ATE501154T1 - Ein cefdinir-zwischenprodukt - Google Patents

Ein cefdinir-zwischenprodukt

Info

Publication number
ATE501154T1
ATE501154T1 AT03787771T AT03787771T ATE501154T1 AT E501154 T1 ATE501154 T1 AT E501154T1 AT 03787771 T AT03787771 T AT 03787771T AT 03787771 T AT03787771 T AT 03787771T AT E501154 T1 ATE501154 T1 AT E501154T1
Authority
AT
Austria
Prior art keywords
cefdinir
cefdinir intermediate
methylcarbonyloxyimino
aminothiazol
cephem
Prior art date
Application number
AT03787771T
Other languages
English (en)
Inventor
Peter Kremminger
Siegfried Wolf
Johannes Ludescher
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Application granted granted Critical
Publication of ATE501154T1 publication Critical patent/ATE501154T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT03787771T 2002-08-13 2003-08-12 Ein cefdinir-zwischenprodukt ATE501154T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AT12232002 2002-08-13
AT15882002 2002-10-18
PCT/EP2003/008944 WO2004016623A1 (en) 2002-08-13 2003-08-12 A cefdinir intermediate

Publications (1)

Publication Number Publication Date
ATE501154T1 true ATE501154T1 (de) 2011-03-15

Family

ID=31888705

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03787771T ATE501154T1 (de) 2002-08-13 2003-08-12 Ein cefdinir-zwischenprodukt

Country Status (8)

Country Link
US (2) US7250508B2 (de)
EP (2) EP1554289B1 (de)
JP (1) JP2006500356A (de)
KR (2) KR20110005727A (de)
AT (1) ATE501154T1 (de)
AU (1) AU2003255424A1 (de)
DE (1) DE60336331D1 (de)
WO (1) WO2004016623A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100451672B1 (ko) * 2001-06-05 2004-10-08 한미약품 주식회사 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법
ITMI20020913A0 (it) * 2002-04-29 2002-04-29 Acs Dobfar Spa Nuova forma cristallina del cefdinir
KR20110005727A (ko) 2002-08-13 2011-01-18 산도즈 아게 세프디니르 중간체
ITMI20022724A1 (it) * 2002-12-20 2004-06-21 Antibioticos Spa Sali cristallini del cefdinir.
CN100357294C (zh) * 2003-03-24 2007-12-26 桑多斯股份公司 7－[2－(2－氨基噻唑－4－基)－2－羟基亚氨基乙酰胺－3－乙烯基－3－头孢烯－4－羧酸(顺式异构体)的新型晶体和其制备方法
US20040242556A1 (en) * 2003-06-02 2004-12-02 Ramesh Dandala Novel crystalline form of cefdinir
US20050137182A1 (en) * 2003-06-02 2005-06-23 Ramesh Dandala Novel crystalline form of cefdinir
US7105659B2 (en) * 2003-06-02 2006-09-12 Aurobind - Pharma Ltd. Process for preparing cefdinir
US20050209211A1 (en) * 2004-03-16 2005-09-22 Devalina Law Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir
US20060069079A1 (en) * 2004-09-27 2006-03-30 Sever Nancy E Stable amorphous cefdinir
US20050245738A1 (en) * 2004-05-03 2005-11-03 Lupin Ltd Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof
GB0416379D0 (en) * 2004-07-22 2004-08-25 Sandoz Ag Organic compounds
GB0416380D0 (en) * 2004-07-22 2004-08-25 Sandoz Ag Organic compounds
WO2006018807A1 (en) * 2004-08-16 2006-02-23 Ranbaxy Laboratories Limited Crystalline forms of cefdinir
NZ554119A (en) * 2004-09-29 2010-07-30 Bayer Schering Pharma Ag Process for the preparation of 4-{4-[({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenoxy}-N-methylpyridine-2-carboxamide
US7839409B2 (en) * 2004-10-18 2010-11-23 Ali Noorbakhsh Acquisition of extended display identification data (EDID) using inter-IC (I2C) protocol
WO2006059753A1 (en) 2004-11-30 2006-06-08 Astellas Pharma Inc. Novel oral pharmaceutical suspension of cefdinir crystal
EP1828208A2 (de) * 2005-10-31 2007-09-05 Teva Pharmaceutical Industries Ltd Kristalline form eines cefdinir-cäsiumsalzes
US20070128268A1 (en) * 2005-12-07 2007-06-07 Herwig Jennewein Pharmaceutical compositions comprising an antibiotic
GB0616865D0 (en) * 2006-08-25 2007-03-28 Phoenix Chemicals Ltd Process
KR101058135B1 (ko) 2008-04-04 2011-08-24 대웅바이오 주식회사 세프디니르 합성에 유용한 중간체 및 이를 이용하여세프디니르를 제조하는 방법
CN102153566B (zh) * 2010-02-11 2012-08-22 深圳市立国药物研究有限公司 头孢地尼的制备方法
CN102010427B (zh) * 2010-11-19 2012-09-12 苏州中联化学制药有限公司 一种头孢地尼的制备方法
CN101974020B (zh) * 2010-11-19 2012-09-12 苏州中联化学制药有限公司 一种头孢地尼的合成方法
JP5619657B2 (ja) * 2011-03-22 2014-11-05 株式会社Ｌｉｘｉｌ 機能性アルミ材及びその電解処理方法
CN102643293A (zh) * 2012-03-30 2012-08-22 石药集团中诺药业（石家庄）有限公司 头孢地尼三元复合物及其用于制备头孢地尼的方法
CN106279207A (zh) * 2016-08-15 2017-01-04 苏州中联化学制药有限公司 一种头孢地尼的合成方法
CN107892676B (zh) * 2017-12-21 2019-11-29 山东金城柯瑞化学有限公司 头孢地尼活性硫酯的制备方法
CN112645898A (zh) * 2020-12-26 2021-04-13 山东金城柯瑞化学有限公司 氨基噻唑乙酰肟酸粒径可控的制备方法
CN113214186A (zh) * 2021-05-18 2021-08-06 山东昌邑四方医药化工有限公司 头孢地尼活性酯的精制方法

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JPS59184186A (ja) * 1983-04-01 1984-10-19 Meiji Seika Kaisha Ltd 新規セフエム化合物
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GB8800295D0 (en) 1988-01-07 1988-02-10 Fujisawa Pharmaceutical Co Process for preparation of 7-(2-amino-thiazol-4-y)-2-hydroxyimino-acetanidol-3-cephem compounds
DK0630380T3 (da) 1992-02-05 2001-12-10 Biochemie Gmbh Fremgangsmåde til rensning af et 3-cephem-4-carboxylsyrederivat
AT403049B (de) 1995-08-14 1997-10-27 Biochemie Gmbh Abreicherung von 7-adca in 3-vinyl-aca
ES2175167T3 (es) * 1995-12-27 2002-11-16 Hanmi Pharmaceutical Co Ltd Procedimiento para la preparacion de cefdinir.
JP3180350B2 (ja) 1996-02-29 2001-06-25 藤沢薬品工業株式会社 β―ラクタム系抗生物質含有錠剤およびその製造法
AT404251B (de) 1996-08-14 1998-10-27 Biochemie Gmbh Neues kristallines salz von cefixim
AT405283B (de) 1997-04-04 1999-06-25 Biochemie Gmbh Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung
PE20000879A1 (es) 1998-04-29 2000-09-23 Dsm Nv METODO PARA CRISTALIZAR UN ANTIBIOTICO ß-LACTAMICO
JP4544692B2 (ja) 2000-04-13 2010-09-15 大塚化学株式会社 ３−ビニル−セフェム化合物の製造方法
JP4192599B2 (ja) * 2000-12-04 2008-12-10 アステラス製薬株式会社 アミノチアゾール誘導体の無水物の製造方法
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US20050080255A1 (en) 2001-12-13 2005-04-14 Yatendra Kumar Crystalline cefdinir potassium dihydrate
BR0215709A (pt) 2002-04-26 2005-03-29 Ranbaxy Lab Ltd Processo para a preparação de cefdinir
ITMI20020913A0 (it) 2002-04-29 2002-04-29 Acs Dobfar Spa Nuova forma cristallina del cefdinir
KR20110005727A (ko) * 2002-08-13 2011-01-18 산도즈 아게 세프디니르 중간체
ITMI20022076A1 (it) 2002-10-01 2004-04-02 Antibioticos Spa Sali di intermedi del cefdinir.
US7244842B2 (en) 2002-11-15 2007-07-17 Orchid Chemicals & Pharmaceuticals Ltd. Amorphous hydrate of a cephalosporin antibiotic
ITMI20022724A1 (it) 2002-12-20 2004-06-21 Antibioticos Spa Sali cristallini del cefdinir.
WO2004058695A1 (en) 2002-12-26 2004-07-15 Lupin Limited Novel intermediates for synthesis of cephalosporins and process for preparation of such intermediates
CN100357294C (zh) 2003-03-24 2007-12-26 桑多斯股份公司 7－[2－(2－氨基噻唑－4－基)－2－羟基亚氨基乙酰胺－3－乙烯基－3－头孢烯－4－羧酸(顺式异构体)的新型晶体和其制备方法
WO2004104010A1 (en) 2003-05-20 2004-12-02 Ranbaxy Laboratories Limited Crystalline form of cefdinir
US20050137182A1 (en) 2003-06-02 2005-06-23 Ramesh Dandala Novel crystalline form of cefdinir
US7105659B2 (en) * 2003-06-02 2006-09-12 Aurobind - Pharma Ltd. Process for preparing cefdinir
US20040242556A1 (en) 2003-06-02 2004-12-02 Ramesh Dandala Novel crystalline form of cefdinir
US20050059818A1 (en) 2003-09-12 2005-03-17 Duerst Richard W. Polymorph of a pharmaceutical
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US20060142261A1 (en) 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060211676A1 (en) 2004-03-16 2006-09-21 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060142563A1 (en) 2004-03-16 2006-06-29 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20060025399A1 (en) 2004-03-16 2006-02-02 Devalina Law Crystalline anhydrous cefdinir and crystalline cefdinir hydrates
US20050209211A1 (en) 2004-03-16 2005-09-22 Devalina Law Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir
US20050215781A1 (en) 2004-03-17 2005-09-29 Orchid Chemicals & Pharmaceuticals Ltd. Novel polymorph of cefdinir
WO2005090360A1 (en) 2004-03-19 2005-09-29 Orchid Chemicals & Pharmaceuticals Limited Novel polymorph of cefdinir
US20060029674A1 (en) 2004-04-09 2006-02-09 Sever Nancy E Stable amorphous Cefdinir
US20060069079A1 (en) 2004-09-27 2006-03-30 Sever Nancy E Stable amorphous cefdinir
US20050245738A1 (en) 2004-05-03 2005-11-03 Lupin Ltd Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof
WO2005121154A1 (en) * 2004-06-08 2005-12-22 Teva Pharmaceutical Industries Ltd. Process for the preparation of cefdinir
WO2006010978A1 (en) 2004-06-30 2006-02-02 Wockhardt Limited Cefdinir polymorphic forms, and imidazole salt
US7741478B2 (en) 2004-07-05 2010-06-22 Orchid Chemicals & Pharmaceuticals Limited Salts in the preparation of cephalosporin antibiotics
GB0416379D0 (en) * 2004-07-22 2004-08-25 Sandoz Ag Organic compounds
WO2006018807A1 (en) 2004-08-16 2006-02-23 Ranbaxy Laboratories Limited Crystalline forms of cefdinir
WO2006035291A1 (en) 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Crystalline forms of cefdinir potassium
ITMI20042231A1 (it) 2004-11-19 2005-02-19 Antibioticos Spa Cefdinir sale d'ammonio in forma cristallina
WO2006059753A1 (en) 2004-11-30 2006-06-08 Astellas Pharma Inc. Novel oral pharmaceutical suspension of cefdinir crystal
GB2421024A (en) 2004-12-07 2006-06-14 Sandoz Ag Cefdinir crystalline form C
WO2006117794A1 (en) 2005-05-02 2006-11-09 Hetero Drugs Limited A novel crystalline form of cefdinir
US20080287673A1 (en) * 2005-06-15 2008-11-20 Parthasaradhi Reddy Bandk Cefdinir process
US20070244315A1 (en) * 2005-10-31 2007-10-18 Kansal Vinod K Process for the preparation of cefdinir

Also Published As

Publication number Publication date
WO2004016623A1 (en) 2004-02-26
US7825241B2 (en) 2010-11-02
EP1554289A1 (de) 2005-07-20
KR20050087776A (ko) 2005-08-31
KR20110005727A (ko) 2011-01-18
US20080081906A1 (en) 2008-04-03
DE60336331D1 (de) 2011-04-21
AU2003255424A1 (en) 2004-03-03
US7250508B2 (en) 2007-07-31
EP1554289B1 (de) 2011-03-09
JP2006500356A (ja) 2006-01-05
US20060025586A1 (en) 2006-02-02
EP1842852A1 (de) 2007-10-10

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