ATE499361T1 - 5- oder 6-substituierte benzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus - Google Patents

5- oder 6-substituierte benzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus

Info

Publication number
ATE499361T1
ATE499361T1 AT04804954T AT04804954T ATE499361T1 AT E499361 T1 ATE499361 T1 AT E499361T1 AT 04804954 T AT04804954 T AT 04804954T AT 04804954 T AT04804954 T AT 04804954T AT E499361 T1 ATE499361 T1 AT E499361T1
Authority
AT
Austria
Prior art keywords
replication
inhibitors
respiratory syncytial
syncytial virus
benzimidazole derivatives
Prior art date
Application number
AT04804954T
Other languages
English (en)
Inventor
Jean-Francois Bonfanti
Koenraad Andries
Jerome Fortin
Philippe Muller
Frederic Doublet
Christophe Meyer
Rudy Willebrords
Tom Gevers
Philip Timmerman
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Application granted granted Critical
Publication of ATE499361T1 publication Critical patent/ATE499361T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04804954T 2003-12-18 2004-12-20 5- oder 6-substituierte benzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus ATE499361T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03104806 2003-12-18
US56686704P 2004-04-30 2004-04-30
PCT/EP2004/053618 WO2005058874A1 (en) 2003-12-18 2004-12-20 5- or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication

Publications (1)

Publication Number Publication Date
ATE499361T1 true ATE499361T1 (de) 2011-03-15

Family

ID=43646156

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04804954T ATE499361T1 (de) 2003-12-18 2004-12-20 5- oder 6-substituierte benzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus

Country Status (19)

Country Link
US (2) US20070093502A1 (de)
EP (1) EP1697347B1 (de)
JP (1) JP2007514719A (de)
KR (1) KR101123055B1 (de)
CN (1) CN1914196B (de)
AR (1) AR046770A1 (de)
AT (1) ATE499361T1 (de)
AU (1) AU2004298459B2 (de)
BR (1) BRPI0417273A (de)
CA (1) CA2548793A1 (de)
DE (1) DE602004031555D1 (de)
DK (1) DK1697347T3 (de)
HR (1) HRP20110313T1 (de)
MX (1) MXPA06007111A (de)
MY (1) MY142783A (de)
RU (1) RU2369606C2 (de)
SI (1) SI1697347T1 (de)
TW (1) TWI382981B (de)
WO (1) WO2005058874A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2419613C2 (ru) * 2005-06-20 2011-05-27 Тиботек Фармасьютикалз Лтд Гетероциклиламиноалкилзамещенные бензимидазолы
AU2012322095B2 (en) 2011-10-14 2017-06-29 Ambit Biosciences Corporation Heterocyclic compounds and use thereof as modulators of type III receptor tyrosine kinases
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
LT3483164T (lt) 2017-03-20 2020-05-11 Forma Therapeutics, Inc. Pirolpirolo kompozicijos kaip piruvato kinazės (pkr) aktyvatoriai
WO2019079369A1 (en) 2017-10-19 2019-04-25 Effector Therapeutics, Inc. BENZIMIDAZOLE INDOLE INHIBITORS OF MNK1 AND MNK2
EP3852791B1 (de) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Aktivierung von pyruvatkinase r
EP3853206B1 (de) 2018-09-19 2024-04-10 Novo Nordisk Health Care AG Behandlung von sichelzellanämie mit einer pyruvatkinase-r-aktivierenden verbindung
HRP20251148T1 (hr) 2019-09-19 2025-11-21 Novo Nordisk Health Care Ag Pripravci koji aktiviraju piruvat-kinazu r (pkr)
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025621A (en) * 1975-01-09 1977-05-24 Purdy Clarence L Method of curing and providing immunity from viral infections
CA1140119A (en) 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
US4556660A (en) 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
KR100190299B1 (ko) 1990-07-19 1999-06-01 디르크 반테 신규한 옥사졸릴 유도체
IL147327A0 (en) * 1999-06-28 2002-08-14 Janssen Pharmaceutica Nv Respiratory syncytial virus replication inhibitors
ES2215670T3 (es) * 1999-06-28 2004-10-16 Janssen Pharmaceutica N.V. Inhibidores de la replicacion del virus sincitial respiratorio.
SI1196408T1 (en) * 1999-06-28 2005-02-28 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
US20040157866A1 (en) * 2001-04-30 2004-08-12 Hisashi Takasugi Amide compounds
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
FR2833948B1 (fr) * 2001-12-21 2004-02-06 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et leur utilisation en tant que medicament

Also Published As

Publication number Publication date
KR101123055B1 (ko) 2012-04-12
US20070093502A1 (en) 2007-04-26
AU2004298459B2 (en) 2011-03-17
KR20060127047A (ko) 2006-12-11
HRP20110313T1 (hr) 2011-05-31
BRPI0417273A (pt) 2007-03-27
MY142783A (en) 2010-12-31
JP2007514719A (ja) 2007-06-07
CN1914196B (zh) 2012-01-25
SI1697347T1 (sl) 2011-06-30
AU2004298459A1 (en) 2005-06-30
EP1697347B1 (de) 2011-02-23
CN1914196A (zh) 2007-02-14
US8278455B2 (en) 2012-10-02
EP1697347A1 (de) 2006-09-06
US20090062278A1 (en) 2009-03-05
TW200531970A (en) 2005-10-01
WO2005058874A1 (en) 2005-06-30
TWI382981B (zh) 2013-01-21
RU2006125727A (ru) 2008-01-27
AR046770A1 (es) 2005-12-21
RU2369606C2 (ru) 2009-10-10
CA2548793A1 (en) 2005-06-30
MXPA06007111A (es) 2006-08-23
DK1697347T3 (da) 2011-06-06
DE602004031555D1 (de) 2011-04-07

Similar Documents

Publication Publication Date Title
DE602004012448D1 (de) Morpholinylhaltige benzimidazole als inhibitoren der replikation von respiratory syncytial virus
DK1723136T3 (da) Piperidinamino-benzimidazol-derivat som inhibitorer af replikation af respiratorisk syncytial virus
NL301090I2 (nl) Entrectinib, dan wel tautomeren, of farmaceutisch aanvaardbare zouten daarvan
DK1633726T3 (da) Pyrimidinderivater, der er egnede til behandling af CRTH2-formidlede sygdomme
DE602005023266D1 (de) Azabenzofuransubstituierte thioharnstoffe als inhibitoren der virusreplikation
DK1656347T3 (da) Substituerede indolderivater til farmaceutisk sammensætning til behandling af luftvejssygdomme
DK3456707T3 (da) 4-(p-quinonyl)-2-hydroxybutanamidderivater til behandling af mitokondriesygdomme
DE602005025733D1 (de) Pyrazolopyrimidinderivate als inhibitoren der cyclinabhängigen kinase
ATE541845T1 (de) 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen
ATE543808T1 (de) 5,6-ring-annelierte indolderivate und ihre verwendung
DK2300443T3 (da) Triazolderivater, der er anvendelige til behandling af sygdomme
DK2146991T3 (da) Triazolopyridin-carboxamid-derivater, fremstilling af samme samt terapeutisk anvendelse deraf
DK1989200T3 (da) [4-(benzo[B]thiophen-2-YL)-pyrimidin-2-YL]-aminderivater som IKK-beta-inhibitorer til behandling af cancer og inflammatoriske sygdomme
DK1817282T3 (da) Til behandling af respiratoriske sygdomme egnede phenoxy derivater
DK1937633T3 (da) Biphenyloxyeddikesyrederivater til behandling af respiratoriske sygdomme
ATE435222T1 (de) Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus
ATE499361T1 (de) 5- oder 6-substituierte benzimidazolderivate als inhibitoren der replikation des respiratory syncytial virus
DK2413933T4 (da) 2,4,6-trifluor-N-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamid til behandling af migræne via oral eller intravenøs indgivelse
DK2043656T3 (da) Hidtil ukendt medicinsk anvendelse af triazinderivater
DK2240456T3 (da) Fremgangsmåde til fremstilling af 3, 5-dihydro-L, 3, 5-triazinderivater af metformin- og paraldehydderivater
DE602006005242D1 (de) Pyrazolopyridinderivate als inhibitoren der kinase 1 des beta-adrenergen rezeptors
DK1960387T3 (da) Isoquinolin- og benzo[h]isoquinolinderivater, fremstilling deraf og terapeutisk anvendelse deraf som antagonister af histamin H3-receptoren
DE602004021850D1 (de) Aminobenzimidazole und benzimidazole als inhibitoren der replikation von respiratory syncytial virus
SI1723136T1 (sl) Piperidin-amino-benzimidazolni derivati kot inhibitorji replikacije respiratornega sincicijskega virusa
DE60326035D1 (de) Dipyridodiazepinone als inhibitoren der reversen transkriptase

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties