ATE503393T1 - Mikropartikelzusammensetzungen und granulat für die oralkontrollierte freisetzung von substanzen zur tierärztlichen verwendung - Google Patents

Mikropartikelzusammensetzungen und granulat für die oralkontrollierte freisetzung von substanzen zur tierärztlichen verwendung

Info

Publication number: ATE503393T1
Authority: AT; Austria
Prior art keywords: core; layer; phenomena; granules; melting point
Prior art date: 2006-08-04

Application number

AT07788057T

Other languages

English (en)

Inventor

Ruggero Bettini

Lauro Arduini

Francesca Bertolini

Claudia Camellini

Original Assignee

Eurhema S R L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-04

Filing date

2007-07-31

Publication date

2011-04-15

2007-07-31 Application filed by Eurhema S R L filed Critical Eurhema S R L

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE503393T1 publication Critical patent/ATE503393T1/de

Links

239000000126 substance Substances 0.000 title abstract 3
239000008187 granular material Substances 0.000 title abstract 2
239000011859 microparticle Substances 0.000 title abstract 2
238000013270 controlled release Methods 0.000 title 1
239000000203 mixture Substances 0.000 title 1
239000013543 active substance Substances 0.000 abstract 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 abstract 2
239000003925 fat Substances 0.000 abstract 2
230000008018 melting Effects 0.000 abstract 2
238000002844 melting Methods 0.000 abstract 2
239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 abstract 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
235000019743 Choline chloride Nutrition 0.000 abstract 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 abstract 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
229910052782 aluminium Inorganic materials 0.000 abstract 1
125000000129 anionic group Chemical group 0.000 abstract 1
235000010323 ascorbic acid Nutrition 0.000 abstract 1
229960005070 ascorbic acid Drugs 0.000 abstract 1
239000011668 ascorbic acid Substances 0.000 abstract 1
230000004888 barrier function Effects 0.000 abstract 1
239000000440 bentonite Substances 0.000 abstract 1
229910000278 bentonite Inorganic materials 0.000 abstract 1
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 abstract 1
229960005069 calcium Drugs 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
229960002713 calcium chloride Drugs 0.000 abstract 1
239000001110 calcium chloride Substances 0.000 abstract 1
229910001628 calcium chloride Inorganic materials 0.000 abstract 1
235000011148 calcium chloride Nutrition 0.000 abstract 1
230000015556 catabolic process Effects 0.000 abstract 1
125000002091 cationic group Chemical group 0.000 abstract 1
229960003178 choline chloride Drugs 0.000 abstract 1
SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 abstract 1
235000015165 citric acid Nutrition 0.000 abstract 1
229960004106 citric acid Drugs 0.000 abstract 1
238000006731 degradation reaction Methods 0.000 abstract 1
GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 abstract 1
235000015872 dietary supplement Nutrition 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000003993 interaction Effects 0.000 abstract 1
229960005337 lysine hydrochloride Drugs 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
229910052901 montmorillonite Inorganic materials 0.000 abstract 1
235000001968 nicotinic acid Nutrition 0.000 abstract 1
229960003512 nicotinic acid Drugs 0.000 abstract 1
239000011664 nicotinic acid Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1
210000004767 rumen Anatomy 0.000 abstract 1
229910021647 smectite Inorganic materials 0.000 abstract 1
229910052708 sodium Inorganic materials 0.000 abstract 1
239000011734 sodium Substances 0.000 abstract 1
230000002195 synergetic effect Effects 0.000 abstract 1
239000001993 wax Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
- A23K40/35—Making capsules specially adapted for ruminants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Polymers & Plastics (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Food Science & Technology (AREA)
Veterinary Medicine (AREA)
Animal Husbandry (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physiology (AREA)
Nutrition Science (AREA)
Medicinal Preparation (AREA)
Fodder In General (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT07788057T 2006-08-04 2007-07-31 Mikropartikelzusammensetzungen und granulat für die oralkontrollierte freisetzung von substanzen zur tierärztlichen verwendung ATE503393T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT001583A ITMI20061583A1 (it)	2006-08-04	2006-08-04	Composizioni di microparticelle e granuli per il rilascio controllato orale di sostanze per uso veterinario
PCT/EP2007/057861 WO2008015203A2 (en)	2006-08-04	2007-07-31	Compositions of microparticles and granules for oral controlled release of substances for veterinary use

Publications (1)

Publication Number	Publication Date
ATE503393T1 true ATE503393T1 (de)	2011-04-15

Family

ID=38512167

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07788057T ATE503393T1 (de)	2006-08-04	2007-07-31	Mikropartikelzusammensetzungen und granulat für die oralkontrollierte freisetzung von substanzen zur tierärztlichen verwendung

Country Status (7)

Country	Link
US (1)	US9717693B2 (de)
EP (1)	EP2046140B1 (de)
AT (1)	ATE503393T1 (de)
CA (1)	CA2659948C (de)
DE (1)	DE602007013564D1 (de)
IT (1)	ITMI20061583A1 (de)
WO (1)	WO2008015203A2 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI1013723B1 (pt) *	2009-04-23	2019-12-10	H J Baker & Bro Inc	composição alimentar para ruminante, e, métodos de suplementação da dieta de um ruminante com lisina e de produção de uma composição alimentar para ruminante
CN101664112B (zh) *	2009-09-11	2011-09-21	无锡正大畜禽有限公司	一种饲料用硫酸粘杆菌素微囊的生产方法
ES2645015T3 (es) *	2010-04-07	2017-12-01	Kemin Industries, Inc.	Micropartículas para la administración oral en animales
US10092533B2 (en)	2010-10-18	2018-10-09	H. J. Baker & Bro., Llc	Granular feed supplement
JP5733709B1 (ja) *	2014-11-18	2015-06-10	ユニ・チャーム株式会社	猫用ペットフードおよびその製造方法
ITBO20150177A1 (it)	2015-04-14	2016-10-14	Fornaciari Miriam	Sistema per somministrazione orale per il rilascio controllato di sostanze attive
IT201700021879A1 (it)	2017-02-27	2018-08-27	Bioscreen Tech S R L	Composizione a rilascio controllato di sostanze fisiologicamente attive e processo per la sua preparazione
IT201700021852A1 (it) *	2017-02-27	2018-08-27	Bioscreen Tech S R L	Composizione a rilascio controllato di sostanze fisiologicamente attive e processo per la sua preparazione
WO2020055270A1 (en) *	2018-09-10	2020-03-19	Argenta Innovation Limited	Sustained release formulations in delivery devices
FR3102933B1 (fr) *	2019-11-07	2023-06-02	Huddle Corp	Aliment ou complément alimentaire pour animaux d’élevage
WO2025101786A1 (en) *	2023-11-07	2025-05-15	Kemin Industries, Inc.	Compositions containing choline propionate for controlling growth of mold and improving animal performance and related methods

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US549571A (en) *		1895-11-12		Paper boxes
US3541204A (en)	1968-12-02	1970-11-17	Ian Ramsay Sibbald	Encapsulated biologically active materials for feeding to ruminants and process for the production thereof
DK160396C (da)	1982-04-02	1991-08-19	Nippon Soda Co	Foderstofadditiver til droevtyggere
US4713245A (en) *	1984-06-04	1987-12-15	Mitsui Toatsu Chemicals, Incorporated	Granule containing physiologically-active substance, method for preparing same and use thereof
BR8506634A (pt)	1984-12-20	1986-09-09	Rhone Poulenc Sante	Composicoes para o revestimento de aditivos alimentares destinados aos ruminantes e granulados sob forma de microcapsulas assim revestidos
FR2606597B1 (fr)	1986-11-17	1989-01-27	Rhone Poulenc Sante	Nouvelle composition pour l'alimentation des ruminants contenant une substance biologiquement active et sa preparation
US5912017A (en)	1987-05-01	1999-06-15	Massachusetts Institute Of Technology	Multiwall polymeric microspheres
US5077053A (en) *	1990-02-12	1991-12-31	Warner-Lambert Company	Zein as a moisture barrier for sugarless edible compositions and method for preparing same
JPH0479844A (ja) *	1990-07-20	1992-03-13	Ajinomoto Co Inc	反芻動物用飼料添加剤
EP0477135A1 (de) *	1990-09-07	1992-03-25	Warner-Lambert Company	Kaubare kugelige überzogene Mikrokapseln und Verfahren zu ihrer Herstellung
US5190775A (en)	1991-05-29	1993-03-02	Balchem Corporation	Encapsulated bioactive substances
AU5961494A (en)	1992-12-30	1994-08-15	Morgan Manufacturing Co., Inc.	Composition and method for ruminant milk production
CA2140298C (en)	1994-01-14	1998-12-08	Thomas L. Meade	Rumen by-pass feed supplement
JPH07289172A (ja) *	1994-04-20	1995-11-07	Ajinomoto Co Inc	反すう動物用飼料添加物
US5958458A (en) *	1994-06-15	1999-09-28	Dumex-Alpharma A/S	Pharmaceutical multiple unit particulate formulation in the form of coated cores
GB9418752D0 (en) *	1994-09-16	1994-11-02	Ici Plc	Animal feedstuffs and additives
IT1292636B1 (it)	1997-06-20	1999-02-08	Ascor Chimici Srl	Composizione a rilascio controllato di sostanze biologicamente attive ad uso zootecnico.
EP0940088A3 (de)	1998-03-04	1999-12-15	Ajinomoto Co., Inc.	Futtermittelzusammensetzung für Wiederkäuer und Verfahren zu ihrer Herstellung
US20040086564A1 (en) *	2002-10-31	2004-05-06	Richardson Paul H.	Dosage forms containing stabilized choline and method for preparing same
ITRN20030021A1 (it)	2003-07-21	2005-01-22	Ascor Chimici Srl	Composizione di materia comprendente particelle contenenti cloruro di colina da somministrare in forma ruminalmente protetta e post-ruminalmente efficace.
EP1646289B1 (de) *	2003-07-21	2010-06-23	VALENTINI S.r.l.	Materialzusammensetzung, die cholinchloridhaltige partikel umfasst, für die verabreichung in pansengeschützter, postruminal wirksamer form
ITMI20041820A1 (it) *	2004-09-24	2004-12-24	Ascor Chimici Srl	Composizione in micro-pellets a rilascio controllato di sostanze fisiologicamente attive, procedimento di preparazione e relativo impiego nel settore zootecnico.

2006
- 2006-08-04 IT IT001583A patent/ITMI20061583A1/it unknown
2007
- 2007-07-31 AT AT07788057T patent/ATE503393T1/de not_active IP Right Cessation
- 2007-07-31 CA CA2659948A patent/CA2659948C/en not_active Expired - Fee Related
- 2007-07-31 US US12/309,828 patent/US9717693B2/en not_active Expired - Fee Related
- 2007-07-31 EP EP07788057A patent/EP2046140B1/de not_active Not-in-force
- 2007-07-31 WO PCT/EP2007/057861 patent/WO2008015203A2/en not_active Ceased
- 2007-07-31 DE DE602007013564T patent/DE602007013564D1/de active Active

Also Published As

Publication number	Publication date
WO2008015203A2 (en)	2008-02-07
CA2659948A1 (en)	2008-02-07
EP2046140B1 (de)	2011-03-30
CA2659948C (en)	2013-12-31
ITMI20061583A1 (it)	2008-02-05
EP2046140A2 (de)	2009-04-15
WO2008015203A3 (en)	2008-04-17
US20100112075A1 (en)	2010-05-06
DE602007013564D1 (de)	2011-05-12
US9717693B2 (en)	2017-08-01

Legal Events

Date	Code	Title	Description
2011-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE503393T1 (de)	2011-04-15	Mikropartikelzusammensetzungen und granulat für die oralkontrollierte freisetzung von substanzen zur tierärztlichen verwendung
UA111464C2 (uk)	2016-05-10	Композиція, що містить моногліцериди органічних кислот c1-c7 та гліцерин, та її застосування як протибактеріального та протипліснявого засобу
BR112012019374A2 (pt)	2016-05-03	composição farmacêutica, pellet de liberação prolongada, composição farmacêutica oral, método para tratamento de uma doença neurodegenerativa ou um dano ao sistema nervoso em um indivíduo necessitado do mesmo e método para preparação de uma formulação de liberação prolongada de um agente ativo
MY188458A (en)	2021-12-10	Formulations for animal feed comprising butyrate salt
AR063304A1 (es)	2009-01-21	Nueva composicion para mejorar la calidad de la piel y proceso para preparar la misma
EP2377396A3 (de)	2012-08-22	Harzzusammensetzung mit freisetzungsgesteuerter Agrarchemikalie, Herstellungsverfahren und Agrarchemikalienformulierung
WO2012034055A3 (en)	2012-07-19	Compounds as c-met kinase inhibitors
PL2103214T3 (pl)	2014-03-31	Zastosowanie związków chinoliny, lub ich soli, jako substancji czynnych w środkach do traktowania gleby lub zaprawiania nasion oraz sposób kontrolowania chorób roślin
SK4070U (sk)	2005-02-04	Farmaceutická kompozícia na riadené uvoľňovanie účinných látok
AR064149A1 (es)	2009-03-18	Sal fumarato de (alfa s , beta r)-6 bromo- alfa-[ 2(dimetilamino ) etil)-2- metoxi - alfa-1-naftalenil- beta- fenil-3- quinolinaetanol
EP2592073A3 (de)	2013-05-29	Humane Proteintyrosinphosphathemmer und ihre Verwendung
BR112015002176A2 (pt)	2017-07-04	composições que compreendem uma mistura pesticida de terpeno e um inseticida
JP2009531457A5 (de)	2010-04-22
HRP20230809T1 (hr)	2023-10-27	Liječenje alzheimerove bolesti u određenoj populaciji bolesnika
MX354942B (es)	2018-03-27	Composiciones para la administración oral a animales, procedimientos de obtención de las mismas y sus usos.
CL2008003261A1 (es)	2009-10-16	Composición farmaceutica en forma de suspension que comprende carisbamato, hipromelosa y agua; proceso para prepararla y su uso para tratar enfermedades tales como epilepsia, dolor neuropatico, temblor y esquizofrenia, entre otras.
JP2010533692A5 (de)	2011-09-01
WO2008066380A3 (en)	2008-07-17	Process for the preparation of powdered oils
BRPI0807285A2 (pt)	2014-05-06	"composição, método para preparar composição farmacêutica, forma unitária de dosagem, método para admnistrar um agente biologicamente ativo a um animal necessitando o agente, método para aumentar a biodisponibilidade de um agente biologicamente ativo, método para preparar uma composição e composto"
WO2012049227A3 (en)	2012-07-05	Novel omega-3 and omega-6 fatty acid compositions and uses thereof
BR112012029946A2 (pt)	2016-09-20	encapsulação de ingredientes em matriz de lactose para formar encapsulados ativos
FI3041579T3 (fi)	2023-06-13	Suun kautta annettavia loislääkekoostumuksia
WO2014022761A3 (en)	2015-07-16	Method of protecting active ingredient from degradation during pelleting
BRPI0821373B8 (pt)	2021-05-25	composições farmacêuticas contendo ao menos um princípio ativo protéico protegido de enzimas digestivas
BR112014014130A2 (pt)	2017-06-13	tratamento ou redução de condições dentárias com ésteres de ascorbilo