ATE505474T1 - Inhibitoren von nukleosidphosphorylasen und nukleosidasen - Google Patents

Inhibitoren von nukleosidphosphorylasen und nukleosidasen

Info

Publication number: ATE505474T1
Authority: AT; Austria
Prior art keywords: inhibitors; compounds; phosphorylases; nucleosidases; methylthioadenosine
Prior art date: 2002-08-21

Application number

AT03792904T

Other languages

English (en)

Inventor

Gary Brian Evans

Richard Hubert Furneaux

Dirk Henning Lenz

Vern L Schramm

Peter Charles Tyler

Olga Vladimirovna Zubkova

Original Assignee

Einstein Coll Med

Ind Res Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-08-21

Filing date

2003-08-21

Publication date

2011-04-15

2003-08-21 Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med

2011-04-15 Application granted granted Critical

2011-04-15 Publication of ATE505474T1 publication Critical patent/ATE505474T1/de

Links

102000010722 N-Glycosyl Hydrolases Human genes 0.000 title abstract 3
108010063372 N-Glycosyl Hydrolases Proteins 0.000 title abstract 3
102000009097 Phosphorylases Human genes 0.000 title abstract 2
108010073135 Phosphorylases Proteins 0.000 title abstract 2
239000003112 inhibitor Substances 0.000 title abstract 2
239000002777 nucleoside Substances 0.000 title 1
150000003833 nucleoside derivatives Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
102100034187 S-methyl-5'-thioadenosine phosphorylase Human genes 0.000 abstract 2
201000010099 disease Diseases 0.000 abstract 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
WUUGFSXJNOTRMR-IOSLPCCCSA-N 5'-S-methyl-5'-thioadenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CSC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 WUUGFSXJNOTRMR-IOSLPCCCSA-N 0.000 abstract 1
108010034457 5'-methylthioadenosine phosphorylase Proteins 0.000 abstract 1
101710185027 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Proteins 0.000 abstract 1
101710081557 Aminodeoxyfutalosine nucleosidase Proteins 0.000 abstract 1
208000035143 Bacterial infection Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
206010037075 Protozoal infections Diseases 0.000 abstract 1
101710136206 S-methyl-5'-thioadenosine phosphorylase Proteins 0.000 abstract 1
210000001744 T-lymphocyte Anatomy 0.000 abstract 1
208000022362 bacterial infectious disease Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
208000015181 infectious disease Diseases 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
108010091901 purine phosphoribosyltransferase Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Dermatology (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Investigating Or Analysing Biological Materials (AREA)
Pyrane Compounds (AREA)
Seal Device For Vehicle (AREA)

AT03792904T 2002-08-21 2003-08-21 Inhibitoren von nukleosidphosphorylasen und nukleosidasen ATE505474T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
NZ52091902		2002-08-21
PCT/NZ2003/000186 WO2004018496A1 (en)	2002-08-21	2003-08-21	Inhibitors of nucleoside phosphorylases and nucleosidases

Publications (1)

Publication Number	Publication Date
ATE505474T1 true ATE505474T1 (de)	2011-04-15

Family

ID=31944950

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT03792904T ATE505474T1 (de)	2002-08-21	2003-08-21	Inhibitoren von nukleosidphosphorylasen und nukleosidasen

Country Status (17)

Country	Link
US (2)	US7553839B2 (de)
EP (1)	EP1539783B1 (de)
JP (1)	JP4682314B2 (de)
KR (1)	KR101081226B1 (de)
CN (1)	CN100379750C (de)
AT (1)	ATE505474T1 (de)
AU (1)	AU2003258911B2 (de)
BR (1)	BRPI0313664B8 (de)
CA (1)	CA2496698C (de)
CY (1)	CY1111700T1 (de)
DE (1)	DE60336734D1 (de)
DK (1)	DK1539783T3 (de)
ES (1)	ES2363766T3 (de)
PT (1)	PT1539783E (de)
RU (1)	RU2330042C2 (de)
SI (1)	SI1539783T1 (de)
WO (1)	WO2004018496A1 (de)

Families Citing this family (42)

