ATE500225T1 - Verfahren zur herstellung von montelukast und salzen davon - Google Patents
Verfahren zur herstellung von montelukast und salzen davonInfo
- Publication number
- ATE500225T1 ATE500225T1 AT04770672T AT04770672T ATE500225T1 AT E500225 T1 ATE500225 T1 AT E500225T1 AT 04770672 T AT04770672 T AT 04770672T AT 04770672 T AT04770672 T AT 04770672T AT E500225 T1 ATE500225 T1 AT E500225T1
- Authority
- AT
- Austria
- Prior art keywords
- salts
- phenyl
- ethenyl
- methyl
- producing montelukast
- Prior art date
Links
- UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 229960005127 montelukast Drugs 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 2
- KVVDRQDTODKIJD-UHFFFAOYSA-N 2-cyclopropylacetic acid Chemical compound OC(=O)CC1CC1 KVVDRQDTODKIJD-UHFFFAOYSA-N 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/IN2004/000212 WO2006008751A2 (en) | 2004-07-19 | 2004-07-19 | Process for the preparation of montelukast and its salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE500225T1 true ATE500225T1 (de) | 2011-03-15 |
Family
ID=35785612
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04770672T ATE500225T1 (de) | 2004-07-19 | 2004-07-19 | Verfahren zur herstellung von montelukast und salzen davon |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20090143590A1 (de) |
| EP (1) | EP1812394B1 (de) |
| AT (1) | ATE500225T1 (de) |
| DE (1) | DE602004031678D1 (de) |
| WO (1) | WO2006008751A2 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA06012220A (es) | 2004-04-21 | 2007-07-18 | Teva Pharma | Procesos para preparar sodio de montelukast. |
| US7812168B2 (en) | 2005-07-05 | 2010-10-12 | Teva Pharmaceutical Industries Ltd. | Purification of montelukast |
| AR057909A1 (es) * | 2005-11-18 | 2007-12-26 | Synthon Bv | Proceso para preparar montelukast y compuestos relacionados, que utiliza un compuesto intermediario derivado de un ester sulfonico. |
| WO2007093873A1 (en) | 2006-02-13 | 2007-08-23 | Council Of Scientific And Industrial Research | Bis-pyrr0l0[2,l-c] [1, 4] benzodiazepine- anthraquinone conjugates as antitumour agents and a process for the preparation thereof |
| IL181485A0 (en) * | 2006-02-21 | 2007-07-04 | Chemagis Ltd | Processes for preparing novel montelukast salts |
| EP2004608B1 (de) * | 2006-04-12 | 2011-09-14 | Glade Organics Private Limited | Verbessertes verfahren zur herstellung von montelukast-natrium |
| EP2069307A4 (de) * | 2006-08-04 | 2010-03-03 | Matrix Lab Ltd | Verfahren zur herstellung von montelukast und salzen daraus |
| EP1886998A1 (de) * | 2006-08-09 | 2008-02-13 | Esteve Quimica, S.A. | Verfahren zur Reinigung von Montelukast und dessen Aminesalzen |
| WO2008023044A1 (en) * | 2006-08-23 | 2008-02-28 | Sandoz Ag | Process for the preparation of montelukast free acid and its amine salts |
| US7700776B2 (en) * | 2006-10-24 | 2010-04-20 | Formosa Laboratories, Inc. | Compounds and preparation for montelukast sodium |
| SI22382A (sl) * | 2006-10-26 | 2008-04-30 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Nov postopek za pripravo montelukasta |
| KR100774088B1 (ko) * | 2006-12-14 | 2007-11-06 | 한미약품 주식회사 | 몬테루카스트의 제조방법 및 이에 사용되는 중간체 |
| ES2320077B1 (es) | 2007-07-31 | 2010-02-26 | Moehs Iberica, S.L. | Proceso de preparacion de un antagonista de leucotrienos y de un intermedio del mismo. |
| WO2009027990A1 (en) * | 2007-08-29 | 2009-03-05 | Morepen Laboratories Limited | Salts of montelukast and process therefor |
| CN101889081B (zh) | 2007-09-28 | 2014-06-18 | 科德克希思公司 | 酮还原酶多肽及其用途 |
| EP2053043A1 (de) | 2007-10-26 | 2009-04-29 | Inke, S.A. | Montelukast-Kristallsalz |
| KR100920314B1 (ko) | 2007-11-20 | 2009-10-08 | 보령제약 주식회사 | 몬테루카스트 신규한 염 및 그의 제조방법 |
| CZ2008167A3 (cs) * | 2008-03-14 | 2010-02-24 | Zentiva, A. S. | Specifické necistoty montelukastu |
| WO2009138993A1 (en) * | 2008-05-13 | 2009-11-19 | Macleods Pharmaceuticals Limited | A process for preparation of montelukast sodium salt |
| US8207343B2 (en) | 2008-05-26 | 2012-06-26 | Laurus Labs Private Limited | Process for preparing montelukast and salts thereof |
| KR101123292B1 (ko) | 2008-09-26 | 2012-03-19 | 주식회사 엘지생명과학 | 몬테루카스트 나트륨염의 제조방법 |
| KR100893756B1 (ko) * | 2009-01-14 | 2009-04-22 | 주식회사 메디켐코리아 | 몬테루카스트의 효율적 제조방법 |
| WO2011004298A1 (en) | 2009-07-09 | 2011-01-13 | Alembic Limited | Montelukast hexamethylenediamine salt and its use for the preparation of montelukast sodium |
| EP2287154A1 (de) | 2009-07-14 | 2011-02-23 | KRKA, D.D., Novo Mesto | Effiziente Synthese zur Herstellung von Montelukast |
| WO2011121091A1 (en) | 2010-03-31 | 2011-10-06 | Krka, D.D., Novo Mesto | Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein |
| HUP1000425A2 (en) | 2010-08-11 | 2012-03-28 | Richter Gedeon Nyrt | Process for the production of montelukast sodium |
| CN102442948B (zh) * | 2011-11-01 | 2013-10-16 | 上海璎黎科技有限公司 | 孟鲁司特钠中间体的制备方法 |
| CN102442947B (zh) * | 2011-11-01 | 2013-10-16 | 上海璎黎科技有限公司 | 孟鲁司特钠中间体的制备方法 |
| ES2710312T3 (es) | 2012-05-18 | 2019-04-24 | Laurus Labs Ltd | Un procedimiento para la preparación de montelukast sódico |
| JP6227963B2 (ja) * | 2013-03-28 | 2017-11-08 | 株式会社トクヤマ | モンテルカストジプロピルアミン塩の結晶を製造する方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU222344B1 (hu) * | 1990-10-12 | 2003-06-28 | Merck Frosst Canada & Co. | Eljárás telítetlen hidroxi-alkil-kinolinsavak, és ezeket tartalmazó gyógyszerkészítmények előállítására |
| TW448160B (en) * | 1993-12-28 | 2001-08-01 | Merck & Co Inc | Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists |
| US5523477A (en) * | 1995-01-23 | 1996-06-04 | Merck & Co., Inc. | Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid |
| WO2003066598A1 (en) * | 2002-02-07 | 2003-08-14 | Dr. Reddy's Laboratories Ltd. | Novel anhydrous amorphous forms of montelukast sodium salt |
| US20050107612A1 (en) * | 2002-12-30 | 2005-05-19 | Dr. Reddy's Laboratories Limited | Process for preparation of montelukast and its salts |
| JP2007508271A (ja) * | 2003-10-10 | 2007-04-05 | シントン・ベスローテン・フェンノートシャップ | 固体状態のモンテルカスト |
| ITMI20050247A1 (it) * | 2005-02-18 | 2006-08-19 | Chemi Spa | Processo per la preparazione di montelukast |
-
2004
- 2004-07-19 WO PCT/IN2004/000212 patent/WO2006008751A2/en not_active Ceased
- 2004-07-19 EP EP04770672A patent/EP1812394B1/de not_active Expired - Lifetime
- 2004-07-19 AT AT04770672T patent/ATE500225T1/de not_active IP Right Cessation
- 2004-07-19 DE DE602004031678T patent/DE602004031678D1/de not_active Expired - Lifetime
- 2004-07-19 US US11/791,049 patent/US20090143590A1/en not_active Abandoned
-
2010
- 2010-11-24 US US12/953,509 patent/US20110137039A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1812394A2 (de) | 2007-08-01 |
| US20090143590A1 (en) | 2009-06-04 |
| EP1812394B1 (de) | 2011-03-02 |
| WO2006008751A3 (en) | 2006-10-26 |
| DE602004031678D1 (de) | 2011-04-14 |
| US20110137039A1 (en) | 2011-06-09 |
| WO2006008751A2 (en) | 2006-01-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |