ATE504647T1 - Chimärer fc gamma rezeptor und verfahren zur bestimmung von adcc-aktivität unter verwendung des rezeptors - Google Patents
Chimärer fc gamma rezeptor und verfahren zur bestimmung von adcc-aktivität unter verwendung des rezeptorsInfo
- Publication number
- ATE504647T1 ATE504647T1 AT08704115T AT08704115T ATE504647T1 AT E504647 T1 ATE504647 T1 AT E504647T1 AT 08704115 T AT08704115 T AT 08704115T AT 08704115 T AT08704115 T AT 08704115T AT E504647 T1 ATE504647 T1 AT E504647T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor
- mouse
- adcc activity
- chimeric
- human
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007020155 | 2007-01-30 | ||
| PCT/JP2008/051333 WO2008093688A1 (ja) | 2007-01-30 | 2008-01-30 | キメラFcγレセプター及び該レセプターを用いたＡＤＣＣ活性測定方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE504647T1 true ATE504647T1 (de) | 2011-04-15 |
Family
ID=39673997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08704115T ATE504647T1 (de) | 2007-01-30 | 2008-01-30 | Chimärer fc gamma rezeptor und verfahren zur bestimmung von adcc-aktivität unter verwendung des rezeptors |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8946385B2 (de) |
| EP (1) | EP2123754B1 (de) |
| JP (1) | JP5299902B2 (de) |
| AT (1) | ATE504647T1 (de) |
| DE (1) | DE602008006041D1 (de) |
| WO (1) | WO2008093688A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2672581A1 (en) * | 2006-12-14 | 2008-06-19 | Forerunner Pharma Research Co., Ltd. | Anti-claudin 3 monoclonal antibody and treatment and diagnosis of cancer using the same |
| EP2123754B1 (de) | 2007-01-30 | 2011-04-06 | Forerunner Pharma Research Co., Ltd. | CHIMÄRER Fc GAMMA REZEPTOR UND VERFAHREN ZUR BESTIMMUNG VON ADCC-AKTIVITÄT UNTER VERWENDUNG DES REZEPTORS |
| WO2010074049A1 (ja) | 2008-12-22 | 2010-07-01 | 株式会社 未来創薬研究所 | 抗hs6st2抗体及びその用途 |
| WO2010073694A1 (ja) | 2008-12-25 | 2010-07-01 | 国立大学法人東京大学 | 抗tm4sf20抗体を用いた癌の診断と治療 |
| RU2011131071A (ru) | 2008-12-26 | 2013-02-10 | Дзе Юниверсити Оф Токио | Диагностика и лечение рака с помощью антитела против lgr7 |
| DK2530091T3 (en) | 2010-01-29 | 2018-05-28 | Chugai Pharmaceutical Co Ltd | ANTI-DLL3 ANTIBODY |
| WO2012144208A1 (ja) | 2011-04-18 | 2012-10-26 | 国立大学法人東京大学 | 抗itm2a抗体を用いる癌の診断および治療 |
| EP2832856A4 (de) | 2012-03-29 | 2016-01-27 | Chugai Pharmaceutical Co Ltd | Anti-lamp5-antikörper und verwendung davon |
| BR112014029417B1 (pt) * | 2012-05-25 | 2023-03-07 | Cellectis | Método ex vivo para a preparação de células t para imunoterapia |
| EP4282419A1 (de) | 2012-12-20 | 2023-11-29 | Purdue Research Foundation | Chimären antigenrezeptor exprimierende t-zellen als antikrebsmittel |
| EP3092304A2 (de) * | 2014-01-08 | 2016-11-16 | 1Globe Biomedical Co., Ltd. | Neuartige synthetische biologiebasierte adcc-technologie |
| CN111690052B (zh) | 2014-04-08 | 2024-06-04 | 瑞泽恩制药公司 | 具有人源化FC-γ受体的非人动物 |
| EP3307876B1 (de) * | 2015-06-10 | 2023-09-13 | ImmunityBio, Inc. | Modifizierte nk-92-zellen zur behandlung von krebs |
| EP3439675A4 (de) | 2016-04-08 | 2019-12-18 | Purdue Research Foundation | Verfahren und zusammensetzungen für car-t-zelltherapie |
| US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| US11311576B2 (en) | 2018-01-22 | 2022-04-26 | Seattle Children's Hospital | Methods of use for CAR T cells |
| US12312416B2 (en) | 2018-02-06 | 2025-05-27 | Seattle Children's Hospital | Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors |
| AU2019225174B2 (en) | 2018-02-23 | 2025-11-20 | Endocyte, Inc. | Sequencing method for CAR T cell therapy |
| EP3768313A4 (de) | 2018-03-20 | 2022-01-05 | Yuh, Chiou Hwa | Gegen vegfr2 und vegfr3 gerichtee doppelfunktionsantikörper |
| IL314733A (en) | 2018-03-26 | 2024-10-01 | Regeneron Pharma | Humanized rodents for testing therapeutic agents |
| CN115210252A (zh) | 2020-02-04 | 2022-10-18 | 西雅图儿童医院（Dba西雅图儿童研究所） | 抗二硝基苯酚的嵌合抗原受体 |
| US11661459B2 (en) | 2020-12-03 | 2023-05-30 | Century Therapeutics, Inc. | Artificial cell death polypeptide for chimeric antigen receptor and uses thereof |
| KR20230118887A (ko) | 2020-12-03 | 2023-08-14 | 센츄리 쎄라퓨틱스 인코포레이티드 | 유전자 조작 세포 및 이의 용도 |
| AR124414A1 (es) | 2020-12-18 | 2023-03-22 | Century Therapeutics Inc | Sistema de receptor de antígeno quimérico con especificidad de receptor adaptable |
| EP4448561A2 (de) * | 2021-12-14 | 2024-10-23 | Dana-Farber Cancer Institute, Inc. | Zusammensetzungen und verfahren zur behandlung von krankheiten |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| DE69535243T2 (de) | 1994-07-13 | 2007-05-10 | Chugai Seiyaku K.K. | Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper |
| EP0962467A4 (de) | 1996-09-26 | 2002-10-30 | Chugai Pharmaceutical Co Ltd | Antikörper gegen menschliches parathormon verwandten peptide |
| JP4033390B2 (ja) | 2002-10-30 | 2008-01-16 | 独立行政法人科学技術振興機構 | 不死化ナチュラルキラー細胞株 |
| JPWO2006067847A1 (ja) | 2004-12-22 | 2008-06-12 | 中外製薬株式会社 | フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法 |
| EP2123754B1 (de) | 2007-01-30 | 2011-04-06 | Forerunner Pharma Research Co., Ltd. | CHIMÄRER Fc GAMMA REZEPTOR UND VERFAHREN ZUR BESTIMMUNG VON ADCC-AKTIVITÄT UNTER VERWENDUNG DES REZEPTORS |
-
2008
- 2008-01-30 EP EP08704115A patent/EP2123754B1/de active Active
- 2008-01-30 US US12/525,031 patent/US8946385B2/en active Active
- 2008-01-30 JP JP2008556119A patent/JP5299902B2/ja not_active Expired - Fee Related
- 2008-01-30 AT AT08704115T patent/ATE504647T1/de not_active IP Right Cessation
- 2008-01-30 WO PCT/JP2008/051333 patent/WO2008093688A1/ja not_active Ceased
- 2008-01-30 DE DE602008006041T patent/DE602008006041D1/de active Active
-
2014
- 2014-12-01 US US14/556,684 patent/US9733245B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20150079610A1 (en) | 2015-03-19 |
| EP2123754A4 (de) | 2010-01-27 |
| EP2123754A1 (de) | 2009-11-25 |
| JPWO2008093688A1 (ja) | 2010-05-20 |
| US20100035280A1 (en) | 2010-02-11 |
| US9733245B2 (en) | 2017-08-15 |
| US8946385B2 (en) | 2015-02-03 |
| JP5299902B2 (ja) | 2013-09-25 |
| DE602008006041D1 (de) | 2011-05-19 |
| EP2123754B1 (de) | 2011-04-06 |
| WO2008093688A1 (ja) | 2008-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |