ATE541845T1 - 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen - Google Patents
2,3-substituierte azaindolderivate zur behandlung von virusinfektionenInfo
- Publication number
- ATE541845T1 ATE541845T1 AT08795630T AT08795630T ATE541845T1 AT E541845 T1 ATE541845 T1 AT E541845T1 AT 08795630 T AT08795630 T AT 08795630T AT 08795630 T AT08795630 T AT 08795630T AT E541845 T1 ATE541845 T1 AT E541845T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- virus infections
- azaindole derivatives
- substituted azaindole
- substituted
- Prior art date
Links
- BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical class C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96870707P | 2007-08-29 | 2007-08-29 | |
| PCT/US2008/010149 WO2009032125A1 (en) | 2007-08-29 | 2008-08-27 | 2,3-substituted azaindole derivatives for treating viral infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE541845T1 true ATE541845T1 (de) | 2012-02-15 |
Family
ID=40227567
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08795630T ATE541845T1 (de) | 2007-08-29 | 2008-08-27 | 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8404845B2 (de) |
| EP (1) | EP2195317B1 (de) |
| JP (2) | JP5258889B2 (de) |
| KR (1) | KR20100065167A (de) |
| CN (1) | CN101842374A (de) |
| AR (1) | AR068108A1 (de) |
| AT (1) | ATE541845T1 (de) |
| AU (1) | AU2008295485B2 (de) |
| CA (1) | CA2697500A1 (de) |
| CL (1) | CL2008002540A1 (de) |
| MX (1) | MX2010002318A (de) |
| PE (1) | PE20090994A1 (de) |
| TW (1) | TW200911807A (de) |
| WO (1) | WO2009032125A1 (de) |
| ZA (1) | ZA201001392B (de) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110104109A1 (en) * | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
| US8546420B2 (en) | 2006-12-22 | 2013-10-01 | Merck Sharp & Dohme Corp. | 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
| BRPI0720625A2 (pt) | 2006-12-22 | 2014-03-25 | Schering Corp | Derivados de indol de 4,5-anel anulados e métodos de uso dos mesmos |
| WO2008136815A2 (en) | 2006-12-22 | 2008-11-13 | Schering Corporation | 5, 6-ring annulated indole derivatives and use thereof |
| JP5258889B2 (ja) | 2007-08-29 | 2013-08-07 | メルク・シャープ・アンド・ドーム・コーポレーション | ウイルス感染症の治療のための2,3−置換アザインドール誘導体 |
| CA2697454C (en) * | 2007-08-29 | 2015-11-03 | Schering Corporation | 2-carboxy substituted indole derivatives and methods of use thereof |
| MX2010005356A (es) * | 2007-11-16 | 2010-05-27 | Schering Corp | Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. |
| EP2222672B1 (de) * | 2007-11-16 | 2013-12-18 | Merck Sharp & Dohme Corp. | 3-aminosulfonylsubstituierte indolderivate und verfahren zu deren anwendung |
| JP5580814B2 (ja) * | 2008-06-13 | 2014-08-27 | メルク・シャープ・アンド・ドーム・コーポレーション | 3環式インドール誘導体およびその使用方法 |
| WO2010010017A1 (en) | 2008-07-23 | 2010-01-28 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
| EP2334662A1 (de) | 2008-09-26 | 2011-06-22 | F. Hoffmann-La Roche AG | Pyrin- oder pyrazinderivate zur behandlung von hcv |
| US9198907B2 (en) | 2009-04-06 | 2015-12-01 | Ptc Therapeutics, Inc. | Combinations of a HCV inhibitor such as bicyclic pyrrole derivatives and a therapeutic agent |
| EP2421831A1 (de) | 2009-04-25 | 2012-02-29 | F. Hoffmann-La Roche AG | Heterocyclische antivirale verbindungen |
| CA2763140A1 (en) | 2009-05-29 | 2010-12-02 | Schering Corporation | Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c |
| AR077004A1 (es) | 2009-06-09 | 2011-07-27 | Hoffmann La Roche | Compuestos heterociclicos antivirales |
| SG176976A1 (en) | 2009-06-24 | 2012-02-28 | Hoffmann La Roche | Heterocyclic antiviral compound |
| BR112012005616A2 (pt) | 2009-09-21 | 2016-06-21 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| CN102040595B (zh) * | 2009-10-22 | 2012-12-12 | 北京协和药厂 | 1,3,4-噻二嗪衍生物,其制备方法和用途 |
| EP2503881B1 (de) | 2009-11-25 | 2015-05-13 | Merck Sharp & Dohme Corp. | Kondensierte trizyklische verbindungen und derivate davon zur behandlung von virenerkrankungen |
| CN101716351B (zh) * | 2009-12-08 | 2012-04-11 | 中国人民解放军军事医学科学院野战输血研究所 | 一类吡啶化合物在制备rna干涉增强剂中的应用 |
| WO2011087740A1 (en) | 2009-12-22 | 2011-07-21 | Schering Corporation | Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases |
| AU2011224698A1 (en) | 2010-03-09 | 2012-11-01 | Merck Sharp & Dohme Corp. | Fused Tricyclic Silyl Compounds and methods of use thereof for the treatment of viral diseases |
| WO2012018534A2 (en) | 2010-07-26 | 2012-02-09 | Schering Corporation | Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases |
| CA2812779A1 (en) | 2010-09-29 | 2012-04-19 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
| EA201391519A1 (ru) | 2011-04-13 | 2014-03-31 | Мерк Шарп И Доум Корп. | 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний |
| US9156872B2 (en) | 2011-04-13 | 2015-10-13 | Merck Sharp & Dohme Corp. | 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| WO2013033899A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases |
| WO2013033900A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases |
| WO2013033901A1 (en) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
| EP2755981A4 (de) | 2011-09-14 | 2015-03-25 | Merck Sharp & Dohme | Silylhaltige heterocyclische derivate sowie verfahren zu ihrer verwendung zur behandlung von virenerkrankungen |
| EP2909209B1 (de) | 2012-10-17 | 2022-08-03 | Merck Sharp & Dohme LLC | 2'-cyan-substituierte nukleosidderivate und verfahren zur verwendung davon zur behandlung von viruserkrankungen |
| AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
| EP2909210A4 (de) | 2012-10-17 | 2016-04-06 | Merck Sharp & Dohme | 2'-disubstituierte nukleosidderivate und verfahren zur verwendung davon zur behandlung von viruserkrankungen |
| AU2013344757A1 (en) | 2012-11-19 | 2015-05-21 | Merck Sharp & Dohme Corp. | 2 -alkynyl substituted nucleoside derivatives for treating viral diseases |
| EP3010512B1 (de) | 2013-06-18 | 2017-12-27 | Merck Sharp & Dohme Corp. | Cyclische phosphonatsubstituierte nukleosidderivate und verfahren zur verwendung davon zur behandlung von virenerkrankungen |
| WO2014205593A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases |
| WO2014205592A1 (en) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Heterocyclic compounds and methods of use thereof for treatment of hepatitis c |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| EP3063140A4 (de) | 2013-10-30 | 2017-11-08 | Merck Sharp & Dohme Corp. | Pseudopolymorphe eines hcv-ns5a-hemmers und verwendungen davon |
| KR20180019234A (ko) | 2015-06-26 | 2018-02-23 | 다케다 야쿠힌 고교 가부시키가이샤 | 콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체 |
| WO2017069173A1 (ja) | 2015-10-20 | 2017-04-27 | 武田薬品工業株式会社 | 複素環化合物 |
| EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
| CN109562113A (zh) | 2016-05-10 | 2019-04-02 | C4医药公司 | 用于靶蛋白降解的螺环降解决定子体 |
| WO2017197051A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | Amine-linked c3-glutarimide degronimers for target protein degradation |
| WO2017197046A1 (en) | 2016-05-10 | 2017-11-16 | C4 Therapeutics, Inc. | C3-carbon linked glutarimide degronimers for target protein degradation |
| ES2989988T3 (es) | 2016-05-10 | 2024-11-28 | C4 Therapeutics Inc | Degronímeros heterorocíclicos para la degradación de proteínas diana |
| EP3471737B1 (de) | 2016-06-20 | 2025-06-04 | Merck Sharp & Dohme LLC | Cyclische phosphonatsubstituierte nukleosidverbindung und verfahren zur verwendung davon für die behandlung von viruserkrankungen |
| CN110769822A (zh) | 2017-06-20 | 2020-02-07 | C4医药公司 | 用于蛋白降解的n/o-连接的降解决定子和降解决定子体 |
| TWI748194B (zh) | 2018-06-28 | 2021-12-01 | 德商菲尼克斯 Fxr有限責任公司 | 含有雙環核心部分之新穎lxr調節劑 |
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| AR029851A1 (es) | 2000-07-21 | 2003-07-16 | Dendreon Corp | Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c |
| AR034127A1 (es) | 2000-07-21 | 2004-02-04 | Schering Corp | Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento |
| CA2427499A1 (en) | 2000-10-10 | 2002-04-18 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppar-.gamma. binding agents |
| CN1301994C (zh) * | 2000-12-12 | 2007-02-28 | 先灵公司 | 作为c型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的二芳基肽 |
| AU2002233928A1 (en) * | 2000-12-18 | 2002-07-01 | Eli Lilly And Company | Cycloalkylfused (g)-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases |
| US7626026B2 (en) | 2001-02-22 | 2009-12-01 | University Of Bradford | Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs for tumour treatment |
| EP2335700A1 (de) * | 2001-07-25 | 2011-06-22 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur |
| JP2006505571A (ja) | 2002-10-15 | 2006-02-16 | リゲル ファーマシューテイカルズ、インコーポレイテッド | 置換されたインドール及びhcv阻害剤としてのその使用 |
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| BRPI0508085A (pt) | 2004-02-27 | 2007-07-17 | Schering Corp | compostos de enxofre como inibidores da ns3 serina protease do vìrus da hepatite c |
| EP1765330A4 (de) | 2004-03-01 | 2007-10-17 | Viropharma Inc | Pyranoindol-derivate und ihre verwendung zur behandlung von hepatitis-c-virus-infektionen oder -erkrankungen |
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| EP1604988A1 (de) | 2004-05-18 | 2005-12-14 | Sanofi-Aventis Deutschland GmbH | Pyridazinonderivate, Methoden, um selbige herzustellen, und ihre Verwendung als Pharmazeutika |
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| US7153848B2 (en) | 2004-08-09 | 2006-12-26 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| CA2577413A1 (en) | 2004-09-23 | 2006-03-30 | Wyeth | Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus |
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| JP4149429B2 (ja) | 2004-10-26 | 2008-09-10 | 本田技研工業株式会社 | 車両の走行安全装置 |
| EP1807397A2 (de) | 2004-10-26 | 2007-07-18 | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. | Tetrazyklische indolderivate als antivirale wirkstoffe |
| AU2006204917A1 (en) | 2005-01-14 | 2006-07-20 | Smithkline Beecham Corporation | Indole derivatives for treating viral infections |
| US20110104109A1 (en) * | 2005-07-13 | 2011-05-05 | Frank Bennett | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
| GB0518390D0 (en) | 2005-09-09 | 2005-10-19 | Angeletti P Ist Richerche Bio | Therapeutic compounds |
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| US8546420B2 (en) * | 2006-12-22 | 2013-10-01 | Merck Sharp & Dohme Corp. | 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections |
| BRPI0720625A2 (pt) | 2006-12-22 | 2014-03-25 | Schering Corp | Derivados de indol de 4,5-anel anulados e métodos de uso dos mesmos |
| WO2008136815A2 (en) * | 2006-12-22 | 2008-11-13 | Schering Corporation | 5, 6-ring annulated indole derivatives and use thereof |
| GB0708141D0 (en) * | 2007-04-26 | 2007-06-06 | Syngenta Participations Ag | Improvements in or relating to organic compounds |
| RU2010111550A (ru) * | 2007-08-29 | 2011-10-10 | Шеринг Корпорейшн (US) | 2,3-замещенные индольные производные для лечения вирусных инфекций |
| JP5258889B2 (ja) | 2007-08-29 | 2013-08-07 | メルク・シャープ・アンド・ドーム・コーポレーション | ウイルス感染症の治療のための2,3−置換アザインドール誘導体 |
| CA2697454C (en) * | 2007-08-29 | 2015-11-03 | Schering Corporation | 2-carboxy substituted indole derivatives and methods of use thereof |
| MX2010005356A (es) * | 2007-11-16 | 2010-05-27 | Schering Corp | Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. |
| EP2222672B1 (de) * | 2007-11-16 | 2013-12-18 | Merck Sharp & Dohme Corp. | 3-aminosulfonylsubstituierte indolderivate und verfahren zu deren anwendung |
| US20100239627A1 (en) * | 2009-03-20 | 2010-09-23 | Wilson Kurt Whitekettle | Quarternary ammonium salts delivery systems |
-
2008
- 2008-08-27 JP JP2010522935A patent/JP5258889B2/ja not_active Expired - Fee Related
- 2008-08-27 US US12/675,270 patent/US8404845B2/en active Active
- 2008-08-27 CN CN200880113532A patent/CN101842374A/zh active Pending
- 2008-08-27 AR ARP080103717A patent/AR068108A1/es not_active Application Discontinuation
- 2008-08-27 TW TW097132727A patent/TW200911807A/zh unknown
- 2008-08-27 EP EP08795630A patent/EP2195317B1/de active Active
- 2008-08-27 AT AT08795630T patent/ATE541845T1/de active
- 2008-08-27 CA CA2697500A patent/CA2697500A1/en not_active Abandoned
- 2008-08-27 AU AU2008295485A patent/AU2008295485B2/en not_active Ceased
- 2008-08-27 WO PCT/US2008/010149 patent/WO2009032125A1/en not_active Ceased
- 2008-08-27 KR KR1020107006653A patent/KR20100065167A/ko not_active Withdrawn
- 2008-08-27 PE PE2008001450A patent/PE20090994A1/es not_active Application Discontinuation
- 2008-08-27 MX MX2010002318A patent/MX2010002318A/es not_active Application Discontinuation
- 2008-08-28 CL CL2008002540A patent/CL2008002540A1/es unknown
-
2010
- 2010-02-25 ZA ZA2010/01392A patent/ZA201001392B/en unknown
-
2013
- 2013-01-09 JP JP2013001656A patent/JP2013064013A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201001392B (en) | 2010-11-24 |
| KR20100065167A (ko) | 2010-06-15 |
| JP2013064013A (ja) | 2013-04-11 |
| CA2697500A1 (en) | 2009-03-12 |
| CL2008002540A1 (es) | 2009-07-17 |
| MX2010002318A (es) | 2010-03-22 |
| TW200911807A (en) | 2009-03-16 |
| AR068108A1 (es) | 2009-11-04 |
| AU2008295485A1 (en) | 2009-03-12 |
| WO2009032125A1 (en) | 2009-03-12 |
| EP2195317A1 (de) | 2010-06-16 |
| PE20090994A1 (es) | 2009-08-03 |
| US20100239527A1 (en) | 2010-09-23 |
| JP2010537982A (ja) | 2010-12-09 |
| JP5258889B2 (ja) | 2013-08-07 |
| CN101842374A (zh) | 2010-09-22 |
| AU2008295485B2 (en) | 2013-09-05 |
| US8404845B2 (en) | 2013-03-26 |
| EP2195317B1 (de) | 2012-01-18 |
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