ATE506392T1 - Blockcopolymer für wirkstoffkonjugate und deren pharmazeutische zusammensetzungen - Google Patents

Blockcopolymer für wirkstoffkonjugate und deren pharmazeutische zusammensetzungen

Info

Publication number
ATE506392T1
ATE506392T1 AT07830599T AT07830599T ATE506392T1 AT E506392 T1 ATE506392 T1 AT E506392T1 AT 07830599 T AT07830599 T AT 07830599T AT 07830599 T AT07830599 T AT 07830599T AT E506392 T1 ATE506392 T1 AT E506392T1
Authority
AT
Austria
Prior art keywords
pharmaceutical compositions
block copolymers
drug conjugates
polyethylene glycol
block copolymer
Prior art date
Application number
AT07830599T
Other languages
English (en)
Inventor
Iulian Bobe
Naoya Shibata
Hiroyuki Saito
Mitsunori Harada
Original Assignee
Nanocarrier Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanocarrier Co Ltd filed Critical Nanocarrier Co Ltd
Application granted granted Critical
Publication of ATE506392T1 publication Critical patent/ATE506392T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3324—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic
    • C08G65/3326—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof cyclic aromatic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33303—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group
    • C08G65/33306—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing amino group acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C08L71/02—Polyalkylene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G2650/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G2650/28—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type
    • C08G2650/50—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule characterised by the polymer type containing nitrogen, e.g. polyetheramines or Jeffamines(r)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/05—Polymer mixtures characterised by other features containing polymer components which can react with one another
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L77/00—Compositions of polyamides obtained by reactions forming a carboxylic amide link in the main chain; Compositions of derivatives of such polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
AT07830599T 2006-10-19 2007-10-19 Blockcopolymer für wirkstoffkonjugate und deren pharmazeutische zusammensetzungen ATE506392T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006285469 2006-10-19
PCT/JP2007/070865 WO2008047948A1 (en) 2006-10-19 2007-10-19 Block copolymer for drug complex and pharmaceutical composition

Publications (1)

Publication Number Publication Date
ATE506392T1 true ATE506392T1 (de) 2011-05-15

Family

ID=39314155

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07830599T ATE506392T1 (de) 2006-10-19 2007-10-19 Blockcopolymer für wirkstoffkonjugate und deren pharmazeutische zusammensetzungen

Country Status (13)

