PL2019837T3 - Związki i kompozycje jako inhibitory proteazy aktywującej kanały - Google Patents

Związki i kompozycje jako inhibitory proteazy aktywującej kanały

Info

Publication number
PL2019837T3
PL2019837T3 PL07762204T PL07762204T PL2019837T3 PL 2019837 T3 PL2019837 T3 PL 2019837T3 PL 07762204 T PL07762204 T PL 07762204T PL 07762204 T PL07762204 T PL 07762204T PL 2019837 T3 PL2019837 T3 PL 2019837T3
Authority
PL
Poland
Prior art keywords
compositions
compounds
protease inhibitors
activating protease
channel activating
Prior art date
Application number
PL07762204T
Other languages
English (en)
Inventor
David C Tully
Arnab K Chatterjee
Hank Michael James Petrassi
Badry Bursulaya
Glen Spraggon
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of PL2019837T3 publication Critical patent/PL2019837T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL07762204T 2006-05-23 2007-05-15 Związki i kompozycje jako inhibitory proteazy aktywującej kanały PL2019837T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80801406P 2006-05-23 2006-05-23
US86062206P 2006-11-22 2006-11-22
PCT/US2007/068987 WO2007140117A1 (en) 2006-05-23 2007-05-15 Compounds and compositions as channel activating protease inhibitors
EP07762204A EP2019837B1 (en) 2006-05-23 2007-05-15 Compounds and compositions as channel activating protease inhibitors

Publications (1)

Publication Number Publication Date
PL2019837T3 true PL2019837T3 (pl) 2011-09-30

Family

ID=38521007

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07762204T PL2019837T3 (pl) 2006-05-23 2007-05-15 Związki i kompozycje jako inhibitory proteazy aktywującej kanały

Country Status (18)

Country Link
US (2) US7939547B2 (pl)
EP (1) EP2019837B1 (pl)
JP (1) JP5270538B2 (pl)
KR (1) KR101069089B1 (pl)
CN (1) CN101443348A (pl)
AR (1) AR061110A1 (pl)
AT (1) ATE502951T1 (pl)
AU (1) AU2007267733B9 (pl)
CA (1) CA2651043A1 (pl)
CL (1) CL2007001482A1 (pl)
DE (1) DE602007013387D1 (pl)
MX (1) MX2008014838A (pl)
PE (1) PE20080101A1 (pl)
PL (1) PL2019837T3 (pl)
PT (1) PT2019837E (pl)
RU (1) RU2419625C2 (pl)
TW (1) TW200808748A (pl)
WO (1) WO2007140117A1 (pl)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0507577D0 (en) * 2005-04-14 2005-05-18 Novartis Ag Organic compounds
US7951823B2 (en) 2006-05-23 2011-05-31 Irm Llc Compounds and compositions as channel activating protease inhibitors
KR20090108131A (ko) 2007-02-09 2009-10-14 아이알엠 엘엘씨 채널 활성화 프로테아제 억제제로서의 화합물 및 조성물
EP2117541A1 (en) * 2007-02-09 2009-11-18 Irm Llc Compounds and compositions as channel activating protease inhibitors
WO2009143493A2 (en) * 2008-05-22 2009-11-26 Attagene Inc. MODULATORS OF TNFα-DEPENDENT SIGNALING PATHWAYS AND USES THEREOF
JP5585822B2 (ja) * 2010-05-11 2014-09-10 東レ・ファインケミカル株式会社 光学活性ニペコチン酸誘導体の製造方法
CN102153579B (zh) * 2011-02-23 2013-05-29 兰州米诺生物科技有限公司 氮-叔丁氧羰基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
KR20140049020A (ko) * 2011-07-26 2014-04-24 사노피 치환된 ３-（티아졸-４-카보닐）- 또는 ３-（티아졸-２-카보닐）아미노프로피온산 유도체 및 이의 약제로서의 용도
RU2014123784A (ru) * 2011-11-25 2015-12-27 Ф. Хоффманн-Ля Рош Аг Новые производные пирролидина в качестве ингибиторов катепсина
HK1210969A1 (en) 2012-01-20 2016-05-13 奥克塞拉有限公司 Substituted heterocyclic compounds for disease treatment
US9724351B2 (en) * 2012-08-23 2017-08-08 Alios Biopharma, Inc. Compounds for the treatment of paramoxyvirus viral infections
KR101890134B1 (ko) 2013-07-08 2018-08-23 우리윈시스템 주식회사 Cctv 감시장치 비트맵에 의한 이미지 데이터 처리 움직임 분석 제어 방법
EP3895529B1 (en) * 2016-02-29 2026-04-29 Regeneron Pharmaceuticals, Inc. Rodents having a humanized tmprss gene
WO2021053058A1 (en) 2019-09-17 2021-03-25 Mereo Biopharma 4 Limited Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease
LT4106757T (lt) 2020-04-16 2023-11-10 Mereo Biopharma 4 Limited Neutrofilų elastazės inhibitoriaus alvelestato panaudojimas kvėpavimo sistemos ligų, nulemtų alfa-1 antitripsino nepakankamumo, gydymui
JP2024540952A (ja) 2021-10-20 2024-11-06 メレオ バイオファーマ ４ リミテッド 線維化の治療における使用のための好中球エラスターゼ阻害剤
AU2023374710A1 (en) * 2022-11-02 2025-06-19 Philochem Ag Carbonic anhydrase ix ligands for targeted delivery applications

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8809316D0 (en) * 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US5523308A (en) * 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
US6211154B1 (en) * 1995-06-07 2001-04-03 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
TW523513B (en) 1996-03-01 2003-03-11 Akzo Nobel Nv Serine protease inhibitors
IL121474A0 (en) * 1996-08-23 1998-02-08 Akzo Nobel Nv Thrombin inhibitors
US6323219B1 (en) * 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
HUP0201295A3 (en) * 1999-01-27 2002-10-28 Ortho Mcneil Pharm Inc Peptidyl heterocyclic ketones useful as tryptase inhibitors
JP2000256396A (ja) * 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
US6797504B1 (en) * 2000-09-08 2004-09-28 Dendreon San Diego Llc Inhibitors of serine protease activity of matriptase or MTSP1
MXPA03000627A (es) * 2000-07-21 2004-07-30 Schering Corp Nuevos peptidos como inhibidores de proteasa serina-ns3 del virus de la hepatitis c.
JP2002138048A (ja) * 2000-08-25 2002-05-14 Dainippon Pharmaceut Co Ltd 複素環式化合物からなる医薬
JP2005060379A (ja) * 2003-07-31 2005-03-10 Dainippon Pharmaceut Co Ltd 複素環式化合物からなる医薬
US7205384B2 (en) * 2003-08-05 2007-04-17 Ortho-Mcneil Pharmaceutical Inc. Process for preparing peptidyl heterocyclic ketone derivatives
WO2005076886A2 (en) 2004-02-05 2005-08-25 Irm Llc Prostasin substrates and inhibitors
US7951823B2 (en) * 2006-05-23 2011-05-31 Irm Llc Compounds and compositions as channel activating protease inhibitors

Also Published As

Publication number Publication date
PE20080101A1 (es) 2008-04-01
EP2019837A1 (en) 2009-02-04
KR20090016725A (ko) 2009-02-17
KR101069089B1 (ko) 2011-09-30
AU2007267733A1 (en) 2007-12-06
US20070276002A1 (en) 2007-11-29
CA2651043A1 (en) 2007-12-06
AU2007267733B9 (en) 2011-04-21
MX2008014838A (es) 2008-12-05
AU2007267733B2 (en) 2011-03-17
TW200808748A (en) 2008-02-16
RU2419625C2 (ru) 2011-05-27
AR061110A1 (es) 2008-08-06
CN101443348A (zh) 2009-05-27
CL2007001482A1 (es) 2008-05-09
JP5270538B2 (ja) 2013-08-21
ATE502951T1 (de) 2011-04-15
PT2019837E (pt) 2011-07-05
WO2007140117A1 (en) 2007-12-06
US20110177055A1 (en) 2011-07-21
US7939547B2 (en) 2011-05-10
RU2008150613A (ru) 2010-06-27
DE602007013387D1 (de) 2011-05-05
JP2009538326A (ja) 2009-11-05
EP2019837B1 (en) 2011-03-23

Similar Documents

Publication Publication Date Title
PT2019837E (pt) Compostos e composições como inibidores das proteases activadoras de canal
PL2104535T3 (pl) Związki i kompozycje jako inhibitory proteazy aktywujące kanały
ZA200706345B (en) Amino-pyridines as inhibitors of ß-secretase
HUS1500049I1 (hu) Protein kináz inhibitor vegyületek és készítmények
IL230972A0 (en) Compounds and preparations as protein kinase inhibitors
IL197724A0 (en) Compounds and compositions as protein kinase inhibitors
IL198315A0 (en) Compounds and compositions as protein kinase inhibitors
IL195619A0 (en) Compositions and methods for joininig non-conjoined iumens
PT2101766T (pt) Composições e métodos de utilização de (r)-pramipexole
ZA200802585B (en) Pyridopyrimidinone inhibitors of Pl3Kα
IL190292A0 (en) PYRIDOPYRIMIDINONE INHIBITORS OF P13Ka
ZA200707650B (en) Azolylacylguanidines as ß-secretase inhibitors
ZA201008169B (en) Compositions and methods comprising variant microbial proteases
ZA200805000B (en) Compositions of lipoxygenase inhibitors
PL2101766T3 (pl) Kompozycje i sposoby stosowania (R)-pramipeksolu
IL198651A0 (en) COMPOSITION COMPRISING (-)-Ôêå9-TRANS-TETRAHYDROCANNABIONOL
BRPI0806970A2 (pt) Compostos e composições como inibidores de protease de ativação de canal
EP2064177A4 (en) PROTEASE INHIBITORS
GB0617171D0 (en) Novel compositions and methods
GB0622400D0 (en) Novel compositions and uses thereof
ZA200904414B (en) Compounds and compositions as channel activating protease inhibitors
HU0600482D0 (en) Composition of additives
GB0604901D0 (en) Improved formulation of COMT inhibitors
EP1744755A4 (en) COMPOUNDS AND COMPOSITIONS AS CATHEPSIN S HEMMER
HU0600759D0 (en) Composition of additives