ATE503747T1 - Verfahren zur herstellung von 6,7-bis(2- methoxyethoxy)-chinazolin-4-on - Google Patents

Verfahren zur herstellung von 6,7-bis(2- methoxyethoxy)-chinazolin-4-on

Info

Publication number: ATE503747T1
Authority: AT; Austria
Prior art keywords: methoxyethoxy; bis; quinazolin; producing; benzoate
Prior art date: 2003-07-30

Application number

AT04748126T

Other languages

English (en)

Inventor

Shigeyoshi Nishino

Kenji Hirotsu

Hidetaka Shima

Hiroyuki Oda

Shinobu Suzuki

Original Assignee

Ube Industries

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-30

Filing date

2004-07-30

Publication date

2011-04-15

2004-07-30 Application filed by Ube Industries filed Critical Ube Industries

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE503747T1 publication Critical patent/ATE503747T1/de

Links

PMQWTUWLIGJTQD-UHFFFAOYSA-N 6,7-bis(2-methoxyethoxy)-1h-quinazolin-4-one Chemical compound N1C=NC(=O)C2=C1C=C(OCCOC)C(OCCOC)=C2 PMQWTUWLIGJTQD-UHFFFAOYSA-N 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
-1 formic acid compound Chemical class 0.000 abstract 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
YZOWMIHUDJVXBH-UHFFFAOYSA-N ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate Chemical compound CCOC(=O)C1=CC(OCCOC)=C(OCCOC)C=C1N YZOWMIHUDJVXBH-UHFFFAOYSA-N 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Catalysts (AREA)

AT04748126T 2003-07-30 2004-07-30 Verfahren zur herstellung von 6,7-bis(2- methoxyethoxy)-chinazolin-4-on ATE503747T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2003282696		2003-07-30
PCT/JP2004/010965 WO2005012264A1 (ja)	2003-07-30	2004-07-30	６，７−ビス（２−メトキシエトキシ）キナゾリン−４−オンの製造法

Publications (1)

Publication Number	Publication Date
ATE503747T1 true ATE503747T1 (de)	2011-04-15

Family

ID=34113782

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04748126T ATE503747T1 (de)	2003-07-30	2004-07-30	Verfahren zur herstellung von 6,7-bis(2- methoxyethoxy)-chinazolin-4-on

Country Status (8)

Country	Link
US (2)	US20060276647A1 (de)
EP (1)	EP1650196B1 (de)
JP (1)	JP4569876B2 (de)
CN (1)	CN100540539C (de)
AT (1)	ATE503747T1 (de)
DE (1)	DE602004032028D1 (de)
ES (1)	ES2362734T3 (de)
WO (1)	WO2005012264A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003064399A1 (fr) *	2002-01-28	2003-08-07	Ube Industries, Ltd.	Procede de production de derive de quinazolin-4-one
EP1841504B1 (de)	2005-01-13	2014-11-19	Bristol-Myers Squibb Company	Substituierte biaryl-verbindungen als faktor-xia-hemmer
CN101798289B (zh) *	2010-02-08	2012-04-18	天津市炜杰科技有限公司	一种埃罗替尼中间体的制备方法
CN102321033B (zh) *	2011-08-22	2013-10-09	江苏辉丰农化股份有限公司	一种它塞瓦的制备方法
WO2013156835A1 (en) *	2012-04-16	2013-10-24	Laurus Labs Private Limited	An improved process for the preparation of erlotinib hydrochloride form a
CN102850279A (zh) *	2012-10-10	2013-01-02	山东金城医药化工股份有限公司	6,7-二(2-甲氧基乙氧基)喹唑啉-4-酮的制备方法
CN104725327B (zh) *	2015-03-03	2017-08-25	山东大学	一种盐酸厄洛替尼的环保制备方法
CN106892821B (zh) *	2015-12-21	2021-06-11	浙江九洲药业股份有限公司	一种3,4-二(2-甲氧基乙氧基)苯甲酸乙酯的制备方法
CN105566233B (zh) *	2015-12-31	2018-08-17	重庆威鹏药业有限公司	厄洛替尼中间体的制备方法
CN106928069B (zh) *	2017-03-21	2019-03-19	上海玉函化工有限公司	一种4,5-二(2-甲氧基乙氧基)-2-硝基苯甲酸乙酯的制备方法
CN108358798A (zh) *	2018-02-12	2018-08-03	黑龙江鑫创生物科技开发有限公司	一种微通道反应器合成厄洛替尼中间体的方法
CN113603650B (zh) *	2021-08-03	2023-03-10	杭州职业技术学院	一种埃罗替尼关键中间体的催化环合制备方法及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3119824A (en) *		1964-01-28		L-substituted-l
US4096144A (en) *	1970-12-08	1978-06-20	Sumitomo Chemical Company, Limited	Process for preparing quinazolinone derivatives and their 2-(N-mono-substituted amino)-phenyl ketone intermediate derivatives
JPS63126867A (ja) *	1986-11-14	1988-05-30	Mitsui Petrochem Ind Ltd	イミダゾ−ル誘導体の製法
JPH0629234B2 (ja) *	1986-12-26	1994-04-20	三井石油化学工業株式会社	α−アシロキシケトン誘導体
PT100905A (pt) *	1991-09-30	1994-02-28	Eisai Co Ltd	Compostos heterociclicos azotados biciclicos contendo aneis de benzeno, ciclo-hexano ou piridina e de pirimidina, piridina ou imidazol substituidos e composicoes farmaceuticas que os contem
US5478852C1 (en) *	1993-09-15	2001-03-13	Sankyo Co	Use of thiazolidinedione derivatives and related antihyperglycemic agents in the treatment of impaired glucose tolerance in order to prevent or delay the onset of noninsulin-dependent diabetes mellitus
US5747498A (en)	1996-05-28	1998-05-05	Pfizer Inc.	Alkynyl and azido-substituted 4-anilinoquinazolines
EP1309567A2 (de) *	2000-08-18	2003-05-14	Millennium Pharmaceuticals, Inc.	Stickstoffhaltige heterozyklische verbindungen
US20040259881A1 (en) *	2001-02-02	2004-12-23	Anjali Pandey	Nitrogenous heterocyclic compounds
JP2002293773A (ja)	2001-03-30	2002-10-09	Sumika Fine Chemicals Co Ltd	キナゾリン誘導体の製造方法
US7132427B2 (en)	2001-06-21	2006-11-07	Ariad Pharmaceuticals, Inc.	Quinazolines and uses thereof
WO2003051849A1 (en) *	2001-12-19	2003-06-26	Ube Industries, Ltd.	Process for producing quinazolin-4-one and derivative thereof
WO2003064399A1 (fr) *	2002-01-28	2003-08-07	Ube Industries, Ltd.	Procede de production de derive de quinazolin-4-one
DE10204150A1 (de)	2002-02-01	2003-08-14	Schott Glas	Erdalkalialuminosilicatglas und Verwendung

2004
- 2004-07-30 WO PCT/JP2004/010965 patent/WO2005012264A1/ja not_active Ceased
- 2004-07-30 ES ES04748126T patent/ES2362734T3/es not_active Expired - Lifetime
- 2004-07-30 JP JP2005512534A patent/JP4569876B2/ja not_active Expired - Fee Related
- 2004-07-30 AT AT04748126T patent/ATE503747T1/de not_active IP Right Cessation
- 2004-07-30 DE DE602004032028T patent/DE602004032028D1/de not_active Expired - Lifetime
- 2004-07-30 CN CNB2004800284205A patent/CN100540539C/zh not_active Expired - Fee Related
- 2004-07-30 EP EP04748126A patent/EP1650196B1/de not_active Expired - Lifetime
- 2004-07-30 US US10/565,981 patent/US20060276647A1/en not_active Abandoned
2009
- 2009-06-15 US US12/484,632 patent/US8133999B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
WO2005012264A1 (ja)	2005-02-10
JP4569876B2 (ja)	2010-10-27
JPWO2005012264A1 (ja)	2007-09-27
EP1650196B1 (de)	2011-03-30
EP1650196A1 (de)	2006-04-26
ES2362734T3 (es)	2011-07-12
US20060276647A1 (en)	2006-12-07
CN100540539C (zh)	2009-09-16
CN1860105A (zh)	2006-11-08
US20090253909A1 (en)	2009-10-08
US8133999B2 (en)	2012-03-13
DE602004032028D1 (de)	2011-05-12
EP1650196A4 (de)	2007-02-28

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Legal Events

Date	Code	Title	Description
2011-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties