DK1697347T3 - 5- eller 6-substituerede benzimidazolderivater som inhibitorer af replikation af respiratorisk syncytial-virus - Google Patents
5- eller 6-substituerede benzimidazolderivater som inhibitorer af replikation af respiratorisk syncytial-virusInfo
- Publication number
- DK1697347T3 DK1697347T3 DK04804954.8T DK04804954T DK1697347T3 DK 1697347 T3 DK1697347 T3 DK 1697347T3 DK 04804954 T DK04804954 T DK 04804954T DK 1697347 T3 DK1697347 T3 DK 1697347T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitors
- respiratory syncytial
- syncytial virus
- virus replication
- benzimidazole derivatives
- Prior art date
Links
- -1 6-substituted benzimidazole Chemical class 0.000 title 1
- 241000725643 Respiratory syncytial virus Species 0.000 title 1
- 229940058303 antinematodal benzimidazole derivative Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000029812 viral genome replication Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03104806 | 2003-12-18 | ||
| US56686704P | 2004-04-30 | 2004-04-30 | |
| PCT/EP2004/053618 WO2005058874A1 (en) | 2003-12-18 | 2004-12-20 | 5- or 6-substituted benzimidazole derivatives as inhibitors of respiratory syncytial virus replication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1697347T3 true DK1697347T3 (da) | 2011-06-06 |
Family
ID=43646156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04804954.8T DK1697347T3 (da) | 2003-12-18 | 2004-12-20 | 5- eller 6-substituerede benzimidazolderivater som inhibitorer af replikation af respiratorisk syncytial-virus |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20070093502A1 (da) |
| EP (1) | EP1697347B1 (da) |
| JP (1) | JP2007514719A (da) |
| KR (1) | KR101123055B1 (da) |
| CN (1) | CN1914196B (da) |
| AR (1) | AR046770A1 (da) |
| AT (1) | ATE499361T1 (da) |
| AU (1) | AU2004298459B2 (da) |
| BR (1) | BRPI0417273A (da) |
| CA (1) | CA2548793A1 (da) |
| DE (1) | DE602004031555D1 (da) |
| DK (1) | DK1697347T3 (da) |
| HR (1) | HRP20110313T1 (da) |
| MX (1) | MXPA06007111A (da) |
| MY (1) | MY142783A (da) |
| RU (1) | RU2369606C2 (da) |
| SI (1) | SI1697347T1 (da) |
| TW (1) | TWI382981B (da) |
| WO (1) | WO2005058874A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0611744B8 (pt) * | 2005-06-20 | 2021-05-25 | Janssen R & D Ireland | benzimidazóis heterociclilaminoalquila substituída, seu processo de preparação e composição farmacêutica |
| RS54936B1 (sr) | 2011-10-14 | 2016-11-30 | Ambit Biosciences Corp | Heterociklična jedinjenja i njihova upotreba kao modulatora receptora tirozin kinaza tipa iii |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| ES2747768T3 (es) | 2017-03-20 | 2020-03-11 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR) |
| US10793551B2 (en) | 2017-10-19 | 2020-10-06 | Effector Therapeutics Inc. | Benzimidazole-indole inhibitors of Mnk1 and Mnk2 |
| ES2989438T3 (es) | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| US12053458B2 (en) | 2018-09-19 | 2024-08-06 | Novo Nordisk Health Care Ag | Treating sickle cell disease with a pyruvate kinase R activating compound |
| US20220378756A1 (en) | 2019-09-19 | 2022-12-01 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4025621A (en) * | 1975-01-09 | 1977-05-24 | Purdy Clarence L | Method of curing and providing immunity from viral infections |
| CA1140119A (en) | 1978-04-03 | 1983-01-25 | Joseph Torremans | N-heterocyclyl-4-piperidinamines |
| US4556660A (en) | 1982-07-12 | 1985-12-03 | Janssen Pharmaceutica N.V. | N-(Bicyclic heterocyclyl)-4-piperidinamines |
| US4634704A (en) | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
| NZ223654A (en) * | 1987-03-09 | 1990-03-27 | Janssen Pharmaceutica Nv | 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions |
| KR100190299B1 (ko) | 1990-07-19 | 1999-06-01 | 디르크 반테 | 신규한 옥사졸릴 유도체 |
| EA005027B1 (ru) * | 1999-06-28 | 2004-10-28 | Янссен Фармацевтика Н.В. | Ингибиторы репликации респираторно-синцитиального вируса |
| EE04592B1 (et) * | 1999-06-28 | 2006-02-15 | Janssen Pharmaceutica N.V. | Respiratoorse süntsütiaalviiruse replikatsiooni inhibiitorid, nende valmistamismeetod, kasutamine ja vaheühendid, farmatseutiline kompositsioon ja selle valmistamismeetod ning produkt |
| SG122814A1 (en) * | 1999-06-28 | 2006-06-29 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors |
| WO2002090347A1 (en) * | 2001-04-30 | 2002-11-14 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds |
| US7030150B2 (en) * | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
| FR2833948B1 (fr) * | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
-
2004
- 2004-12-20 RU RU2006125727/04A patent/RU2369606C2/ru not_active IP Right Cessation
- 2004-12-20 EP EP04804954A patent/EP1697347B1/en not_active Expired - Lifetime
- 2004-12-20 DE DE602004031555T patent/DE602004031555D1/de not_active Expired - Lifetime
- 2004-12-20 HR HR20110313T patent/HRP20110313T1/hr unknown
- 2004-12-20 AT AT04804954T patent/ATE499361T1/de not_active IP Right Cessation
- 2004-12-20 US US10/596,521 patent/US20070093502A1/en not_active Abandoned
- 2004-12-20 JP JP2006544465A patent/JP2007514719A/ja active Pending
- 2004-12-20 AR ARP040104808A patent/AR046770A1/es not_active Application Discontinuation
- 2004-12-20 KR KR1020067014248A patent/KR101123055B1/ko not_active Expired - Fee Related
- 2004-12-20 CA CA002548793A patent/CA2548793A1/en not_active Abandoned
- 2004-12-20 CN CN2004800416543A patent/CN1914196B/zh not_active Expired - Lifetime
- 2004-12-20 BR BRPI0417273-6A patent/BRPI0417273A/pt not_active Application Discontinuation
- 2004-12-20 WO PCT/EP2004/053618 patent/WO2005058874A1/en not_active Ceased
- 2004-12-20 MY MYPI20045258A patent/MY142783A/en unknown
- 2004-12-20 TW TW093139735A patent/TWI382981B/zh not_active IP Right Cessation
- 2004-12-20 MX MXPA06007111A patent/MXPA06007111A/es active IP Right Grant
- 2004-12-20 AU AU2004298459A patent/AU2004298459B2/en not_active Ceased
- 2004-12-20 SI SI200431657T patent/SI1697347T1/sl unknown
- 2004-12-20 DK DK04804954.8T patent/DK1697347T3/da active
-
2008
- 2008-10-17 US US12/253,450 patent/US8278455B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20090062278A1 (en) | 2009-03-05 |
| WO2005058874A1 (en) | 2005-06-30 |
| BRPI0417273A (pt) | 2007-03-27 |
| TWI382981B (zh) | 2013-01-21 |
| AU2004298459A1 (en) | 2005-06-30 |
| EP1697347B1 (en) | 2011-02-23 |
| DE602004031555D1 (de) | 2011-04-07 |
| KR101123055B1 (ko) | 2012-04-12 |
| SI1697347T1 (sl) | 2011-06-30 |
| RU2369606C2 (ru) | 2009-10-10 |
| RU2006125727A (ru) | 2008-01-27 |
| MY142783A (en) | 2010-12-31 |
| JP2007514719A (ja) | 2007-06-07 |
| EP1697347A1 (en) | 2006-09-06 |
| HRP20110313T1 (hr) | 2011-05-31 |
| KR20060127047A (ko) | 2006-12-11 |
| US20070093502A1 (en) | 2007-04-26 |
| TW200531970A (en) | 2005-10-01 |
| AR046770A1 (es) | 2005-12-21 |
| AU2004298459B2 (en) | 2011-03-17 |
| CN1914196A (zh) | 2007-02-14 |
| MXPA06007111A (es) | 2006-08-23 |
| CN1914196B (zh) | 2012-01-25 |
| ATE499361T1 (de) | 2011-03-15 |
| CA2548793A1 (en) | 2005-06-30 |
| US8278455B2 (en) | 2012-10-02 |
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