ATE503836T1 - Fermentative produktion von sialinsäure (neu5ac) mit hoher ausbeute - Google Patents
Fermentative produktion von sialinsäure (neu5ac) mit hoher ausbeuteInfo
- Publication number
- ATE503836T1 ATE503836T1 AT07820804T AT07820804T ATE503836T1 AT E503836 T1 ATE503836 T1 AT E503836T1 AT 07820804 T AT07820804 T AT 07820804T AT 07820804 T AT07820804 T AT 07820804T AT E503836 T1 ATE503836 T1 AT E503836T1
- Authority
- AT
- Austria
- Prior art keywords
- sialic acid
- neu5ac
- microorganism
- high yield
- fermentative production
- Prior art date
Links
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 title abstract 2
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 title abstract 2
- 238000012262 fermentative production Methods 0.000 title 1
- 244000005700 microbiome Species 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- TXCIAUNLDRJGJZ-UHFFFAOYSA-N CMP-N-acetyl neuraminic acid Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-UHFFFAOYSA-N 0.000 abstract 2
- TXCIAUNLDRJGJZ-BILDWYJOSA-N CMP-N-acetyl-beta-neuraminic acid Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@]1(C(O)=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-BILDWYJOSA-N 0.000 abstract 2
- 241000283986 Lepus Species 0.000 abstract 1
- 101710179749 N-acetylmannosamine kinase Proteins 0.000 abstract 1
- 108700023220 N-acetylneuraminate lyases Proteins 0.000 abstract 1
- 102000048245 N-acetylneuraminate lyases Human genes 0.000 abstract 1
- 108010035265 N-acetylneuraminate synthase Proteins 0.000 abstract 1
- 108091006161 SLC17A5 Proteins 0.000 abstract 1
- 102100029954 Sialic acid synthase Human genes 0.000 abstract 1
- LFTYTUAZOPRMMI-CFRASDGPSA-N UDP-N-acetyl-alpha-D-glucosamine Chemical compound O1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](NC(=O)C)[C@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-CFRASDGPSA-N 0.000 abstract 1
- LFTYTUAZOPRMMI-UHFFFAOYSA-N UNPD164450 Natural products O1C(CO)C(O)C(O)C(NC(=O)C)C1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-UHFFFAOYSA-N 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84864506P | 2006-10-03 | 2006-10-03 | |
| PCT/EP2007/060422 WO2008040717A2 (en) | 2006-10-03 | 2007-10-02 | High yield production of sialic acid (neu5ac) by fermentation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE503836T1 true ATE503836T1 (de) | 2011-04-15 |
Family
ID=39154131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07820804T ATE503836T1 (de) | 2006-10-03 | 2007-10-02 | Fermentative produktion von sialinsäure (neu5ac) mit hoher ausbeute |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20110165626A1 (de) |
| EP (1) | EP2076601B1 (de) |
| JP (1) | JP2010505403A (de) |
| AT (1) | ATE503836T1 (de) |
| CA (1) | CA2665332A1 (de) |
| DE (1) | DE602007013588D1 (de) |
| WO (1) | WO2008040717A2 (de) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101809143A (zh) | 2006-09-26 | 2010-08-18 | 锡拉丘兹大学 | 用于增加唾液酸产量的代谢工程大肠杆菌 |
| BR112012025364A2 (pt) * | 2010-04-07 | 2015-09-22 | Novartis Ag | método para geração de partícula semelhante a vírus de parvovírus b19 |
| WO2013019625A2 (en) * | 2011-07-29 | 2013-02-07 | The University Of Wyoming | Methods of using a bacterial glcnac-6-p 2'-epimerase to promote sialylation of glycoconjugates |
| US9816107B2 (en) | 2011-07-29 | 2017-11-14 | The University Of Wyoming | Transgenic insect cells comprising a bacterial GlcNAc-6-P 2′-epimerase |
| US9783838B2 (en) * | 2011-11-07 | 2017-10-10 | The Regents Of The University Of California | PmST3 enzyme for chemoenzymatic synthesis of alpha-2-3-sialosides |
| ES2930286T3 (es) | 2013-03-14 | 2022-12-09 | Glycosyn LLC | Microorganismos y métodos para producir oligosacáridos sialilados y que contienen N-acetilglucosamina |
| CN103602627B (zh) * | 2013-11-25 | 2015-03-18 | 武汉中科光谷绿色生物技术有限公司 | 一种产n-乙酰神经氨酸大肠杆菌工程菌及其构建方法和应用 |
| EP3149188A1 (de) | 2014-05-27 | 2017-04-05 | Universitetet I Tromsø - Norges Arktiske Universitet | Verwendung einer n-acetylneuraminat-lyase aus dem bakterium aliivibrio salmonicida bei der herstellung von neuraminsäure und derivate davon |
| CN104628794B (zh) * | 2015-03-10 | 2017-05-10 | 武汉中科光谷绿色生物技术有限公司 | 一种对微生物发酵法生产的n‑乙酰神经氨酸进行分离提纯的方法 |
| CN107267577A (zh) * | 2016-04-05 | 2017-10-20 | 孙镧 | 微生物发酵生产n‑乙酰‑d‑氨基葡萄糖和/或d‑氨基葡萄糖盐的方法 |
| EP3473644A1 (de) | 2017-10-17 | 2019-04-24 | Jennewein Biotechnologie GmbH | Fermentative herstellung von n-acetylneuraminsäure |
| EP3486326A1 (de) | 2017-11-21 | 2019-05-22 | Jennewein Biotechnologie GmbH | Verfahren zur reinigung von n-acetylneuraminsäure aus einer fermentationsbrühe |
| FR3110176B1 (fr) | 2020-05-12 | 2022-05-13 | Institut Nat Des Sciences Appliquees De Toulouse | Souche et procédé de production d’oligosaccharides |
| EP4192945A1 (de) * | 2020-08-10 | 2023-06-14 | Inbiose N.V. | Zelluläre herstellung sialylierter di- und/oder oligosaccharide |
| US20240368651A1 (en) * | 2020-08-10 | 2024-11-07 | Inbiose N.V. | Cellular production of di- and/or oligosaccharides |
| CN112342234B (zh) * | 2020-10-27 | 2023-02-21 | 江南大学 | 一种调控n-乙酰神经氨酸产量提高的重组枯草芽孢杆菌 |
| CN113249285A (zh) * | 2021-05-13 | 2021-08-13 | 浙江工业大学 | 一种高产n-乙酰神经氨酸的重组枯草芽孢杆菌及其构建方法、应用 |
| US20240409974A1 (en) * | 2021-10-08 | 2024-12-12 | Kyowa Hakko Bio Co., Ltd. | Microorganism having ability to produce n-acetylneuraminic acid and/or n-acetylneuraminic acid-containing carbohydrate and method for producing n-acetylneuraminic acid and/or n-acetylneuraminic acid-containing carbohydrate using said microorganism |
| CN115125278B (zh) * | 2022-08-25 | 2022-11-18 | 山东合成远景生物科技有限公司 | 一种生产聚唾液酸用的补料液及聚唾液酸制备方法 |
| WO2025032496A1 (en) | 2023-08-07 | 2025-02-13 | Carbocode S.A | Sialylation of glycosphingolipids |
| WO2025032497A1 (en) | 2023-08-07 | 2025-02-13 | Carbocode S.A. | Sialylation method |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE193551T1 (de) | 1991-03-18 | 2000-06-15 | Scripps Research Inst | Oligosaccharide als enzymsubstrate und - inhibitoren: verfahren und zusammensetzungen |
| US7329514B2 (en) | 2002-02-28 | 2008-02-12 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing n-acetylneuraminic acid |
| EP1730293A2 (de) * | 2004-03-17 | 2006-12-13 | Glycofi, Inc. | Verfahren zur konstruktion eines cytidinmonophosphat-sialinsäure-synthesewegs in pilzen und hefen |
| WO2006034225A2 (en) * | 2004-09-17 | 2006-03-30 | Neose Technologies, Inc. | Production of oligosaccharides by microorganisms |
-
2007
- 2007-10-02 US US12/444,081 patent/US20110165626A1/en not_active Abandoned
- 2007-10-02 WO PCT/EP2007/060422 patent/WO2008040717A2/en not_active Ceased
- 2007-10-02 DE DE602007013588T patent/DE602007013588D1/de active Active
- 2007-10-02 EP EP07820804A patent/EP2076601B1/de not_active Not-in-force
- 2007-10-02 JP JP2009530872A patent/JP2010505403A/ja active Pending
- 2007-10-02 CA CA002665332A patent/CA2665332A1/en not_active Abandoned
- 2007-10-02 AT AT07820804T patent/ATE503836T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008040717A2 (en) | 2008-04-10 |
| EP2076601A2 (de) | 2009-07-08 |
| CA2665332A1 (en) | 2008-04-10 |
| JP2010505403A (ja) | 2010-02-25 |
| WO2008040717A3 (en) | 2008-06-12 |
| US20110165626A1 (en) | 2011-07-07 |
| EP2076601B1 (de) | 2011-03-30 |
| DE602007013588D1 (de) | 2011-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |