ATE501157T1 - Formulierungen von borsäure-verbindungen - Google Patents

Formulierungen von borsäure-verbindungen

Info

Publication number
ATE501157T1
ATE501157T1 AT02709145T AT02709145T ATE501157T1 AT E501157 T1 ATE501157 T1 AT E501157T1 AT 02709145 T AT02709145 T AT 02709145T AT 02709145 T AT02709145 T AT 02709145T AT E501157 T1 ATE501157 T1 AT E501157T1
Authority
AT
Austria
Prior art keywords
boronic acid
formulations
boric acid
acid compounds
compounds
Prior art date
Application number
AT02709145T
Other languages
English (en)
Inventor
Shanker Gupta
Original Assignee
Us Of America Represented By The Secretary Dept Of Health And Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23004871&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE501157(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Us Of America Represented By The Secretary Dept Of Health And Human Services filed Critical Us Of America Represented By The Secretary Dept Of Health And Human Services
Application granted granted Critical
Publication of ATE501157T1 publication Critical patent/ATE501157T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/04—Esters of boric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
AT02709145T 2001-01-25 2002-01-25 Formulierungen von borsäure-verbindungen ATE501157T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26416001P 2001-01-25 2001-01-25
PCT/US2002/001907 WO2002059130A1 (en) 2001-01-25 2002-01-25 Formulation of boronic acid compounds

Publications (1)

Publication Number Publication Date
ATE501157T1 true ATE501157T1 (de) 2011-03-15

Family

ID=23004871

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02709145T ATE501157T1 (de) 2001-01-25 2002-01-25 Formulierungen von borsäure-verbindungen

Country Status (14)

Country Link
US (5) US6713446B2 (de)
EP (4) EP3078667B1 (de)
JP (2) JP2004517932A (de)
AT (1) ATE501157T1 (de)
AU (1) AU2002243646B2 (de)
CA (2) CA2435146C (de)
CY (2) CY1111488T1 (de)
DE (1) DE60239384D1 (de)
DK (3) DK1355910T3 (de)
ES (2) ES2702732T3 (de)
FI (1) FI2251344T4 (de)
PT (2) PT3078667T (de)
TR (1) TR201819416T4 (de)
WO (2) WO2002059130A1 (de)

Families Citing this family (154)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
PT3078667T (pt) 2001-01-25 2018-12-28 The United States Of America Represented By The Sec Dep Of Health And Human Services Formulação de compostos de ácido borónico
AU2003263343A1 (en) * 2002-09-09 2004-03-29 Trigen Limited Boronic acid salts ant their use in the treatment of thromobis
US20050282757A1 (en) * 2002-09-09 2005-12-22 Trigen Limited Peptide boronic acid compounds useful in anticoagulation
US7112572B2 (en) * 2002-09-09 2006-09-26 Trigen Limited Multivalent metal salts of boronic acids
US20050119226A1 (en) * 2003-09-09 2005-06-02 Trigen Limited Methods for synthesizing organoboronic compounds and products thereof
US20060084592A1 (en) * 2002-09-09 2006-04-20 Trigen Limited Peptide boronic acid inhibitors
US20050176651A1 (en) * 2002-09-09 2005-08-11 Trigen Limited Peptide boronic acids useful in making salts thereof
US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7223745B2 (en) 2003-08-14 2007-05-29 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US20060052390A1 (en) * 2003-12-24 2006-03-09 Scios, Inc. Treatment of multiple myeloma by p38 MAP kinase and proteasome inhibition
GB0405272D0 (en) * 2004-03-09 2004-04-21 Trigen Ltd Compounds
AU2011265442B2 (en) * 2004-03-30 2014-12-04 Millennium Pharmaceuticals, Inc. Synthesis of boronic ester and acid compounds
AU2016202747B2 (en) * 2004-03-30 2017-11-23 Millennium Pharmaceuticals, Inc. Synthesis of boronic ester and acid compounds
RS53259B (sr) * 2004-03-30 2014-08-29 Millennium Pharmaceuticals Inc. Sinteza bortezomiba
WO2006012395A2 (en) 2004-07-23 2006-02-02 Susan Marie Royalty Peptidase inhibitors
TW200618820A (en) * 2004-11-05 2006-06-16 Alza Corp Liposome formulations of boronic acid compounds
US8017395B2 (en) 2004-12-17 2011-09-13 Lifescan, Inc. Seeding cells on porous supports
US7468383B2 (en) * 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
JP2008539273A (ja) * 2005-04-29 2008-11-13 コーザン バイオサイエンシス インコーポレイテッド １７−ａａｇ又は１７−ａｇ又はどちらかのプロドラッグをプロテアソーム阻害剤と組み合わせて使用する多発性骨髄腫の治療方法
AU2006202209B2 (en) * 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
EP1888123B1 (de) * 2005-06-08 2013-01-09 Janssen Biotech, Inc. Zelltherapie für augendegeneration
JP5436860B2 (ja) * 2005-11-09 2014-03-05 オニキス セラピューティクス， インク． 酵素阻害のための化合物
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
NZ573759A (en) 2006-06-19 2012-03-30 Proteolix Inc Peptide epoxyketones for proteasome inhibition
AU2007221966A1 (en) * 2006-12-08 2008-06-26 Centenary Institute Of Cancer Medicine And Cell Biology Assay for response to proteasome inhibitors
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
US9096832B2 (en) 2007-07-31 2015-08-04 Lifescan, Inc. Differentiation of human embryonic stem cells
EP2178888B1 (de) 2007-08-06 2012-07-04 Millennium Pharmaceuticals, Inc. Proteasominhibitoren
AU2016253697A1 (en) * 2007-08-06 2016-11-24 Millennium Pharmaceuticals, Inc. Proteasome inhibitors
EA034601B1 (ru) * 2007-08-06 2020-02-25 Милленниум Фармасьютикалз, Инк. Способ получения бороновых кислот
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
JP2010539183A (ja) * 2007-09-12 2010-12-16 ドクター・レディーズ・ラボラトリーズ・リミテッド ボルテゾミブおよびその生成のためのプロセス
EA018973B1 (ru) 2007-10-04 2013-12-30 Оникс Терапьютикс, Инк. Кристаллические пептидные кето-эпоксидные ингибиторы протеаз и синтез кето-эпоксидов аминокислот
US7838673B2 (en) 2007-10-16 2010-11-23 Millennium Pharmaceuticals, Inc. Proteasome inhibitors
JP5600595B2 (ja) 2007-10-16 2014-10-01 ミレニアム ファーマシューティカルズ， インコーポレイテッド プロテアソーム阻害剤
ATE523585T1 (de) 2007-11-27 2011-09-15 Lifescan Inc Differenzierung menschlicher embryonaler stammzellen
CA2959401C (en) 2008-02-21 2021-12-07 Centocor Ortho Biotech Inc. Methods, surface modified plates and compositions for cell attachment, cultivation and detachment
AU2013203964B2 (en) * 2008-06-17 2015-04-23 Takeda Pharmaceutical Company Limited Boronate ester compounds and pharmaceutical compositions thereof
HRP20150592T4 (hr) * 2008-06-17 2025-02-14 Millennium Pharmaceuticals, Inc Organoborni esterski spojevi i njihove farmaceutske kompozicije
KR101651661B1 (ko) 2008-06-30 2016-08-26 얀센 바이오테크 인코포레이티드 만능 줄기 세포의 분화
US20100028307A1 (en) * 2008-07-31 2010-02-04 O'neil John J Pluripotent stem cell differentiation
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
EP2344165A4 (de) * 2008-10-01 2012-12-05 Reddys Lab Ltd Dr Pharmazeutische zusammensetzungen mit boronsäureverbindungen
BRPI0919668A2 (pt) 2008-10-21 2018-05-29 Onyx Therapeutics, Inc. terapia de combinação com epóxi-cetonas de peptídeo
MX2011004563A (es) * 2008-10-31 2011-06-01 Centocor Ortho Biotech Inc Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico.
CN102272291B (zh) 2008-10-31 2018-01-16 詹森生物科技公司 人胚胎干细胞向胰腺内分泌谱系的分化
PL2366021T3 (pl) 2008-11-20 2017-12-29 Janssen Biotech, Inc. Hodowla pluripotencjalnych komórek macierzystych na mikronośnikach
PL2366022T3 (pl) * 2008-11-20 2016-11-30 Sposoby i kompozycje do przyłączania i hodowli komórek na podłożach planarnych
WO2010089768A2 (en) * 2009-01-09 2010-08-12 Sun Pharma Advanced Research Company Limited Pharmaceutical composition
CN102369011A (zh) 2009-03-12 2012-03-07 健泰科生物技术公司 用于治疗造血恶性肿瘤的磷酸肌醇3-激酶抑制剂化合物与化学治疗剂的组合
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
DK2411535T3 (en) * 2009-03-24 2015-07-13 Janssen Pharmaceutica Nv BIOMAR RUNNING FOR ASSESSMENT OF PERIPHERAL NEUROPATHY RESPONSE TO TREATMENT WITH a proteasome inhibitor
EP2238973A1 (de) * 2009-04-07 2010-10-13 Cephalon France Lyophilisierte Präparate von Proteasominhibitoren
CN101928329B (zh) * 2009-06-19 2013-07-17 北京大学 三肽硼酸(酯)类化合物、其制备方法和应用
KR20170118969A (ko) 2009-07-20 2017-10-25 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
ES2693088T3 (es) * 2009-07-20 2018-12-07 Janssen Biotech, Inc. Diferenciación de células madre embriónicas humanas
AU2010276402B2 (en) 2009-07-20 2014-07-03 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
ES2557316T3 (es) 2009-09-08 2016-01-25 F. Hoffmann-La Roche Ag Compuestos de piridín-3-il-carboxamida 4-sustituidos y métodos de utilización
AU2010300259A1 (en) 2009-10-01 2012-04-26 Janssen Pharmaceutica Nv Proteasome inhibitors for treating cancer
EP2498793B1 (de) 2009-11-13 2019-07-10 Onyx Therapeutics, Inc. Oprozomib zur verwendung in der metastasensuppression
WO2011087822A1 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
AU2010333839C1 (en) 2009-12-23 2016-07-21 Janssen Biotech Inc. Differentiation of human embryonic stem cells
MX339669B (es) 2009-12-23 2016-06-02 Janssen Biotech Inc Diferenciacion de celulas madres embrionarias humanas.
US20110178287A1 (en) 2010-01-19 2011-07-21 Cerulean Pharma Inc. Cyclodextrin-based polymers for therapeutic delivery
CN107189979B (zh) * 2010-03-01 2021-05-04 詹森生物科技公司 纯化衍生自多能干细胞的细胞的方法
PH12012501719A1 (en) 2010-03-01 2012-11-12 Onyx Therapeutics Inc Compounds for immunoproteasome inhibition
US8263578B2 (en) 2010-03-18 2012-09-11 Innopharma, Inc. Stable bortezomib formulations
EP2547333B1 (de) * 2010-03-18 2017-08-23 Innopharma, Inc. Stabile bortezomibformulierungen
JP5933523B2 (ja) 2010-03-31 2016-06-08 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． １−アミノ−２−シクロプロピルエチルボロン酸の誘導体
US8697646B2 (en) 2010-04-07 2014-04-15 Onyx Therapeutics, Inc. Crystalline peptide epoxyketone immunoproteasome inhibitor
EP2566571A4 (de) * 2010-05-05 2013-11-20 Univ Winthrop Hospital Redundantes schrittmachersystem mit geführter und ungeführter schrittsteuerung
KR101986176B1 (ko) 2010-05-12 2019-06-05 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
CN103037903A (zh) 2010-05-18 2013-04-10 天蓝制药公司 用于治疗自身免疫性疾病或其它疾病的组合物和方法
AU2011296381B2 (en) 2010-08-31 2016-03-31 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
WO2012030540A2 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
WO2012030539A2 (en) 2010-08-31 2012-03-08 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
US9126997B1 (en) 2010-09-07 2015-09-08 Northwestern University Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma
AU2011312264B2 (en) * 2010-10-05 2015-07-02 Fresenius Kabi Usa, Llc Bortezomib formulations stabilised with boric acid
EP2627636B1 (de) 2010-10-14 2015-09-02 Synthon BV Verfahren zur herstellung von bortezomib und den zwischenprodukten für das verfahren
PL2742356T3 (pl) 2011-08-11 2016-11-30 Środki prognostyczne w leczeniu nowotworów
IN2014CN00572A (de) 2011-08-19 2015-04-03 Glaxo Group Ltd
CA2855368A1 (en) 2011-11-11 2013-05-16 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
CA2855356A1 (en) 2011-11-11 2013-05-16 Millennium Pharmaceuticals, Inc. Biomarkers of response to proteasome inhibitors
US9388386B2 (en) 2011-12-22 2016-07-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into single hormonal insulin positive cells
WO2013112598A1 (en) 2012-01-24 2013-08-01 Millennium Pharmaceuticals, Inc. Method of treatment of nasopharyngeal caner
CA2862492A1 (en) 2012-01-24 2013-08-01 Millennium Pharmaceuticals, Inc. Methods of treatment of cancer
EP2819673B1 (de) 2012-03-02 2016-09-07 Dr. Reddy's Laboratories Ltd. Pharmazeutische zusammensetzungen mit borsäureverbindungen
CA2866590A1 (en) 2012-03-07 2013-09-12 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
CA2784240C (en) 2012-03-27 2014-07-08 Innopharma, Inc. Stable bortezomib formulations
WO2013184888A1 (en) 2012-06-08 2013-12-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells
EA021179B1 (ru) * 2012-06-15 2015-04-30 Ощество С Ограниченной Ответственностью "Тева" Лиофилизат соединения бороновой кислоты
US9309283B2 (en) 2012-07-09 2016-04-12 Onyx Therapeutics, Inc. Prodrugs of peptide epoxy ketone protease inhibitors
WO2014041324A1 (en) 2012-09-11 2014-03-20 Cipla Limited Process for preparing of bortezamib
WO2014076713A2 (en) 2012-11-16 2014-05-22 Shilpa Medicare Limited Crystalline bortezomib process
RU2687379C2 (ru) 2012-12-31 2019-05-13 Янссен Байотек, Инк. Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
WO2014105543A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Culturing of human embryonic stem cells at the air-liquid interface for differentiation into pancreatic endocrine cells
RU2684215C2 (ru) 2012-12-31 2019-04-04 Янссен Байотек, Инк. Способ получения панкреатических эндокринных клеток (варианты) и способ увеличения выхода бета-клеток
CN103070835B (zh) * 2013-01-31 2015-01-07 江苏奥赛康药业股份有限公司 一种含硼替佐米的冻干组合物及其制备方法
WO2014170628A1 (en) 2013-04-16 2014-10-23 Cipla Limited Process for the preparation of bortezomib mannitol ester
WO2015025000A1 (en) * 2013-08-23 2015-02-26 Synthon B.V. Pharmaceutical compositions comprising bortezomib
CA2925935A1 (en) 2013-10-03 2015-04-09 Millennium Pharmaceuticals, Inc. Method for the prophylaxis or treatment of systemic lupus erythematosus and/or lupus nephritis
CN104586776B (zh) * 2013-10-30 2017-05-17 扬子江药业集团上海海尼药业有限公司 以硼替佐米为活性成分的制剂及其制备方法
JP6468562B2 (ja) * 2013-11-21 2019-02-13 国立大学法人北海道大学 プロテアソーム阻害性化合物
WO2015117136A1 (en) * 2014-02-03 2015-08-06 Ohio State Innovation Foundation Boronic acid esters and pharmaceutical formulations thereof
JP6588969B2 (ja) 2014-05-16 2019-10-09 ヤンセン バイオテツク，インコーポレーテツド 膵内分泌細胞内のｍａｆａ発現を強化するための小分子の使用
SG10202003693RA (en) 2014-05-20 2020-05-28 Millennium Pharm Inc Boron-containing proteasome inhibitors for use after primary cancer therapy
DE102014010218A1 (de) 2014-07-10 2016-01-14 Immunologik Gmbh Mittel zur Behandlung retroviraler Infektionen
DE102014010220A1 (de) 2014-07-10 2016-01-14 Immunologik Gmbh Mittel zur Behandlung retroviraler Infektionen
EP4180041A1 (de) 2014-08-07 2023-05-17 Mayo Foundation for Medical Education and Research Verbindungen und verfahren zur behandlung von krebs
EP3031811A1 (de) 2014-12-09 2016-06-15 Teva Pharmaceuticals Ltd. Apfelsäureester aus Bortezomib
WO2016110870A1 (en) 2015-01-07 2016-07-14 Emcure Pharmaceuticals Limited Pharmaceutical composition of bortezomid
MA41505A (fr) * 2015-02-11 2017-12-19 Millennium Pharm Inc Nouvelle forme cristalline d'un inhibiteur de protéasome
EP3270891A1 (de) 2015-03-17 2018-01-24 Leon-Nanodrugs GmbH Nanopartikel mit einer stabilisierten boronsäureverbindung
KR101891728B1 (ko) * 2015-04-20 2018-08-24 동아에스티 주식회사 펩타이드 붕소산 화합물을 함유하는 안정화 약학 제제
US9752093B2 (en) * 2015-06-04 2017-09-05 Chevron Oronite Company Llc Borated polyol ester of hindered phenol antioxidant/friction modifier with enhanced performance
EP3120836A1 (de) 2015-07-22 2017-01-25 Stada Arzneimittel Ag Gebrauchsfertige bortezomib-lösung