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US5985848A (en) *	1997-10-14	1999-11-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside metabolism
PT1165564E (pt)	1999-04-08	2009-04-16	Einstein Coll Med	Processo para a preparação de inibidores do metabolismo de nucleósidos
US7553839B2 (en)	2002-08-21	2009-06-30	Industrial Research Limited	5h-pyrrolo[3,2-D] pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
NZ523970A (en) *	2003-02-04	2005-02-25	Ind Res Ltd	Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
CN1871240B (zh) *	2003-08-26	2012-11-07	帝人制药株式会社	吡咯并嘧啶酮衍生物
US7557113B2 (en)	2003-08-26	2009-07-07	Teijin Pharma Limited	Substituted pyrrolo[3,2-d]pyrimidine derivatives
NZ533360A (en) *	2004-06-04	2007-02-23	Ind Res Ltd	Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
WO2006014913A2 (en) *	2004-07-27	2006-02-09	Biocryst Pharmaceuticals, Inc.	Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase
NZ540160A (en) *	2005-05-20	2008-03-28	Einstein Coll Med	Inhibitors of nucleoside phosphorylases
WO2007016291A2 (en) *	2005-07-27	2007-02-08	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) *	2005-12-15	2008-07-31	Ind Res Ltd	Deazapurine analogs of 1'-aza-l-nucleosides
US20090053221A1 (en) *	2006-01-17	2009-02-26	Cheung Nai-Kong V	Immune response enhancing glucan
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AU2006200809B2 (en) *	2006-02-24	2013-11-07	Albert Einstein College Of Medicine Of Yeshiva University	Methods of treating cancer
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WO2007097647A1 (en) *	2006-02-24	2007-08-30	Albert Einstein College Of Medicine Of Yeshiva University	Methods of treating cancer
CN101094080B (zh) *	2006-06-22	2012-06-20	华为技术有限公司	一种即按即通系统中的计费方法
US8383636B2 (en) *	2006-09-07	2013-02-26	Industrial Research Limited	Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
ES2362805T3 (es)	2006-09-07	2011-07-13	Industrial Research Limited	Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas.
DK2114925T3 (da) *	2006-12-22	2012-05-29	Ind Res Ltd	Azetidin-analoger af nucleosidase- og phosphorylase-inhibitorer
WO2009082247A1 (en) *	2007-12-21	2009-07-02	Industrial Research Limited	Process for preparing immucillins having a methylene link
UA103195C2 (uk)	2008-08-11	2013-09-25	Глаксосмитклайн Ллк	Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
WO2010033236A2 (en)	2008-09-22	2010-03-25	Albert Einstein College Of Medicine Of Yeshiva University	Methods and compositions for treating bacterial infections by inhibiting quorum sensing
MX2011009928A (es) *	2009-03-24	2012-03-16	Biocryst Pharm Inc	Sales farmaceuticas utiles de 7[(3r, 4r)-3-hidroxi-4-hidroximetil- pirrolidin-1-ilmetil]-3,5-dihidro-pirrol[3,2-d]pirimidin-4-ona.
JP5861243B2 (ja)	2009-07-17	2016-02-16	アルバートアインシュタインカレッジオブメディシンオブイエシバユニバーシティ	５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤
US9290501B2 (en)	2010-11-29	2016-03-22	Albert Einstein College Of Medicine, Inc.	Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
WO2012122532A2 (en) *	2011-03-09	2012-09-13	Biocryst Pharmaceuticals, Inc.	Compositions and methods for treatment of hyperuricemia
WO2013014052A1 (en)	2011-07-22	2013-01-31	Glaxosmithkline Llc	Composition
JP6063571B2 (ja)	2012-08-07	2017-01-18	アルバートアインシュタインカレッジオブメディシン，インコーポレイティド	ヘリコバクター・ピロリ感染の治療
US9173872B2 (en)	2012-08-24	2015-11-03	Glaxosmithkline Llc	Pyrazolopyrimidine compounds
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JP6216387B2 (ja)	2012-11-20	2017-10-18	グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅＬＬＣ	新規化合物
SMT201700378T1 (it)	2012-11-20	2017-09-07	Glaxosmithkline Llc	Nuovi composti
KR20150085081A (ko)	2012-11-20	2015-07-22	글락소스미스클라인 엘엘씨	신규 화합물
WO2014205199A2 (en)	2013-06-22	2014-12-24	Nitor Therapeutics	Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency
EP3104707B1 (de)	2014-02-12	2020-07-15	Albert Einstein College of Medicine, Inc.	Behandlung von infektionen mit h. pylori mittels mtan-inhibitoren
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US5985848A (en)	1997-10-14	1999-11-16	Albert Einstein College Of Medicine Of Yeshiva University	Inhibitors of nucleoside metabolism
PT1165564E (pt)	1999-04-08	2009-04-16	Einstein Coll Med	Processo para a preparação de inibidores do metabolismo de nucleósidos
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NZ523970A (en)	2003-02-04	2005-02-25	Ind Res Ltd	Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en)	2004-06-04	2007-02-23	Ind Res Ltd	Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
WO2006014913A2 (en)	2004-07-27	2006-02-09	Biocryst Pharmaceuticals, Inc.	Inhibitors of 5'-methylthioadenosine phosphorylase and 5'methylthioadenosine/s-adenosylhomocysteine nucleosidase
NZ540160A (en)	2005-05-20	2008-03-28	Einstein Coll Med	Inhibitors of nucleoside phosphorylases
WO2007016291A2 (en)	2005-07-27	2007-02-08	Albert Einstein College Of Medicine Of Yeshiva University	Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en)	2005-12-15	2008-07-31	Ind Res Ltd	Deazapurine analogs of 1'-aza-l-nucleosides
WO2007097647A1 (en)	2006-02-24	2007-08-30	Albert Einstein College Of Medicine Of Yeshiva University	Methods of treating cancer
JP2009528996A (ja)	2006-02-24	2009-08-13	インダストリアルリサーチリミテッド	ヌクレオシドホスホリラーゼ及びヌクレオシダーゼの阻害剤を用いて疾患を処置する方法
ES2362805T3 (es)	2006-09-07	2011-07-13	Industrial Research Limited	Inhibidores aminoacíclicos de nucleósido fosforilasas e hidrolasas.
US8383636B2 (en)	2006-09-07	2013-02-26	Industrial Research Limited	Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
EP2066671A1 (de)	2006-09-26	2009-06-10	Albert Einstein College Of Medicine Of Yeshiva University	Übergangsstatus-struktur menschlicher 5'-methylthioadenosin-phosphorylase
DK2114925T3 (da)	2006-12-22	2012-05-29	Ind Res Ltd	Azetidin-analoger af nucleosidase- og phosphorylase-inhibitorer
WO2009082247A1 (en)	2007-12-21	2009-07-02	Industrial Research Limited	Process for preparing immucillins having a methylene link
WO2010033236A2 (en)	2008-09-22	2010-03-25	Albert Einstein College Of Medicine Of Yeshiva University	Methods and compositions for treating bacterial infections by inhibiting quorum sensing
JP5861243B2 (ja)	2009-07-17	2016-02-16	アルバートアインシュタインカレッジオブメディシンオブイエシバユニバーシティ	５’−メチルチオアデノシンホスホリラーゼ及びヌクレオシダーゼの３−ヒドロキシピロリジン阻害剤

2003
- 2003-08-21 US US10/524,995 patent/US7553839B2/en not_active Expired - Lifetime
- 2003-08-21 SI SI200332011T patent/SI1539783T1/sl unknown
- 2003-08-21 ES ES03792904T patent/ES2363766T3/es not_active Expired - Lifetime
- 2003-08-21 EP EP03792904A patent/EP1539783B1/de not_active Expired - Lifetime
- 2003-08-21 CN CNB038243547A patent/CN100379750C/zh not_active Expired - Lifetime
- 2003-08-21 RU RU2005107714/04A patent/RU2330042C2/ru active
- 2003-08-21 DK DK03792904.9T patent/DK1539783T3/da active
- 2003-08-21 DE DE60336734T patent/DE60336734D1/de not_active Expired - Lifetime
- 2003-08-21 AU AU2003258911A patent/AU2003258911B2/en not_active Expired
- 2003-08-21 WO PCT/NZ2003/000186 patent/WO2004018496A1/en not_active Ceased
- 2003-08-21 AT AT03792904T patent/ATE505474T1/de active
- 2003-08-21 JP JP2004530687A patent/JP4682314B2/ja not_active Expired - Lifetime
- 2003-08-21 BR BRPI0313664A patent/BRPI0313664B8/pt active IP Right Grant
- 2003-08-21 CA CA2496698A patent/CA2496698C/en not_active Expired - Lifetime
- 2003-08-21 KR KR1020057002959A patent/KR101081226B1/ko not_active Expired - Lifetime
- 2003-08-21 PT PT03792904T patent/PT1539783E/pt unknown
2009
- 2009-06-03 US US12/455,537 patent/US8173662B2/en not_active Expired - Lifetime
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JP2006501239A (ja)	2006-01-12
RU2330042C2 (ru)	2008-07-27
SI1539783T1 (sl)	2011-08-31
AU2003258911A1 (en)	2004-03-11
US20090239885A1 (en)	2009-09-24
CA2496698C (en)	2012-01-24
BR0313664A (pt)	2005-07-12
US7553839B2 (en)	2009-06-30
EP1539783B1 (de)	2011-04-13
DK1539783T3 (da)	2011-06-20
BRPI0313664B8 (pt)	2021-05-25
CN100379750C (zh)	2008-04-09
WO2004018496A1 (en)	2004-03-04
CN1692120A (zh)	2005-11-02
KR20050093756A (ko)	2005-09-23
HK1085219A1 (zh)	2006-08-18
CA2496698A1 (en)	2004-03-04
EP1539783A1 (de)	2005-06-15
US20060160765A1 (en)	2006-07-20
PT1539783E (pt)	2011-06-01
RU2005107714A (ru)	2006-01-20
EP1539783A4 (de)	2010-05-19
AU2003258911B2 (en)	2009-11-19
DE60336734D1 (de)	2011-05-26
JP4682314B2 (ja)	2011-05-11
BRPI0313664B1 (pt)	2021-03-23
ES2363766T3 (es)	2011-08-16
US8173662B2 (en)	2012-05-08
KR101081226B1 (ko)	2011-11-07
CY1111700T1 (el)	2015-10-07

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