ATE502951T1 - Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer - Google Patents

Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer

Info

Publication number
ATE502951T1
ATE502951T1 AT07762204T AT07762204T ATE502951T1 AT E502951 T1 ATE502951 T1 AT E502951T1 AT 07762204 T AT07762204 T AT 07762204T AT 07762204 T AT07762204 T AT 07762204T AT E502951 T1 ATE502951 T1 AT E502951T1
Authority
AT
Austria
Prior art keywords
compositions
compounds
channel
protease inhibitors
activate protease
Prior art date
Application number
AT07762204T
Other languages
English (en)
Inventor
David Tully
Arnab Chatterjee
Hank Petrassi
Badry Bursulaya
Glen Spraggon
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Application granted granted Critical
Publication of ATE502951T1 publication Critical patent/ATE502951T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT07762204T 2006-05-23 2007-05-15 Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer ATE502951T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80801406P 2006-05-23 2006-05-23
US86062206P 2006-11-22 2006-11-22
PCT/US2007/068987 WO2007140117A1 (en) 2006-05-23 2007-05-15 Compounds and compositions as channel activating protease inhibitors

Publications (1)

Publication Number Publication Date
ATE502951T1 true ATE502951T1 (de) 2011-04-15

Family

ID=38521007

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07762204T ATE502951T1 (de) 2006-05-23 2007-05-15 Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer

Country Status (18)

Country Link
US (2) US7939547B2 (de)
EP (1) EP2019837B1 (de)
JP (1) JP5270538B2 (de)
KR (1) KR101069089B1 (de)
CN (1) CN101443348A (de)
AR (1) AR061110A1 (de)
AT (1) ATE502951T1 (de)
AU (1) AU2007267733B9 (de)
CA (1) CA2651043A1 (de)
CL (1) CL2007001482A1 (de)
DE (1) DE602007013387D1 (de)
MX (1) MX2008014838A (de)
PE (1) PE20080101A1 (de)
PL (1) PL2019837T3 (de)
PT (1) PT2019837E (de)
RU (1) RU2419625C2 (de)
TW (1) TW200808748A (de)
WO (1) WO2007140117A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0507577D0 (en) * 2005-04-14 2005-05-18 Novartis Ag Organic compounds
EP2027143A2 (de) * 2006-05-23 2009-02-25 Irm Llc Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer
CA2677487A1 (en) 2007-02-09 2008-08-14 Irm Llc Compounds and compositions as channel activating protease inhibitors
CA2677485A1 (en) * 2007-02-09 2008-08-14 Irm Llc Compounds and compositions as channel activating protease inhibitors
WO2009143493A2 (en) * 2008-05-22 2009-11-26 Attagene Inc. MODULATORS OF TNFα-DEPENDENT SIGNALING PATHWAYS AND USES THEREOF
JP5585822B2 (ja) * 2010-05-11 2014-09-10 東レ・ファインケミカル株式会社 光学活性ニペコチン酸誘導体の製造方法
CN102153579B (zh) * 2011-02-23 2013-05-29 兰州米诺生物科技有限公司 氮-叔丁氧羰基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
MY162786A (en) * 2011-07-26 2017-07-14 Sanofi Sa Substituted 3-thiazoloamino-propionic acid derivatives and their use as pharmaceuticals
MX2014006211A (es) * 2011-11-25 2014-08-08 Hoffmann La Roche Nuevos derivados de pirrolidina como inhibidores de catepsina.
EP2804605A4 (de) * 2012-01-20 2015-07-08 Acucela Inc Substituierte heterocyclische verbindungen zur behandlung von krankheiten
KR20150046259A (ko) 2012-08-23 2015-04-29 앨리오스 바이오파마 인크. 파라믹소바이러스 바이러스성 감염의 치료용 화합물
KR101890134B1 (ko) 2013-07-08 2018-08-23 우리윈시스템 주식회사 Cctv 감시장치 비트맵에 의한 이미지 데이터 처리 움직임 분석 제어 방법
CN109068621B (zh) * 2016-02-29 2021-07-20 再生元制药公司 具有人源化的tmprss基因的啮齿类动物
AU2020349353A1 (en) 2019-09-17 2022-04-14 Duke University Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
HUE064089T2 (hu) 2020-04-16 2024-02-28 Mereo Biopharma 4 Ltd Alvelesztat neutrofil elasztáz inhibitort alkalmazó módszerek alfa-1-antitripszin hiány által közvetített légzõszervi megbetegedés kezelésére
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis
CN120390747A (zh) * 2022-11-02 2025-07-29 菲罗化学股份公司 用于靶向递送应用的碳酸酐酶ix配体

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8809316D0 (en) * 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US6211154B1 (en) * 1995-06-07 2001-04-03 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5523308A (en) * 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
TW523513B (en) * 1996-03-01 2003-03-11 Akzo Nobel Nv Serine protease inhibitors
IL121474A0 (en) * 1996-08-23 1998-02-08 Akzo Nobel Nv Thrombin inhibitors
US6323219B1 (en) * 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
BR0007778A (pt) * 1999-01-27 2002-06-04 Ortho Mcneil Pharm Inc Peptidila cetonas heterocìclicas úteis como inibidores de triptase
JP2000256396A (ja) * 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
US6797504B1 (en) * 2000-09-08 2004-09-28 Dendreon San Diego Llc Inhibitors of serine protease activity of matriptase or MTSP1
US7012066B2 (en) * 2000-07-21 2006-03-14 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
JP2002138048A (ja) * 2000-08-25 2002-05-14 Dainippon Pharmaceut Co Ltd 複素環式化合物からなる医薬
JP2005060379A (ja) * 2003-07-31 2005-03-10 Dainippon Pharmaceut Co Ltd 複素環式化合物からなる医薬
US7205384B2 (en) * 2003-08-05 2007-04-17 Ortho-Mcneil Pharmaceutical Inc. Process for preparing peptidyl heterocyclic ketone derivatives
US20050222383A1 (en) 2004-02-05 2005-10-06 Irm Llc Prostasin substrates and inhibitors
EP2027143A2 (de) * 2006-05-23 2009-02-25 Irm Llc Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer

Also Published As

Publication number Publication date
AU2007267733B9 (en) 2011-04-21
US20110177055A1 (en) 2011-07-21
MX2008014838A (es) 2008-12-05
US7939547B2 (en) 2011-05-10
PE20080101A1 (es) 2008-04-01
CA2651043A1 (en) 2007-12-06
AR061110A1 (es) 2008-08-06
WO2007140117A1 (en) 2007-12-06
TW200808748A (en) 2008-02-16
US20070276002A1 (en) 2007-11-29
PT2019837E (pt) 2011-07-05
RU2008150613A (ru) 2010-06-27
CL2007001482A1 (es) 2008-05-09
KR20090016725A (ko) 2009-02-17
RU2419625C2 (ru) 2011-05-27
AU2007267733A1 (en) 2007-12-06
DE602007013387D1 (de) 2011-05-05
AU2007267733B2 (en) 2011-03-17
JP5270538B2 (ja) 2013-08-21
CN101443348A (zh) 2009-05-27
PL2019837T3 (pl) 2011-09-30
KR101069089B1 (ko) 2011-09-30
EP2019837A1 (de) 2009-02-04
JP2009538326A (ja) 2009-11-05
EP2019837B1 (de) 2011-03-23

Similar Documents

Publication Publication Date Title
DE602007013387D1 (de) Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer
ATE493174T1 (de) Verbindungen und zusammensetzungen als kanal- aktivierende proteasehemmer
ATE492545T1 (de) Verbindungen und zusammensetzungen als proteinkinase-hemmer
SMAP200900058A (it) Composti e composizioni come inibitori di proteinachinasi
SM201000108B (it) Composti e composizioni come inibitori di proteinachinasi
SMAP200900020A (it) Composti e composizioni come inibitori di proteinachinasi
SMAP200900031A (it) Composti e composizioni come inibitori di proteinachinasi
ATE434618T1 (de) Spirozyklische verbindungen als hdac-hemmer
LTPA2017010I1 (lt) Proteazomos inhibitoriai
BRPI0717460A2 (pt) Composições de inibidores de chk1
ATE543816T1 (de) Azacycloalkanderivate als inhibitoren von stearoyl-coenzym-a-delta-9-desaturase
CY2015014I1 (el) Μακροκυκλικοι αναστολεις της πρωτεασης σερινης της ηπατιτιδας c
DE602007013436D1 (de) N-methylaminomethyl-isoindol-verbindungen und diese enthaltende zusammensetzungen und diese verwendende verfahren
BRPI0807547A2 (pt) Inibidores de aspartil protease hetercíclicos
ATE493411T1 (de) Pyrroloä2, 3-büpyridin-4-yl- benzolsulfonamidverbindungen als ikk2-hemmer
BRPI0913623A2 (pt) Composições e métodos compreendendo variantes de proteases microbianas
DK1940839T3 (da) Pyridopyrimidione Inhibitors of P13Ka
BRPI0810851A2 (pt) Compostos de enxofre com inibidores da serina protease ns3 do vírus da hepatite c
CR10409A (es) Spirocyclic nitriles as protease inhibitors
BRPI0806970A2 (pt) Compostos e composições como inibidores de protease de ativação de canal
BRPI0718141A2 (pt) Composições de frangrâncias
SMAP200900061A (it) Composizioni di azimilide dicloridrato
ATE495153T1 (de) Arylsulfonylpyrrolidine als 5-ht6-inhibitoren
EP2069390A4 (de) Opsin-stabilisierende verbindungen und anwendungsverfahren dafür
ATE529092T1 (de) Antiperspirans-zusammensetzungen

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 2019837

Country of ref document: EP