EP3120837A1 (de) 2015-07-22 2017-01-25 Stada Arzneimittel Ag Verfahren zur herstellung einer bortezomibester-lösung
JP6705911B2 (ja) 2016-04-14 2020-06-03 ヤンセン バイオテツク，インコーポレーテツド 多能性幹細胞の中腸内胚葉細胞への分化
JP6223508B2 (ja) * 2016-06-27 2017-11-01 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤
WO2018038687A1 (en) 2016-08-22 2018-03-01 Mustafa Nevzat Ilaç Sanayii A.Ş. Pharmaceutical formulations comprising a bortezomib-cyclodextrin complex
EP3565549B1 (de) 2017-01-09 2022-03-09 Shuttle Pharmaceuticals, Inc. Selektive histondeacetylaseinhibitoren zur behandlung von menschlichen erkrankungen
US11584733B2 (en) 2017-01-09 2023-02-21 Shuttle Pharmaceuticals, Inc. Selective histone deacetylase inhibitors for the treatment of human disease
CA3054241A1 (en) 2017-02-24 2018-08-30 Bayer Aktiengesellschaft Use of radium ra-223 chloride for the treatment of multiple myeloma
EP3589659B1 (de) 2017-02-28 2025-04-09 Mayo Foundation for Medical Education and Research Kombinationen zur verwendung bei der behandlung von krebs
CN106916177B (zh) * 2017-03-23 2019-04-23 南京陵瑞医药科技有限公司 一种氘代的二肽硼酸或其酯类化合物及其合成方法与用途
JP2018177649A (ja) * 2017-04-04 2018-11-15 日本化薬株式会社 ボルテゾミブを含有する医薬組成物
CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
WO2019006426A2 (en) 2017-06-30 2019-01-03 Massachusetts Institute Of Technology RAMIFIED MULTIFUNCTIONAL MACROMONOMERS AND RELATED POLYMERS AND USES THEREOF
RU2659160C1 (ru) * 2017-07-10 2018-06-28 Акционерное Общество "Фарм-Синтез" Способ получения лиофилизата бортезомиба и фармацевтическая композиция, содержащая бортезомиб в форме стабильного лиофилизованного продукта, полученная указанным способом
JP2020533382A (ja) 2017-09-14 2020-11-19 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ 癌の組合せ治療
JP2018024694A (ja) * 2017-10-03 2018-02-15 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤
JP7423028B2 (ja) * 2017-11-01 2024-01-29 日医工岐阜工場株式会社 ボルテゾミブを含有する凍結乾燥医薬組成物
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
EP3737376B1 (de) 2018-01-09 2024-04-17 Shuttle Pharmaceuticals, Inc. Selektive histondeacetylaseinhibitoren zur behandlung von menschlichen erkrankungen
US12419832B2 (en) 2018-01-29 2025-09-23 Cognos Therapeutics, Inc. Intratumoral delivery of bortezomib
US11243207B2 (en) 2018-03-29 2022-02-08 Mayo Foundation For Medical Education And Research Assessing and treating cancer
CN108451911B (zh) * 2018-04-04 2020-05-22 重庆惠源医药有限公司 一种硼替佐米制剂的制备方法
WO2019200367A1 (en) 2018-04-13 2019-10-17 Massachusetts Institute Of Technology Brush prodrugs and uses thereof
EP3781139A1 (de) 2018-04-18 2021-02-24 F. Hoffmann-La Roche AG Kombinationstherapie mit einem bet-inhibitor und einem proteasominhibitor
CN110540547A (zh) * 2018-05-28 2019-12-06 秦艳茹 一种肽硼酸酯类化合物的合成与用途
US20210393656A1 (en) * 2019-01-11 2021-12-23 Intas Pharmaceuticals Ltd. A process for preparation of a stable pharmaceutical composition of bortezomib
AU2020278465B2 (en) * 2019-05-20 2026-04-23 Dana-Farber Cancer Institute, Inc. Boronic ester prodrugs and uses thereof
JP7387330B2 (ja) * 2019-08-09 2023-11-28 東和薬品株式会社 ボルテゾミブ保存用容器
AU2020368453A1 (en) 2019-10-16 2022-04-21 Massachusetts Institute Of Technology Brush prodrugs and uses thereof
US11986486B2 (en) * 2020-11-02 2024-05-21 Spes Pharmaceuticals Inc. Aqueous compositions of bortezomib
US20230062279A1 (en) 2021-08-12 2023-03-02 Extrovis Ag Pharmaceutical compositions of bortezomib
US20230097975A1 (en) 2021-09-24 2023-03-30 MAIA Pharmaceuticals, Inc. Bortezomib compositions
US20250295771A1 (en) 2022-05-11 2025-09-25 Celgene Corporation Methods and uses related to t cell therapy and production of same
US20250302954A1 (en) 2022-05-11 2025-10-02 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy
WO2024069240A2 (en) 2022-09-29 2024-04-04 Takeda Pharmaceutical Company Limited Cd38-binding fusion protein combination therapy
WO2024097905A1 (en) 2022-11-02 2024-05-10 Celgene Corporation Methods of treatment with t cell therapy and immunomodulatory agent maintenance therapy
WO2025080942A1 (en) * 2023-10-13 2025-04-17 The Brigham And Women’S Hospital, Inc. Proteasome inhibitors and methods of use thereof

