ATE541845T1 - 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen - Google Patents

2,3-substituierte azaindolderivate zur behandlung von virusinfektionen

Info

Publication number
ATE541845T1
ATE541845T1 AT08795630T AT08795630T ATE541845T1 AT E541845 T1 ATE541845 T1 AT E541845T1 AT 08795630 T AT08795630 T AT 08795630T AT 08795630 T AT08795630 T AT 08795630T AT E541845 T1 ATE541845 T1 AT E541845T1
Authority
AT
Austria
Prior art keywords
treatment
virus infections
azaindole derivatives
substituted azaindole
substituted
Prior art date
Application number
AT08795630T
Other languages
English (en)
Inventor
Gopinadhan Anilkumar
Stuart Rosenblum
Srikanth Venkatraman
F Njoroge
Joseph Kozlowski
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE541845T1 publication Critical patent/ATE541845T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT08795630T 2007-08-29 2008-08-27 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen ATE541845T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US96870707P 2007-08-29 2007-08-29
PCT/US2008/010149 WO2009032125A1 (en) 2007-08-29 2008-08-27 2,3-substituted azaindole derivatives for treating viral infections

Publications (1)

Publication Number Publication Date
ATE541845T1 true ATE541845T1 (de) 2012-02-15

Family

ID=40227567

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08795630T ATE541845T1 (de) 2007-08-29 2008-08-27 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen

Country Status (15)

Country Link
US (1) US8404845B2 (de)
EP (1) EP2195317B1 (de)
JP (2) JP5258889B2 (de)
KR (1) KR20100065167A (de)
CN (1) CN101842374A (de)
AR (1) AR068108A1 (de)
AT (1) ATE541845T1 (de)
AU (1) AU2008295485B2 (de)
CA (1) CA2697500A1 (de)
CL (1) CL2008002540A1 (de)
MX (1) MX2010002318A (de)
PE (1) PE20090994A1 (de)
TW (1) TW200911807A (de)
WO (1) WO2009032125A1 (de)
ZA (1) ZA201001392B (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110104109A1 (en) * 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
US8546420B2 (en) 2006-12-22 2013-10-01 Merck Sharp & Dohme Corp. 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections
BRPI0720625A2 (pt) 2006-12-22 2014-03-25 Schering Corp Derivados de indol de 4,5-anel anulados e métodos de uso dos mesmos
WO2008136815A2 (en) 2006-12-22 2008-11-13 Schering Corporation 5, 6-ring annulated indole derivatives and use thereof
JP5258889B2 (ja) 2007-08-29 2013-08-07 メルク・シャープ・アンド・ドーム・コーポレーション ウイルス感染症の治療のための2,3−置換アザインドール誘導体
CA2697454C (en) * 2007-08-29 2015-11-03 Schering Corporation 2-carboxy substituted indole derivatives and methods of use thereof
MX2010005356A (es) * 2007-11-16 2010-05-27 Schering Corp Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos.
EP2222672B1 (de) * 2007-11-16 2013-12-18 Merck Sharp & Dohme Corp. 3-aminosulfonylsubstituierte indolderivate und verfahren zu deren anwendung
JP5580814B2 (ja) * 2008-06-13 2014-08-27 メルク・シャープ・アンド・ドーム・コーポレーション 3環式インドール誘導体およびその使用方法
WO2010010017A1 (en) 2008-07-23 2010-01-28 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
EP2334662A1 (de) 2008-09-26 2011-06-22 F. Hoffmann-La Roche AG Pyrin- oder pyrazinderivate zur behandlung von hcv
US9198907B2 (en) 2009-04-06 2015-12-01 Ptc Therapeutics, Inc. Combinations of a HCV inhibitor such as bicyclic pyrrole derivatives and a therapeutic agent
EP2421831A1 (de) 2009-04-25 2012-02-29 F. Hoffmann-La Roche AG Heterocyclische antivirale verbindungen
CA2763140A1 (en) 2009-05-29 2010-12-02 Schering Corporation Antiviral compounds composed of three linked aryl moieties to treat diseases such as hepatitis c
AR077004A1 (es) 2009-06-09 2011-07-27 Hoffmann La Roche Compuestos heterociclicos antivirales
SG176976A1 (en) 2009-06-24 2012-02-28 Hoffmann La Roche Heterocyclic antiviral compound
BR112012005616A2 (pt) 2009-09-21 2016-06-21 Hoffmann La Roche compostos antivirais heterocíclicos
CN102040595B (zh) * 2009-10-22 2012-12-12 北京协和药厂 1,3,4-噻二嗪衍生物,其制备方法和用途
EP2503881B1 (de) 2009-11-25 2015-05-13 Merck Sharp & Dohme Corp. Kondensierte trizyklische verbindungen und derivate davon zur behandlung von virenerkrankungen
CN101716351B (zh) * 2009-12-08 2012-04-11 中国人民解放军军事医学科学院野战输血研究所 一类吡啶化合物在制备rna干涉增强剂中的应用
WO2011087740A1 (en) 2009-12-22 2011-07-21 Schering Corporation Fused tricyclic compounds and methods of use thereof for the treatment of viral diseases
AU2011224698A1 (en) 2010-03-09 2012-11-01 Merck Sharp & Dohme Corp. Fused Tricyclic Silyl Compounds and methods of use thereof for the treatment of viral diseases
WO2012018534A2 (en) 2010-07-26 2012-02-09 Schering Corporation Substituted biphenylene compounds and methods of use thereof for the treatment of viral diseases
CA2812779A1 (en) 2010-09-29 2012-04-19 Merck Sharp & Dohme Corp. Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases
EA201391519A1 (ru) 2011-04-13 2014-03-31 Мерк Шарп И Доум Корп. 2'-замещенные нуклеозидные производные и способы их применения для лечения вирусных заболеваний
US9156872B2 (en) 2011-04-13 2015-10-13 Merck Sharp & Dohme Corp. 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
EP2755981A4 (de) 2011-09-14 2015-03-25 Merck Sharp & Dohme Silylhaltige heterocyclische derivate sowie verfahren zu ihrer verwendung zur behandlung von virenerkrankungen
EP2909209B1 (de) 2012-10-17 2022-08-03 Merck Sharp & Dohme LLC 2'-cyan-substituierte nukleosidderivate und verfahren zur verwendung davon zur behandlung von viruserkrankungen
AR092959A1 (es) 2012-10-17 2015-05-06 Merck Sharp & Dohme Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales
EP2909210A4 (de) 2012-10-17 2016-04-06 Merck Sharp & Dohme 2'-disubstituierte nukleosidderivate und verfahren zur verwendung davon zur behandlung von viruserkrankungen
AU2013344757A1 (en) 2012-11-19 2015-05-21 Merck Sharp & Dohme Corp. 2 -alkynyl substituted nucleoside derivatives for treating viral diseases
EP3010512B1 (de) 2013-06-18 2017-12-27 Merck Sharp & Dohme Corp. Cyclische phosphonatsubstituierte nukleosidderivate und verfahren zur verwendung davon zur behandlung von virenerkrankungen
WO2014205593A1 (en) 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for treatment of viral diseases
WO2014205592A1 (en) 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Heterocyclic compounds and methods of use thereof for treatment of hepatitis c
GB201317363D0 (en) 2013-10-01 2013-11-13 Eisai Ltd Novel compounds
EP3063140A4 (de) 2013-10-30 2017-11-08 Merck Sharp & Dohme Corp. Pseudopolymorphe eines hcv-ns5a-hemmers und verwendungen davon
KR20180019234A (ko) 2015-06-26 2018-02-23 다케다 야쿠힌 고교 가부시키가이샤 콜린성 무스카린 m1 수용체의 조절제로서의 2,3-디히드로-4h-1,3-벤족사진-4-온 유도체
WO2017069173A1 (ja) 2015-10-20 2017-04-27 武田薬品工業株式会社 複素環化合物
EP3241830A1 (de) 2016-05-04 2017-11-08 Bayer CropScience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
CN109562113A (zh) 2016-05-10 2019-04-02 C4医药公司 用于靶蛋白降解的螺环降解决定子体
WO2017197051A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Amine-linked c3-glutarimide degronimers for target protein degradation
WO2017197046A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. C3-carbon linked glutarimide degronimers for target protein degradation
ES2989988T3 (es) 2016-05-10 2024-11-28 C4 Therapeutics Inc Degronímeros heterorocíclicos para la degradación de proteínas diana
EP3471737B1 (de) 2016-06-20 2025-06-04 Merck Sharp & Dohme LLC Cyclische phosphonatsubstituierte nukleosidverbindung und verfahren zur verwendung davon für die behandlung von viruserkrankungen
CN110769822A (zh) 2017-06-20 2020-02-07 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
TWI748194B (zh) 2018-06-28 2021-12-01 德商菲尼克斯 Fxr有限責任公司 含有雙環核心部分之新穎lxr調節劑

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE648639C (de) 1935-05-19 1937-08-05 I G Farbenindustrie Akt Ges Verfahren zur Darstellung von Dipyrrolen
US3632805A (en) * 1967-12-08 1972-01-04 Sumitomo Chemical Co Process for producing 1-aminoalkyl-benzodiazepine derivatives
AU575854B2 (en) * 1983-10-04 1988-08-11 Shionogi & Co., Ltd. 7beta-(carboxyalkenamido) cephalosporins
NZ220764A (en) * 1986-07-02 1989-09-27 Shionogi & Co Crystalline form of 7beta((z)-2-(2-aminothiazol-4-yl)-4- carboxybut-2-enoylamino)-3-cephem-4-carboxylic acid and pharmaceutical compositions
US5017380A (en) * 1986-07-02 1991-05-21 Shionogi & Co., Ltd. Gelatin hard capsule containing crystalline hydrate of oral cephalosporin
CA2038925A1 (en) 1990-03-26 1991-09-27 Takashi Sohda Indole derivatives, their production and use
JPH04149429A (ja) 1990-10-12 1992-05-22 Fuji Photo Film Co Ltd ハロゲン化銀カラー反転写真感光材料およびそれを用いた画像形成方法
IT1278077B1 (it) 1995-05-25 1997-11-17 Angeletti P Ist Richerche Bio Metodologia per riprodurre in vitro le attivita' di rna polimerasi rna-dipendente e di nucleotidiltransferasi terminale codificate dal
US5922757A (en) 1996-09-30 1999-07-13 The Regents Of The University Of California Treatment and prevention of hepatic disorders
CZ298749B6 (cs) 1996-10-18 2008-01-16 Vertex Pharmaceuticals Incorporated Inhibitory serinových proteáz a farmaceutické prostředky s jejich obsahem
GB9623908D0 (en) 1996-11-18 1997-01-08 Hoffmann La Roche Amino acid derivatives
WO1999007734A2 (en) 1997-08-11 1999-02-18 Boehringer Ingelheim (Canada) Ltd. Hepatitis c inhibitor peptide analogues
FR2768146B1 (fr) 1997-09-05 2000-05-05 Oreal Nouveaux composes de la famille des indole-carboxyliques et leur utilisation
JP4748911B2 (ja) * 2000-04-05 2011-08-17 シェーリング コーポレイション N−環状p2部分を含むc型肝炎ウイルスの大環状ns3‐セリンプロテアーゼ阻害剤
CN1432022A (zh) 2000-04-19 2003-07-23 先灵公司 含有烷基和芳基丙氨酸p2部分的丙型肝炎病毒的大环ns3-丝氨酸蛋白酶抑制剂
CZ303213B6 (cs) * 2000-07-21 2012-05-23 Schering Corporation Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostredek
RU2003105221A (ru) 2000-07-21 2004-09-20 Шеринг Корпорейшн (US) Новые пептиды, как ингибиторы ns3-серинпротеазы вируса гепатита с
AR029851A1 (es) 2000-07-21 2003-07-16 Dendreon Corp Nuevos peptidos como inhibidores de ns3-serina proteasa del virus de hepatitis c
AR034127A1 (es) 2000-07-21 2004-02-04 Schering Corp Imidazolidinonas como inhibidores de ns3-serina proteasa del virus de hepatitis c, composicion farmaceutica, un metodo para su preparacion, y el uso de las mismas para la manufactura de un medicamento
CA2427499A1 (en) 2000-10-10 2002-04-18 Smithkline Beecham Corporation Substituted indoles, pharmaceutical compositions containing such indoles and their use as ppar-.gamma. binding agents
CN1301994C (zh) * 2000-12-12 2007-02-28 先灵公司 作为c型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的二芳基肽
AU2002233928A1 (en) * 2000-12-18 2002-07-01 Eli Lilly And Company Cycloalkylfused (g)-indole compounds as spla2-inhibitors in the treatment of inflammatory diseases
US7626026B2 (en) 2001-02-22 2009-12-01 University Of Bradford Pyrrolo-indole and pyrrolo-quinoline derivatives as prodrugs for tumour treatment
EP2335700A1 (de) * 2001-07-25 2011-06-22 Boehringer Ingelheim (Canada) Ltd. Hepatitis C Virus Polymerase Inhibitoren mit heterobicylischer Struktur
JP2006505571A (ja) 2002-10-15 2006-02-16 リゲル ファーマシューテイカルズ、インコーポレイテッド 置換されたインドール及びhcv阻害剤としてのその使用
US20050075331A1 (en) * 2003-10-06 2005-04-07 Pratt John K. Anti-infective agents
JP4980715B2 (ja) 2003-05-30 2012-07-18 ジェミン エックス ファーマシューティカルズ カナダ インコーポレイテッド がんまたはウイルス疾患を治療するための三環性複素環化合物、組成物および方法
GB0323845D0 (en) * 2003-10-10 2003-11-12 Angeletti P Ist Richerche Bio Chemical compounds,compositions and uses
PE20050925A1 (es) * 2003-11-10 2005-11-29 Schering Corp Anticuerpo recombinante humanizado anti-interleuquina 10
BRPI0508085A (pt) 2004-02-27 2007-07-17 Schering Corp compostos de enxofre como inibidores da ns3 serina protease do vìrus da hepatite c
EP1765330A4 (de) 2004-03-01 2007-10-17 Viropharma Inc Pyranoindol-derivate und ihre verwendung zur behandlung von hepatitis-c-virus-infektionen oder -erkrankungen
PE20060309A1 (es) * 2004-05-06 2006-04-13 Schering Corp (1r,2s,5s)-n-[(1s)-3-amino-1-(ciclobutilmetil)-2,3-dioxopropil]-3-[(2s)-2[[[(1,1-dimetiletil)amino]carbonil]amino]-3,3-dimetil-1-oxobutil]-6,6-dimetil-3-azabiciclo[3.1.o]hexan-2-carboxamida como inhibidor de la ns3/ns4a serina proteasa del virus de l
EP1604988A1 (de) 2004-05-18 2005-12-14 Sanofi-Aventis Deutschland GmbH Pyridazinonderivate, Methoden, um selbige herzustellen, und ihre Verwendung als Pharmazeutika
WO2007084413A2 (en) 2004-07-14 2007-07-26 Ptc Therapeutics, Inc. Methods for treating hepatitis c
US7153848B2 (en) 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
CA2577413A1 (en) 2004-09-23 2006-03-30 Wyeth Carbazole and cyclopentaindole derivatives to treat infection with hepatitis c virus
DE102004047272A1 (de) 2004-09-24 2006-04-06 Schering Ag Inhibitoren der löslichen Adenylatzyklase
JP4149429B2 (ja) 2004-10-26 2008-09-10 本田技研工業株式会社 車両の走行安全装置
EP1807397A2 (de) 2004-10-26 2007-07-18 Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. Tetrazyklische indolderivate als antivirale wirkstoffe
AU2006204917A1 (en) 2005-01-14 2006-07-20 Smithkline Beecham Corporation Indole derivatives for treating viral infections
US20110104109A1 (en) * 2005-07-13 2011-05-05 Frank Bennett Tetracyclic indole derivatives and their use for treating or preventing viral infections
GB0518390D0 (en) 2005-09-09 2005-10-19 Angeletti P Ist Richerche Bio Therapeutic compounds
MX2008004024A (es) 2005-09-23 2009-02-27 Schering Corp Antagonistas de receptor de glutamato metabotropico-1 tetraciclicos fusionados como agentes terapeuticos.
JP2009523732A (ja) * 2006-01-13 2009-06-25 ピーティーシー セラピューティクス,インコーポレーテッド C型肝炎の治療方法
CA2641859A1 (en) * 2006-02-09 2007-08-16 Schering Corporation Combinations comprising hcv protease inhibitor(s) and hcv polymerase inhibitor(s), and methods of treatment related thereto
US8546420B2 (en) * 2006-12-22 2013-10-01 Merck Sharp & Dohme Corp. 4, 5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections
BRPI0720625A2 (pt) 2006-12-22 2014-03-25 Schering Corp Derivados de indol de 4,5-anel anulados e métodos de uso dos mesmos
WO2008136815A2 (en) * 2006-12-22 2008-11-13 Schering Corporation 5, 6-ring annulated indole derivatives and use thereof
GB0708141D0 (en) * 2007-04-26 2007-06-06 Syngenta Participations Ag Improvements in or relating to organic compounds
RU2010111550A (ru) * 2007-08-29 2011-10-10 Шеринг Корпорейшн (US) 2,3-замещенные индольные производные для лечения вирусных инфекций
JP5258889B2 (ja) 2007-08-29 2013-08-07 メルク・シャープ・アンド・ドーム・コーポレーション ウイルス感染症の治療のための2,3−置換アザインドール誘導体
CA2697454C (en) * 2007-08-29 2015-11-03 Schering Corporation 2-carboxy substituted indole derivatives and methods of use thereof
MX2010005356A (es) * 2007-11-16 2010-05-27 Schering Corp Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos.
EP2222672B1 (de) * 2007-11-16 2013-12-18 Merck Sharp & Dohme Corp. 3-aminosulfonylsubstituierte indolderivate und verfahren zu deren anwendung
US20100239627A1 (en) * 2009-03-20 2010-09-23 Wilson Kurt Whitekettle Quarternary ammonium salts delivery systems

Also Published As

Publication number Publication date
ZA201001392B (en) 2010-11-24
KR20100065167A (ko) 2010-06-15
JP2013064013A (ja) 2013-04-11
CA2697500A1 (en) 2009-03-12
CL2008002540A1 (es) 2009-07-17
MX2010002318A (es) 2010-03-22
TW200911807A (en) 2009-03-16
AR068108A1 (es) 2009-11-04
AU2008295485A1 (en) 2009-03-12
WO2009032125A1 (en) 2009-03-12
EP2195317A1 (de) 2010-06-16
PE20090994A1 (es) 2009-08-03
US20100239527A1 (en) 2010-09-23
JP2010537982A (ja) 2010-12-09
JP5258889B2 (ja) 2013-08-07
CN101842374A (zh) 2010-09-22
AU2008295485B2 (en) 2013-09-05
US8404845B2 (en) 2013-03-26
EP2195317B1 (de) 2012-01-18

Similar Documents

Publication Publication Date Title
ATE541845T1 (de) 2,3-substituierte azaindolderivate zur behandlung von virusinfektionen
BRPI0816116A2 (pt) Derivados de indol 2,3-substituídos para o tratamento de infecções virais.
ATE527241T1 (de) Pyridiazinonderivate zur behandlung von tumoren
PT2109602E (pt) Derivados de tetraciclina para o tratamento de infecções bacterianas, virais e parasitárias
ATE550329T1 (de) Heterobicyclische sulfonamidderivate zur behandlung von diabetes
DE602005026984D1 (de) Chinolin-derivate zur behandlung von latenter tuberkulose
LTC1830843I2 (lt) Indolidono dariniai, skirti fibrozinių ligų gydymui arba prevencijai
AP2010005480A0 (en) Small molecule inhibitors for the treatment or prevention of denque virus infection.
DE602005023172D1 (de) Hydantoinderivate zur behandlung von entzündlichen erkrankungen
ATE534633T1 (de) Indazolderivate zur behandlung von hsp90- induzierten krankheiten
ATE532507T1 (de) Neramexane zur behandlung von subakuten tinnitus
IL187904A (en) Use of quinoline derivatives for the preparation of bacterial preparations for the treatment of bacteria caused by bacteria
EP2135858A4 (de) Zusammensetzung zur behandlung von infektionserkrankungen
DE602005017503D1 (de) Biphenyloxyessigsäure - derivate zur behandlung von atemwegserkränkungen
ATE476414T1 (de) Biphenyloxyessigsäurederivate zur behandlung von atemwegserkrankungen
ATE533774T1 (de) Neuartige nukleosidanaloge zur behandlung von virusinfektionen
BRPI0720323A2 (pt) composto, método de tratamento, composição farmacêutica e uso do composto
CL2007001542A1 (es) Compuestos derivados de aminotiazoles, composicion farmaceutica; y uso para el tratamiento de infecciones bacterianas.
ATE525355T1 (de) 1-ä(4-äbenzoyl(methyl)aminoü-3- (phenyl)butylüazetidinderivate zur behandlung von gastrointestinalen erkrankungen 1
ATE532787T1 (de) Polycyclische mittel zur behandlung von infektionen mit dem respiratory syncytial virus
DE602006021192D1 (de) Visnadin zur Behandlung von Kopfhautjucken
NO20053348D0 (no) Farmasoytisk sammensetning for behandling av virusangrep.
DE602006003094D1 (de) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin-derivate zur behandlung von unfruchtbarkeit
ATE424823T1 (de) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin- derivate als arzneimittel zur behandlung von unfruchtbarkeit
DE602005016141D1 (de) S-mirtazapin zur behandlung von hitzewallungen