ATE502008T1 - Zur behandlung von auf die modulation des dopamin-d3-rezeptors ansprechenden erkrankungen geeignete aminomethylsubstituierte bicyclische aromatische verbindungen - Google Patents
Zur behandlung von auf die modulation des dopamin-d3-rezeptors ansprechenden erkrankungen geeignete aminomethylsubstituierte bicyclische aromatische verbindungenInfo
- Publication number
- ATE502008T1 ATE502008T1 AT05798340T AT05798340T ATE502008T1 AT E502008 T1 ATE502008 T1 AT E502008T1 AT 05798340 T AT05798340 T AT 05798340T AT 05798340 T AT05798340 T AT 05798340T AT E502008 T1 ATE502008 T1 AT E502008T1
- Authority
- AT
- Austria
- Prior art keywords
- treatment
- dopamine
- bicyclic aromatic
- receptor
- modulation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US61874404P | 2004-10-14 | 2004-10-14 | |
| PCT/EP2005/011093 WO2006040180A1 (en) | 2004-10-14 | 2005-10-14 | Aminomethyl substituted bicyclic aromatic compounds suitable for treating disorders that respond to modulation of the dopamine d3 receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE502008T1 true ATE502008T1 (de) | 2011-04-15 |
Family
ID=35355570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05798340T ATE502008T1 (de) | 2004-10-14 | 2005-10-14 | Zur behandlung von auf die modulation des dopamin-d3-rezeptors ansprechenden erkrankungen geeignete aminomethylsubstituierte bicyclische aromatische verbindungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8486984B2 (de) |
| EP (1) | EP1809598B1 (de) |
| JP (1) | JP5032993B2 (de) |
| AT (1) | ATE502008T1 (de) |
| CA (1) | CA2583973C (de) |
| DE (1) | DE602005026965D1 (de) |
| ES (1) | ES2363348T3 (de) |
| MX (1) | MX2007004354A (de) |
| TW (1) | TW200628438A (de) |
| WO (1) | WO2006040180A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1747779A1 (de) * | 2005-07-28 | 2007-01-31 | Laboratorios Del Dr. Esteve, S.A. | Tetrahydro-b-carbolinsulfonamid-Derivate als 5-HT6 Liganden |
| JP2009541248A (ja) * | 2006-06-20 | 2009-11-26 | エフ．ホフマン−ラ ロシュ アーゲー | アリールスルホンアミジルテトラリン誘導体及びそれらの使用 |
| ES2539382T3 (es) * | 2009-12-22 | 2015-06-30 | Cephalon, Inc. | Derivados tricíclicos y su uso farmacéutico y composiciones |
| CA2835261C (en) * | 2011-05-06 | 2019-06-04 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| JP6878460B2 (ja) * | 2016-04-15 | 2021-05-26 | 浙江中科▲創▼越▲薬▼▲業▼有限公司 | 複素環カルボン酸アミド配位子および銅触媒によるハロゲン化アリールのカップリング反応におけるその使用 |
| WO2020120576A1 (en) * | 2018-12-11 | 2020-06-18 | Fundació Institut De Recerca Biomèdica (Irb Barcelona) | p38α AUTOPHOSPHORYLATION INHIBITORS |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995004713A1 (en) | 1993-08-06 | 1995-02-16 | The Upjohn Company | 2-aminoindans as selective dopamine d3 ligands |
| PT807101E (pt) * | 1995-02-01 | 2001-12-28 | Upjohn Co | 2-aminoindanos comoligandos selectivos de dopamina d3 |
| ES2192677T3 (es) | 1996-05-30 | 2003-10-16 | Baker Hughes Inc | Control de la corrosion por el acido naptenico con compuestos de tiofosforo. |
| RU2185372C2 (ru) * | 1996-05-31 | 2002-07-20 | Фармация Энд Апджон Компани | Алкилзамещенные циклические амины в качестве селективных лигандов d3-допамина |
| JP3868096B2 (ja) * | 1997-02-27 | 2007-01-17 | 武田薬品工業株式会社 | アミン誘導体、その製造法および剤 |
| JP2002003370A (ja) * | 1999-09-20 | 2002-01-09 | Takeda Chem Ind Ltd | メラニン凝集ホルモン拮抗剤 |
-
2005
- 2005-10-14 US US11/665,287 patent/US8486984B2/en not_active Expired - Fee Related
- 2005-10-14 JP JP2007536107A patent/JP5032993B2/ja not_active Expired - Fee Related
- 2005-10-14 ES ES05798340T patent/ES2363348T3/es not_active Expired - Lifetime
- 2005-10-14 WO PCT/EP2005/011093 patent/WO2006040180A1/en not_active Ceased
- 2005-10-14 TW TW094135905A patent/TW200628438A/zh unknown
- 2005-10-14 MX MX2007004354A patent/MX2007004354A/es active IP Right Grant
- 2005-10-14 CA CA2583973A patent/CA2583973C/en not_active Expired - Fee Related
- 2005-10-14 AT AT05798340T patent/ATE502008T1/de not_active IP Right Cessation
- 2005-10-14 DE DE602005026965T patent/DE602005026965D1/de not_active Expired - Lifetime
- 2005-10-14 EP EP05798340A patent/EP1809598B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE602005026965D1 (de) | 2011-04-28 |
| JP5032993B2 (ja) | 2012-09-26 |
| ES2363348T3 (es) | 2011-08-01 |
| HK1106494A1 (en) | 2008-03-14 |
| TW200628438A (en) | 2006-08-16 |
| CA2583973A1 (en) | 2006-04-20 |
| EP1809598A1 (de) | 2007-07-25 |
| MX2007004354A (es) | 2007-07-17 |
| CA2583973C (en) | 2013-07-30 |
| US8486984B2 (en) | 2013-07-16 |
| US20110144146A1 (en) | 2011-06-16 |
| JP2008516916A (ja) | 2008-05-22 |
| WO2006040180A1 (en) | 2006-04-20 |
| EP1809598B1 (de) | 2011-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2010003949A (es) | N-fenil-bipirrolidina carboxamidas sustituidas y uso terapeutico de las mismas. | |
| MX2010003948A (es) | N-fenil-birrolidin ureas sustituidas y uso terapeutico de las mismas. | |
| SG135192A1 (en) | Substituted pyrazoline compounds, their preparation and use as medicaments | |
| IL205003A0 (en) | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof | |
| UY28473A1 (es) | Nuevos compuestos | |
| ATE389395T1 (de) | Substituierte 2-aminotetraline zur vorbeugenden behandlung von morbus parkinson | |
| MX2010004003A (es) | N-fenil-pirrolidinilmetlipirrolidin amidas sustituidas y uso terapeutico de las mismas. | |
| UA101797C2 (ru) | Карбонилированные (аза)циклогексаны как лиганды d3-рецептора допамину | |
| EA201071006A1 (ru) | Набор, композиция, продукт или лекарственное средство для лечения нарушения познавательной способности | |
| MA32943B1 (fr) | Piperidine spiro pyrrolidione et piperidinone substituees, leur preparation et leur utilisation therapeutique | |
| TW200745043A (en) | Substituted pyrazoline compounds, their preparation and use as medicaments | |
| UA104880C2 (uk) | Заміщені тетрагідропіранспіропіролідинон і тетрагідропіранспіропіперидинон, спосіб їх одержання й застосування в лікувальних цілях | |
| TW200626158A (en) | Naphthaline derivatives | |
| PT1778837E (pt) | Tratamento de doenças neurodegenerativas por utilização de inibidores de scd4 | |
| MX2009008176A (es) | Derivados de tetrahidro-naftaleno sustituidos con heterociclos, su preparacion y su uso como medicamentos. | |
| DE602005026965D1 (de) | Zur behandlung von auf die modulation des dopamin-d3-rezeptors ansprechenden erkrankungen geeignete aminomethylsubstituierte bicyclische aromatische verbindungen | |
| ATE524171T1 (de) | Verwendung von 2-(2-nitro-4- trifluormethylbenzoyl)-1,3-cyclohexandion bei der behandlung der parkinson-krankheit | |
| EA200700707A1 (ru) | Производные 2-ациламинотиазола | |
| TW200745042A (en) | Substituted pyrazoline compounds, their preparation and use as medicaments | |
| ATE540922T1 (de) | Zur behandlung von erkrankungen, die auf eine modulation des dopamin-d3-rezeptors ansprechen, geeignete aminoethylaromatische verbindungen | |
| ATE429910T1 (de) | Chlor enthaltende guanabenz derivate zur behandlung von prionerkrankungen | |
| ECSP12011718A (es) | Utilización de derivados del indol como activadores de nurr-1, para la aplicación en tratamientos de enfermedades como el parkinson | |
| ATE496031T1 (de) | Für die behandlung von auf die modulierung des dopamin-d3-rezeptors ansprechende erkrankungen geeignete aryloxyethylaminverbindungen | |
| TW200738640A (en) | Substituted pyrazoline compounds, their preparation and use as medicaments |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |