法
CN105646344B (zh) * 2016-02-29 2018-08-14 山东新时代药业有限公司 一种孟鲁司特的纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050107612A1 (en) * 2002-12-30 2005-05-19 Dr. Reddy's Laboratories Limited Process for preparation of montelukast and its salts
EP1708708A1 (en) * 2004-01-30 2006-10-11 Teva Pharmaceutical Industries Ltd. Montelukast free acid polymorphs
EP1711166A1 (en) * 2004-02-03 2006-10-18 Chemagis Ltd. Stable amorphous forms of montelukast sodium
US7189853B2 (en) * 2004-04-15 2007-03-13 Dr. Reddy's Laboratories Limited Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts
US20080214822A1 (en) * 2004-11-30 2008-09-04 Medichem, S.A. Process For the Preparation of a Leukotriene Antagonist
WO2006064269A2 (en) * 2004-12-17 2006-06-22 Cipla Limited Salts of leukotriene antagonist montelukast

Also Published As

Publication number Publication date
US20100029945A1 (en) 2010-02-04
IL195622A (en) 2011-03-31
EP2066638A1 (en) 2009-06-10
RU2009108271A (ru) 2010-09-20
EP2066638B1 (en) 2011-02-23
PL2066638T3 (pl) 2011-07-29
CN101490005A (zh) 2009-07-22
HRP20110322T1 (hr) 2011-06-30
EP2066638B8 (en) 2011-10-12
CA2657017A1 (en) 2008-02-14
DE602007012728D1 (de) 2011-04-07
JP2010500324A (ja) 2010-01-07
EP1886997A1 (en) 2008-02-13
CN101490005B (zh) 2011-08-31
AU2007283613A1 (en) 2008-02-14
PT2066638E (pt) 2011-05-16
WO2008017667A1 (en) 2008-02-14
ATE499345T1 (de) 2011-03-15
IL195622A0 (en) 2009-09-01
MX2008015135A (es) 2008-12-15
AU2007283613A8 (en) 2009-01-22
ES2361239T3 (es) 2011-06-15
SI2066638T1 (sl) 2011-06-30
KR20090037445A (ko) 2009-04-15

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