Family Cites Families (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5825042B2 (ja) * 1979-08-10 1983-05-25 科学技術庁無機材質研究所長 衝撃圧縮によるダイヤモンド粉末の合成法
FI60700C (fi) 1980-04-09 1982-03-10 Ksv Chemicals Oy Foerfarande foer framstaellning av 1,2-diacyl-sn-glyceroler
US4434188A (en) * 1981-12-17 1984-02-28 National Institute For Researches In Inorganic Materials Method for synthesizing diamond
IT1153974B (it) 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4499082A (en) 1983-12-05 1985-02-12 E. I. Du Pont De Nemours And Company α-Aminoboronic acid peptides
DE3502902A1 (de) * 1984-01-31 1985-08-08 Futaba Denshi Kogyo K.K., Mobara, Chiba Ionenstrahl-aufdampfvorrichtung
US4743522A (en) * 1985-09-13 1988-05-10 Minolta Camera Kabushiki Kaisha Photosensitive member with hydrogen-containing carbon layer
JPS63107898A (ja) * 1986-10-23 1988-05-12 Natl Inst For Res In Inorg Mater プラズマを用いるダイヤモンドの合成法
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
US5242904A (en) 1987-06-05 1993-09-07 The Dupont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
US5250720A (en) 1987-06-05 1993-10-05 The Dupont Merck Pharmaceutical Company Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases
US4822466A (en) * 1987-06-25 1989-04-18 University Of Houston - University Park Chemically bonded diamond films and method for producing same
US4816291A (en) * 1987-08-19 1989-03-28 The Regents Of The University Of California Process for making diamond, doped diamond, diamond-cubic boron nitride composite films
JPS6461396A (en) * 1987-09-01 1989-03-08 Idemitsu Petrochemical Co Synthesis of diamond and installation therefor
NZ226170A (en) 1987-09-18 1990-07-26 Ethicon Inc Stable freeze-dried pharmaceutical composition containing epidermal growth factor
EP0315574A3 (de) 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin-Inhibitoren
US5106948A (en) * 1988-05-27 1992-04-21 Mao Foundation For Medical Education And Research Cytotoxic boronic acid peptide analogs
US4925701A (en) * 1988-05-27 1990-05-15 Xerox Corporation Processes for the preparation of polycrystalline diamond films
US4928629A (en) * 1988-06-13 1990-05-29 Iowa State University Research Foundation, Inc. Egg inoculation method
US4862529A (en) * 1988-07-13 1989-09-05 Hill-Rom Company, Inc. Hospital bed convertible to chair
US4919974A (en) * 1989-01-12 1990-04-24 Ford Motor Company Making diamond composite coated cutting tools
JP2730145B2 (ja) * 1989-03-07 1998-03-25 住友電気工業株式会社 単結晶ダイヤモンド層の形成法
US5082359A (en) * 1989-11-28 1992-01-21 Epion Corporation Diamond films and method of growing diamond films on nondiamond substrates
US4954365A (en) * 1989-12-18 1990-09-04 The United States Of America As Represented By The Secretary Of The Army Method of preparing a thin diamond film
US5071677A (en) * 1990-05-24 1991-12-10 Houston Advanced Research Center Halogen-assisted chemical vapor deposition of diamond
CA2049673A1 (en) * 1990-11-26 1992-05-27 James F. Fleischer Cvd diamond by alternating chemical reactions
US5620512A (en) * 1993-10-27 1997-04-15 University Of Chicago Diamond film growth from fullerene precursors
US5849079A (en) * 1991-11-25 1998-12-15 The University Of Chicago Diamond film growth argon-carbon plasmas
US5370855A (en) * 1991-11-25 1994-12-06 Gruen; Dieter M. Conversion of fullerenes to diamond
US5772760A (en) * 1991-11-25 1998-06-30 The University Of Chicago Method for the preparation of nanocrystalline diamond thin films
US5209916A (en) * 1991-11-25 1993-05-11 Gruen Dieter M Conversion of fullerenes to diamond
US5989511A (en) * 1991-11-25 1999-11-23 The University Of Chicago Smooth diamond films as low friction, long wear surfaces
US6592839B2 (en) * 1991-11-25 2003-07-15 The University Of Chicago Tailoring nanocrystalline diamond film properties
US5360477A (en) * 1992-03-04 1994-11-01 Semiconductor Energy Laboratory Co., Ltd. Method for forming diamond and apparatus for forming the same
US5505953A (en) 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
US5439492A (en) * 1992-06-11 1995-08-08 General Electric Company Fine grain diamond workpieces
US5273788A (en) * 1992-07-20 1993-12-28 The University Of Utah Preparation of diamond and diamond-like thin films
US5449531A (en) * 1992-11-09 1995-09-12 North Carolina State University Method of fabricating oriented diamond films on nondiamond substrates and related structures
US5308661A (en) * 1993-03-03 1994-05-03 The Regents Of The University Of California Pretreatment process for forming a smooth surface diamond film on a carbon-coated substrate
US5935944A (en) 1993-09-10 1999-08-10 Neutron Technology Corporation Formulation for I.V. administration of the boron delivery drug, boronophenylalanine (BPA)
US5492900A (en) 1993-09-10 1996-02-20 Neutron Technology Corporation Method for enhancing the solubility of the boron delivery drug, boronophenylalanine (BPA)
TW280770B (de) 1993-10-15 1996-07-11 Takeda Pharm Industry Co Ltd
US5574017A (en) 1994-07-05 1996-11-12 Gutheil; William G. Antibacterial agents
US6083903A (en) * 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
US5614649A (en) 1994-11-14 1997-03-25 Cephalon, Inc. Multicatalytic protease inhibitors
US5897924A (en) * 1995-06-26 1999-04-27 Board Of Trustees Operating Michigan State University Process for depositing adherent diamond thin films
ATE240113T1 (de) 1997-02-15 2003-05-15 Millennium Pharm Inc Behandlung von infarkten durch inhibierung von nf-kappab
US5962049A (en) 1997-03-31 1999-10-05 Miljkovic; Dusan Boron carbohydrate complexes and uses thereof
EP1017398A1 (de) 1997-09-25 2000-07-12 Proscript, Inc. Proteasome inhibitoren, inhibitoren des ubiquitinweges oder verbindungen, die mit der durch den ubiquitinweg enstehenden nf-kb aktivierung interferieren zur behandlung von entzündlichen und autoimmunerkrankungen
US5985842A (en) 1998-05-14 1999-11-16 Miljkovic; Dusan Boron compounds/complexes to control hair growth, and methods of use
US5935994A (en) 1998-05-29 1999-08-10 Nimni; Marcel E. Nutritionally balanced dermal composition and method
US6169076B1 (en) 1999-03-31 2001-01-02 Glcosyn Pharmaceuticals, Inc. P-Boronophenylalanine complexes with fructose and related carbohydrates and polyols
WO2001002601A2 (en) 1999-07-07 2001-01-11 Du Pont Pharmaceuticals Company Cell-based assay systems for examining hcv ns3 protease activity
US6422077B1 (en) * 2000-04-06 2002-07-23 The University Of Chicago Ultrananocrystalline diamond cantilever wide dynamic range acceleration/vibration/pressure sensor
US6783589B2 (en) * 2001-01-19 2004-08-31 Chevron U.S.A. Inc. Diamondoid-containing materials in microelectronics
PT3078667T (pt) 2001-01-25 2018-12-28 The United States Of America Represented By The Sec Dep Of Health And Human Services Formulação de compostos de ácido borónico
US6619076B2 (en) * 2001-10-12 2003-09-16 David W. Boling Method and apparatus for cooking starch

Also Published As

Publication number Publication date
EP2251344A1 (de) 2010-11-17
AU2002243646B2 (en) 2006-06-22
CY1111488T1 (el) 2015-08-05
US20020169114A1 (en) 2002-11-14
DK2251344T4 (da) 2024-05-13
DE60239384D1 (de) 2011-04-21
ES2571219T3 (es) 2024-09-23
ES2571219T8 (es) 2025-05-16
US6699835B2 (en) 2004-03-02
US6713446B2 (en) 2004-03-30
EP1355910B1 (de) 2011-03-09
JP2004517931A (ja) 2004-06-17
TR201819416T4 (tr) 2019-01-21
EP2251344B1 (de) 2016-03-30
JP4162491B2 (ja) 2008-10-08
EP3078667B1 (de) 2018-11-21
US7109323B2 (en) 2006-09-19
CA2435146A1 (en) 2002-08-01
WO2002059131A1 (en) 2002-08-01
PT1355910E (pt) 2011-03-24
JP2004517932A (ja) 2004-06-17
EP1360189A1 (de) 2003-11-12
CY1121142T1 (el) 2020-05-29
PT3078667T (pt) 2018-12-28
CA2435146C (en) 2011-03-29
CA2435124A1 (en) 2002-08-01
DK1355910T3 (da) 2011-06-27
WO2002059130A1 (en) 2002-08-01
HK1149936A1 (en) 2011-10-21
US20040063623A1 (en) 2004-04-01
US20040138411A1 (en) 2004-07-15
EP1355910A1 (de) 2003-10-29
US20050282742A1 (en) 2005-12-22
EP2251344B2 (de) 2024-04-24
US20020188100A1 (en) 2002-12-12
DK3078667T3 (en) 2019-01-07
US6958319B2 (en) 2005-10-25
ES2702732T3 (es) 2019-03-05
FI2251344T4 (fi) 2024-04-29
DK2251344T3 (en) 2016-05-09
EP3078667A1 (de) 2016-10-12

Similar Documents

Publication Publication Date Title
DE60239384D1 (de) Formulierungen von borsäure-verbindungen
IL94915A0 (en) Substituted quinazolinones and pharmaceutical compositions containing them
DK0392317T3 (da) Benzimidazoler, lægemidler indeholdende disse forbindelser og fremgangsmåder til deres fremstilling
CY1111822T1 (el) Παραγωγα σπειροϊνδολινοπιπεριδινης ονες
PT911333E (pt) Derivados de pirazolo¬4,3-d|pirimidina e composicoes farmaceuticas que os contenham
CA2278201A1 (en) Novel modifications to 2-amino-4-(4-fluorobenzylamino)-1-ethoxycarbonyl-aminobenzene, and processes for their preparation
NO176550C (no) Fremgangsmåte for fremstilling av stabile, pressede, farmasöytiske formuleringer inneholdende en forbindelse
WO2003016282A3 (en) Substituted 1h-dihydropyrazoles, their preparation and use
FI93831B (fi) Tetratsolit, jotka ovat verenpainetta alentavien yhdisteiden välituotteita
DK1381432T3 (da) HSA-frie interferon-beta-præparater
IL115790A0 (en) Pharmaceutical compositions containing boronic ester and acid compounds and methods for the preparation thereof
DK0468470T3 (da) Benzimidazoler, lægemidler indeholdende sådanne forbindelser og fremgangsmåde til deres fremstilling
DK1200418T3 (da) Nematodicide trifluorbutener
EP0237051A3 (en) Prodrug compounds, process for the preparation thereof and sustained release preparation comprising the same
BR1100987A (pt) Composto, composição farmacêutica da matéria, e, composição veterinária
GB9820525D0 (en) Formulation
IT1293778B1 (it) 1,4,7,10-tetraazabiciclo(8.2.2.)tetradecan-2 one, sua preparazione e suo uso per la preparazione di tetraazamacrocicli
NO930768L (no) Substituerte aminofosfonatderivater, fremgangsmaate for deres fremstilling og farmasoeytiske preparater derav
DK0614362T3 (da) Farmaceutiske præparater på basis af ebastin og dermed analoge forbindelser
DE60002733D1 (de) Diester prodrugs von decahydroischinoline-3-carbonsäure
DK1279677T3 (da) GD3-mimetiske peptider
DK1192139T3 (da) Fremstilling af quinolinsubstituerede carbonat- og carbamatderivater
DK0552765T3 (da) benzimidazoler, farmaceutiske præparater indeholdende disse og fremgangsmåde til deres fremstilling
DK0380038T3 (da) 3-Phenyl-5,6-dihydrobenz(c)acridin-7-carboxylsyrer og beslægtede forbindelser som kemoterapeutiske midler mod cancer
DE69405815D1 (de) Acylharnstoffe

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1355910

Country of ref document: EP