Country Link
US (1) US8519051B2 (de)
EP (1) EP2077293B1 (de)
JP (1) JP4781435B2 (de)
KR (1) KR101444274B1 (de)
CN (2) CN102516533B (de)
AT (1) ATE506392T1 (de)
AU (1) AU2007311980B2 (de)
CA (1) CA2666697C (de)
DE (1) DE602007014087D1 (de)
DK (1) DK2077293T3 (de)
ES (1) ES2364987T3 (de)
NZ (1) NZ575964A (de)
WO (1) WO2008047948A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2718003C (en) * 2008-03-10 2016-05-03 The University Of Tokyo Copolymer including uncharged hydrophilic block and cationic polyamino acid block having hydrophobic group in part of side chains, and use thereof
WO2010013836A1 (ja) * 2008-07-29 2010-02-04 ナノキャリア株式会社 薬物内包アクティブターゲット型高分子ミセル、医薬組成物
EP2474306B1 (de) * 2009-08-31 2016-11-09 NanoCarrier Co., Ltd. Partikelzusammensetzung und medizinische vorrichtung damit
JP4829351B2 (ja) * 2010-02-05 2011-12-07 ナノキャリア株式会社 易崩壊型ポリマーミセル組成物
CN103502319B (zh) * 2011-03-31 2015-11-25 那野伽利阿株式会社 包含含有硼酸化合物的嵌段共聚物的医药组合物
BR112014011831A2 (pt) 2011-11-17 2017-05-09 Nat Univ Corp Tokyo Medical & Dental Univ copolímero em bloco tendo grupo ácido fenilborônico nele introduzido e o uso deste
US9919059B2 (en) 2012-12-10 2018-03-20 Massachusetts Institute Of Technology Multistage nanoparticle drug delivery system for the treatment of solid tumors
EP2942348B1 (de) 2014-05-07 2017-10-25 Johannes Gutenberg-Universität Mainz Thiol-geschützte Aminosäurederivate und ihre Verwendungen
WO2015170757A1 (ja) 2014-05-08 2015-11-12 国立大学法人 東京大学 医薬組成物
JP6235755B2 (ja) 2014-07-02 2017-11-22 ザ リサーチ ファウンデイション フォー ザ ステイト ユニバーシティー オブ ニューヨーク 高いカーゴ対サーファクタント比を有するサーファクタント除去ミセル組成物
EP3181136B1 (de) * 2014-08-11 2019-11-27 The University of Tokyo Mizelle mit epirubicin-komplexiertem blockcopolymer und antikrebsmittel und pharmazeutische zusammensetzungen mit dieser mizelle zur behandlung von krebs, resistentem krebs oder metastasierendem krebs
US10328159B2 (en) * 2014-10-03 2019-06-25 Engenic Molecular Delivery Pty Ltd. Enhanced loading of intact, bacterially derived vesicles with small molecule compounds
US10232050B1 (en) 2014-12-12 2019-03-19 Clemson University Multi-functional particles and methods of using the same
US11633355B2 (en) 2014-12-12 2023-04-25 Clemson University Research Foundation Multi-functional particles and methods of using the same
TW201737946A (zh) * 2016-03-30 2017-11-01 Nanocarrier Co Ltd 藥物複合化嵌段共聚合體、嵌段共聚合體及藥物複合化嵌段共聚合體之製造方法
CN106008964B (zh) * 2016-05-20 2018-07-03 中国科学院长春应用化学研究所 一种水溶性的氨基酸嵌段共聚物及其制备方法和应用
EP3960242B8 (de) * 2019-04-24 2025-03-12 Institute Of Science Tokyo Konjugat und krebstherapeutikum
BR112023000886A2 (pt) * 2020-07-31 2023-02-07 Toray Industries Método para avaliar a pureza de um fármaco, complexo ou sal farmaceuticamente aceitável do mesmo, e, método para produzir um complexo ou um sal farmaceuticamente aceitável do mesmo
CN112675148B (zh) * 2020-12-30 2023-08-11 内蒙古民族大学 一种多功能高效药物递送系统及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2864143B2 (ja) 1990-03-20 1999-03-03 富士通株式会社 信号検出回路
JP3270592B2 (ja) 1992-10-26 2002-04-02 日本化薬株式会社 ブロック共重合体−抗癌剤複合体医薬製剤
JP3682475B2 (ja) 1993-08-31 2005-08-10 靖久 桜井 水溶性抗癌剤
WO1997012895A1 (fr) 1995-09-29 1997-04-10 Japan Science And Technology Corporation Nouveaux derives de composes d'anthracycline, et preparations medicamenteuses les contenant
JPH11335267A (ja) * 1998-05-27 1999-12-07 Nano Career Kk 水難溶性薬物を含有するポリマーミセル系
JP3523821B2 (ja) * 2000-02-09 2004-04-26 ナノキャリア株式会社 薬物が封入されたポリマーミセルの製造方法および該ポリマーミセル組成物
JP2003034653A (ja) 2001-07-17 2003-02-07 Dai Ichi Seiyaku Co Ltd 最適化されたｄｄｓ化合物
JP2004018494A (ja) 2002-06-19 2004-01-22 Japan Science & Technology Corp ブロック共重合体−薬剤複合体の製造法
US20050129731A1 (en) * 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
JPWO2005054302A1 (ja) 2003-12-05 2007-12-06 中外製薬株式会社 薬物担体及びその製造方法
WO2006115293A1 (ja) 2005-04-22 2006-11-02 The University Of Tokyo ｐＨ応答性高分子ミセルの調製に用いる新規ブロック共重合体及びその製造法

Also Published As

Publication number Publication date
JP4781435B2 (ja) 2011-09-28
AU2007311980B2 (en) 2012-05-31
KR20090066302A (ko) 2009-06-23
ES2364987T3 (es) 2011-09-20
WO2008047948A1 (en) 2008-04-24
CA2666697C (en) 2015-03-31
US20100298495A1 (en) 2010-11-25
EP2077293B1 (de) 2011-04-20
DK2077293T3 (da) 2011-08-15
AU2007311980A1 (en) 2008-04-24
CA2666697A1 (en) 2008-04-24
JPWO2008047948A1 (ja) 2010-02-25
CN102516533A (zh) 2012-06-27
KR101444274B1 (ko) 2014-09-26
CN101528815B (zh) 2011-12-28
US8519051B2 (en) 2013-08-27
CN101528815A (zh) 2009-09-09
CN102516533B (zh) 2015-04-29
DE602007014087D1 (de) 2011-06-01
HK1130073A1 (en) 2009-12-18
EP2077293A1 (de) 2009-07-08
EP2077293A4 (de) 2009-12-23
NZ575964A (en) 2011-12-22

Similar Documents

Publication Publication Date Title
DE602007014087D1 (de) Blockcopolymer für wirkstoffkonjugate und deren pharmazeutische zusammensetzungen
CY1123035T1 (el) Μεθοδοι και συνθεσεις με βαση συζευγματα τοξινης της διφθεριτιδας-ιντερλευκινης-3
ATE505551T1 (de) Konjugate zur zuführung an knochen und verfahren zu deren verwendung beim hinführen von proteinen zum knochen
NO20083573L (no) Amfifile polymerer for opploseliggjoring og malrettet avgivelse av legemidler
ATE432955T1 (de) Polyglutamat-aminosäure-konjugate und verfahren
WO2006110776A3 (en) Polyethylene glycol cojugates of antimicrobial agents
WO2007148230A3 (en) Grafted polymers and uses thereof
WO2008124735A3 (en) Multi-functional polyglutamate drug carriers
MY157914A (en) Oral compositions comprising siloxane polymers
BRPI0414017B8 (pt) pró-fármaco polimérico de múltiplos braços, composição farmacêutica e método para a preparação de um pró-fármaco polimérico de múltiplos braços.
WO2008141110A3 (en) Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs
EA200301250A1 (ru) Фармацевтические композиции, содержащие слаборастворимые и/или чувствительные к кислотам лекарственные средства и нейтрализованные кислотные полимеры
BRPI0604313A (pt) estrutura polimérica semelhante a dendrìmero para a produção de conjugados de interesse farmacêutico
WO2008085556A3 (en) Surfactant-free nanoparticles for drug delivery
DK1543063T3 (da) Medikament levering
BRPI0511966A (pt) composições farmacêuticas contendo polietileno glicol tendo um peso molecular menor do que 600 daltons
WO2004062588A3 (en) Water-soluble polymeric bone-targeting drug delivery system
WO2008141107A8 (en) Compositions that include a hydrophobic compound and a polyamino acid conjugate
WO2007149804A3 (en) Lactam polymer derivatives
MX2010004899A (es) Conjugados de neurturina novedosos para uso farmaceutico.
SI1868581T1 (sl) Farmacevtski sestavki z izboljšanim profilom topnosti za slabo topna zdravila
TW200624464A (en) Amphiphilic block copolymer and pharmaceutical formulation comprising the same
WO2006102484A3 (en) Symmetrically branched polymer conjugates and microarray assays
MY153244A (en) Solubilization and targeted delivery of drugs with self-assembling amphiphilic polymers
UA109646C2 (uk) Терапевтичне застосування кон'югатів білка з полімером

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 2077293

Country of ref document: EP