ATE500221T1 - Verfahren zur herstellung von hydroisoindolin- tachykinin-rezeptorantagonisten - Google Patents
Verfahren zur herstellung von hydroisoindolin- tachykinin-rezeptorantagonistenInfo
- Publication number
- ATE500221T1 ATE500221T1 AT06786450T AT06786450T ATE500221T1 AT E500221 T1 ATE500221 T1 AT E500221T1 AT 06786450 T AT06786450 T AT 06786450T AT 06786450 T AT06786450 T AT 06786450T AT E500221 T1 ATE500221 T1 AT E500221T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor antagonists
- producing
- tachykinin receptor
- hydroisoindoline
- hydroisoindoline tachykinin
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000002462 tachykinin receptor antagonist Substances 0.000 title 1
- 102100024304 Protachykinin-1 Human genes 0.000 abstract 3
- 101000831616 Homo sapiens Protachykinin-1 Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 abstract 2
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 101800003906 Substance P Proteins 0.000 abstract 1
- 102000003141 Tachykinin Human genes 0.000 abstract 1
- 206010046543 Urinary incontinence Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000002464 receptor antagonist Substances 0.000 abstract 1
- 229940044551 receptor antagonist Drugs 0.000 abstract 1
- 108060008037 tachykinin Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69823705P | 2005-07-11 | 2005-07-11 | |
| US69876105P | 2005-07-13 | 2005-07-13 | |
| PCT/US2006/026293 WO2007008564A1 (en) | 2005-07-11 | 2006-07-07 | Process for making hydroisoindoline tachykinin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500221T1 true ATE500221T1 (de) | 2011-03-15 |
Family
ID=37307311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06786450T ATE500221T1 (de) | 2005-07-11 | 2006-07-07 | Verfahren zur herstellung von hydroisoindolin- tachykinin-rezeptorantagonisten |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20100036135A1 (de) |
| EP (1) | EP1904445B1 (de) |
| JP (1) | JP2009500452A (de) |
| AT (1) | ATE500221T1 (de) |
| AU (1) | AU2006269383A1 (de) |
| CA (1) | CA2612844A1 (de) |
| DE (1) | DE602006020450D1 (de) |
| WO (1) | WO2007008564A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6731684B1 (en) | 1998-09-29 | 2004-05-04 | General Instrument Corporation | Method and apparatus for detecting scene changes and adjusting picture coding type in a high definition television encoder |
| AU2007293393A1 (en) * | 2006-09-06 | 2008-03-13 | Merck & Co., Inc. | Liquid and semi-solid pharmaceutical formulations for oral administration of a substituted amide |
| WO2008124143A1 (en) * | 2007-04-10 | 2008-10-16 | Merck & Co., Inc. | Hydroxymethyl ether hydroisoindoline tachykinin receptor antagonists |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| HK1223820A1 (zh) | 2013-06-24 | 2017-08-11 | Menlo Therapeutics Inc. | Nk-1受体拮抗剂司洛匹坦在瘙痒中的用途 |
| IL312486B2 (en) | 2017-04-10 | 2025-05-01 | Chase Therapeutics Corp | NK1 antagonist combination and method for treating synucleinopathies |
| JP7158425B2 (ja) | 2017-06-30 | 2022-10-21 | チェイス セラピューティクス コーポレイション | Ｎｋ－１アンタゴニスト組成物およびうつ病の処置における使用法 |
| US20220048912A1 (en) | 2018-12-12 | 2022-02-17 | Janssen Biopharma, Inc. | Cyclobutyl nucleoside analogs as anti-virals |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002534955A (ja) | 1995-10-18 | 2002-10-15 | メルク エンド カンパニー インコーポレーテッド | シクロペンチルタキキニン受容体アンタゴニスト |
| AR047439A1 (es) * | 2004-01-27 | 2006-01-18 | Merck & Co Inc | Antagonistas del receptor hidroisoindolina taquiquinina |
-
2006
- 2006-07-07 DE DE602006020450T patent/DE602006020450D1/de active Active
- 2006-07-07 CA CA002612844A patent/CA2612844A1/en not_active Abandoned
- 2006-07-07 US US11/922,446 patent/US20100036135A1/en not_active Abandoned
- 2006-07-07 JP JP2008521437A patent/JP2009500452A/ja not_active Withdrawn
- 2006-07-07 AT AT06786450T patent/ATE500221T1/de not_active IP Right Cessation
- 2006-07-07 EP EP06786450A patent/EP1904445B1/de not_active Not-in-force
- 2006-07-07 WO PCT/US2006/026293 patent/WO2007008564A1/en not_active Ceased
- 2006-07-07 AU AU2006269383A patent/AU2006269383A1/en not_active Abandoned
- 2006-07-11 US US11/484,208 patent/US7544815B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1904445B1 (de) | 2011-03-02 |
| DE602006020450D1 (de) | 2011-04-14 |
| WO2007008564A1 (en) | 2007-01-18 |
| CA2612844A1 (en) | 2007-01-18 |
| US20070015923A1 (en) | 2007-01-18 |
| EP1904445A1 (de) | 2008-04-02 |
| AU2006269383A1 (en) | 2007-01-18 |
| JP2009500452A (ja) | 2009-01-08 |
| US7544815B2 (en) | 2009-06-09 |
| US20100036135A1 (en) | 2010-02-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |